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Molecular and Cellular Biology Volume 32, 2012 - Issue 7
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Article

Viral Factors Reveal a Role for REF/Aly in Nuclear RNA Stability

Sarah H. StubbsDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
,
Olga V. HunterDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
,
Ashley HooverDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
&
Nicholas K. ConradDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USACorrespondence[email protected]
Pages 1260-1270 | Received 12 Oct 2011, Accepted 13 Jan 2012, Published online: 20 Mar 2023

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Nidhi Goswami, Archana Singh, Shiv Bharadwaj, Amaresh Kumar Sahoo & Indrakant K. Singh. (2023) Targeting neuroblastoma by small-molecule inhibitors of human ALYREF protein: mechanistic insights using molecular dynamics simulations. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-16.
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Irfana Saleem, Sameer Mirza, Aniruddha Sarkar, Mohsin Raza, Bhopal Mohapatra, Insha Mushtaq, Jun Hyun Kim, Nitish K. Mishra, Mansour A. Alsaleem, Emad A. Rakha, Fang Qiu, Chittibabu Guda, Hamid Band & Vimla Band. (2021) The Mammalian Ecdysoneless Protein Interacts with RNA Helicase DDX39A To Regulate Nuclear mRNA Export. Molecular and Cellular Biology 41:7.
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William Garland & Torben Heick Jensen. (2019) Nuclear sorting of RNA. WIREs RNA 11:2.
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Andrew BeltCappellino, Vladimir Majerciak, Alexei Lobanov, Justin Lack, Maggie Cam & Zhi-Ming Zheng. (2019) CRISPR/Cas9-Mediated Knockout and In Situ Inversion of the ORF57 Gene from All Copies of the Kaposi's Sarcoma-Associated Herpesvirus Genome in BCBL-1 Cells . Journal of Virology 93:21.
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Richard B Tunnicliffe, Colin Levy, Hilda D Ruiz Nivia, Rozanne M Sandri-Goldin & Alexander P Golovanov. (2019) Structural identification of conserved RNA binding sites in herpesvirus ORF57 homologs: implications for PAN RNA recognition. Nucleic Acids Research 47:4, pages 1987-2001.
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Julio C. Ruiz, Olga V. Hunter & Nicholas K. Conrad. (2019) Kaposi’s sarcoma-associated herpesvirus ORF57 protein protects viral transcripts from specific nuclear RNA decay pathways by preventing hMTR4 recruitment. PLOS Pathogens 15:2, pages e1007596.
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Whitney L. Bullard, Erik K. Flemington, Rolf Renne & Scott A. Tibbetts. (2018) Connivance, Complicity, or Collusion? The Role of Noncoding RNAs in Promoting Gammaherpesvirus Tumorigenesis. Trends in Cancer 4:11, pages 729-740.
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Jason M. Schifano, Kathleen Corcoran, Hemant Kelkar & Dirk P. Dittmer. (2017) Expression of the Antisense-to-Latency Transcript Long Noncoding RNA in Kaposi's Sarcoma-Associated Herpesvirus. Journal of Virology 91:4.
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Sophie Schumann, Belinda Baquero-Perez & Adrian Whitehouse. (2016) Interactions between KSHV ORF57 and the novel human TREX proteins, CHTOP and CIP29. Journal of General Virology 97:8, pages 1904-1910.
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Carolin Vogt & Jens Bohne. (2016) The KSHV RNA regulator ORF57 : target specificity and its role in the viral life cycle . WIREs RNA 7:2, pages 173-185.
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Nicholas K. Conrad. (2016) New insights into the expression and functions of the Kaposi's sarcoma-associated herpesvirus long noncoding PAN RNA. Virus Research 212, pages 53-63.
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Tomas J. Bos, Julia K. Nussbacher, Stefan Aigner & Gene W. Yeo. 2016. RNA Processing. RNA Processing 61 88 .
Carolin Vogt, Christian Hackmann, Alona Rabner, Lars Koste, Susann Santag, Semra Kati, Yael Mandel-Gutfreund, Thomas F. Schulz & Jens Bohne. (2015) ORF57 Overcomes the Detrimental Sequence Bias of Kaposi's Sarcoma-Associated Herpesvirus Lytic Genes. Journal of Virology 89:9, pages 5097-5109.
