Advanced search
Publication Cover
Molecular and Cellular Biology Volume 15, 1995 - Issue 10
Submit an article Journal homepage
13
Views
258
CrossRef citations to date
0
Altmetric
Research Article

The Cellular Response to Neuregulins Is Governed by Complex Interactions of the erbB Receptor Family

David J. Riese II1 Department of Pathology, Yale University School of Medicine, New Haven, Connecticut06520-8023
,
Tom M. van Raaij1 Department of Pathology, Yale University School of Medicine, New Haven, Connecticut06520-8023
,
Gregory D. Plowman2 Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, Washington98121
,
Glenn C. Andrews3 Pfizer Central Research, Groton, Connecticut06340
&
David F. Stern1 Department of Pathology, Yale University School of Medicine, New Haven, Connecticut06520-8023Correspondence[email protected]
Pages 5770-5776 | Received 11 May 1995, Accepted 17 Jul 1995, Published online: 30 Mar 2023

Citations (258)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (13)

Mara P. Steinkamp, Shalini T. Low-Nam, Shujie Yang, Keith A. Lidke, Diane S. Lidke & Bridget S. Wilson. (2014) erbB3 Is an Active Tyrosine Kinase Capable of Homo- and Heterointeractions. Molecular and Cellular Biology 34:6, pages 965-977.
Read now
Kristy J. Wilson, Christopher Mill, Sydney Lambert, Jennifer Buchman, Timothy R. Wilson, Victor Hernandez-Gordillo, Richard M. Gallo, Laura M.C. Ades, Jeffrey Settleman & David J. Riese$suffix/text()$suffix/text(). (2012) EGFR ligands exhibit functional differences in models of paracrine and autocrine signaling. Growth Factors 30:2, pages 107-116.
Read now
Jonas Cicenas$suffix/text()$suffix/text(). (2007) The potential role of the EGFR/ERBB2 heterodimer in breast cancer. Expert Opinion on Therapeutic Patents 17:6, pages 607-616.
Read now
Richard M. Gallo & David J. Riese II. (2007) The antibody sc-33040-R fails to specifically recognize phosphorylation of ErbB4 on tyrosine1056. Growth Factors 25:5, pages 329-333.
Read now
Chengfeng Yang, Ying Liu, Mark A. Lemmon & Marcelo G. Kazanietz. (2006) Essential Role for Rac in Heregulin β1 Mitogenic Signaling: a Mechanism That Involves Epidermal Growth Factor Receptor and Is Independent of ErbB4. Molecular and Cellular Biology 26:3, pages 831-842.
Read now
Stuart S. Hobbs, Richard M. Gallo & David J. Riese$suffix/text()$suffix/text(). (2005) Phe45 of NRG2β is critical for the affinity of NRG2β for ErbB4 and for potent stimulation of ErbB4 signaling by NRG2β. Growth Factors 23:4, pages 273-283.
Read now
Senthil K. Muthuswamy, Michael Gilman & Joan S. Brugge. (1999) Controlled Dimerization of ErbB Receptors Provides Evidence for Differential Signaling by Homo- and Heterodimers. Molecular and Cellular Biology 19:10, pages 6845-6857.
Read now
Roger J. Daly. (1999) Take Your Partners, Please — Signal Diversification by the erbB Family of Receptor Tyrosine Kinases. Growth Factors 16:4, pages 255-263.
Read now
Mohammed Rahmatullah, Allen Schroering, Katrina Rothblum, Richard C. Stahl, Bobbi Urban & David J. Carey. (1998) Synergistic Regulation of Schwann Cell Proliferation by Heregulin and Forskolin. Molecular and Cellular Biology 18:11, pages 6245-6252.
Read now
Ronit Pinkas-Kramarski, Maya Shelly, Bradley C. Guarino, Ling Mei Wang, Ljuba Lyass, Iris Alroy, Mauricio Alamandi, Angera Kuo, James D. Moyer, Sara Lavi, Miriam Eisenstein, Barry J. Ratzkin, Rony Seger, Sarah S. Bacus, Jacalyn H. Pierce, Glenn C. Andrews & Yosef Yarden. (1998) ErbB Tyrosine Kinases and the Two Neuregulin Families Constitute a Ligand-Receptor Network. Molecular and Cellular Biology 18:10, pages 6090-6101.
Read now
Laurie M Strawn & Laura K Shawver. (1998) Tyrosine kinases in disease: overview of kinase inhibitors as therapeutic agents and current drugs in clinical trials. Expert Opinion on Investigational Drugs 7:4, pages 553-573.
Read now
Eldad Tzahar, Hadassa Waterman, Xiomei Chen, Gil Levkowitz, Devarajan Karunagaran, Sara Lavi, Barry J. Ratzkin & Yosef Yarden. (1996) A Hierarchical Network of Interreceptor Interactions Determines Signal Transduction by Neu Differentiation Factor/Neuregulin and Epidermal Growth Factor. Molecular and Cellular Biology 16:10, pages 5276-5287.
Read now
Roger R. Beerli, Diana Graus-Porta, Kathie Woods-Cook, Xiaomei Chen, Yosef Yarden & Nancy E. Hynes. (1995) Neu Differentiation Factor Activation of ErbB-3 and ErbB-4 Is Cell Specific and Displays a Differential Requirement for ErbB-2. Molecular and Cellular Biology 15:12, pages 6496-6505.
Read now

Articles from other publishers (245)

Noboru Ishiyama, Matthew O'Connor, Andrei Salomatov, Darlene Romashko, Shalabh Thakur, Ahmet Mentes, Julia F. Hopkins, Garrett M. Frampton, Lee A. Albacker, Anna Kohlmann, Christopher Roberts & Elizabeth Buck. (2023) Computational and Functional Analyses of HER2 Mutations Reveal Allosteric Activation Mechanisms and Altered Pharmacologic Effects. Cancer Research 83:9, pages 1531-1542.
Crossref
Akitaka Yamasaki, Rikuto Miyake, Yuta Hara, Hideki Okuno, Takuya Imaida, Kouki Okita, Shogo Okazaki, Yasutoshi Akiyama, Kenji Hirotani, Yuichi Endo, Kazue Masuko, Takashi Masuko & Yoshihisa Tomioka. (2023) Dual‐targeting therapy against HER3 / MET in human colorectal cancers . Cancer Medicine 12:8, pages 9684-9696.
Crossref
Zhengxing Zhou, Chengmin Zhang, Zhiyuan Ma, Hu Wang, Biguang Tuo, Xiaoming Cheng, Xuemei Liu & Taolang Li. (2022) Pathophysiological role of ion channels and transporters in HER2-positive breast cancer. Cancer Gene Therapy 29:8-9, pages 1097-1104.
Crossref
Shwetha Srinivasan, Raju Regmi, Xingcheng Lin, Courtney A. Dreyer, Xuyan Chen, Steven D. Quinn, Wei He, Matthew A. Coleman, Kermit L. CarrawayIIIIII, Bin Zhang & Gabriela S. Schlau-Cohen. (2022) Ligand-induced transmembrane conformational coupling in monomeric EGFR. Nature Communications 13:1.
Crossref
Svenja Kemmer, Mireia Berdiel-Acer, Eileen Reinz, Johanna Sonntag, Nooraldeen Tarade, Stephan Bernhardt, Mirjam Fehling-Kaschek, Max Hasmann, Ulrike Korf, Stefan Wiemann & Jens Timmer. (2022) Disentangling ERBB Signaling in Breast Cancer Subtypes—A Model-Based Analysis. Cancers 14:10, pages 2379.
Crossref
Deepankar Chakroborty, Veera K. Ojala, Anna M. Knittle, Jasmin Drexler, Mahlet Z. Tamirat, Regina Ruzicka, Karin Bosch, Johanna Woertl, Susanne Schmittner, Laura L. Elo, Mark S. Johnson, Kari J. Kurppa, Flavio Solca & Klaus Elenius. (2022) An Unbiased Functional Genetics Screen Identifies Rare Activating ERBB4 Mutations. Cancer Research Communications 2:1, pages 10-27.
