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Molecular and Cellular Biology Volume 15, 1995 - Issue 2
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Research Article

The Nonconserved Hinge Region and Distinct Amino-Terminal Domains of the RORα Orphan Nuclear Receptor Isoforms are Required for Proper DNA Bending and RORα-DNA Interactions

Linda D. B. McBroomMolecular Oncology Group, Departments of Biochemistry, Medicine, and Oncology, McGill University, Royal Victoria Hospital, Montréal, QuébecH3A 1A1, Canada
,
Grace FlockMolecular Oncology Group, Departments of Biochemistry, Medicine, and Oncology, McGill University, Royal Victoria Hospital, Montréal, QuébecH3A 1A1, Canada
&
Vincent GiguèreMolecular Oncology Group, Departments of Biochemistry, Medicine, and Oncology, McGill University, Royal Victoria Hospital, Montréal, QuébecH3A 1A1, Canada
Pages 796-808 | Received 27 Jun 1994, Accepted 04 Nov 1994, Published online: 30 Mar 2023

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Guoqiang Jiang, Una Lee & Frances M. Sladek. (1997) Proposed Mechanism for the Stabilization of Nuclear Receptor DNA Binding via Protein Dimerization. Molecular and Cellular Biology 17:11, pages 6546-6554.
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Robert Sladek, Jo-Ann Bader & Vincent Giguère. (1997) The Orphan Nuclear Receptor Estrogen-Related Receptor α Is a Transcriptional Regulator of the Human Medium-Chain Acyl Coenzyme A Dehydrogenase Gene. Molecular and Cellular Biology 17:9, pages 5400-5409.
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Jongsook Kim, Georgius de Haan, Ann M. Nardulli & David J. Shapiro. (1997) Prebending the Estrogen Response Element Destabilizes Binding of the Estrogen Receptor DNA Binding Domain. Molecular and Cellular Biology 17:6, pages 3173-3180.
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Isabelle Dussault & Vincent Giguère. (1997) Differential Regulation of the N-myc Proto-Oncogene by RORα and RVR, Two Orphan Members of the Superfamily of Nuclear Hormone Receptors. Molecular and Cellular Biology 17:4, pages 1860-1867.
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Barbara S. Nikolajczyk, Barbara Nelsen & Ranjan Sen. (1996) Precise Alignment of Sites Required for μ Enhancer Activation in B Cells. Molecular and Cellular Biology 16:8, pages 4544-4554.
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Heather P. Harding & Mitchell A. Lazar. (1995) The Monomer-Binding Orphan Receptor Rev-Erb Represses Transcription as a Dimer on a Novel Direct Repeat. Molecular and Cellular Biology 15:9, pages 4791-4802.
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Vincent Giguère, Linda D. B. McBroom & Grace Flock. (1995) Determinants of Target Gene Specificity for RORα1: Monomeric DNA Binding by an Orphan Nuclear Receptor. Molecular and Cellular Biology 15:5, pages 2517-2526.
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Mian Huang, Shelby Bolin, Hannah Miller & Ho Leung Ng. (2020) RORγ Structural Plasticity and Druggability. International Journal of Molecular Sciences 21:15, pages 5329.
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Yuk Hang Chan, Ka Hou Chu & King Ming Chan. (2019) Ecdysteroid-mimicking compounds act as both agonists and antagonists to the crustacean ecdysone receptor. Chemosphere 237, pages 124551.
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Yi Fang, Jinlong Zhang, Yihai Li, Xiaofei Guo, Junjie Li, Rongzhen Zhong & Xiaosheng Zhang. (2019) Melatonin-induced demethylation of antioxidant genes increases antioxidant capacity through RORα in cumulus cells of prepubertal lambs. Free Radical Biology and Medicine 131, pages 173-183.
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Kyeongkyu Kim, Ji Min Lee, Young Suk Yu, Hyunkyung Kim, Hye Jin Nam, Hyeong-Gon Moon, Dong-Young Noh, Keun Il Kim, Sungsoon Fang & Sung Hee Baek. (2017) RORα2 requires LSD1 to enhance tumor progression in breast cancer. Scientific Reports 7:1.
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Sascha Rutz, Celine Eidenschenk, James R. Kiefer & Wenjun Ouyang. (2016) Post-translational regulation of RORγt—A therapeutic target for the modulation of interleukin-17-mediated responses in autoimmune diseases. Cytokine & Growth Factor Reviews 30, pages 1-17.
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Yuuki Imai, Min-Young Youn, Kazuki Inoue, Ichiro Takada, Alexander Kouzmenko & Shigeaki Kato. (2013) Nuclear Receptors in Bone Physiology and Diseases. Physiological Reviews 93:2, pages 481-523.
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