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Research Article

Dioxin Induces Localized, Graded Changes in Chromatin Structure: Implications for Cyp1A1 Gene Transcription

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Pages 3714-3721 | Received 08 Mar 1995, Accepted 12 Apr 1995, Published online: 30 Mar 2023

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Angela Perucatti, Viviana Genualdo, Maria A. Colonna, Francesco Giannico, Domenico Incarnato, Giuseppe Lubrano-Lavadera, Ciro Iorio, Luisa Vonghia, Anna Caputi-Jambrenghi, Leopoldo Iannuzzi & Alessandra Iannuzzi. (2016) Chromosome instability in lymphocytes of Friesian cows naturally exposed to dioxins being raised close to a metallurgic factory area in southern Italy. Caryologia 69:2, pages 133-140.
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Hyunsung P. Ko, Steven T. Okino, Qiang Ma & James P. Whitlock$suffix/text()$suffix/text(). (1997) Transactivation Domains Facilitate Promoter Occupancy for the Dioxin-Inducible CYP1A1 Gene In Vivo. Molecular and Cellular Biology 17:7, pages 3497-3507.
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Ann-Kristin Östlund Farrants, Patrik Blomquist, Hyockman Kwon & Örjan Wrange. (1997) Glucocorticoid Receptor-Glucocorticoid Response Element Binding Stimulates Nucleosome Disruption by the SWI/SNF Complex. Molecular and Cellular Biology 17:2, pages 895-905.
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James P. Whitlock, Christine H. Chichester, Robert M. Bedgood, Steven T. Okino, Hyunsung P. Ko, Qiang Ma, Liqun Dong, Hui Li & Regina Clarkekatzenberg. (1997) Induction of Drug-Metabolizing Enzymes by Dioxin. Drug Metabolism Reviews 29:4, pages 1107-1127.
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Qiang Ma & James P. Whitlock$suffix/text()$suffix/text(). (1996) The Aromatic Hydrocarbon Receptor Modulates the Hepa 1c1c7 Cell Cycle and Differentiated State Independently of Dioxin. Molecular and Cellular Biology 16:5, pages 2144-2150.
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Hyunsung P. Ko, Steven T. Okino, Qiang Ma & James P. Whitlock$suffix/text()$suffix/text(). (1996) Dioxin-Induced CYP1A1 Transcription In Vivo: the Aromatic Hydrocarbon Receptor Mediates Transactivation, Enhancer-Promoter Communication, and Changes in Chromatin Structure. Molecular and Cellular Biology 16:1, pages 430-436.
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Brenden W. Smith, Elizabeth A. Stanford, David H. Sherr & George J. Murphy. (2016) Genome Editing of the CYP1A1 Locus in iPSCs as a Platform to Map AHR Expression throughout Human Development . Stem Cells International 2016, pages 1-11.
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Kevin W. Trotter & Trevor K. Archer. 2012. Chromatin Remodeling. Chromatin Remodeling 89 102 .
Oliver Hankinson. 2011. The AH Receptor in Biology and Toxicology. The AH Receptor in Biology and Toxicology 93 100 .
Qiang Ma. 2011. The AH Receptor in Biology and Toxicology. The AH Receptor in Biology and Toxicology 33 45 .
G. P. Di Meo, A. Perucatti, V. Genualdo, A. Caputi-Jambrenghi, R. Rasero, C. Nebbia & L. Iannuzzi. (2010) Chromosome fragility in dairy cows exposed to dioxins and dioxin-like PCBs. Mutagenesis 26:2, pages 269-272.
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Robert T. Taylor, Feng Wang, Erin L. Hsu & Oliver Hankinson. (2009) Roles of Coactivator Proteins in Dioxin Induction of CYP1A1 and CYP1B1 in Human Breast Cancer Cells. Toxicological Sciences 107:1, pages 1-8.
Crossref
Akua K. Oduro, Michael K. Fritsch & Fern E. Murdoch. (2008) Chromatin context dominates estrogen regulation of pS2 gene expression. Experimental Cell Research 314:15, pages 2796-2810.