Crossref
Lauren M. Lucas, Vipasha Dwivedi, Jared I. Senfeld, Richard L. Cullum, Christopher P. Mill, J. Tyler Piazza, Ianthe N. Bryant, Laura J. Cook, S. Tyler Miller, James H. LottIVIV, Connor M. Kelley, Elizabeth L. Knerr, Jessica A. Markham, David P. Kaufmann, Megan A. Jacobi, Jianzhong Shen & David J. RieseIIII. (2022) The Yin and Yang of ERBB4: Tumor Suppressor and Oncoprotein. Pharmacological Reviews 74:1, pages 18-47.
Crossref
Mohammed I. El-Gamal, Nada H. Mewafi, Nada E. Abdelmotteleb, Minnatullah A. Emara, Hamadeh Tarazi, Rawan M. Sbenati, Moustafa M. Madkour, Seyed-Omar Zaraei, Afnan I. Shahin & Hanan S. Anbar. (2021) A Review of HER4 (ErbB4) Kinase, Its Impact on Cancer, and Its Inhibitors. Molecules 26:23, pages 7376.
Crossref
Maria A. Ortiz, Tatiana Mikhailova, Xiang Li, Baylee A. Porter, Alaji Bah & Leszek Kotula. (2021) Src family kinases, adaptor proteins and the actin cytoskeleton in epithelial-to-mesenchymal transition. Cell Communication and Signaling 19:1.
Crossref
Shu-Lun Jiang, Di-An Fang & Dong-Po Xu. (2021) Transcriptome changes of Takifugu obscurus liver after acute exposure to phenanthrene . Physiological Genomics 53:3, pages 116-124.
Crossref
Richard L. Cullum, Lauren M. Lucas, Jared I. Senfeld, John T. Piazza, Logan T. Neel, Kanupriya Whig, Ling Zhai, Mackenzie H. Harris, Cristina C. Rael, Darby C. Taylor, Laura J. Cook, David P. Kaufmann, Christopher P. Mill, Megan A. Jacobi, Forrest T. Smith, Mark Suto, Robert Bostwick, Ram B. Gupta, Allan E. David & David J. Riese, II. (2020) Development and application of high-throughput screens for the discovery of compounds that disrupt ErbB4 signaling: Candidate cancer therapeutics. PLOS ONE 15:12, pages e0243901.
Crossref
Andrew Geissler, Sergey Ryzhov & Douglas B. Sawyer. (2020) Neuregulins: protective and reparative growth factors in multiple forms of cardiovascular disease. Clinical Science 134:19, pages 2623-2643.
Crossref
Anna Gumà, Francisco Díaz-Sáez, Marta Camps & Antonio Zorzano. (2020) Neuregulin, an Effector on Mitochondria Metabolism That Preserves Insulin Sensitivity. Frontiers in Physiology 11.
Crossref
Steven F. Grieco, Gina Wang, Ananya Mahapatra, Cary Lai, Todd C. Holmes & Xiangmin Xu. (2019) Neuregulin and ErbB expression is regulated by development and sensory experience in mouse visual cortex. Journal of Comparative Neurology 528:3, pages 419-432.
Crossref
Anh Thai‐Quynh Nguyen, So‐young Lee, Hyun Jung Chin, Quy Van‐Chanh Le & Daekee Lee. (2019) Kinase activity of ERBB3 contributes to intestinal organoids growth and intestinal tumorigenesis. Cancer Science 111:1, pages 137-147.
Crossref
Sean P. Kennedy, Jeremy Z. R. Han, Neil Portman, Max Nobis, Jordan F. Hastings, Kendelle J. Murphy, Sharissa L. Latham, Antonia L. Cadell, Dushan Miladinovic, Gabriella R. Marriott, Yolande E. I. O’Donnell, Robert F. Shearer, James T. Williams, Amaya Garcia Munoz, Thomas R. Cox, D. Neil Watkins, Darren N. Saunders, Paul Timpson, Elgene Lim, Walter Kolch & David R. Croucher. (2019) Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer. Breast Cancer Research 21:1.
Crossref
Shuang Wu, Yong Huang, Yian Xing, Lianhua Chen, Meirong Yang & Shitong Li. (2019) Two Pathways Regulate Differential Expression of nAChRs Between the Orbicularis Oris and Gastrocnemius. Journal of Surgical Research 243, pages 130-142.
Crossref
Jamie S. Rush, Joanne L. Peterson & Brian P. Ceresa. (2018) Betacellulin (BTC) Biases the EGFR To Dimerize with ErbB3. Molecular Pharmacology 94:6, pages 1382-1390.
Crossref
Kanika Bajaj Pahuja, Thong T. Nguyen, Bijay S. Jaiswal, Kumar Prabhash, Tarjani M. Thaker, Kate Senger, Subhra Chaudhuri, Noelyn M. Kljavin, Aju Antony, Sameer Phalke, Prasanna Kumar, Marco Mravic, Eric W. Stawiski, Derek Vargas, Steffen Durinck, Ravi Gupta, Arati Khanna-Gupta, Sally E. Trabucco, Ethan S. Sokol, Ryan J. Hartmaier, Ashish Singh, Anuradha Chougule, Vaishakhi Trivedi, Amit Dutt, Vijay Patil, Amit Joshi, Vanita Noronha, James Ziai, Sripad D. Banavali, Vedam Ramprasad, William F. DeGrado, Raphael Bueno, Natalia Jura & Somasekar Seshagiri. (2018) Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations. Cancer Cell 34:5, pages 792-806.e5.
Crossref
Ruth A. Mitchell, Rodney B. Luwor & Antony W. Burgess. (2018) Epidermal growth factor receptor: Structure-function informing the design of anticancer therapeutics. Experimental Cell Research 371:1, pages 1-19.
Crossref
Thomas Efferth. (2017) Cancer combination therapy of the sesquiterpenoid artesunate and the selective EGFR-tyrosine kinase inhibitor erlotinib. Phytomedicine 37, pages 58-61.
Crossref
Ashfaque Memon, Stephen Gilliver, Michael Borre, Jan Sundquist, Kristina Sundquist, Ebba Nexo & Boe Sorensen. (2017) Soluble HER3 predicts survival in bladder cancer patients. Oncology Letters.
Crossref
Christopher H. Lieu, Manuel Hidalgo, Jordan D. Berlin, Andrew H. Ko, Andres Cervantes, Patricia LoRusso, David E. Gerber, J. Paul Eder, S. Gail Eckhardt, Amy V. Kapp, Amy Tsuhako, Bruce McCall, Andrea Pirzkall, Anne Uyei & Josep Tabernero. (2017) A Phase Ib Dose-Escalation Study of the Safety, Tolerability, and Pharmacokinetics of Cobimetinib and Duligotuzumab in Patients with Previously Treated Locally Advanced or Metastatic Cancers with Mutant KRAS. The Oncologist 22:9, pages 1024-e89.
Crossref
Bettina van LengerichChristopher AgnewElias M. PuchnerBo HuangNatalia Jura. (2017) EGF and NRG induce phosphorylation of HER3/ERBB3 by EGFR using distinct oligomeric mechanisms. Proceedings of the National Academy of Sciences 114:14.
Crossref
George King, Megan E. Smith, Max H. Cake & Heber C. Nielsen. (2016) What is the identity of fibroblast-pneumocyte factor?. Pediatric Research 80:6, pages 768-776.
Crossref
Masayuki Shimada, Takashi Umehara & Yumi Hoshino. (2016) Roles of epidermal growth factor (EGF)-like factor in the ovulation process. Reproductive Medicine and Biology 15:4, pages 201-216.
Crossref
Paul N. Durfee, Yu-Shen Lin, Darren R. Dunphy, Ayşe J. Muñiz, Kimberly S. Butler, Kevin R. Humphrey, Amanda J. Lokke, Jacob O. Agola, Stanley S. Chou, I-Ming Chen, Walker Wharton, Jason L. Townson, Cheryl L. Willman & C. Jeffrey Brinker. (2016) Mesoporous Silica Nanoparticle-Supported Lipid Bilayers (Protocells) for Active Targeting and Delivery to Individual Leukemia Cells. ACS Nano 10:9, pages 8325-8345.
Crossref
Sean P. Kennedy, Jordan F. Hastings, Jeremy Z. R. Han & David R. Croucher. (2016) The Under-Appreciated Promiscuity of the Epidermal Growth Factor Receptor Family. Frontiers in Cell and Developmental Biology 4.
