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Molecular and Cellular Biology Volume 32, 2012 - Issue 12
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Article

LST8 Regulates Cell Growth via Target-of-Rapamycin Complex 2 (TORC2)

Tao Wanga Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA;c National Institute of Biological Sciences, Beijing, ChinaCorrespondence[email protected]
,
Rachel Blumhagena Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
,
Uyen Laoa Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
,
Ying Kuoc National Institute of Biological Sciences, Beijing, China
&
Bruce A. Edgara Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA;b German Cancer Research Center-Center for Molecular Biology Heidelberg Alliance, Heidelberg, Germany
Pages 2203-2213 | Received 06 Nov 2011, Accepted 16 Mar 2012, Published online: 20 Mar 2023

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Jianling Xie & Chris G Proud. (2014) Signaling crosstalk between the mTOR complexes. Translation 2:1.
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Anna Frappaolo, Angela Karimpour-Ghahnavieh, Giuliana Cesare, Stefano Sechi, Roberta Fraschini, Thomas Vaccari & Maria Grazia Giansanti. (2022) GOLPH3 protein controls organ growth by interacting with TOR signaling proteins in Drosophila. Cell Death & Disease 13:11.
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Anna A. Ogienko, Evgeniya S. Omelina, Oleg V. Bylino, Mikhail A. Batin, Pavel G. Georgiev & Alexey V. Pindyurin. (2022) Drosophila as a Model Organism to Study Basic Mechanisms of Longevity. International Journal of Molecular Sciences 23:19, pages 11244.
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Mario Villa-González, Gerardo Martín-López & María José Pérez-Álvarez. (2022) Dysregulation of mTOR Signaling after Brain Ischemia. International Journal of Molecular Sciences 23:5, pages 2814.
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Zheng Li, Wenliang Qian, Wei Song, Tujing Zhao, Yan Yang, Weina Wang, Ling Wei, Dongchao Zhao, Yaoyao Li, Norbert Perrimon, Qingyou Xia & Daojun Cheng. (2022) A salivary gland-secreted peptide regulates insect systemic growth. Cell Reports 38:8, pages 110397.
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Milad Ghomlaghi, Guang Yang, Sung-Young Shin, David E. James & Lan K. Nguyen. (2021) Dynamic modelling of the PI3K/MTOR signalling network uncovers biphasic dependence of mTORC1 activity on the mTORC2 subunit SIN1. PLOS Computational Biology 17:9, pages e1008513.
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Stefano Sechi, Angela Karimpour-Ghahnavieh, Anna Frappaolo, Laura Di Francesco, Roberto Piergentili, Eugenia Schininà, Pier Paolo D’Avino & Maria Grazia Giansanti. (2021) Identification of GOLPH3 Partners in Drosophila Unveils Potential Novel Roles in Tumorigenesis and Neural Disorders. Cells 10:9, pages 2336.
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Yongchao Han, Na Zhuang & Tao Wang. (2021) Roles of PINK1 in regulation of systemic growth inhibition induced by mutations of PTEN in Drosophila. Cell Reports 34:12, pages 108875.
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Michael J Texada, Takashi Koyama & Kim Rewitz. (2020) Regulation of Body Size and Growth Control. Genetics 216:2, pages 269-313.
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Shilpi Verghese, Indrayani Waghmare, Shree Ram Singh & Madhuri Kango-Singh. 2020. Molecular Genetics of Axial Patterning, Growth and Disease in Drosophila Eye. Molecular Genetics of Axial Patterning, Growth and Disease in Drosophila Eye 215 257 .
Subramanian P. Ramanathan, Matej Krajnc & Matthew C. Gibson. (2019) Cell-Size Pleomorphism Drives Aberrant Clone Dispersal in Proliferating Epithelia. Developmental Cell 51:1, pages 49-61.e4.
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Zongxu Yue, Zhimeng Lv, Yina Shao, Weiwei Zhang, Xuelin Zhao, Ming Guo & Chenghua Li. (2019) Cloning and characterization of the target protein subunit lst8 of rapamycin in Apostichopus japonicus. Fish & Shellfish Immunology 92, pages 460-468.
