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Molecular and Cellular Biology Volume 15, 1995 - Issue 12
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Research Article

Increased Expression of LD1 Genes Transcribed by RNA Polymerase I in Leishmania donovani as a Result of Duplication into the rRNA Gene Locus

Michael J. Lodes1 Seattle Biomedical Research Institute, Seattle, Washington98109-1651
,
Gilles Merlin1 Seattle Biomedical Research Institute, Seattle, Washington98109-1651
,
Theo deVos1 Seattle Biomedical Research Institute, Seattle, Washington98109-1651
,
Anirban Ghosh2 Pathobiology Department, University of Washington, Seattle, Washington98195
,
Rentala Madhubala2 Pathobiology Department, University of Washington, Seattle, Washington98195
,
Peter J. Myler1 Seattle Biomedical Research Institute, Seattle, Washington98109-1651;3 School of Life Sciences, Jawaharlal Nehru University, New Delhi110067, India
&
Kenneth Stuart1 Seattle Biomedical Research Institute, Seattle, Washington98109-1651;3 School of Life Sciences, Jawaharlal Nehru University, New Delhi110067, IndiaCorrespondence[email protected]
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Pages 6845-6853 | Received 13 Mar 1995, Accepted 08 Sep 1995, Published online: 30 Mar 2023

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Frederico J. Gueiros-Filho & Stephen M. Beverley. (1996) Selection against the Dihydrofolate Reductase-Thymidylate Synthase (DHFR-TS) Locus as a Probe of Genetic Alterations in Leishmania major. Molecular and Cellular Biology 16:10, pages 5655-5663.
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Katherine Grondin, Gaétan Roy & Marc Ouellette. (1996) Formation of Extrachromosomal Circular Amplicons with Direct or Inverted Duplications in Drug-Resistant Leishmania tarentolae. Molecular and Cellular Biology 16:7, pages 3587-3595.
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Articles from other publishers (34)

Vincent Boivin, Gaspard Reulet, Olivier Boisvert, Sonia Couture, Sherif Abou Elela & Michelle S Scott. (2020) Reducing the structure bias of RNA-Seq reveals a large number of non-annotated non-coding RNA. Nucleic Acids Research 48:5, pages 2271-2286.
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Emmanuel Tetaud, Michèle Lefebvre, Diane-Ethna M'Bang-Benet, Lucien Crobu, Corinne Blancard, Yvon Sterkers, Michel Pages, Patrick Bastien & Gilles Merlin. (2016) TbFlabarin, a flagellar protein of Trypanosoma brucei, highlights differences between Leishmania and Trypanosoma flagellar-targeting signals. Experimental Parasitology 166, pages 97-107.
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Pablo Smircich, María Ana Duhagon & Beatriz Garat. (2015) Conserved Curvature of RNA Polymerase I Core Promoter Beyond rRNA Genes: The Case of the Tritryps. Genomics, Proteomics & Bioinformatics 13:6, pages 355-363.
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Laurence Lachaud, Nathalie Bourgeois, Nada Kuk, Christelle Morelle, Lucien Crobu, Gilles Merlin, Patrick Bastien, Michel Pagès & Yvon Sterkers. (2014) Constitutive mosaic aneuploidy is a unique genetic feature widespread in the Leishmania genus. Microbes and Infection 16:1, pages 61-66.
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Michèle Lefebvre, Emmanuel Tetaud, Magali Thonnus, Bénédicte Salin, Fanny Boissier, Corinne Blancard, Cécile Sauvanet, Christelle Metzler, Benoît Espiau, Annelise Sahin & Gilles Merlin. (2013) LdFlabarin, a New BAR Domain Membrane Protein of Leishmania Flagellum. PLoS ONE 8:9, pages e76380.
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Jan-Peter Daniels, Keith Gull & Bill Wickstead. (2010) Cell Biology of the Trypanosome Genome. Microbiology and Molecular Biology Reviews 74:4, pages 552-569.