Crossref
David R. CroucherMary IconomouJordan F. HastingsSean P. KennedyJeremy Z. R. HanRobert F. ShearerJessie McKennaAdrian WanJoseph LauSamuel AparicioDarren N. Saunders. (2016) Bimolecular complementation affinity purification (BiCAP) reveals dimer-specific protein interactions for ERBB2 dimers. Science Signaling 9:436.
Crossref
JINKYOUNG KIM, JIYUN LEE, SOON YOUNG JANG, CHUNGYEUL KIM, YOOJIN CHOI & AEREE KIM. (2016) Anticancer effect of metformin on estrogen receptor-positive and tamoxifen-resistant breast cancer cell lines. Oncology Reports 35:5, pages 2553-2560.
Crossref
Mi Joo Chung, Jong Hoon Lee, Sung Hwan Kim, Young Jin Suh & Hyun Joo Choi. (2016) Simple Prediction Model of Axillary Lymph Node Positivity After Analyzing Molecular and Clinical Factors in Early Breast Cancer. Medicine 95:20, pages e3689.
Crossref
Ijeoma Umelo, Amir Noeparast, Gang Chen, Marleen Renard, Caroline Geers, Johan Vansteenkiste, Philippe Giron, Olivier De Wever, Erik Teugels & Jacques De Grève. (2015) Identification of a novel HER3 activating mutation homologous to EGFR-L858R in lung cancer. Oncotarget 7:3, pages 3068-3083.
Crossref
Ean‐Jeong Seo, Ching‐Fen Wu, Henny J. Greten & Thomas Efferth. 2015. Ethnopharmacology. Ethnopharmacology 169 178 .
Onat Kadioglu, Jingming Cao, Mohamed E. M. Saeed, Henry Johannes Greten & Thomas Efferth. (2014) Targeting epidermal growth factor receptors and downstream signaling pathways in cancer by phytochemicals. Targeted Oncology 10:3, pages 337-353.
Crossref
Claire E. Nash, Georgia Mavria, Euan W. Baxter, Deborah L. Holliday, Darren C. Tomlinson, Darren Treanor, Vera Novitskaya, Fedor Berditchevski, Andrew M. Hanby & Valerie Speirs. (2015) Development and characterisation of a 3D multi-cellular in vitro model of normal human breast: a tool for cancer initiation studies . Oncotarget 6:15, pages 13731-13741.
Crossref
Kieran BruneJames FrankAndreas SchwingshacklJames Finigan & Venkataramana K. Sidhaye. (2015) Pulmonary epithelial barrier function: some new players and mechanisms. American Journal of Physiology-Lung Cellular and Molecular Physiology 308:8, pages L731-L745.
Crossref
James H. Finigan, Vihas T. VasuJyoti V. ThaikoottathilRangnath MishraMohammad A. Shatat, Robert J. Mason & Jeffrey A. Kern. (2015) HER2 activation results in β-catenin-dependent changes in pulmonary epithelial permeability. American Journal of Physiology-Lung Cellular and Molecular Physiology 308:2, pages L199-L207.
Crossref
Matthew D. Ward & Daniel J. Leahy. (2015) Kinase Activator-Receiver Preference in ErbB Heterodimers Is Determined by Intracellular Regions and Is Not Coupled to Extracellular Asymmetry. Journal of Biological Chemistry 290:3, pages 1570-1579.
Crossref
Fresia Pareja, Gur Pines & Yosef Yarden. 2015. Receptor Tyrosine Kinases: Family and Subfamilies. Receptor Tyrosine Kinases: Family and Subfamilies 107 164 .
Da-Wei Dai, Zheng Xu, Xin Chen, Lei Yuan, Ai-Jun Zhang, Peng-Qi Zhang, You-Ming Lu & Zhi-Feng Deng. (2013) Distinct roles of neuregulin in different models of neuropathic pain. Neurological Sciences 35:4, pages 531-536.
Crossref
Andrew T. Krueger, Carsten Kroll, Edgar Sanchez, Linda G. Griffith & Barbara Imperiali. (2014) Tailoring Chimeric Ligands for Studying and Biasing ErbB Receptor Family Interactions. Angewandte Chemie International Edition 53:10, pages 2662-2666.
Crossref
Andrew T. Krueger, Carsten Kroll, Edgar Sanchez, Linda G. Griffith & Barbara Imperiali. (2014) Tailoring Chimeric Ligands for Studying and Biasing ErbB Receptor Family Interactions. Angewandte Chemie 126:10, pages 2700-2704.
Crossref
Wenle Xia, Emanual F PetricoinIIIIII, Sumin Zhao, Leihua Liu, Takuya Osada, Qing Cheng, Julia D Wulfkuhle, William R Gwin, Xiaoyi Yang, Rosa I Gallagher, Sarah Bacus, H Kim Lyerly & Neil L Spector. (2013) An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models. Breast Cancer Research 15:5.
Crossref
Jerrica L. Breindel, Jonathan W. Haskins, Elizabeth P. Cowell, Minghui Zhao, Don X. Nguyen & David F. Stern. (2013) EGF Receptor Activates MET through MAPK to Enhance Non–Small Cell Lung Carcinoma Invasion and Brain Metastasis. Cancer Research 73:16, pages 5053-5065.
Crossref
Suparna Wedam & Stanley Lipkowitz. 2013. Handbook of Therapeutic Biomarkers in Cancer. Handbook of Therapeutic Biomarkers in Cancer 77 120 .
Gottfried E. Konecny. (2013) Emerging strategies for the dual inhibition of HER2-positive breast cancer. Current Opinion in Obstetrics & Gynecology 25:1, pages 55-65.
Crossref
Michio Hiroshima, Yuko Saeki, Mariko Okada-Hatakeyama & Yasushi Sako. (2012) Dynamically varying interactions between heregulin and ErbB proteins detected by single-molecule analysis in living cells. Proceedings of the National Academy of Sciences 109:35, pages 13984-13989.
Crossref
C-R Pradeep, A Zeisel, W J Köstler, M Lauriola, J Jacob-Hirsch, B Haibe-Kains, N Amariglio, N Ben-Chetrit, A Emde, I Solomonov, G Neufeld, M Piccart, I Sagi, C Sotiriou, G Rechavi, E Domany, C Desmedt & Y Yarden. (2011) Modeling invasive breast cancer: growth factors propel progression of HER2-positive premalignant lesions. Oncogene 31:31, pages 3569-3583.
Crossref
Yosef Yarden & Gur Pines. (2012) The ERBB network: at last, cancer therapy meets systems biology. Nature Reviews Cancer 12:8, pages 553-563.
Crossref
Berta Luzón-Toro, Ana Torroglosa, Rocío Núñez-Torres, María Valle Enguix-Riego, Raquel María Fernández, Juan Carlos de Agustín, Guillermo Antiñolo & Salud Borrego. (2012) Comprehensive Analysis of NRG1 Common and Rare Variants in Hirschsprung Patients. PLoS ONE 7:5, pages e36524.
Crossref
Kristy J. WilsonChristopher P. MillRichard M. GalloElizabeth M. CameronHenry VanBrocklinJeffrey SettlemanDavid J. RieseIIII. (2012) The Q43L mutant of neuregulin 2β is a pan-ErbB receptor antagonist. Biochemical Journal 443:1, pages 133-144.
Crossref
Steven M. Jay, Elma Kurtagic, Luis M. Alvarez, Seymour de Picciotto, Edgar Sanchez, Jessica F. Hawkins, Robin N. Prince, Yadir Guerrero, Carolyn L. Treasure, Richard T. Lee & Linda G. Griffith. (2011) Engineered Bivalent Ligands to Bias ErbB Receptor-mediated Signaling and Phenotypes. Journal of Biological Chemistry 286:31, pages 27729-27740.
Crossref
Arvin C. DarKevan M. Shokat. (2011) The Evolution of Protein Kinase Inhibitors from Antagonists to Agonists of Cellular Signaling. Annual Review of Biochemistry 80:1, pages 769-795.
Crossref
Sylwia Ammoun & C. Oliver Hanemann. (2011) Emerging therapeutic targets in schwannomas and other merlin-deficient tumors. Nature Reviews Neurology 7:7, pages 392-399.