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Yoonha Hwang, Laura C. Kim, Wenqiang Song, Deanna N. Edwards, Rebecca S. Cook & Jin Chen. (2019) Disruption of the Scaffolding Function of mLST8 Selectively Inhibits mTORC2 Assembly and Function and Suppresses mTORC2-Dependent Tumor Growth In Vivo . Cancer Research 79:13, pages 3178-3184.
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Suxia Ren, Zengyi Huang, Yuqiang Jiang & Tao Wang. (2018) dTBC1D7 regulates systemic growth independently of TSC through insulin signaling. Journal of Cell Biology 217:2, pages 517-526.
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Xun Chen & Dion Dickman. (2017) Development of a tissue-specific ribosome profiling approach in Drosophila enables genome-wide evaluation of translational adaptations. PLOS Genetics 13:12, pages e1007117.
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Suam Gonzalez & Charalampos Rallis. (2017) The TOR Signaling Pathway in Spatial and Temporal Control of Cell Size and Growth. Frontiers in Cell and Developmental Biology 5.
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Peter L. Lee, Su Myung Jung & David A. Guertin. (2017) The Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and Beyond. Trends in Endocrinology & Metabolism 28:5, pages 319-339.
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Gabriela David-Morrison, Zhen Xu, Yan-Ning Rui, Wu-Lin Charng, Manish Jaiswal, Shinya Yamamoto, Bo Xiong, Ke Zhang, Hector Sandoval, Lita Duraine, Zhongyuan Zuo, Sheng Zhang & Hugo J. Bellen. (2016) WAC Regulates mTOR Activity by Acting as an Adaptor for the TTT and Pontin/Reptin Complexes. Developmental Cell 36:2, pages 139-151.
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T. Keith Blackwell, Michael J. Steinbaugh, John M. Hourihan, Collin Y. Ewald & Meltem Isik. (2015) SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans. Free Radical Biology and Medicine 88, pages 290-301.
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Ying Kuo, Huanwei Huang, Tao Cai & Tao Wang. (2015) Target of Rapamycin Complex 2 regulates cell growth via Myc in Drosophila. Scientific Reports 5:1.
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Irena Jevtov, Margarita Zacharogianni, Marinke M. van Oorschot, Guus van Zadelhoff, Angelica Aguilera-Gomez, Igor Vuillez, Ineke Braakman, Ernst Hafen, Hugo Stocker & Catherine Rabouille. (2015) TORC2 mediates the heat stress response in Drosophila by promoting the formation of stress granules . Journal of Cell Science.
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Masaki Mizunuma, Elke Neumann‐Haefelin, Natalie Moroz, Yujie Li & T. Keith Blackwell. (2014) m TORC 2‐ SGK ‐1 acts in two environmentally responsive pathways with opposing effects on longevity . Aging Cell 13:5, pages 869-878.
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Vanessa Ruf, Christina Holzem, Tobias Peyman, Gerd Walz, T. Keith Blackwell & Elke Neumann-Haefelin. (2013) TORC2 signaling antagonizes SKN-1 to induce C. elegans mesendodermal embryonic development. Developmental Biology 384:2, pages 214-227.
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Y Kuo, S Ren, U Lao, B A Edgar & T Wang. (2013) Suppression of polyglutamine protein toxicity by co-expression of a heat-shock protein 40 and a heat-shock protein 110. Cell Death & Disease 4:10, pages e833-e833.
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Tyson E. Graber, Patrick K. McCamphill & Wayne S. Sossin. (2013) A recollection of mTOR signaling in learning and memory. Learning & Memory 20:10, pages 518-530.
Crossref
Marion Cornu, Verena Albert & Michael N Hall. (2013) mTOR in aging, metabolism, and cancer. Current Opinion in Genetics & Development 23:1, pages 53-62.
Crossref
Shilpi Verghese, Indrayani Waghmare, Shree Ram Singh & Madhuri Kango-Singh. 2013. Molecular Genetics of Axial Patterning, Growth and Disease in the Drosophila Eye. Molecular Genetics of Axial Patterning, Growth and Disease in the Drosophila Eye 229 270 .

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