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Molecular and Cellular Biology Volume 15, 1995 - Issue 11
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Research Article

Requirement of the SH3 and SH2 Domains for the Inhibitory Function of Tyrosine Protein Kinase p50csk in T Lymphocytes

Jean-François Cloutier1 Departments of McGill Cancer Centre, Montréal, Québec, CanadaH3G 1Y6;2 Departments of Medicine, Montréal, Québec, CanadaH3G 1Y6
,
Lionel M. L. Chow1 Departments of McGill Cancer Centre, Montréal, Québec, CanadaH3G 1Y6;2 Departments of Medicine, Montréal, Québec, CanadaH3G 1Y6
&
André Veillette1 Departments of McGill Cancer Centre, Montréal, Québec, CanadaH3G 1Y6;2 Departments of Medicine, Montréal, Québec, CanadaH3G 1Y6;3 Departments of Biochemistry, Montréal, Québec, CanadaH3G 1Y6;4 Departments of Oncology, McGill University, Montréal, Québec, CanadaH3G 1Y6;5 Departments of Medicine, Montréal, Québec, CanadaH3G 1A4;6 Departments of Oncology, Montreal General Hospital, Montréal, Québec, CanadaH3G 1A4Correspondence[email protected]
Pages 5937-5944 | Received 30 May 1995, Accepted 11 Aug 1995, Published online: 30 Mar 2023

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Bing Wang, Serge Lemay, Schickwann Tsai & André Veillette. (2001) SH2 Domain-Mediated Interaction of Inhibitory Protein Tyrosine Kinase Csk with Protein Tyrosine Phosphatase-HSCF. Molecular and Cellular Biology 21:4, pages 1077-1088.
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Darren M. Kamikura, Hanane Khoury, Christiane Maroun, Monica A. Naujokas & Morag Park. (2000) Enhanced Transformation by a Plasma Membrane-Associated Met Oncoprotein: Activation of a Phosphoinositide 3′-Kinase-Dependent Autocrine Loop Involving Hyaluronic Acid and CD44. Molecular and Cellular Biology 20:10, pages 3482-3496.
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Serge Lemay, Dominique Davidson, Sylvain Latour & André Veillette. (2000) Dok-3, a Novel Adapter Molecule Involved in the Negative Regulation of Immunoreceptor Signaling. Molecular and Cellular Biology 20:8, pages 2743-2754.
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Zen-ichiro Honda, Takeshi Suzuki, Hajime Kono, Masato Okada, Tadashi Yamamoto, Chisei Ra, Yutaka Morita & Kazuhiko Yamamoto. (2000) Sequential Requirements of the N-Terminal Palmitoylation Site and SH2 Domain of Src Family Kinases in the Initiation and Progression of FcɛRI Signaling. Molecular and Cellular Biology 20:5, pages 1759-1771.
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Articles from other publishers (46)

Gongqin Sun & Marina K. Ayrapetov. (2023) Dissection of the catalytic and regulatory structure-function relationships of Csk protein tyrosine kinase. Frontiers in Cell and Developmental Biology 11.
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Ben F. BrianIVIV, Frances V. Sjaastad & Tanya S. Freedman. (2022) SH3-domain mutations selectively disrupt Csk homodimerization or PTPN22 binding. Scientific Reports 12:1.
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Janice Sarmiento, Robert H. Wallis, Terri Ning, Leili Marandi, Gary Chao, André Veillette, Åke Lernmark, Andrew D. Paterson & Philippe Poussier. (2015) A Functional Polymorphism of Ptpn22 Is Associated with Type 1 Diabetes in the BioBreeding Rat . The Journal of Immunology 194:2, pages 615-629.
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Nicole M. Chapman & Jon C. D. Houtman. (2014) Functions of the FAK family kinases in T cells: beyond actin cytoskeletal rearrangement. Immunologic Research 59:1-3, pages 23-34.
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Ying Xim Tan, Boryana N Manz, Tanya S Freedman, Chao Zhang, Kevan M Shokat & Arthur Weiss. (2013) Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling. Nature Immunology 15:2, pages 186-194.