Crossref
Ilene Boucher, Amanuel Kehasse, Meredith Marcincin, Celeste Rich, Nader Rahimi & Vickery Trinkaus-Randall. (2011) Distinct Activation of Epidermal Growth Factor Receptor by UTP Contributes to Epithelial Cell Wound Repair. The American Journal of Pathology 178:3, pages 1092-1105.
Crossref
Shannon E. Telesco, Andrew J. Shih, Fei Jia & Ravi Radhakrishnan. (2011) A multiscale modeling approach to investigate molecular mechanisms of pseudokinase activation and drug resistance in the HER3/ErbB3 receptor tyrosine kinase signaling network. Molecular BioSystems 7:6, pages 2066.
Crossref
David F. Stern. (2010) EGFs and ERBBs—Brief history and prospects. Seminars in Cell & Developmental Biology 21:9, pages 917-921.
Crossref
Nadia Hedhli & Kerry Strong Russell. (2010) Cytostatic Drugs, Neuregulin Activation of ErbB Receptors, and Angiogenesis. Current Hypertension Reports 12:6, pages 411-417.
Crossref
Amber B. Pfister, Robert C. Wood, Pedro J.I. Salas, Delma L. Zea & Victoria P. Ramsauer. (2010) Early response to ErbB2 over-expression in polarized Caco-2 cells involves partial segregation from ErbB3 by relocalization to the apical surface and initiation of survival signaling. Journal of Cellular Biochemistry 111:3, pages 643-652.
Crossref
Agadha Wickremesekera, Christopher M. Hovens & Andrew H. Kaye. (2010) Expression of ErbB-1 and ErbB-2 in meningioma. Journal of Clinical Neuroscience 17:9, pages 1155-1158.
Crossref
Robert D. Fisher, Mark Ultsch, Andreas Lingel, Gabriele Schaefer, Lily Shao, Sara Birtalan, Sachdev S. Sidhu & Charles Eigenbrot. (2010) Structure of the Complex between HER2 and an Antibody Paratope Formed by Side Chains from Tryptophan and Serine. Journal of Molecular Biology 402:1, pages 217-229.
Crossref
Robert C. Doebele, Ana B. Oton, Nir Peled, D. Ross Camidge & Paul A. BunnJr.Jr.. (2010) New strategies to overcome limitations of reversible EGFR tyrosine kinase inhibitor therapy in non-small cell lung cancer. Lung Cancer 69:1, pages 1-12.
Crossref
Dorota Bartusik, Boguslaw Tomanek, Erika Lattová, Hélène Perreault & Gino Fallone. (2010) Ex vivo assays of CEM cells cultured and treated in the three dimensional cultures. Biomedicine & Pharmacotherapy 64:6, pages 390-395.
Crossref
Sandra V. Fernandez, Kara E. Snider, Yue-Zhong Wu, Irma H. Russo, Christoph Plass & Jose Russo. (2010) DNA methylation changes in a human cell model of breast cancer progression. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 688:1-2, pages 28-35.
Crossref
Fumin Shi, Shannon E. Telesco, Yingting Liu, Ravi Radhakrishnan & Mark A. Lemmon. (2010) ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation. Proceedings of the National Academy of Sciences 107:17, pages 7692-7697.
Crossref
Jennifer L. Gilmore, Ryan M. Gonterman, Keshav Menon, Gwendolen Lorch, David J. RieseIIII, Alex Robling & John Foley. (2009) Reconstitution of Amphiregulin–Epidermal Growth Factor Receptor Signaling in Lung Squamous Cell Carcinomas Activates PTHrP Gene Expression and Contributes to Cancer-Mediated Diseases of the Bone. Molecular Cancer Research 7:10, pages 1714-1728.
Crossref
Antonio G. Tristano. (2009) Tyrosine kinases as targets in rheumatoid arthritis. International Immunopharmacology 9:1, pages 1-9.
Crossref
Sara Reinhard, Eric Vela, Nicole Bombara, George H. DeVries & Timothy D. Raabe. (2008) Developmental Regulation of Neuregulin1 Isoforms and erbB Receptor Expression in Intact Rat Dorsal Root Ganglia. Neurochemical Research 34:1, pages 17-22.
Crossref
Y.-J. J. Chen, L. W. Role & D. A. Talmage. 2009. Handbook of Neurochemistry and Molecular Neurobiology. Handbook of Neurochemistry and Molecular Neurobiology 243 265 .
Egle AvizienyteRichard A. WardAndrew P. Garner. (2008) Comparison of the EGFR resistance mutation profiles generated by EGFR-targeted tyrosine kinase inhibitors and the impact of drug combinations. Biochemical Journal 415:2, pages 197-206.
Crossref
Yasuko HonjoJonathan KnissJudith S. Eisen. (2008) Neuregulin-mediated ErbB3 signaling is required for formation of zebrafish dorsal root ganglion neurons. Development 135:15, pages 2615-2625.
Crossref
Anjali Naresh, Ann D. Thor, Susan M. Edgerton, Kathleen C. Torkko, Rakesh Kumar & Frank E. Jones. (2008) The HER4/4ICD Estrogen Receptor Coactivator and BH3-Only Protein Is an Effector of Tamoxifen-Induced Apoptosis. Cancer Research 68:15, pages 6387-6395.
Crossref
Oumarou Samna Soumana, Norbert Garnier & Monique Genest. (2008) Insight into the recognition patterns of the ErbB receptor family transmembrane domains: heterodimerization models through molecular dynamics search. European Biophysics Journal 37:6, pages 851-864.
Crossref
David F. Stern. (2008) ERBB3/HER3 and ERBB2/HER2 Duet in Mammary Development and Breast Cancer. Journal of Mammary Gland Biology and Neoplasia 13:2, pages 215-223.
Crossref
Jacqueline M. Lafky, Jason A. Wilken, Andre T. Baron & Nita J. Maihle. (2008) Clinical implications of the ErbB/epidermal growth factor (EGF) receptor family and its ligands in ovarian cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1785:2, pages 232-265.
Crossref
Taeko Kakizawa, Shizuyo Koide-Yoshida, Tooru Kimura, Hiromasa Uchimura, Yoshio Hayashi, Kazuki Saito & Yoshiaki Kiso. (2008) Fmoc-based solid phase chemical synthesis of 71-meric neuregulin 1-β1, an epidermal growth factor-like domain. Journal of Peptide Science 14:3, pages 261-266.
Crossref
Andrea Sassen, Justine Rochon, Peter Wild, Arndt Hartmann, Ferdinand Hofstaedter, Stephan Schwarz & Gero Brockhoff. (2008) Cytogenetic analysis of HER1/EGFR, HER2, HER3 and HER4 in 278 breast cancer patients. Breast Cancer Research 10:1.
Crossref
Howard M. Stern. 2008. EGFR Signaling Networks in Cancer Therapy. EGFR Signaling Networks in Cancer Therapy 14 29 .
Valerie Stone Hawthorne & Dihua Yu. 2008. Regulation of Gene Expression in the Tumor Environment. Regulation of Gene Expression in the Tumor Environment 43 56 .
Agadha Wickremesekera, Christopher M. Hovens & Andrew H. Kaye. (2007) Expression of ErbB-1 and 2 in vestibular schwannomas. Journal of Clinical Neuroscience 14:12, pages 1199-1206.
Crossref
Kristy J. Wilson, Christopher P. Mill, Elizabeth M. Cameron, Stuart S. Hobbs, Robert P. Hammer & David J. RieseIIII. (2007) Inter-conversion of neuregulin2 full and partial agonists for ErbB4. Biochemical and Biophysical Research Communications 364:2, pages 351-357.
Crossref
Jin Pu, Colin D. McCaig, Lin Cao, Zhiqiang Zhao, Jeffrey E. Segall & Min Zhao. (2007) EGF receptor signalling is essential for electric-field-directed migration of breast cancer cells. Journal of Cell Science 120:19, pages 3395-3403.
Crossref
Ilene Boucher, LingLing Yang, Courtney Mayo, Veronica Klepeis & Vickery Trinkaus-Randall. (2007) Injury and nucleotides induce phosphorylation of epidermal growth factor receptor: MMP and HB-EGF dependent pathway. Experimental Eye Research 85:1, pages 130-141.
