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Article

The Laforin-Malin Complex Negatively Regulates Glycogen Synthesis by Modulating Cellular Glucose Uptake via Glucose Transporters

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Pages 652-663 | Received 28 Sep 2011, Accepted 16 Nov 2011, Published online: 20 Mar 2023

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Inés Maestro, Patricia Boya & Ana Martinez. (2020) Serum- and glucocorticoid-induced kinase 1, a new therapeutic target for autophagy modulation in chronic diseases. Expert Opinion on Therapeutic Targets 24:3, pages 231-243.
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L. Kumarasinghe, M.A. Garcia-Gimeno, J. Ramirez, U. Mayor, J.L. Zugaza & P. Sanz. (2023) P-Rex1 is a novel substrate of the E3 ubiquitin ligase Malin associated with Lafora disease. Neurobiology of Disease 177, pages 105998.
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Samantha A. Streicher, Unhee Lim, S. Lani Park, Yuqing Li, Xin Sheng, Victor Hom, Lucy Xia, Loreall Pooler, John Shepherd, Lenora W. M. Loo, Burcu F. Darst, Heather M. Highland, Linda M. Polfus, David Bogumil, Thomas Ernst, Steven Buchthal, Adrian A. Franke, Veronica Wendy Setiawan, Maarit Tiirikainen, Lynne R. Wilkens, Christopher A. Haiman, Daniel O. Stram, Iona Cheng & Loïc Le Marchand. (2021) Genome-wide association study of pancreatic fat: The Multiethnic Cohort Adiposity Phenotype Study. PLOS ONE 16:7, pages e0249615.
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Komal Taneja & Subramaniam Ganesh. (2020) Dendritic spine abnormalities correlate with behavioral and cognitive deficits in mouse models of Lafora disease. Journal of Comparative Neurology 529:6, pages 1099-1120.
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Priyanka Sinha, Bhupender Verma & Subramaniam Ganesh. (2020) Trehalose Ameliorates Seizure Susceptibility in Lafora Disease Mouse Models by Suppressing Neuroinflammation and Endoplasmic Reticulum Stress. Molecular Neurobiology 58:3, pages 1088-1101.
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Chunyu Li, Qianqian Wei, Xiaojing Gu, Yongping Chen, Xueping Chen, Bei Cao, Ruwei Ou & Huifang Shang. (2019) Decreased Glycogenolysis by miR-338-3p Promotes Regional Glycogen Accumulation Within the Spinal Cord of Amyotrophic Lateral Sclerosis Mice. Frontiers in Molecular Neuroscience 12.
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Ramona C. Nicolescu, Sara Al-Khawaga, Berge A. Minassian & Khalid Hussain. (2019) Diabetes Mellitus in a Patient With Lafora Disease: Possible Links With Pancreatic β-Cell Dysfunction and Insulin Resistance. Frontiers in Pediatrics 6.
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Anupama Rai & Subramaniam Ganesh. 2019. Models, Molecules and Mechanisms in Biogerontology. Models, Molecules and Mechanisms in Biogerontology 57 89 .
M. Kathryn Brewer & Matthew S. Gentry. 2019. Brain Glycogen Metabolism. Brain Glycogen Metabolism 17 81 .
Maria García-Gimeno, Erwin Knecht & Pascual Sanz. (2018) Lafora Disease: A Ubiquitination-Related Pathology. Cells 7:8, pages 87.
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Rashmi Parihar, Anupama Rai & Subramaniam Ganesh. (2018) Lafora disease: from genotype to phenotype. Journal of Genetics 97:3, pages 611-624.
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Anupama Rai, Pankaj Kumar Singh, Virender Singh, Vipendra Kumar, Rohit Mishra, Ashwani Kumar Thakur, Anita Mahadevan, Susarla Krishna Shankar, Nihar Ranjan Jana & Subramaniam Ganesh. (2018) Glycogen synthase protects neurons from cytotoxicity of mutant huntingtin by enhancing the autophagy flux. Cell Death & Disease 9:2.
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M. Kathryn Brewer, Amanda R. Sherwood, Vikas V. Dukhande & Matthew S. Gentry. 2018. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 2803 2815 .
Anupama Rai, Rohit Mishra & Subramaniam Ganesh. (2017) Suppression of leptin signaling reduces polyglucosan inclusions and seizure susceptibility in a mouse model for Lafora disease. Human Molecular Genetics 26:24, pages 4778-4785.
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Mamta Upadhyay, Saloni Agarwal, Pratibha Bhadauriya & Subramaniam Ganesh. (2017) Loss of laforin or malin results in increased Drp1 level and concomitant mitochondrial fragmentation in Lafora disease mouse models. Neurobiology of Disease 100, pages 39-51.
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M. Kathryn Brewer, Amanda R. Sherwood, Vikas V. Dukhande & Matthew S. Gentry. 2017. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 1 13 .
Navodita Jain, Rohit Mishra & Subramaniam Ganesh. (2016) FoxO3a-mediated autophagy is down-regulated in the laforin deficient mice, an animal model for Lafora progressive myoclonus epilepsy. Biochemical and Biophysical Research Communications 474:2, pages 321-327.
