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Molecular and Cellular Biology Volume 15, 1995 - Issue 11
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Research Article

The Yeast SEN3 Gene Encodes a Regulatory Subunit of the 26S Proteasome Complex Required for Ubiquitin-Dependent Protein Degradation In Vivo

Douglas J. DeMarini1 Laboratory of Genetics and Molecular Biology, University of Wisconsin, Madison, Wisconsin53706
,
Feroz R. Papa2 Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois60637
,
Sowmya Swaminathan2 Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois60637
,
Doris Ursic1 Laboratory of Genetics and Molecular Biology, University of Wisconsin, Madison, Wisconsin53706
,
Theodore P. Rasmussen1 Laboratory of Genetics and Molecular Biology, University of Wisconsin, Madison, Wisconsin53706
,
Michael R. Culbertson1 Laboratory of Genetics and Molecular Biology, University of Wisconsin, Madison, Wisconsin53706
&
Mark Hochstrasser2 Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois60637Correspondence[email protected]
 show all
Pages 6311-6321 | Received 27 Jun 1995, Accepted 03 Aug 1995, Published online: 30 Mar 2023

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Jessica Tsalikis, Mena Abdel-Nour, Armin Farahvash, Matthew T. Sorbara, Stephanie Poon, Dana J. Philpott & Stephen E. Girardin. (2019) Isoginkgetin, a Natural Biflavonoid Proteasome Inhibitor, Sensitizes Cancer Cells to Apoptosis via Disruption of Lysosomal Homeostasis and Impaired Protein Clearance. Molecular and Cellular Biology 39:10.
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Sylvie L. Beaudenon, Maria R. Huacani, Guangli Wang, Donald P. McDonnell & Jon M. Huibregtse. (1999) Rsp5 Ubiquitin-Protein Ligase Mediates DNA Damage-Induced Degradation of the Large Subunit of RNA Polymerase II in Saccharomyces cerevisiae. Molecular and Cellular Biology 19:10, pages 6972-6979.
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Junko Takeuchi, Masahiro Fujimuro, Hideyosi Yokosawa, Keiji Tanaka & Akio Toh-e. (1999) Rpn9 Is Required for Efficient Assembly of the Yeast 26S Proteasome. Molecular and Cellular Biology 19:10, pages 6575-6584.
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Michael H. Glickman, David M. Rubin, Victor A. Fried & Daniel Finley. (1998) The Regulatory Particle of the Saccharomyces cerevisiae Proteasome. Molecular and Cellular Biology 18:6, pages 3149-3162.
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Articles from other publishers (50)