Crossref
Lyle D. Burgoon & Timothy R. Zacharewski. (2008) Automated Quantitative Dose-Response Modeling and Point of Departure Determination for Large Toxicogenomic and High-Throughput Screening Data Sets. Toxicological Sciences 104:2, pages 412-418.
Crossref
Steven T. Okino, Linda C. Quattrochi, Deepa Pookot, Mieko Iwahashi & Rajvir Dahiya. (2007) A Dioxin-Responsive Enhancer 3′ of the Human CYP1A2 Gene . Molecular Pharmacology 72:6, pages 1457-1465.
Crossref
Gary ZeRuth & Richard S. Pollenz. (2007) Functional analysis of cis-regulatory regions within the dioxin-inducible CYP1A promoter/enhancer region from zebrafish (Danio rerio). Chemico-Biological Interactions 170:2, pages 100-113.
Crossref
Steven T. Okino, Deepa Pookot, Shahana Majid, Hong Zhao, Long-Cheng Li, Robert F. Place & Rajvir Dahiya. (2007) Chromatin changes on theGSTP1 promoter associated with its inactivation in prostate cancer. Molecular Carcinogenesis 46:10, pages 839-846.
Crossref
Satoko Niimi, Eun-Young Kim, Hisato Iwata, Michio X. Watanabe, Genta Yasunaga, Yoshihiro Fujise & Shinsuke Tanabe. (2007) Identification and hepatic expression profiles of cytochrome P450 1–4 isozymes in common minke whales (Balaenoptera acutorostrata). Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 147:4, pages 667-681.
Crossref
Theresa N. Operaña, Nghia Nguyen, Shujuan Chen, Deirdre Beaton & Robert H. Tukey. (2007) Human CYP1A1GFP Expression in Transgenic Mice Serves as a Biomarker for Environmental Toxicant Exposure. Toxicological Sciences 95:1, pages 98-107.
Crossref
Steven T. Okino, Deepa Pookot, Long-Cheng Li, Hong Zhao, Shinji Urakami, Hiroaki Shiina, Mikio Igawa & Rajvir Dahiya. (2006) Epigenetic Inactivation of the Dioxin-Responsive Cytochrome P4501A1 Gene in Human Prostate Cancer . Cancer Research 66:15, pages 7420-7428.
Crossref
Quanyuan Zhang, Yangjin Bae, Jongsook Kim Kemper & Byron Kemper. (2006) Analysis of multiple nuclear receptor binding sites for CAR/RXR in the phenobarbital responsive unit of CYP2B2. Archives of Biochemistry and Biophysics 451:2, pages 119-127.
Crossref
Jennifer K. Hockings, Patricia A. Thorne, Michael Q. Kemp, Sherif S. Morgan, Ornella Selmin & Donato F. Romagnolo. (2006) The Ligand Status of the Aromatic Hydrocarbon Receptor Modulates Transcriptional Activation of BRCA-1 Promoter by Estrogen. Cancer Research 66:4, pages 2224-2232.
Crossref
A. Perucatti, G.P. Di Meo, S. Albarella, F. Ciotola, D. Incarnato, A.Caputi Jambrenghi, V. Peretti, G. Vonghia & L. Iannuzzi. (2006) Increased frequencies of both chromosome abnormalities and SCEs in two sheep flocks exposed to high dioxin levels during pasturage. Mutagenesis 21:1, pages 67-75.
Crossref
Carolyn J. Broccardo, Ruth E. Billings, Melvin E. Andersen & William H. Hanneman. (2005) Probing the Control Elements of the CYP1A1 Switching Module in H4IIE Hepatoma Cells. Toxicological Sciences 88:1, pages 82-94.
Crossref
Marc Majora, Markus Frericks, Vladimir Temchura, Gaby Reichmann & Charlotte Esser. (2005) Detection of a novel population of fetal thymocytes characterized by preferential emigration and a TCRγδ+ T cell fate after dioxin exposure. International Immunopharmacology 5:12, pages 1659-1674.
