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Molecular and Cellular Biology Volume 15, 1995 - Issue 9
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Research Article

A Drosophila shc Gene Product Is Implicated in Signaling by the DER Receptor Tyrosine Kinase

Ka-Man Venus Lai1 Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, OntarioM5G 1X5, Canada;2 Department of Molecular and Medical Genetics, University of Toronto, Toronto, OntarioM5S 1A8, Canada
,
Jean Paul Olivier1 Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, OntarioM5G 1X5, Canada;2 Department of Molecular and Medical Genetics, University of Toronto, Toronto, OntarioM5S 1A8, Canada
,
Gerald D. Gish1 Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, OntarioM5G 1X5, Canada
,
Mark Henkemeyer1 Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, OntarioM5G 1X5, Canada
,
Jane Mcglade1 Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, OntarioM5G 1X5, Canada
&
Tony Pawson1 Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, OntarioM5G 1X5, Canada;2 Department of Molecular and Medical Genetics, University of Toronto, Toronto, OntarioM5S 1A8, CanadaCorrespondence[email protected]
Pages 4810-4818 | Received 08 May 1995, Accepted 26 Jun 1995, Published online: 30 Mar 2023

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Bo Zhang, Dieter Egli, Oleg Georgiev & Walter Schaffner. (2001) The Drosophila Homolog of Mammalian Zinc Finger Factor MTF-1 Activates Transcription in Response to Heavy Metals. Molecular and Cellular Biology 21:14, pages 4505-4514.
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S. H. Ong, G. R. Guy, Y. R. Hadari, S. Laks, N. Gotoh, J. Schlessinger & I. Lax. (2000) FRS2 Proteins Recruit Intracellular Signaling Pathways by Binding to Diverse Targets on Fibroblast Growth Factor and Nerve Growth Factor Receptors. Molecular and Cellular Biology 20:3, pages 979-989.
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Sarah J. Fashena & Kai Zinn. (1997) Transmembrane Glycoprotein gp150 Is a Substrate for Receptor Tyrosine Phosphatase DPTP10D in Drosophila Cells. Molecular and Cellular Biology 17:12, pages 6859-6867.
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Kodimangalam S. Ravichandran, Ming-Ming Zhou, Joanne C. Pratt, John E. Harlan, Scott F. Walk, Stephen W. Fesik & Steven J. Burakoff. (1997) Evidence for a Requirement for Both Phospholipid and Phosphotyrosine Binding via the Shc Phosphotyrosine-Binding Domain In Vivo. Molecular and Cellular Biology 17:9, pages 5540-5549.
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Stacey L. Harmer & Anthony L. DeFranco. (1997) Shc Contains Two Grb2 Binding Sites Needed for Efficient Formation of Complexes with SOS in B Lymphocytes. Molecular and Cellular Biology 17:7, pages 4087-4095.
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Noriko Gotoh, Masashi Toyoda & Masabumi Shibuya. (1997) Tyrosine Phosphorylation Sites at Amino Acids 239 and 240 of Shc Are Involved in Epidermal Growth Factor-Induced Mitogenic Signaling That Is Distinct from Ras/Mitogen-Activated Protein Kinase Activation. Molecular and Cellular Biology 17:4, pages 1824-1831.
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Articles from other publishers (39)