Crossref
R C Ishizawar, T Miyake & S J Parsons. (2006) c-Src modulates ErbB2 and ErbB3 heterocomplex formation and function. Oncogene 26:24, pages 3503-3510.
Crossref
Martina I. Okwueze, Nancy L. Cardwell, Alonda C. Pollins & Lillian B. Nanney. (2007) Modulation of Porcine Wound Repair with a Transfected ErbB3 Gene and Relevant EGF-Like Ligands. Journal of Investigative Dermatology 127:5, pages 1030-1041.
Crossref
Mari Maegawa, Kenji Takeuchi, Eishi Funakoshi, Katsumi Kawasaki, Kazuto Nishio, Nobuyoshi Shimizu & Fumiaki Ito. (2007) Growth Stimulation of Non–Small Cell Lung Cancer Cell Lines by Antibody against Epidermal Growth Factor Receptor Promoting Formation of ErbB2/ErbB3 Heterodimers. Molecular Cancer Research 5:4, pages 393-401.
Crossref
S H Choi, J M Mendrola & M A Lemmon. (2006) EGF-independent activation of cell-surface EGF receptors harboring mutations found in gefitinib-sensitive lung cancer. Oncogene 26:11, pages 1567-1576.
Crossref
Mia Thompson, Simone Lauderdale, Maree J. Webster, Victor Z. Chong, Benjamin McClintock, Richard Saunders & Cynthia Shannon Weickert. (2007) Widespread expression of ErbB2, ErbB3 and ErbB4 in non-human primate brain. Brain Research 1139, pages 95-109.
Crossref
Jie-Ying Liao, Lin-Lin Li, Qun Wei & Jia-Chang Yue. (2007) Heregulinβ activates store-operated Ca2+ channels through c-erbB2 receptor level-dependent pathway in human breast cancer cells. Archives of Biochemistry and Biophysics 458:2, pages 244-252.
Crossref
Ming Tan & Dihua Yu. 2007. Breast Cancer Chemosensitivity. Breast Cancer Chemosensitivity 119 129 .
T. S. Wehrman, W. J. Raab, C. L. Casipit, R. Doyonnas, J. H. Pomerantz & H. M. Blau. (2006) A system for quantifying dynamic protein interactions defines a role for Herceptin in modulating ErbB2 interactions. Proceedings of the National Academy of Sciences 103:50, pages 19063-19068.
Crossref
Richard M. Gallo, Ianthe Bryant, Rachael Fry, Eric E. Williams & David J. RieseIIII. (2006) Phosphorylation of ErbB4 on Tyr1056 is critical for inhibition of colony formation by prostate tumor cell lines. Biochemical and Biophysical Research Communications 349:1, pages 372-382.
Crossref
Beatrice Howard & Alan Ashworth. (2006) Signalling Pathways Implicated in Early Mammary Gland Morphogenesis and Breast Cancer. PLoS Genetics 2:8, pages e112.
Crossref
M. Dreilich, A. Wanders, D. Brattström, S. Bergström, P. Hesselius, G. Wagenius & M. Bergqvist. (2006) HER-2 overexpression (3+) in patients with squamous cell esophageal carcinoma correlates with poorer survival. Diseases of the Esophagus 19:4, pages 224-231.
Crossref
Raymond M. Esper, Mark S. Pankonin & Jeffrey A. Loeb. (2006) Neuregulins: Versatile growth and differentiation factors in nervous system development and human disease. Brain Research Reviews 51:2, pages 161-175.
Crossref
Victoria P. Ramsauer, Vanessa Pino, Amjad Farooq, Coralie A. Carothers Carraway, Pedro J.I. Salas & Kermit L. Carraway. (2006) Muc4–ErbB2 Complex Formation and Signaling in Polarized CACO-2 Epithelial Cells Indicate That Muc4 Acts as an Unorthodox Ligand for ErbB2. Molecular Biology of the Cell 17:7, pages 2931-2941.
Crossref
Zhiyou Zhang, Lisa Prentiss, Deborah Heitzman, Richard C. Stahl, Frank DiPino & David J. Carey. (2006) Neuregulin isoforms in dorsal root ganglion neurons: Effects of the cytoplasmic domain on localization and membrane shedding of Nrg-1 type I. Journal of Neuroscience Research 84:1, pages 1-12.
Crossref
Lixing Zhan, Bin Xiang & Senthil K. Muthuswamy. (2006) Controlled Activation of ErbB1/ErbB2 Heterodimers Promote Invasion of Three-Dimensional Organized Epithelia in an ErbB1-Dependent Manner: Implications for Progression of ErbB2-Overexpressing Tumors. Cancer Research 66:10, pages 5201-5208.
Crossref
Jennifer L. GilmoreRichard M. GalloDavid J. RieseIIII. (2006) The epidermal growth factor receptor (EGFR)-S442F mutant displays increased affinity for neuregulin-2β and agonist-independent coupling with downstream signalling events. Biochemical Journal 396:1, pages 79-88.
Crossref
D R Emlet, R Schwartz, K A Brown, A A Pollice, C A Smith & S E Shackney. (2006) HER2 expression as a potential marker for response to therapy targeted to the EGFR. British Journal of Cancer 94:8, pages 1144-1153.
Crossref
Gilad Silberberg, Ariel Darvasi, Ronit Pinkas-Kramarski & Ruth Navon. (2006) The involvement ofErbB4 with schizophrenia: Association and expression studies. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 141B:2, pages 142-148.
Crossref
Pinliang Hu, Tao Zhou, Lu Qian, Jianing Wang, Ming Shi, Ming Yu, Yi Yang, Xuemin Zhang, Beifen Shen & Ning Guo. (2006) Sequestering ErbB2 in endoplasmic reticulum by its autoinhibitor from translocation to cell surface: An autoinhibition mechanism of ErbB2 expression. Biochemical and Biophysical Research Communications 342:1, pages 19-27.
Crossref
Gottfried E. Konecny, Mark D. Pegram, Natarajan Venkatesan, Richard Finn, Guorong Yang, Martina Rahmeh, Michael Untch, David W. Rusnak, Glenn Spehar, Robert J. Mullin, Barry R. Keith, Tona M. Gilmer, Mark Berger, Karl C. Podratz & Dennis J. Slamon. (2006) Activity of the Dual Kinase Inhibitor Lapatinib (GW572016) against HER-2-Overexpressing and Trastuzumab-Treated Breast Cancer Cells. Cancer Research 66:3, pages 1630-1639.
Crossref
Chengsen Xue, Fubo Liang, Radma Mahmood, Magalis Vuolo, Jeffrey Wyckoff, Hong Qian, Kun-Lin Tsai, Mimi Kim, Joseph Locker, Zhong-Yin Zhang & Jeffrey E. Segall. (2006) ErbB3-Dependent Motility and Intravasation in Breast Cancer Metastasis. Cancer Research 66:3, pages 1418-1426.
Crossref
Eric K. Rowinsky. 2006. Breast Cancer and Molecular Medicine. Breast Cancer and Molecular Medicine 741 780 .
Anthony McCabe, Marisa Dolled-Filhart, Robert L. Camp & David L. Rimm. (2005) Automated Quantitative Analysis (AQUA) of In Situ Protein Expression, Antibody Concentration, and Prognosis. JNCI: Journal of the National Cancer Institute 97:24, pages 1808-1815.
Crossref
Pinliang Hu, Jiannan Feng, Tao Zhou, Jianing Wang, Baofeng Jing, Ming Yu, Meiru Hu, Xuemin Zhang, Beifen Shen & Ning Guo. (2005) In vivo identification of the interaction site of ErbB2 extracellular domain with its autoinhibitor. Journal of Cellular Physiology 205:3, pages 335-343.
Crossref
Caining Jin, Peiguo Ding, Ying Wang & Dalong Ma. (2005) Regulation of EGF receptor signaling by the MARVEL domain-containing protein CKLFSF8. FEBS Letters 579:28, pages 6375-6382.
Crossref
Naciba Benlimame, Qiang He, Su Jie, Dingzhang Xiao, Ying Jie Xu, Martin Loignon, David D. Schlaepfer & Moulay A. Alaoui-Jamali. (2005) FAK signaling is critical for ErbB-2/ErbB-3 receptor cooperation for oncogenic transformation and invasion. Journal of Cell Biology 171:3, pages 505-516.