Crossref
Satoko Niimi, Michio X. Watanabe, Eun-Young Kim, Hisato Iwata, Genta Yasunaga, Yoshihiro Fujise & Shinsuke Tanabe. (2005) Molecular cloning and mRNA expression of cytochrome P4501A1 and 1A2 in the liver of common minke whales (Balaenoptera acutorostrata). Marine Pollution Bulletin 51:8-12, pages 784-793.
Crossref
Oliver Hankinson. (2005) Role of coactivators in transcriptional activation by the aryl hydrocarbon receptor. Archives of Biochemistry and Biophysics 433:2, pages 379-386.
Crossref
Yanan Tian, Sui Ke, Min Chen & Tao Sheng. (2003) Interactions between the Aryl Hydrocarbon Receptor and P-TEFb. Journal of Biological Chemistry 278:45, pages 44041-44048.
Crossref
David S Riddick, Chunja Lee, Anahita Bhathena & Yoav E Timsit. (2003) The 2001 Veylien Henderson Award of the Society of Toxicology of Canada. Positive and negative transcriptional regulation of cytochromes P450 by polycyclic aromatic hydrocarbons. Canadian Journal of Physiology and Pharmacology 81:1, pages 59-77.
Crossref
Rashmeet K Reen, Adam Cadwallader & Gary H Perdew. (2002) The subdomains of the transactivation domain of the aryl hydrocarbon receptor (AhR) inhibit AhR and estrogen receptor transcriptional activity. Archives of Biochemistry and Biophysics 408:1, pages 93-102.
Crossref
Song Wang & Oliver Hankinson. (2002) Functional Involvement of the Brahma/SWI2-related Gene 1 Protein in Cytochrome P4501A1 Transcription Mediated by the Aryl Hydrocarbon Receptor Complex. Journal of Biological Chemistry 277:14, pages 11821-11827.
Crossref
Mark A. Bittinger & Christopher A. Bradfield. 2002. Wiley Encyclopedia of Molecular Medicine. Wiley Encyclopedia of Molecular Medicine.
Mohan B. Kumar, Preeti Ramadoss, Rashmeet K. Reen, John P. Vanden Heuvel & Gary H. Perdew. (2001) The Q-rich Subdomain of the Human AhReceptor Transactivation Domain Is Required for Dioxin-mediated Transcriptional Activity. Journal of Biological Chemistry 276:45, pages 42302-42310.
Crossref
Lin Gao & James P. WhitlockJr.Jr.. (2001) Accessibility and Activity of the Promoter for a Dioxin-Inducible Ecto-ATPase Gene. Archives of Biochemistry and Biophysics 392:2, pages 270-278.
Crossref
Andrew Maier, Timothy P. Dalton & Alvaro Puga. (2000) Disruption of dioxin-inducible phase I and phase II gene expression patterns by cadmium, chromium, and arsenic. Molecular Carcinogenesis 28:4, pages 225-235.
Crossref
Steven T. Okino & James P. WhitlockJr.Jr.. 2000. 241 264 .
Shinsuke Kanamura & Jun Watanabe. 2000. 109 152 .
Patricia M. Garrison & Michael S. Denison. (2000) Analysis of the murine AhR gene promoter. Journal of Biochemical and Molecular Toxicology 14:1, pages 1-10.
Crossref
Mohan B. Kumar, Rex W. Tarpey & Gary H. Perdew. (1999) Differential Recruitment of Coactivator RIP140 byAh and Estrogen Receptors. Journal of Biological Chemistry 274:32, pages 22155-22164.
Crossref
Christian C. Abnet, Robert L. Tanguay, Warren Heideman & Richard E. Peterson. (1999) Transactivation Activity of Human, Zebrafish, and Rainbow Trout Aryl Hydrocarbon Receptors Expressed in COS-7 Cells: Greater Insight into Species Differences in Toxic Potency of Polychlorinated Dibenzo-p-dioxin, Dibenzofuran, and Biphenyl Congeners. Toxicology and Applied Pharmacology 159:1, pages 41-51.