Fani Papagiannouli. (2022) Endocytosis at the Crossroad of Polarity and Signaling Regulation: Learning from Drosophila melanogaster and Beyond. International Journal of Molecular Sciences 23:9, pages 4684.
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Miles W DeAngelis, Joseph D Coolon & Ruth I Johnson. (2021) Comparative transcriptome analyses of the Drosophila pupal eye . G3 Genes|Genomes|Genetics 11:1.
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Marianne Malartre. (2016) Regulatory mechanisms of EGFR signalling during Drosophila eye development. Cellular and Molecular Life Sciences 73:9, pages 1825-1843.
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Baby Periyanayaki Muthusamy, Erine H. Budi, Yoko Katsuno, Matthew K. Lee, Susan M. Smith, Amer M. Mirza, Rosemary J. Akhurst & Rik Derynck. (2015) ShcA Protects against Epithelial–Mesenchymal Transition through Compartmentalized Inhibition of TGF-β-Induced Smad Activation. PLOS Biology 13:12, pages e1002325.
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Melanie K. B. Wills & Nina Jones. (2012) Teaching an old dogma new tricks: twenty years of Shc adaptor signalling. Biochemical Journal 447:1, pages 1-16.
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Matthew J Smith, W Rod Hardy, Guang-Yao Li, Marilyn Goudreault, Steven Hersch, Pavel Metalnikov, Andrei Starostine, Tony Pawson & Mitsuhiko Ikura. (2010) The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1. The EMBO Journal 29:5, pages 884-896.
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Tony Pawson & Piers Nash. 2010. Handbook of Cell Signaling. Handbook of Cell Signaling 399 411 .
Willis X. Li. (2005) Functions and mechanisms of receptor tyrosine kinase Torso signaling: Lessons fromDrosophila embryonic terminal development. Developmental Dynamics 232:3, pages 656-672.
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Orli Sagi, Marina Wolfson, Natalie Utko, Khachik Muradian & Vadim Fraifeld. (2005) p66ShcA and ageing: modulation by longevity-promoting agent aurintricarboxylic acid. Mechanisms of Ageing and Development 126:2, pages 249-254.
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Marco Gallio, Camilla Englund, Per Kylsten & Christos Samakovlis. (2004) Rhomboid 3 orchestrates Slit-independent repulsion of tracheal branches at the CNS midline. Development 131:15, pages 3605-3614.
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Ming-Shyue Lee, Tsukasa Igawa & Ming-Fong Lin. (2004) Tyrosine-317 of p52Shc mediates androgen-stimulated proliferation signals in human prostate cancer cells. Oncogene 23:17, pages 3048-3058.
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Mark Settle, Michael D Gordon, Mythili Nadella, David Dankort, William Muller & J Roger Jacobs. (2003) Genetic identification of effectors downstream of Neu (ErbB-2) autophosphorylation sites in a Drosophila model. Oncogene 22:13, pages 1916-1926.
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Li Zhang, Ulrike Lorenz & Kodi S. Ravichandran. (2003) Role of Shc in T-cell development and function. Immunological Reviews 191:1, pages 183-195.
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Tony Pawson & Piers Nash. 2003. Handbook of Cell Signaling. Handbook of Cell Signaling 379 386 .
Kodi S Ravichandran. (2001) Signaling via Shc family adapter proteins. Oncogene 20:44, pages 6322-6330.
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John P. O'Bryan. 2001. Regulators and Effectors of Small GTPases, Part G. Regulators and Effectors of Small GTPases, Part G 3 15 .
Hannah Robertson, Gary R Hime, Hania Lada & David DL Bowtell. (2000) A Drosophila analogue of v-Cbl is a dominant-negative oncoprotein in vivo. Oncogene 19:29, pages 3299-3308.
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Rachel M. Kulansky Poltilove, Aviva R. Jacobs, Carol Renfrew Haft, Pin Xu & Simeon I. Taylor. (2000) Characterization of Drosophila Insulin Receptor Substrate. Journal of Biological Chemistry 275:30, pages 23346-23354.
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David Warren, Andrew J. Heilpern, Kent Berg & Naomi Rosenberg. (2000) The Carboxyl Terminus of v-Abl Protein Can Augment SH2 Domain Function. Journal of Virology 74:10, pages 4495-4504.
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Ka-Man Venus Lai & Tony Pawson. (2000) The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo. Genes & Development 14:9, pages 1132-1145.
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Stefan Luschnig, Jana Krauss, Kerstin Bohmann, Isabelle Desjeux & Christiane Nüsslein-Volhard. (2000) The Drosophila SHC Adaptor Protein Is Required for Signaling by a Subset of Receptor Tyrosine Kinases. Molecular Cell 5:2, pages 231-241.
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Brian J. Galletta, Xi-Ping Niu, Mary Ruth S. Erickson & Susan M. Abmayr. (1999) Identification of a Drosophila homologue to vertebrate Crk by interaction with MBC. Gene 228:1-2, pages 243-252.