Crossref
Aeree Kim, Bolin Liu, Dalia Ordonez-Ercan, Kathy M Alvarez, Lynn D Jones, Christine McKimmey, Susan M Edgerton, XiaoHe Yang & Ann D Thor. (2005) Functional interaction between mouse erbB3 and wild-type rat c-neu in transgenic mouse mammary tumor cells. Breast Cancer Research 7:5.
Crossref
Beatrice Howard, Heena Panchal, Afshan McCarthy & Alan Ashworth. (2005) Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specification . Genes & Development 19:17, pages 2078-2090.
Crossref
Hideaki Dote, David Cerna, William E. Burgan, Kevin Camphausen & Philip J. Tofilon. (2005) ErbB3 Expression Predicts Tumor Cell Radiosensitization Induced by Hsp90 Inhibition. Cancer Research 65:15, pages 6967-6975.
Crossref
David E. Nethery, Bethany B. Moore, George Minowada, James Carroll, Jihane A. Faress & Jeffrey A. Kern. (2005) Expression of mutant human epidermal receptor 3 attenuates lung fibrosis and improves survival in mice. Journal of Applied Physiology 99:1, pages 298-307.
Crossref
Yi Peter Hu, Srinivas Venkateswarlu, Natalia Sergina, Gillian Howell, Patricia St. Clair, Lisa E. Humphrey, Wenhui Li, Jennie Hauser, Elizabeth Zborowska, James K.V. Willson & Michael G. Brattain. (2005) Reorganization of ErbB Family and Cell Survival Signaling after Knock-down of ErbB2 in Colon Cancer Cells. Journal of Biological Chemistry 280:29, pages 27383-27392.
Crossref
Shari A. Price-Schiavi, Eran Andrechek, Nebila Idris, Peter Li, Min Rong, Jin Zhang, Coralie A. Carothers Carraway, William J. Muller & Kermit L. Carraway. (2005) Expression, location, and interactions of ErbB2 and its intramembrane ligand Muc4 (sialomucin complex) in rat mammary gland during pregnancy. Journal of Cellular Physiology 203:1, pages 44-53.
Crossref
Christopher W. Gregory, Young E. Whang, Wesley McCall, Xiaoyin Fei, Yuanbo Liu, Liliana A. Ponguta, Frank S. French, Elizabeth M. Wilson & H. Shelton EarpIIIIII. (2005) Heregulin-Induced Activation of HER2 and HER3 Increases Androgen Receptor Transactivation and CWR-R1 Human Recurrent Prostate Cancer Cell Growth. Clinical Cancer Research 11:5, pages 1704-1712.
Crossref
Michael P. DiGiovanna, David F. Stern, Susan M. Edgerton, Steve G. Whalen, Dan MooreIIII & Ann D. Thor. (2005) Relationship of Epidermal Growth Factor Receptor Expression to ErbB-2 Signaling Activity and Prognosis in Breast Cancer Patients. Journal of Clinical Oncology 23:6, pages 1152-1160.
Crossref
Robert B. Hegeman, Glenn Liu, George Wilding & Douglas G. McNeel. (2004) Newer Therapies in Advanced Prostate Cancer. Clinical Prostate Cancer 3:3, pages 150-156.
Crossref
Naoko Brown, Kaushik Deb, Bibhash C. Paria, Sanjoy K. Das & Jeff Reese. (2004) Embryo-Uterine Interactions via the Neuregulin Family of Growth Factors During Implantation in the Mouse1. Biology of Reproduction 71:6, pages 2003-2011.
Crossref
Radu Marches & Jonathan W. Uhr. (2004) Enhancement of the p27Kip1-mediated antiproliferative effect of trastuzumab (Herceptin) on HER2-overexpressing tumor cells. International Journal of Cancer 112:3, pages 492-501.
Crossref
Christopher C. Williams, June G. Allison, Gregory A. Vidal, Matthew E. Burow, Barbara S. Beckman, Luis Marrero & Frank E. Jones. (2004) The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone. Journal of Cell Biology 167:3, pages 469-478.
Crossref
Qunfang Li, Sharlin Ahmed & Jeffrey A. Loeb. (2004) Development of an Autocrine Neuregulin Signaling Loop with Malignant Transformation of Human Breast Epithelial Cells. Cancer Research 64:19, pages 7078-7085.
Crossref
Rodney B Luwor, Hong-Jian Zhu, Francesca Walker, Angela A Vitali, Rushika M Perera, Antony W Burgess, Andrew M Scott & Terrance G Johns. (2004) The tumor-specific de2–7 epidermal growth factor receptor (EGFR) promotes cells survival and heterodimerizes with the wild-type EGFR. Oncogene 23:36, pages 6095-6104.
Crossref
Sean Caenepeel, Glen Charydczak, Sucha Sudarsanam, Tony Hunter & Gerard Manning. (2004) The mouse kinome: Discovery and comparative genomics of all mouse protein kinases. Proceedings of the National Academy of Sciences 101:32, pages 11707-11712.
Crossref
Alain C. Mita, Monica M. Mita & Eric K. Rowinsky. (2004) Development of Rationally Designed, Target-Based Agents for the Treatment of Advanced Colorectal Cancer. Clinical Colorectal Cancer 4:2, pages 107-123.
Crossref
M Hatakeyama, N Yumoto, X Yu, M Shirouzu, S Yokoyama & A Konagaya. (2004) Transformation potency of ErbB heterodimer signaling is determined by B-Raf kinase. Oncogene 23:29, pages 5023-5031.
Crossref
Yun Zhu & Frank E. Jones. (2004) The ErbB signaling network is coordinately expressed and activated in the mouse prostate. The Prostate 60:1, pages 68-75.
Crossref
James G. Jackson, Patricia St. Clair, Mark X. Sliwkowski & Michael G. Brattain. (2004) Blockade of Epidermal Growth Factor- or Heregulin-Dependent ErbB2 Activation with the Anti-ErbB2 Monoclonal Antibody 2C4 Has Divergent Downstream Signaling and Growth Effects. Cancer Research 64:7, pages 2601-2609.
Crossref
Mina D Marmor, Kochupurakkal Bose Skaria & Yosef Yarden. (2004) Signal transduction and oncogenesis by ErbB/HER receptors. International Journal of Radiation Oncology*Biology*Physics 58:3, pages 903-913.
Crossref
Dhara N Amin, Archibald S Perkins & David F Stern. (2003) Gene expression profiling of ErbB receptor and ligand-dependent transcription. Oncogene 23:7, pages 1428-1438.
Crossref
Eric K. Rowinsky. (2004) The erbB Family: Targets for Therapeutic Development Against Cancer and Therapeutic Strategies Using Monoclonal Antibodies and Tyrosine Kinase Inhibitors. Annual Review of Medicine 55:1, pages 433-457.
Crossref
Stuart S Hobbs, Elizabeth M Cameron, Robert P Hammer, Ann T D Le, Richard M Gallo, Erika N Blommel, Stephanie L Coffing, Han Chang & David J RieseIIII. (2003) Five carboxyl-terminal residues of neuregulin2 are critical for stimulation of signaling by the ErbB4 receptor tyrosine kinase. Oncogene 23:4, pages 883-893.
Crossref
Maarten L. Janmaat & Giuseppe Giaccone. (2003) Small-Molecule Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors. The Oncologist 8:6, pages 576-586.
Crossref
Ana B. Espinosa, PhD, Maria D. Tabernero, MD, PhD, Maria C. GarcÍa-MacÍas, MD,Daniel Primo, PhD, Amalia GÓmez Bernal, MD, Juan J. Cruz, MD PhD, Manuel Ramos, MD, Jaime Font de Mora, PhD, Alberto GÓmez Alonso, MD, PhD & Alberto Orfao, MD, PhD. (2003) Her-2/neu Gene Amplification in Familial vs Sporadic Breast Cancer; Impact on the Behavior of the Disease. American Journal of Clinical Pathology 120:6, pages 917-927.