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Nicole M. Chapman, Sean F. Connolly, Erin L. Reinl & Jon C. D. Houtman. (2013) Focal Adhesion Kinase Negatively Regulates Lck Function Downstream of the T Cell Antigen Receptor. The Journal of Immunology 191:12, pages 6208-6221.
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Jessica G. Borger, Andrew Filby & Rose Zamoyska. (2013) Differential Polarization of C-Terminal Src Kinase between Naive and Antigen-Experienced CD8+ T Cells. The Journal of Immunology 190:7, pages 3089-3099.
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Rebecca J. Brownlie & Rose Zamoyska. (2013) T cell receptor signalling networks: branched, diversified and bounded. Nature Reviews Immunology 13:4, pages 257-269.
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María Luisa de la Puerta, Antonio G. Trinidad, María del Carmen Rodríguez, José María de Pereda, Mariano Sánchez Crespo, Yolanda Bayón & Andrés Alonso. (2013) The Autoimmunity Risk Variant LYP-W620 Cooperates with CSK in the Regulation of TCR Signaling. PLoS ONE 8:1, pages e54569.
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WENJUAN YU, YUEWEI WANG, MIAOZI GONG, FEI PEI & JIE ZHENG. (2012) Phosphoprotein associated with glycosphingolipid microdomains 1 inhibits the proliferation and invasion of human prostate cancer cells in vitro through suppression of Ras activation. Oncology Reports 28:2, pages 606-614.
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Jamie R. SchoenbornYing Xim TanChao ZhangKevan M. ShokatArthur Weiss. (2011) Feedback Circuits Monitor and Adjust Basal Lck-Dependent Events in T Cell Receptor Signaling. Science Signaling 4:190.
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Liudmilla RubbiBjörn TitzLauren BrownErica GalvanEvangelia KomisopoulouSharon S. ChenTracey LowMartik TahmasianBrian SkaggsMarkus MüschenMatteo PellegriniThomas G. Graeber. (2011) Global Phosphoproteomics Reveals Crosstalk Between Bcr-Abl and Negative Feedback Mechanisms Controlling Src Signaling. Science Signaling 4:166.
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Pavel Otáhal, Supansa Pata, Pavla Angelisová, Václav Hořejší & Tomáš Brdička. (2011) The effects of membrane compartmentalization of csk on TCR signaling. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1813:2, pages 367-376.
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Nicholas M. Levinson, Patrick R. Visperas & John Kuriyan. (2009) The Tyrosine Kinase Csk Dimerizes through Its SH3 Domain. PLoS ONE 4:11, pages e7683.
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K. M. Torgersen, E. M. Aandahl & K. Taskén. 2008. Protein-Protein Interactions as New Drug Targets. Protein-Protein Interactions as New Drug Targets 327 363 .
Anita Posevitz-Fejfár, Michal Šmída, Stefanie Kliche, Roland Hartig, Burkhart Schraven & Jonathan A. Lindquist. (2008) A displaced PAG enhances proximal signaling and SDF-1-induced T cell migration. European Journal of Immunology 38:1, pages 250-259.
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Marina K. Ayrapetov, Nguyen Hai Nam, Guofeng Ye, Anil Kumar, Keykavous Parang & Gongqin Sun. (2005) Functional Diversity of Csk, Chk, and Src SH2 Domains due to a SingleResidueVariation. Journal of Biological Chemistry 280:27, pages 25780-25787.
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Stefanie Kliche, Jonathan A. Lindquist & Burkhart Schraven. (2004) Transmembrane adapters: structure, biochemistry and biology. Seminars in Immunology 16:6, pages 367-377.
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Václav Hořejšı&#x;. (2004) Transmembrane adaptor proteins in membrane microdomains: important regulators of immunoreceptor signaling. Immunology Letters 92:1-2, pages 43-49.
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Hidetada Matsuoka, Shigeyuki Nada & Masato Okada. (2004) Mechanism of Csk-mediated Down-regulation of Src Family Tyrosine Kinases in Epidermal Growth Factor Signaling. Journal of Biological Chemistry 279:7, pages 5975-5983.