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Urte Gayko, Vaughn Cleghon, Terry Copeland, Deborah K. Morrison & Norbert Perrimon. (1999) Synergistic activities of multiple phosphotyrosine residues mediate full signaling from the Drosophila Torso receptor tyrosine kinase . Proceedings of the National Academy of Sciences 96:2, pages 523-528.
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Elena Cattaneo & Pier Giuseppe Pelicci. (1998) Emerging roles for SH2/PTB-containing Shc adaptor proteins in the developing mammalian brain. Trends in Neurosciences 21:11, pages 476-481.
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Hajime Ishihara, Toshiyasu Sasaoka, Tsutomu Wada, Manabu Ishiki, Tetsuro Haruta, Isao Usui, Minoru Iwata, Atsuko Takano, Tatsuhito Uno, Eiichi Ueno & Masashi Kobayashi. (1998) Relative Involvement of Shc Tyrosine 239/240 and Tyrosine 317 on Insulin Induced Mitogenic Signaling in Rat1 Fibroblasts Expressing Insulin Receptors. Biochemical and Biophysical Research Communications 252:1, pages 139-144.
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Ken-ichi Sato, Tetsuji Otsuki, Miwa Kimoto, Miki Kakumoto, Alexander A. Tokmakov, Yutaka Watanabe & Yasuo Fukami. (1998) c-Src and Phosphatidylinositol 3-Kinase Are Involved in NGF-Dependent Tyrosine Phosphorylation of Shc in PC12 Cells. Biochemical and Biophysical Research Communications 250:2, pages 223-228.
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J-P. Borg & B. Margolis. 1998. Protein Modules in Signal Transduction. Protein Modules in Signal Transduction 23 38 .
Ken-ichi Sato, Noriko Gotoh, Tetsuji Otsuki, Miki Kakumoto, Mamoru Aoto, Alexander A. Tokmakov, Masabumi Shibuya & Yasuo Fukami. (1997) Tyrosine Residues 239 and 240 of Shc Are Phosphatidylinositol 4,5-Bisphosphate-Dependent Phosphorylation Sites by c-Src. Biochemical and Biophysical Research Communications 240:2, pages 399-404.
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Pamela A. Blaikie, Emmanuel Fournier, Stephen M. Dilworth, Daniel Birnbaum, Jean-Paul Borg & Benjamin Margolis. (1997) The Role of the Shc Phosphotyrosine Interaction/Phosphotyrosine Binding Domain and Tyrosine Phosphorylation Sites in Polyoma Middle T Antigen-mediated Cell Transformation. Journal of Biological Chemistry 272:33, pages 20671-20677.
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Luciano Conti, Claudio De Fraja, Massimo Gulisano, Enrica Migliaccio, Stefano Govoni & Elena Cattaneo. (1997) Expression and activation of SH2/PTB-containing ShcA adaptor protein reflects the pattern of neurogenesis in the mammalian brain. Proceedings of the National Academy of Sciences 94:15, pages 8185-8190.
Crossref
Yiru Xu, Deng-Fu Guo, Mari Davidson, Tadashi Inagami & Graham Carpenter. (1997) Interaction of the Adaptor Protein Shc and the Adhesion Molecule Cadherin. Journal of Biological Chemistry 272:21, pages 13463-13466.
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Isao Oishi, Shin Sugiyama, Zhao-Jun Liu, Hirohei Yamamura, Yasuyoshi Nishida & Yasuhiro Minami. (1997) A Novel Drosophila Receptor Tyrosine Kinase Expressed Specifically in the Nervous System. Journal of Biological Chemistry 272:18, pages 11916-11923.
Crossref
Hajime Ishihara, Toshiyasu Sasaoka, Manabu Ishiki, Yasumitsu Takata, Takeshi Imamura, Isao Usui, W. John Langlois, Tasuku Sawa & Masashi Kobayashi. (1997) Functional Importance of Shc Tyrosine 317 on Insulin Signaling in Rat1 Fibroblasts Expressing Insulin Receptors. Journal of Biological Chemistry 272:14, pages 9581-9586.
Crossref
Shun-Cheng Li, Ka-Man Venus Lai, Gerald D. Gish, Wendy E. Parris, Peter van der Geer, Julie Forman-Kay & Tony Pawson. (1996) Characterization of the Phosphotyrosine-binding Domain of the Drosophila Shc Protein. Journal of Biological Chemistry 271:50, pages 31855-31862.
Crossref
Peter van der Geer, Sandra Wiley, Gerald D. Gish & Tony Pawson. (1996) The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein–protein interactions. Current Biology 6:11, pages 1435-1444.
Crossref
Joseph M. Verdi, Rosemarie Schmandt, Arash Bashirullah, Sara Jacob, Ralph Salvino, Constance G. Craig, Amgen EST Program, Howard D. Lipshitz & C.Jane McGlade. (1996) Mammalian NUMB is an evolutionarily conserved signaling adapter protein that specifies cell fate. Current Biology 6:9, pages 1134-1145.
Crossref
Ben Margolis. (1996) The PI/PTB domain: A new protein interaction domain involved in growth factor receptor signaling. Journal of Laboratory and Clinical Medicine 128:3, pages 235-241.
Crossref
Laura Bonfini, Enrica Migliaccio, Giuliana Pelicci, Luisa Lanfrancone & PierGiuseppe Pelicci. (1996) Not all Shc's roads lead to Ras. Trends in Biochemical Sciences 21:7, pages 257-261.
Crossref
Hiroshi Maruta & Antony W. BurgessDavid D. L. Bowtell. 1996. Regulation of the RAS Signaling Network. Regulation of the RAS Signaling Network 1 46 .

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