Crossref
James P. WhitlockJr.Jr.. (1999) INDUCTION OF CYTOCHROME P4501A1. Annual Review of Pharmacology and Toxicology 39:1, pages 103-125.
Crossref
Gordon L. Hager & Gilberto Fragoso. 1999. Chromatin. Chromatin 626 638 .
M.S. Denison, D. Phelan, G.M. Winter & M.H. Ziccardi. (1998) Carbaryl, a Carbamate Insecticide, Is a Ligand for the Hepatic Ah (Dioxin) Receptor. Toxicology and Applied Pharmacology 152:2, pages 406-414.
Crossref
Anup Dey & Daniel W. Nebert. (1998) Markedly Increased Constitutive CYP1A1 mRNA Levels in the Fertilized Ovum of the Mouse. Biochemical and Biophysical Research Communications 251:2, pages 657-661.
Crossref
Cody L. Wilson & Stephen Safe. (2016) Mechanisms of Ligand-Induced Aryl Hydrocarbon Receptor-Mediated Biochemical and Toxic Responses. Toxicologic Pathology 26:5, pages 657-671.
Crossref
Steven T. Okino, Christine H. Chichester & James P. WhitlockJr.Jr.. (1998) Hypoxia-inducible Mammalian Gene Expression Analyzed in Vivo at a TATA-driven Promoter and at an Initiator-driven Promoter. Journal of Biological Chemistry 273:37, pages 23837-23843.
Crossref
Lin Gao, Liqun Dong & James P. WhitlockJr.Jr.. (1998) A Novel Response to Dioxin. Journal of Biological Chemistry 273:25, pages 15358-15365.
Crossref
Leying Zhang, Üzen Savas, David L. Alexander & Colin R. Jefcoate. (1998) Characterization of the Mouse Cyp1B1 Gene. Journal of Biological Chemistry 273:9, pages 5174-5183.
Crossref
. (1998) Review. bchm 379:4-5, pages 377-400.
Crossref
Satish C. Dogra, Murray L. Whitelaw & Brian K. May. (1998) TRANSCRIPTIONAL ACTIVATION OF CYTOCHROME P450 GENES BY DIFFERENT CLASSES OF CHEMICAL INDUCERS. Clinical and Experimental Pharmacology and Physiology 25:1, pages 1-9.
Crossref
Liqun Dong, Qiang Ma & James P. WhitlockJr.Jr.. (1997) Down-regulation of Major Histocompatibility ComplexQ1 Gene Expression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Journal of Biological Chemistry 272:47, pages 29614-29619.
Crossref
Joe S. Mymryk, Christy J. Fryer, Lee A. Jung & Trevor K. Archer. (1997) Analysis of Chromatin Structurein Vivo. Methods 12:1, pages 105-114.
Crossref
Arthur D. Riggs & Gerd P. Pfeifer. 1997. In Vivo Footprinting. In Vivo Footprinting 47 72 .
Jennifer V. Schmidt & Christopher A. Bradfield. (1996) AH RECEPTOR SIGNALING PATHWAYS. Annual Review of Cell and Developmental Biology 12:1, pages 55-89.
Crossref
Yue-Hwa Chen & Robert H. Tukey. (1996) Protein Kinase C Modulates Regulation of the CYP1A1 Gene by the Aryl Hydrocarbon Receptor. Journal of Biological Chemistry 271:42, pages 26261-26266.
Crossref
Hui Li, Hyunsung P. Ko & James P. WhitlockJr.Jr.. (1996) Induction of Phosphoglycerate Kinase 1 Gene Expression by Hypoxia. Journal of Biological Chemistry 271:35, pages 21262-21267.
Crossref
Liqun Dong, Qiang Ma & James P. WhitlockJr.Jr.. (1996) DNA Binding by the Heterodimeric Ah Receptor. Journal of Biological Chemistry 271:14, pages 7942-7948.
Crossref

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