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Research Article

Activation of the High-Affinity Immunoglobulin E Receptor FcεRI in RBL-2H3 Cells Is Inhibited by Syk SH2 Domains

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Pages 4149-4157 | Received 07 Feb 1995, Accepted 02 May 1995, Published online: 30 Mar 2023

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Masahiro Nishi, Eric D. Werner, Byung-Chul Oh, J. Daniel Frantz, Sirano Dhe-Paganon, Lone Hansen, Jongsoon Lee & Steven E. Shoelson. (2005) Kinase Activation through Dimerization by Human SH2-B. Molecular and Cellular Biology 25:7, pages 2607-2621.
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Friedemann Kiefer, John Brumell, Nadia Al-Alawi, Sylvain Latour, Alec Cheng, André Veillette, Sergio Grinstein & Tony Pawson. (1998) The Syk Protein Tyrosine Kinase Is Essential for Fcγ Receptor Signaling in Macrophages and Neutrophils. Molecular and Cellular Biology 18:7, pages 4209-4220.
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Charles L Cywin, Bao-Ping Zhao, Daniel W McNeil, Matt Hrapchak, Anthony S ProkopowiczIIIIII, Daniel R Goldberg, Tina M Morwick, Amy Gao, Scott Jakes, Mohammed Kashem, Ronald L Magolda, Richard M Soll, Mark R Player, Mark A Bobko, James Rinker, Renee L DesJarlais & Michael P Winters. (2003) Discovery and SAR of novel Naphthyridines as potent inhibitors of spleen tyrosine kinase (SYK). Bioorganic & Medicinal Chemistry Letters 13:8, pages 1415-1418.
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Frank J Dekker, Nico J de Mol, Marcel J.E Fischer & Rob M.J Liskamp. (2003) Amino propynyl benzoic acid building block in rigid spacers of divalent ligands binding to the syk SH2 domains with equally high affinity as the natural ligand. Bioorganic & Medicinal Chemistry Letters 13:7, pages 1241-1244.
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Noriyuki Yamamoto, Haruki Hasegawa, Hitomi Seki, Karl Ziegelbauer & Takahiro Yasuda. (2003) Development of a high-throughput fluoroimmunoassay for Syk kinase and Syk kinase inhibitors. Analytical Biochemistry 315:2, pages 256-261.
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Noriyuki Yamamoto, Michitaka Shichijo & Toshio Kokubo. (2002) Establishment of the superoxide production assay with human monocytic cell line, U937, for the evaluation of Syk kinase inhibitors. Journal of Immunological Methods 268:2, pages 123-130.
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Kiyonao SadaS. M. Shahjahan MiahKoichiro MaenoShinkou KyoXiujuan QuHirohei Yamamura. (2002) Regulation of FcεRI-mediated degranulation by an adaptor protein 3BP2 in rat basophilic leukemia RBL-2H3 cells. Blood 100:6, pages 2138-2144.
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Kiyonao Sada, Juan Zhang & Reuben P. Siraganian. (2001) SH2 domain–mediated targeting, but not localization, of Syk in the plasma membrane is critical for FcεRI signaling. Blood 97:5, pages 1352-1359.
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Juan Zhang, Melvin L. Billingsley, Randall L. Kincaid & Reuben P. Siraganian. (2000) Phosphorylation of Syk Activation Loop Tyrosines Is Essential for Syk Function. Journal of Biological Chemistry 275:45, pages 35442-35447.
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Martin Turner, Edina Schweighoffer, Francesco Colucci, James P Di Santo & Victor L Tybulewicz. (2000) Tyrosine kinase SYK: essential functions for immunoreceptor signalling. Immunology Today 21:3, pages 148-154.
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Caroline Péneff, Marie-Paule Lefranc & Piona Dariavach. (2000) Characterisation and specificity of two single-chain Fv antibodies directed to the protein tyrosine kinase Syk. Journal of Immunological Methods 236:1-2, pages 105-115.
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R. Xu & I. Pecht. 1999. Immunoreceptor Tyrosine-based Inhibition Motifs. Immunoreceptor Tyrosine-based Inhibition Motifs 159 168 .
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A. Nigel Carter. (1997) Permeabilization Strategies to Study Protein Phosphorylation. Current Protocols in Protein Science 10:1.
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Katsuhiro Moriya, Juan Rivera, Sandra Odom, Yoshinori Sakuma, Kenzo Muramato, Tatsuya Yoshiuchi, Mitsuaki Miyamoto & Koji Yamada. (1997) ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of Fcɛ receptor I-mediated activation of Syk. Proceedings of the National Academy of Sciences 94:23, pages 12539-12544.
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Majed M. Hamawy, Mark Swieter, Stephan E. Mergenhagen & Reuben P. Siraganian. (1997) Reconstitution of High Affinity IgE Receptor-mediated Secretion By Transfecting Protein Tyrosine Kinase pp125FAK. Journal of Biological Chemistry 272:48, pages 30498-30503.
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Tony J. Fleming, Emmanuel Donnadieu, Chang Ho Song, Francois Van Laethem, Stephen J. Galli & Jean-Pierre Kinet. (1997) Negative Regulation of FcεRI-mediated Degranulation by CD81. Journal of Experimental Medicine 186:8, pages 1307-1314.
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Steven K. Melford, Martin Turner, Stephen J. Briddon, Victor L.J. Tybulewicz & Stephen P. Watson. (1997) Syk and Fyn Are Required by Mouse Megakaryocytes for the Rise in Intracellular Calcium Induced by a Collagen-related Peptide. Journal of Biological Chemistry 272:44, pages 27539-27542.
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