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Jonathan A. Lindquist, Luca Simeoni & Burkhart Schraven. (2003) Transmembrane adapters: attractants for cytoplasmic effectors. Immunological Reviews 191:1, pages 165-182.
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André VeilletteSylvain LatourDominique Davidson. (2002) Negative Regulation of Immunoreceptor Signaling. Annual Review of Immunology 20:1, pages 669-707.
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Akira Ogawa, Yoshiharu Takayama, Hiroaki Sakai, Khoon Tee Chong, Satoru Takeuchi, Atsushi Nakagawa, Shigeyuki Nada, Masato Okada & Tomitake Tsukihara. (2002) Structure of the Carboxyl-terminal Src Kinase, Csk. Journal of Biological Chemistry 277:17, pages 14351-14354.
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Knut Martin Torgersen, Torkel Vang, Hilde Abrahamsen, Sheraz Yaqub & Kjetil Taskén. (2002) Molecular mechanisms for protein kinase A-mediated modulation of immune function. Cellular Signalling 14:1, pages 1-9.
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Frank Scholle, Richard Longnecker & Nancy Raab-Traub. (2001) Analysis of the Phosphorylation Status of Epstein–Barr Virus LMP2A in Epithelial Cells. Virology 291:2, pages 208-214.
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Alexander Shekhtman, Ranajeet Ghose, Dongxia Wang, Philip A. Cole & David Cowburn. (2001) Novel mechanism of regulation of the non-receptor protein tyrosine kinase csk: insights from NMR mapping studies and site-directed mutagenesis. Journal of Molecular Biology 314:1, pages 129-138.
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Knut Martin Torgersen, Torkel Vang, Hilde Abrahamsen, Sheraz Yaqub, Václav Hor̆ejšı́, Burkhart Schraven, Bent Rolstad, Tomas Mustelin & Kjetil Taskén. (2001) Release from Tonic Inhibition of T Cell Activation through Transient Displacement of C-terminal Src Kinase (Csk) from Lipid Rafts. Journal of Biological Chemistry 276:31, pages 29313-29318.
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Sylvain Latour & André Veillette. (2001) Proximal protein tyrosine kinases in immunoreceptor signaling. Current Opinion in Immunology 13:3, pages 299-306.
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Michael L Dustin & Andrew C Chan. (2000) Signaling Takes Shape in the Immune System. Cell 103:2, pages 283-294.
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Satoru Takeuchi, Yoshiharu Takayama, Akira Ogawa, Keiko Tamura & Masato Okada. (2000) Transmembrane Phosphoprotein Cbp Positively Regulates the Activity of the Carboxyl-terminal Src Kinase, Csk. Journal of Biological Chemistry 275:38, pages 29183-29186.
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Masahiro Kawabuchi, Yoshinori Satomi, Toshifumi Takao, Yasutsugu Shimonishi, Shigeyuki Nada, Katsuya Nagai, Alexander Tarakhovsky & Masato Okada. (2000) Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases. Nature 404:6781, pages 999-1003.
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Gongqin Sun & Raymond J.A. Budde. (1999) Mutations in the N-Terminal Regulatory Region Reduce the Catalytic Activity of Csk, but Do Not Affect Its Recognition of Src. Archives of Biochemistry and Biophysics 367:2, pages 167-172.
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Frank Scholle, Richard Longnecker & Nancy Raab-Traub. (1999) Epithelial Cell Adhesion to Extracellular Matrix Proteins Induces Tyrosine Phosphorylation of the Epstein-Barr Virus Latent Membrane Protein 2: a Role for C-Terminal Src Kinase. Journal of Virology 73:6, pages 4767-4775.
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Svetozar Grgurevich, Anwar Mikhael & Daniel W. McVicar. (1999) The Csk Homologous Kinase, Chk, Binds Tyrosine Phosphorylated Paxillin in Human Blastic T Cells. Biochemical and Biophysical Research Communications 256:3, pages 668-675.