Crossref
Victoria P. Ramsauer, Coralie A.Carothers Carraway, Pedro J.I. Salas & Kermit L. Carraway. (2003) Muc4/Sialomucin Complex, the Intramembrane ErbB2 Ligand, Translocates ErbB2 to the Apical Surface in Polarized Epithelial Cells. Journal of Biological Chemistry 278:32, pages 30142-30147.
Crossref
G. Hudelist, C.F. Singer, M. Manavi, K. Pischinger, E. Kubista & K. Czerwenka. (2003) Co-Expression of ErbB-Family Members in Human Breast Cancer: Her-2/neu is the Preferred Dimerization Candidate in Nodal-positive Tumors. Breast Cancer Research and Treatment 80:3, pages 353-361.
Crossref
Thomas Holbro, Roger R. Beerli, Francisca Maurer, Magdalena Koziczak, Carlos F. BarbasIIIIII & Nancy E. Hynes. (2003) The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation. Proceedings of the National Academy of Sciences 100:15, pages 8933-8938.
Crossref
Sergio Anastasi, Loredana Fiorentino, Monia Fiorini, Rocco Fraioli, Gianluca Sala, L Castellani, Stefano Alemà, Maurizio Alimandi & Oreste Segatto. (2003) Feedback inhibition by RALT controls signal output by the ErbB network. Oncogene 22:27, pages 4221-4234.
Crossref
V. Grunwald & M. Hidalgo. (2003) Developing Inhibitors of the Epidermal Growth Factor Receptor for Cancer Treatment. JNCI Journal of the National Cancer Institute 95:12, pages 851-867.
Crossref
DAVID C. LEE, SUSAN WOHLER SUNNARBORG, C. LEANN HINKLE, TIMOTHY J. MYERS, MARY STEVENSON, WILLIAM E. RUSSELL, BEVERLY J. CASTNER, MARY J. GERHART, RAYMOND J. PAXTON, ROY A. BLACK, AILEEN CHANG & LESLIE F. JACKSON. (2003) TACE/ADAM17 Processing of EGFR Ligands Indicates a Role as a Physiological Convertase. Annals of the New York Academy of Sciences 995:1, pages 22-38.
Crossref
Pazit Tal-Or, Ayelet Di-Segni, Zipora Lupowitz & Ronit Pinkas-Kramarski. (2003) Neuregulin promotes autophagic cell death of prostate cancer cells. The Prostate 55:2, pages 147-157.
Crossref
Catelijne Stortelers, Sebastian P. van der Woning, Saskia Jacobs-Oomen, Miriam Wingens & Everardus J.J. van Zoelen. (2003) Selective Formation of ErbB-2/ErbB-3 Heterodimers Depends on the ErbB-3 Affinity of Epidermal Growth Factor-like Ligands. Journal of Biological Chemistry 278:14, pages 12055-12063.
Crossref
Eric E Williams, Laurie J Trout, Richard M Gallo, Sarah E Pitfield, Ianthe Bryant, Desi J Penington & David J RieseIIII. (2003) A constitutively active ErbB4 mutant inhibits drug-resistant colony formation by the DU-145 and PC-3 human prostate tumor cell lines. Cancer Letters 192:1, pages 67-74.
Crossref
Jonathan A. Ewald, John C. Wilkinson, Cheryl A. Guyer & James V. Staros. (2003) Ligand- and kinase activity-independent cell survival mediated by the epidermal growth factor receptor expressed in 32D cells. Experimental Cell Research 282:2, pages 121-131.
Crossref
Graham Carpenter. 2003. The EGF Receptor Family. The EGF Receptor Family 69 80 .
Ami Citri, Kochupurakkal Bose Skaria & Yosef Yarden. 2003. The EGF Receptor Family. The EGF Receptor Family 57 68 .
Stuart S Hobbs, Stephanie L Coffing, Ann TD Le, Elizabeth M Cameron, Eric E Williams, Michelle Andrew, Erika N Blommel, Robert P Hammer, Han Chang & David J RieseIIII. (2002) Neuregulin isoforms exhibit distinct patterns of ErbB family receptor activation. Oncogene 21:55, pages 8442-8452.
Crossref
Lily YenNaciba BenlimameZeng-Rong NieDingzhang XiaoTaiqi WangAla-Eddin Al MoustafaHiroyasu EsumiJulie Milanini, Nancy E. Hynes, Gilles Pages & Moulay A. Alaoui-Jamali. (2002) Differential Regulation of Tumor Angiogenesis by Distinct ErbB Homo- and Heterodimers. Molecular Biology of the Cell 13:11, pages 4029-4044.
Crossref
STEVEN A. CRONE & KUO-FEN LEE. (2002) Gene Targeting Reveals Multiple Essential Functions of the Neuregulin Signaling System during Development of the Neuroendocrine and Nervous Systems. Annals of the New York Academy of Sciences 971:1, pages 547-553.
Crossref
Kudsia Feroz, Eric Williams & David J. RieseIIII. (2002) ErbB2 and ErbB3 do not quantitatively modulate ligand-induced ErbB4 tyrosine phosphorylation. Cellular Signalling 14:9, pages 793-798.
Crossref
Elicia Penuel, Robert W. Akita & Mark X. Sliwkowski. (2002) Identification of a Region within the ErbB2/HER2 Intracellular Domain That Is Necessary for Ligand-independent Association. Journal of Biological Chemistry 277:32, pages 28468-28473.
Crossref
Xiaochun Yu, Kailash D. Sharma, Tsuyoshi Takahashi, Ryo Iwamoto & Eisuke Mekada. (2002) Ligand-independent Dimer Formation of Epidermal Growth Factor Receptor (EGFR) Is a Step Separable from Ligand-induced EGFR Signaling. Molecular Biology of the Cell 13:7, pages 2547-2557.
Crossref
Jessica C Morcinek, Christin Weisser, Eva Geissinger, Manfred Schartl & Claudia Wellbrock. (2002) Activation of STAT5 triggers proliferation and contributes to anti-apoptotic signalling mediated by the oncogenic Xmrk kinase. Oncogene 21:11, pages 1668-1678.
Crossref
Xiuwen Tang, Ian H. Batty & C. Peter Downes. (2002) Muscarinic Receptors Mediate Phospholipase C-dependent Activation of Protein Kinase B via Ca2+, ErbB3, and Phosphoinositide 3-Kinase in 1321N1 Astrocytoma Cells. Journal of Biological Chemistry 277:1, pages 338-344.
Crossref
Cynthia A. Heinlein & Chawnshang Chang. 2002. Androgens and Androgen Receptor. Androgens and Androgen Receptor 57 90 .
Chris Moore, Marco Leu, Ulrich Müller & Hans Rudolf Brenner. (2001) Induction of multiple signaling loops by MuSK during neuromuscular synapse formation. Proceedings of the National Academy of Sciences 98:25, pages 14655-14660.
Crossref
Zuleima Aguilar & Dennis J. Slamon. (2001) The Transmembrane Heregulin Precursor Is Functionally Active. Journal of Biological Chemistry 276:47, pages 44099-44107.
Crossref
S Erlich, Y Goldshmit, Z Lupowitz & R Pinkas-Kramarski. (2001) ErbB-4 activation inhibits apoptosis in PC12 cells. Neuroscience 107:2, pages 353-362.
Crossref
Song-Kyu Park, Robert Miller, Ian Krane & Timothy Vartanian. (2001) The erbB2 gene is required for the development of terminally differentiated spinal cord oligodendrocytes. Journal of Cell Biology 154:6, pages 1245-1258.
Crossref
Nicolas G Azios, Farida Jhabvala Romero, Michael C Denton, Joni K Doherty & Gail M Clinton. (2001) Expression of herstatin, an autoinhibitor of HER-2/neu, inhibits transactivation of HER-3 by HER-2 and blocks EGF activation of the EGF receptor. Oncogene 20:37, pages 5199-5209.
Crossref
Colleen Sweeney, Douglas Fambrough, Christine Huard, A. John Diamonti, Eric S. Lander, Lewis C. Cantley & Kermit L. CarrawayIIIIII. (2001) Growth Factor-specific Signaling Pathway Stimulation and Gene Expression Mediated by ErbB Receptors. Journal of Biological Chemistry 276:25, pages 22685-22698.
