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Research Article

The V(D)J Recombinational and Transcriptional Activities of the Immunoglobulin Heavy-Chain Intronic Enhancer Can Be Mediated through Distinct Protein-Binding Sites in a Transgenic Substrate

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Pages 3217-3226 | Received 15 Dec 1994, Accepted 14 Mar 1995, Published online: 30 Mar 2023

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Fatima-Zohra Braikia, Caroline Conte, Mohamed Moutahir, Yves Denizot, Michel Cogné & Ahmed Amine Khamlichi. (2015) Developmental Switch in the Transcriptional Activity of a Long-Range Regulatory Element. Molecular and Cellular Biology 35:19, pages 3370-3380.
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Raj Kamal Tripathi, Noëlle Mathieu, Salvatore Spicuglia, Dominique Payet, Christophe Verthuy, Gaëlle Bouvier, Danielle Depetris, Marie-Geneviève Mattei, William M. HempeL & Pierre Ferrier. (2000) Definition of a T-Cell Receptor β Gene Core Enhancer of V(D)J Recombination by Transgenic Mapping. Molecular and Cellular Biology 20:1, pages 42-53.
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Michael L. Sikes, Cristina C. Suarez & Eugene M. Oltz. (1999) Regulation of V(D)J Recombination by Transcriptional Promoters. Molecular and Cellular Biology 19:4, pages 2773-2781.
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Zhiyong Wang, Adrian Goldstein, Rui-Ting Zong, Danjun Lin, Ellis J. Neufeld, Richard H. Scheuermann & Philip W. Tucker. (1999) Cux/CDP Homeoprotein Is a Component of NF-μNR and Represses the Immunoglobulin Heavy Chain Intronic Enhancer by Antagonizing the Bright Transcription Activator. Molecular and Cellular Biology 19:1, pages 284-295.
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Wei Dang, Xiao-hong Sun & Ranjan Sen. (1998) ETS-Mediated Cooperation between Basic Helix-Loop-Helix Motifs of the Immunoglobulin μ Heavy-Chain Gene Enhancer. Molecular and Cellular Biology 18:3, pages 1477-1488.
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Barbara S. Nikolajczyk, Barbara Nelsen & Ranjan Sen. (1996) Precise Alignment of Sites Required for μ Enhancer Activation in B Cells. Molecular and Cellular Biology 16:8, pages 4544-4554.
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Articles from other publishers (48)

Chloé Oudinet, Fatima-Zohra Braikia, Audrey Dauba & Ahmed Amine Khamlichi. (2020) Recombination may occur in the absence of transcription in the immunoglobulin heavy chain recombination centre. Nucleic Acids Research 48:7, pages 3553-3566.
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Christopher M. Kirkham, James N. Scott, Joan Boyes & Sarah Bevington. 2014. Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development. Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development 331 363 .
David G. Schatz & Yanhong Ji. (2011) Recombination centres and the orchestration of V(D)J recombination. Nature Reviews Immunology 11:4, pages 251-263.
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Christian Vettermann & Mark S. Schlissel. (2010) Allelic exclusion of immunoglobulin genes: models and mechanisms. Immunological Reviews 237:1, pages 22-42.
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Iratxe Abarrategui & Michael S. Krangel. 2009. V(D)J Recombination. V(D)J Recombination 93 102 .
Hansen Du, Haruhiko Ishii, Michael J. Pazin & Ranjan Sen. (2008) Activation of 12/23-RSS-Dependent RAG Cleavage by hSWI/SNF Complex in the Absence of Transcription. Molecular Cell 31:5, pages 641-649.
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Danjuan Lin, Gregory C Ippolito, Rui-Ting Zong, James Bryant, Janet Koslovsky & Philip Tucker. (2007) Bright/ARID3A contributes to chromatin accessibility of the immunoglobulin heavy chain enhancer. Molecular Cancer 6:1.
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Huifei Liu, Marc Schmidt-Supprian, Yujiang Shi, Elias Hobeika, Natasha Barteneva, Hassan Jumaa, Roberta Pelanda, Michael Reth, Jane Skok, Klaus Rajewsky & Yang Shi. (2007) Yin Yang 1 is a critical regulator of B-cell development. Genes & Development 21:10, pages 1179-1189.
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Andrew Franklin. (2006) Hypothesis: A biological role for germline transcription in the mechanism of V(D)J recombination – implications for initiation of allelic exclusion. Immunology & Cell Biology 84:4, pages 396-403.
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Inka Pawlitzky, Christina V. Angeles, Andrea M. Siegel, Michelle L. Stanton, Roy Riblet & Peter H. Brodeur. (2006) Identification of a Candidate Regulatory Element within the 5′ Flanking Region of the Mouse Igh Locus Defined by Pro-B Cell-Specific Hypersensitivity Associated with Binding of PU.1, Pax5, and E2A . The Journal of Immunology 176:11, pages 6839-6851.
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Robin Milley Cobb, Kenneth J. Oestreich, Oleg A. Osipovich & Eugene M. Oltz. 2006. 45 109 .
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Haruhiko Ishii, Ranjan Sen & Michael J. Pazin. (2004) Combinatorial Control of DNase I-hypersensitive Site Formation and Erasure by Immunoglobulin Heavy Chain Enhancer-binding Proteins. Journal of Biological Chemistry 279:8, pages 7331-7338.
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Ping Sieh & Jianzhu Chen. (2001) Distinct Control of the Frequency and Allelic Exclusion of the Vβ Gene Rearrangement at the TCRβ Locus. The Journal of Immunology 167:4, pages 2121-2129.
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