Veronica Gatti, Sara De Domenico, Gerry Melino & Angelo Peschiaroli. (2023) Senataxin and R-loops homeostasis: multifaced implications in carcinogenesis. Cell Death Discovery 9:1.
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Craig L. Bennett & Albert R. La Spada. (2021) SUMOylated Senataxin functions in genome stability, RNA degradation, and stress granule disassembly, and is linked with inherited ataxia and motor neuron disease. Molecular Genetics & Genomic Medicine 9:12.
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Craig L. Bennett, Bryce L. Sopher & Albert R. La Spada. (2020) Tight expression regulation of senataxin, linked to motor neuron disease and ataxia, is required to avert cell-cycle block and nucleolus disassembly. Heliyon 6:6, pages e04165.
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Yinglu Zhang, Yujin Chun, Stephen Buratowski & Liang Tong. (2019) Identification of Three Sequence Motifs in the Transcription Termination Factor Sen1 that Mediate Direct Interactions with Nrd1. Structure 27:7, pages 1156-1161.e4.
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Craig L. Bennett, Somasish G. Dastidar, Shuo-Chien Ling, Bilal Malik, Travis Ashe, Mandheer Wadhwa, Derek B. Miller, Changwoo Lee, Matthew B. Mitchell, Michael A. van Es, Christopher Grunseich, Yingzhang Chen, Bryce L. Sopher, Linda Greensmith, Don W. Cleveland & Albert R. La Spada. (2018) Senataxin mutations elicit motor neuron degeneration phenotypes and yield TDP-43 mislocalization in ALS4 mice and human patients. Acta Neuropathologica 136:3, pages 425-443.
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Hannah E. Mischo, Yujin Chun, Kevin M. Harlen, Brendan M. Smalec, Somdutta Dhir, L. Stirling Churchman & Stephen Buratowski. (2018) Cell-Cycle Modulation of Transcription Termination Factor Sen1. Molecular Cell 70:2, pages 312-326.e7.
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Craig L. Bennett & Albert R. La Spada. 2018. RNA Metabolism in Neurodegenerative Diseases. RNA Metabolism in Neurodegenerative Diseases 265 281 .
Wentao Li & Shisheng Li. (2016) Facilitators and Repressors of Transcription‐coupled DNA Repair in Saccharomyces cerevisiae . Photochemistry and Photobiology 93:1, pages 259-267.
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Stephen Martin-Tumasz & David A. Brow. (2015) Saccharomyces cerevisiae Sen1 Helicase Domain Exhibits 5′- to 3′-Helicase Activity with a Preference for Translocation on DNA Rather than RNA. Journal of Biological Chemistry 290:38, pages 22880-22889.
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Craig L. Bennett, Yingzhang Chen, Marissa Vignali, Russell S. Lo, Amanda G. Mason, Asli Unal, Nabiha P. Huq Saifee, Stanley Fields & Albert R. La Spada. (2013) Protein Interaction Analysis of Senataxin and the ALS4 L389S Mutant Yields Insights into Senataxin Post-Translational Modification and Uncovers Mutant-Specific Binding with a Brain Cytoplasmic RNA-Encoded Peptide. PLoS ONE 8:11, pages e78837.
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Rina Rosenzweig, Vered Bronner, Daoning Zhang, David Fushman & Michael H. Glickman. (2012) Rpn1 and Rpn2 Coordinate Ubiquitin Processing Factors at Proteasome. Journal of Biological Chemistry 287:18, pages 14659-14671.
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Haiqing Yi, Julie L. Friedman & Paulo A. Ferreira. (2007) The Cyclophilin-like Domain of Ran-binding Protein-2 Modulates Selectively the Activity of the Ubiquitin-Proteasome System and Protein Biogenesis. Journal of Biological Chemistry 282:48, pages 34770-34778.
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António J. Marques, Christoph Glanemann, Paula C. Ramos & R. Jürgen Dohmen. (2007) The C-terminal Extension of the β7 Subunit and Activator Complexes Stabilize Nascent 20 S Proteasomes and Promote Their Maturation. Journal of Biological Chemistry 282:48, pages 34869-34876.
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A. G. Bassuk, Y. Z. Chen, S. D. Batish, N. Nagan, P. Opal, P. F. Chance & C. L. Bennett. (2006) In cis autosomal dominant mutation of Senataxin associated with tremor/ataxia syndrome. Neurogenetics 8:1, pages 45-49.
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Petra Wendler, Andrea Lehmann, Katharina Janek, Sabine Baumgart & Cordula Enenkel. (2004) The Bipartite Nuclear Localization Sequence of Rpn2 Is Required for Nuclear Import of Proteasomal Base Complexes via Karyopherin αβ and Proteasome Functions. Journal of Biological Chemistry 279:36, pages 37751-37762.
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Nevan J. Krogan, Wen-Tao Peng, Gerard Cagney, Mark D. Robinson, Robin Haw, Gouqing Zhong, Xinghua Guo, Xin Zhang, Veronica Canadien, Dawn P. Richards, Bryan K. Beattie, Atanas Lalev, Wen Zhang, Armaity P. Davierwala, Sanie Mnaimneh, Andrei Starostine, Aaron P. Tikuisis, Jorg Grigull, Nira Datta, James E. Bray, Timothy R. Hughes, Andrew Emili & Jack F. Greenblatt. (2004) High-Definition Macromolecular Composition of Yeast RNA-Processing Complexes. Molecular Cell 13:2, pages 225-239.
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Nathan W. Bays, Sharon K. Wilhovsky, Ami Goradia, Kelley Hodgkiss-Harlow & Randolph Y. Hampton. (2001) HRD4/NPL4 Is Required for the Proteasomal Processing of Ubiquitinated ER Proteins . Molecular Biology of the Cell 12:12, pages 4114-4128.
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Youming Xie & Alexander Varshavsky. (2001) RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: A negative feedback circuit. Proceedings of the National Academy of Sciences 98:6, pages 3056-3061.
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Junko Takeuchi & Akio Toh-e. (2001) Genetic dissection of the yeast 26S proteasome: Cell cycledefects caused by the Δrpn9 mutation. Biochimie 83:3-4, pages 333-340.
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Alexander Y. Amerik, Jonathan Nowak, Sowmya Swaminathan & Mark Hochstrasser. (2000) The Doa4 Deubiquitinating Enzyme Is Functionally Linked to the Vacuolar Protein-sorting and Endocytic Pathways. Molecular Biology of the Cell 11:10, pages 3365-3380.
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