Crossref
Mehdi Houimel, Pascal Schneider, Alexei Terskikh & Jean-Pierre Mach. (2001) Selection of peptides and synthesis of pentameric peptabody molecules reacting specifically with ErbB-2 receptor. International Journal of Cancer 92:5, pages 748-755.
Crossref
Yosef Yarden & Mark X. Sliwkowski. (2001) Untangling the ErbB signalling network. Nature Reviews Molecular Cell Biology 2:2, pages 127-137.
Crossref
Koichiro Satoh, Shinichi Kikuchi, Masayuki Sekimata, Yukihito Kabuyama, Miwako K. Homma & Yoshimi Homma. (2001) Involvement of ErbB-2 in rheumatoid synovial cell growth. Arthritis & Rheumatism 44:2, pages 260-265.
Crossref
Stefan W. Stoll, Sanjay Kansra, Scott Peshick, David W. Fry, Wilbur R. Leopold, Jane F. Wiesen, Maria Sibilia, Tong Zhang, Zena Werb, Rik Derynck, Erwin F. Wagner & James T. Elder. (2001) Differential Utilization and Localization of ErbB Receptor Tyrosine Kinases in Skin Compared to Normal and Malignant Keratinocytes. Neoplasia 3:4, pages 339-350.
Crossref
Daniel Harari & Yosef Yarden. (2000) Molecular mechanisms underlying ErbB2/HER2 action in breast cancer. Oncogene 19:53, pages 6102-6114.
Crossref
A.D. ThorS. LiuS. EdgertonD. MooreIIIIK.M. KasowitzC.C. BenzD.F. SternM.P. DiGiovanna. (2000) Activation (Tyrosine Phosphorylation) of ErbB-2 (HER-2/neu): A Study of Incidence and Correlation With Outcome in Breast Cancer. Journal of Clinical Oncology 18:18, pages 3230-3239.
Crossref
Kouji Yamada, Naohiro Ichino, Kazuhiro Nishii, Hirohide Sawada, Shigeki Higashiyama, Hiroshi Ishiguro & Toshiharu Nagatsu. (2000) Characterization of the human NTAK gene structure and distribution of the isoforms for rat NTAK mRNA. Gene 255:1, pages 15-24.
Crossref
Elena Odintsova, Tsuyoshi Sugiura & Fedor Berditchevski. (2000) Attenuation of EGF receptor signaling by a metastasis suppressor, the tetraspanin CD82/KAI-1. Current Biology 10:16, pages 1009-1012.
Crossref
Paivi J. Miettinen, Mari-Anne Huotari, Tarja Koivisto, Jarkko Ustinov, Jaan Palgi, Suvi Rasilainen, Eero Lehtonen, Jorma Keski-Oja & Timo Otonkoski. (2000) Impaired migration and delayed differentiation of pancreatic islet cells in mice lacking EGF-receptors. Development 127:12, pages 2617-2627.
Crossref
David F Stern. (2000) Tyrosine kinase signalling in breast cancer: ErbB family receptor tyrosine kinases. Breast Cancer Research 2:3.
Crossref
Z.Selcuk Tuncer, Gyorgy L. Vegh, Vilmos Fulop, David R. Genest, Samuel C. Mok & Ross S. Berkowitz. (2000) Expression of Epidermal Growth Factor Receptor-Related Family Products in Gestational Trophoblastic Diseases and Normal Placenta and Its Relationship with Development of Postmolar Tumor. Gynecologic Oncology 77:3, pages 389-393.
Crossref
Neil V. Patel, Michael J. Acarregui, Jeanne M. Snyder, Jonathan M. Klein, Mark X. Sliwkowski & Jeffrey A. Kern. (2000) Neuregulin-1 and Human Epidermal Growth Factor Receptors 2 and 3 Play a Role in Human Lung Development In Vitro . American Journal of Respiratory Cell and Molecular Biology 22:4, pages 432-440.
Crossref
Anna Vaskovsky, Zipora Lupowitz, Shlomit Erlich & Ronit Pinkas-Kramarski. (2000) ErbB-4 Activation Promotes Neurite Outgrowth in PC12 Cells. Journal of Neurochemistry 74:3, pages 979-987.
Crossref
Kerry Strong Russell, David F. Stern, Peter J. Polverini & Jeffrey R. Bender. (1999) Neuregulin activation of ErbB receptors in vascular endothelium leads to angiogenesis. American Journal of Physiology-Heart and Circulatory Physiology 277:6, pages H2205-H2211.
Crossref
Hitoshi Noguchi, Choitsu Sakamoto, Ken Wada, Tomonori Akamatsu, Tohru Uchida, Atsushi Tatsuguchi, Hirofumi Matsui, Hirokazu Fukui, Takahiro Fujimori & Masato Kasuga. (1999) Expression of heregulin α, erbB2, and erbB3 and their influences on proliferation of gastric epithelial cells. Gastroenterology 117:5, pages 1119-1127.
Crossref
Zuleima Aguilar, Robert W Akita, Richard S Finn, B Lillian Ramos, Mark D Pegram, Fairooz F Kabbinavar, Richard J Pietras, Paul Pisacane, Mark X Sliwkowski & Dennis J Slamon. (1999) Biologic effects of heregulin/neu differentiation factor on normal and malignant human breast and ovarian epithelial cells. Oncogene 18:44, pages 6050-6062.
Crossref
Frank E. Jones, Thomas Welte, Xin-Yuan Fu & David F. Stern. (1999) Erbb4 Signaling in the Mammary Gland Is Required for Lobuloalveolar Development and Stat5 Activation during Lactation. Journal of Cell Biology 147:1, pages 77-88.
Crossref
Marian L. Saxon & David C. Lee. (1999) Mutagenesis Reveals a Role for Epidermal Growth Factor Receptor Extracellular Subdomain IV in Ligand Binding. Journal of Biological Chemistry 274:40, pages 28356-28362.
Crossref
Amy Francis, Timothy D. Raabe, Duanzhi Wen & George H. DeVries. (1999) Neuregulins and ErbB receptors in cultured neonatal astrocytes. Journal of Neuroscience Research 57:4, pages 487-494.
Crossref
Manuela Campiglio, Suhad Ali, Piotr G. Knyazev & Axel Ullrich. (1999) Characteristics of EGFR family-mediated HRG signals in human ovarian cancer. Journal of Cellular Biochemistry 73:4, pages 522-532.
Crossref
Riccardo Polosa, Gaetano Prosperini, Shih-Hsing Leir, Stephen T. Holgate, Peter M. Lackie & Donna E. Davies. (1999) Expression of c-erbB Receptors and Ligands in Human Bronchial Mucosa. American Journal of Respiratory Cell and Molecular Biology 20:5, pages 914-923.
Crossref
D Harari, E Tzahar, J Romano, M Shelly, JH Pierce, GC Andrews & Y Yarden. (1999) Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase. Oncogene 18:17, pages 2681-2689.
Crossref
Leah N. Klapper, Stefanie Glathe, Nora Vaisman, Nancy E. Hynes, Glenn C. Andrews, Michael Sela & Yosef Yarden. (1999) The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factors. Proceedings of the National Academy of Sciences 96:9, pages 4995-5000.
Crossref
Peter O Hackel, Esther Zwick, Norbert Prenzel & Axel Ullrich. (1999) Epidermal growth factor receptors: critical mediators of multiple receptor pathways. Current Opinion in Cell Biology 11:2, pages 184-189.
Crossref
Caterina Bianco, Subha Kannan, Marta De Santis, Masaharu Seno, Careen K. Tang, Isabel Martinez-Lacaci, Nancy Kim, Brenda Wallace-Jones, Marc E. Lippman, Andreas D. Ebert, Christian Wechselberger & David S. Salomon. (1999) Cripto-1 Indirectly Stimulates the Tyrosine Phosphorylation oferb B-4 through a Novel Receptor. Journal of Biological Chemistry 274:13, pages 8624-8629.
Crossref
Robert A. Harris, Thomas J. Eichholtz, Ian D. Hiles, Martin J. Page & Michael J. O'Hare. (1999) New model of ErbB-2 over-expression in human mammary luminal epithelial cells. International Journal of Cancer 80:3, pages 477-484.
Crossref

Displaying 200 of 258 citing articles. Use the download link below to view the full list of citing articles.

Download full citations list

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.