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Manju Jain & Rentala Madhubala. (2008) Characterization and localization of ORFF gene from the LD1 locus of Leishmania donovani. Gene 416:1-2, pages 1-10.
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Annelise Sahin, Benoît Espiau, Emmanuel Tetaud, Armelle Cuvillier, Lydia Lartigue, Audrey Ambit, Derrick R. Robinson & Gilles Merlin. (2008) The Leishmania ARL-1 and Golgi Traffic. PLoS ONE 3:2, pages e1620.
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Peter J. Myler. 2008. Drug Targets in Kinetoplastid Parasites. Drug Targets in Kinetoplastid Parasites 133 140 .
Jian Zhao, Mei Cao, Jie Zhang, Qun Sun, Qian Chen & Zhi-rong Yang. (2006) Pathological effects of the mushroom toxin α-amanitin on BALB/c mice. Peptides 27:12, pages 3047-3052.
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Liane Casagrande, Jeronimo C. Ruiz, Stephen M. Beverley & Angela K. Cruz. (2005) Identification of a DNA fragment that increases mitotic stability of episomal linear DNAs in Leishmania major. International Journal for Parasitology 35:9, pages 973-980.
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Santiago Martínez-Calvillo, Kenneth Stuart & Peter J. Myler. (2005) Ploidy changes associated with disruption of two adjacent genes on Leishmania major chromosome 1. International Journal for Parasitology 35:4, pages 419-429.
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Alka Saxena, Elizabeth A. Worthey, Shaofeng Yan, Aaron Leland, Kenneth D. Stuart & Peter J. Myler. (2003) Evaluation of differential gene expression in Leishmania major Friedlin procyclics and metacyclics using DNA microarray analysis. Molecular and Biochemical Parasitology 129:1, pages 103-114.
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Bindu Sukumaran, Poonam Tewary, Shailendra Saxena & Rentala Madhubala. (2003) Vaccination with DNA encoding ORFF antigen confers protective immunity in mice infected with Leishmania donovani. Vaccine 21:11-12, pages 1292-1299.
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Tereza C Orlando, Mary Anne T Rubio, Nancy R Sturm, David A Campbell & Lucile M Floeter-Winter. (2002) Intergenic and external transcribed spacers of ribosomal RNA genes in lizard-infecting Leishmania: molecular structure and phylogenetic relationship to mammal-infecting Leishmania in the subgenus Leishmania (Leishmania). Memórias do Instituto Oswaldo Cruz 97:5, pages 695-701.
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Guoliang Fu & Sara E. Melville. (2002) Polymorphism in the subtelomeric regions of chromosomes of Kinetoplastida. Transactions of the Royal Society of Tropical Medicine and Hygiene 96, pages S31-S40.
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Vandana S Dole, Peter J Myler, Kenneth D Stuart & Rentala Madhubala. (2002) Expression of biopterin transporter (BT1) protein in Leishmania . FEMS Microbiology Letters 208:1, pages 89-91.
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Shaofeng Yan, Santiago Martinez-Calvillo, Achim Schnaufer, Susan Sunkin, Peter J Myler & Kenneth Stuart. (2002) A low-background inducible promoter system in Leishmania donovani. Molecular and Biochemical Parasitology 119:2, pages 217-223.
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Santiago Martı́nez-Calvillo, Susan M. Sunkin, Shao-feng Yan, Mark Fox, Kenneth Stuart & Peter J. Myler. (2001) Genomic organization and functional characterization of the Leishmania major Friedlin ribosomal RNA gene locus. Molecular and Biochemical Parasitology 116:2, pages 147-157.
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Susan M. Sunkin, Paul McDonagh, Mark L. Cunningham, Stephen M. Beverley, Kenneth Stuart & Peter J. Myler. (2001) Conservation of the LD1 region in Leishmania includes DNA implicated in LD1 amplification. Molecular and Biochemical Parasitology 113:2, pages 315-321.