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Vladimir Majerciak, Natalia Pripuzova, Calvin Chan, Nicholas Temkin, Suzanne I. Specht & Zhi-Ming Zheng. (2015) Stability of Structured Kaposi's Sarcoma-Associated Herpesvirus ORF57 Protein Is Regulated by Protein Phosphorylation and Homodimerization. Journal of Virology 89:6, pages 3256-3274.
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Emi Sei, Tao Wang, Olga V. Hunter, Yang Xie & Nicholas K. Conrad. (2015) HITS-CLIP Analysis Uncovers a Link between the Kaposi’s Sarcoma-Associated Herpesvirus ORF57 Protein and Host Pre-mRNA Metabolism. PLOS Pathogens 11:2, pages e1004652.
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Vladimir Majerciak & Zhi-Ming Zheng. (2015) KSHV ORF57, a Protein of Many Faces. Viruses 7:2, pages 604-633.
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Dinesh Verma, Da-Jiang Li, Brian Krueger, Rolf Renne & Sankar Swaminathan. (2015) Identification of the Physiological Gene Targets of the Essential Lytic Replicative Kaposi's Sarcoma-Associated Herpesvirus ORF57 Protein. Journal of Virology 89:3, pages 1688-1702.
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Sarah H. Stubbs & Nicholas K. Conrad. (2015) Depletion of REF/Aly alters gene expression and reduces RNA polymerase II occupancy. Nucleic Acids Research 43:1, pages 504-519.
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Cyprian Rossetto & Gregory Pari. (2014) PAN’s Labyrinth: Molecular Biology of Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) PAN RNA, a Multifunctional Long Noncoding RNA. Viruses 6:11, pages 4212-4226.
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Richard B. Tunnicliffe, Guillaume M. Hautbergue, Stuart A. Wilson, Priti Kalra & Alexander P. Golovanov. (2014) Competitive and Cooperative Interactions Mediate RNA Transfer from Herpesvirus Saimiri ORF57 to the Mammalian Export Adaptor ALYREF. PLoS Pathogens 10:2, pages e1003907.
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Lydia V. McClure, Rodney P. Kincaid, James M. Burke, Adam Grundhoff & Christopher S. Sullivan. (2013) Comprehensive Mapping and Analysis of Kaposi's Sarcoma-Associated Herpesvirus 3′ UTRs Identify Differential Posttranscriptional Control of Gene Expression in Lytic versus Latent Infection. Journal of Virology 87:23, pages 12838-12849.
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Stefan M. Bresson & Nicholas K. Conrad. (2013) The Human Nuclear Poly(A)-Binding Protein Promotes RNA Hyperadenylation and Decay. PLoS Genetics 9:10, pages e1003893.
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Dinesh Verma, Eun A Kim & Sankar Swaminathan. (2013) Cell-Based Screening Assay for Antiviral Compounds Targeting the Ability of Herpesvirus Posttranscriptional Regulatory Proteins To Stabilize Viral mRNAs. Journal of Virology 87:19, pages 10742-10751.
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Sophie Schumann, Brian Jackson, Belinda Baquero-Perez & Adrian Whitehouse. (2013) Kaposi’s Sarcoma-Associated Herpesvirus ORF57 Protein: Exploiting All Stages of Viral mRNA Processing. Viruses 5:8, pages 1901-1923.
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Xiaochen Tian, Gayathri Devi-Rao, Alexander P. Golovanov & Rozanne M. Sandri-Goldin. (2013) The Interaction of the Cellular Export Adaptor Protein Aly/REF with ICP27 Contributes to the Efficiency of Herpes Simplex Virus 1 mRNA Export. Journal of Virology 87:13, pages 7210-7217.
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Laurie T Krug. (2013) Complexities of gammaherpesvirus transcription revealed by microarrays and RNAseq. Current Opinion in Virology 3:3, pages 276-284.
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Olga V. Hunter, Emi Sei, R. Blake Richardson & Nicholas K. Conrad. (2013) Chromatin Immunoprecipitation and Microarray Analysis Suggest Functional Cooperation between Kaposi's Sarcoma-Associated Herpesvirus ORF57 and K-bZIP. Journal of Virology 87:7, pages 4005-4016.
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Da-Jiang Li, Dinesh Verma & Sankar Swaminathan. (2012) Binding of Cellular Export Factor REF/Aly by Kaposi's Sarcoma-Associated Herpesvirus (KSHV) ORF57 Protein Is Not Required for Efficient KSHV Lytic Replication. Journal of Virology 86:18, pages 9866-9874.
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