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Yvonne Oligschlaeger, Marie Miglianico, Vivian Dahlmans, Carla Rubio-Villena, Dipanjan Chanda, Maria Adelaida Garcia-Gimeno, Will A. Coumans, Yilin Liu, J. Willem Voncken, Joost J.F.P. Luiken, Jan F.C. Glatz, Pascual Sanz & Dietbert Neumann. (2016) The interaction between AMPKβ2 and the PP1-targeting subunit R6 is dynamically regulated by intracellular glycogen content. Biochemical Journal 473:7, pages 937-947.
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David M. Dias, Joana Furtado, Emeric Wasielewski, Rui Cruz, Bernard CostelloLindsay ColeTiago Q. Faria, Philipp Baaske, Rui M.  M. Brito, Alessio CiulliIsaura Simões, Sandra Macedo-Ribeiro, Carlos Faro, Carlos F. G. C. Geraldes & Pedro Castanheira. (2016) Biophysical characterization of laforin–carbohydrate interaction. Biochemical Journal 473:3, pages 335-345.
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Pankaj Kumar Singh & Subramaniam Ganesh. 2016. Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging. Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging 187 195 .
M. Kathryn Brewer, Amanda R. Sherwood, Vikas V. Dukhande & Matthew S. Gentry. 2016. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 1 13 .
Shuchi Mittal, Mamta Upadhyay, Pankaj Kumar Singh, Rashmi Parihar & Subramaniam Ganesh. (2015) Interdependence of laforin and malin proteins for their stability and functions could underlie the molecular basis of locus heterogeneity in Lafora disease. Journal of Biosciences 40:5, pages 863-871.
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Mamta Upadhyay, Smriti Gupta, Pratibha Bhadauriya & Subramaniam Ganesh. (2015) Lafora disease proteins laforin and malin negatively regulate the HIPK2-p53 cell death pathway. Biochemical and Biophysical Research Communications 464:1, pages 106-111.
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Filippo Sean Giorgi, Francesca Biagioni, Paola Lenzi, Alessandro Frati & Francesco Fornai. (2014) The role of autophagy in epileptogenesis and in epilepsy-induced neuronal alterations. Journal of Neural Transmission 122:6, pages 849-862.
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Yvonne Oligschlaeger, Marie Miglianico, Dipanjan Chanda, Roland Scholz, Ramon F. Thali, Roland Tuerk, David I. Stapleton, Paul R. Gooley & Dietbert Neumann. (2015) The Recruitment of AMP-activated Protein Kinase to Glycogen Is Regulated by Autophosphorylation. Journal of Biological Chemistry 290:18, pages 11715-11728.
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Pankaj Kumar Singh & Sweta Singh. (2015) Changing Shapes of Glycogen–Autophagy Nexus in Neurons: Perspective from a Rare Epilepsy. Frontiers in Neurology 6.
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Jingwen You, Lin Wang, Juxiang Huang, Minghu Jiang, Qingchun Chen, Yangming Wang & Zhenfu Jiang. (2014) Low glucose transporter SLC2A5-inhibited human normal adjacent lung adenocarcinoma cytoplasmic pro-B cell development mechanism network. Molecular and Cellular Biochemistry 399:1-2, pages 71-76.
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Sarah M. RonnebaumCam Patterson & Jonathan C. Schisler. (2014) Minireview: Hey U(PS): Metabolic and Proteolytic Homeostasis Linked via AMPK and the Ubiquitin Proteasome System. Molecular Endocrinology 28:10, pages 1602-1615.
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Yan Liu, Li Zeng, Keli Ma, Otto Baba, Pen Zheng, Yang Liu & Yin Wang. (2013) Laforin–Malin Complex Degrades Polyglucosan Bodies in Concert with Glycogen Debranching Enzyme and Brain Isoform Glycogen Phosphorylase. Molecular Neurobiology 49:2, pages 645-657.
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Pankaj Kumar Singh, Sweta Singh & Subramaniam Ganesh. (2013) Activation of serum/glucocorticoid-induced kinase 1 (SGK1) underlies increased glycogen levels, mTOR activation, and autophagy defects in Lafora disease. Molecular Biology of the Cell 24:24, pages 3776-3786.
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Valentina Gburcik, Mark E. Cleasby & James A. Timmons. (2013) Loss of neuronatin promotes “browning” of primary mouse adipocytes while reducing Glut1-mediated glucose disposal. American Journal of Physiology-Endocrinology and Metabolism 304:8, pages E885-E894.
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Carlos Romá-Mateo, Pascual Sanz & Matthew S. Gentry. (2012) Deciphering the role of malin in the lafora progressive myoclonus epilepsy. IUBMB Life 64:10, pages 801-808.
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Shweta Singh & Subramaniam Ganesh. (2012) Phenotype variations in Lafora progressive myoclonus epilepsy: possible involvement of genetic modifiers?. Journal of Human Genetics 57:5, pages 283-285.
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