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Jean-François Cloutier & André Veillette. (1999) Cooperative Inhibition of  T-Cell Antigen Receptor Signaling by a Complex between a Kinase and a Phosphatase. Journal of Experimental Medicine 189:1, pages 111-121.
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Thomas P. Dousa. (1999) Cyclic-3′,5′-nucleotide phosphodiesterase isozymes in cell biology and pathophysiology of the kidney. Kidney International 55:1, pages 29-62.
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Alexander Gregorieff, Jean-François Cloutier & André Veillette. (1998) Sequence Requirements for Association of Protein-tyrosine Phosphatase PEP with the Src Homology 3 Domain of Inhibitory Tyrosine Protein Kinase p50. Journal of Biological Chemistry 273:21, pages 13217-13222.
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Atsushi Hirao, Xu-Ling Huang, Toshio Suda & Naoto Yamaguchi. (1998) Overexpression of C-terminal Src Kinase Homologous Kinase Suppresses Activation of Lyn Tyrosine Kinase Required for VLA5-mediated Dami Cell Spreading. Journal of Biological Chemistry 273:16, pages 10004-10010.
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Kurt E Amrein, Juliette Molnos, Jan Dirk zur Hausen, Nicholas Flint, Belá Takacs & Paul Burn. (1998) Csk-mediated phosphorylation of substrates is regulated by substrate tyrosine phosphorylation. Il Farmaco 53:4, pages 266-272.
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Zen-ichiro Honda, Takeshi Suzuki, Naoto Hirose, Makoto Aihara, Takao Shimizu, Shigeyuki Nada, Masato Okada, Chisei Ra, Yutaka Morita & Koji Ito. (1997) Roles of C-terminal Src Kinase in the Initiation and the Termination of the High Affinity IgE Receptor-mediated Signaling. Journal of Biological Chemistry 272:41, pages 25753-25760.
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Dominique Davidson, Jean-François Cloutier, Alexander Gregorieff & André Veillette. (1997) Inhibitory Tyrosine Protein Kinase p50 Is Associated with Protein-tyrosine Phosphatase PTP-PEST in Hemopoietic and Non-hemopoietic Cells. Journal of Biological Chemistry 272:37, pages 23455-23462.
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Milena Vuica, Stephen Desiderio & Jonathan P. Schneck. (1997) Differential Effects of B Cell Receptor and B Cell Receptor–FcγRIIB1 Engagement on Docking of Csk to GTPase-activating Protein (GAP)-associated p62. Journal of Experimental Medicine 186:2, pages 259-267.
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Yong Wan, Kendra Bence, Akiko Hata, Tomohiro Kurosaki, Andre Veillette & Xin-Yun Huang. (1997) Genetic Evidence for a Tyrosine Kinase Cascade Preceding the Mitogen-activated Protein Kinase Cascade in Vertebrate G Protein Signaling. Journal of Biological Chemistry 272:27, pages 17209-17215.
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Maria Ruzzene, Zhou Songyang, Oriano Marin, Arianna Donella-Deana, Anna Maria Brunati, Barbara Guerra, Patrizia Agostinis, Lewis C. Cantley & Lorenzo A. Pinna. (1997) Sequence Specificity of C-Terminal Src Kinase (Csk). A Comparison with Src-Related Kinases C-Fgr and Lyn. European Journal of Biochemistry 246:2, pages 433-439.
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Dominique Davidson, Lionel M.L. Chow & André Veillette. (1997) Chk, a Csk Family Tyrosine Protein Kinase, Exhibits Csk-like Activity in Fibroblasts, but Not in an Antigen-specific T-cell Line. Journal of Biological Chemistry 272:2, pages 1355-1362.
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Cécile Bougeret, Thierry Delaunay, Francisco Romero, Pascale Jullien, Hisataka Sabe, Hidesaburo Hanafusa, Richard Benarous & Siegmund Fischer. (1996) Detection of a Physical and Functional Interaction between Csk and Lck Which Involves the SH2 Domain of Csk and Is Mediated by Autophosphorylation of Lck on Tyrosine 394. Journal of Biological Chemistry 271:13, pages 7465-7472.
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