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Gaétan Roy, Christoph Kündig, Martin Olivier, Barbara Papadopoulou & Marc Ouellette. (2001) Adaptation of Leishmania Cells to in Vitro Culture Results in a More Efficient Reduction and Transport of Biopterin. Experimental Parasitology 97:3, pages 161-168.
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Shaofeng Yan, Peter J. Myler & Kenneth Stuart. (2001) Tetracycline regulated gene expression in Leishmania donovani. Molecular and Biochemical Parasitology 112:1, pages 61-69.
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Gaétan Roy, Carole Dumas, Denis Sereno, Ying Wu, Ajay K. Singh, Michel J. Tremblay, Marc Ouellette, Martin Olivier & Barbara Papadopoulou. (2000) Episomal and stable expression of the luciferase reporter gene for quantifying Leishmania spp. infections in macrophages and in animal models. Molecular and Biochemical Parasitology 110:2, pages 195-206.
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A. CuvillierF. RedonJ.C. AntoineP. ChardinT. DeVosG. Merlin. (2000) LdARL-3A, a Leishmania promastigote-specific ADP-ribosylation factor-like protein, is essential for flagellum integrity. Journal of Cell Science 113:11, pages 2065-2074.
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Susan M Sunkin, Patti Kiser, Peter J Myler & Kenneth Stuart. (2000) The size difference between Leishmania major Friedlin chromosome one homologues is localized to sub-telomeric repeats at one chromosomal end. Molecular and Biochemical Parasitology 109:1, pages 1-15.
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Jane Mannion-Henderson, John A Flaspohler, Kayde R Lemley, Wayne L Rickoll & Marilyn Parsons. (2000) Isolation and characterization of Leishmania mutants defective in glycosomal protein import. Molecular and Biochemical Parasitology 106:2, pages 225-237.
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Anirban Ghosh, R. Madhubala, Peter J. Myler & Kenneth D. Stuart. (1999) Leishmania donovani: Characterization and Expression of ORFF, a Gene Amplified from the LDI Locus. Experimental Parasitology 93:4, pages 225-230.
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Anass Haimeur, Chantal Guimond, Sylvie Pilote, Rita Mukhopadhyay, Barry P. Rosen, Richard Poulin & Marc Ouellette. (1999) Elevated levels of polyamines and trypanothione resulting from overexpression of the ornithine decarboxylase gene in arsenite-resistant Leishmania. Molecular Microbiology 34:4, pages 726-735.
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Craig Lemley, Shaofeng Yan, Vandana S Dole, Rentala Madhubala, Mark L Cunningham, Stephen M Beverley, Peter J Myler & Kenneth D Stuart. (1999) The Leishmania donovani LD1 locus gene ORFG encodes a biopterin transporter (BT1). Molecular and Biochemical Parasitology 104:1, pages 93-105.
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Shaofeng Yan, Michael J Lodes, Mark Fox, Peter J Myler & Kenneth Stuart. (1999) Characterization of the Leishmania donovani ribosomal RNA promoter. Molecular and Biochemical Parasitology 103:2, pages 197-210.
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John A. Flaspohler, Kayde Lemley & Marilyn Parsons. (1999) A dominant negative mutation in the GIM1 gene of Leishmania donovani is responsible for defects in glycosomal protein localization. Molecular and Biochemical Parasitology 99:1, pages 117-128.
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Guoliang Fu, Sara Melville, Susan Brewster, Jon Warner & Douglas C Barker. (1998) Analysis of the genomic organisation of a small chromosome of Leishmania braziliensis M2903 reveals two genes encoding GTP-binding proteins, one of which belongs to a new G-protein family and is an antigen. Gene 210:2, pages 325-333.
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M. Segovia & G. Ortiz. (1997) LD1 amplifications in Leishmania. Parasitology Today 13:9, pages 342-348.
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Annette Dresel & Joachim Clos. (1997) Transcription of theLeishmania major Hsp70-IGene Locus Does Not Proceed through the Noncoding Region. Experimental Parasitology 86:3, pages 206-212.
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