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Molecular and Cellular Biology Volume 15, 1995 - Issue 9
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Research Article

FER-1, an Enhancer of the Ferritin H Gene and a Target of E1A-Mediated Transcriptional Repression

Yoshiaki Tsuji1 Departments of Cancer Biology, Bowman Gray School of Medicine and Comprehensive Cancer Center of Wake Forest University, Winston-Salem, North Carolina27157
,
Naoki Akebi2 Department of Urology, Okayama University School of Medicine, Okayama700, Japan
,
T. K. Lam3 Prince of Wales Hospital, Shatin, New Territories, Hong Kong
,
Yusaku Nakabeppu4 Department of Biochemistry, Medical Institute of Bioregulation, Kyushu University, Fukuoka812, Japan
,
Suzy V. Torti5 Biochemistry, Bowman Gray School of Medicine and Comprehensive Cancer Center of Wake Forest University, Winston-Salem, North Carolina27157
&
Frank M. Torti1 Departments of Cancer Biology, Bowman Gray School of Medicine and Comprehensive Cancer Center of Wake Forest University, Winston-Salem, North Carolina27157;6 Medicine, Bowman Gray School of Medicine and Comprehensive Cancer Center of Wake Forest University, Winston-Salem, North Carolina27157
Pages 5152-5164 | Received 15 Feb 1995, Accepted 28 Jun 1995, Published online: 30 Mar 2023

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Kenta Iwasaki, Elizabeth L. MacKenzie, Kiros Hailemariam, Kensuke Sakamoto & Yoshiaki Tsuji. (2006) Hemin-Mediated Regulation of an Antioxidant-Responsive Element of the Human Ferritin H Gene and Role of Ref-1 during Erythroid Differentiation of K562 Cells. Molecular and Cellular Biology 26:7, pages 2845-2856.
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Yoshiaki Tsuji, Hitoshi Ayaki, Susan P. Whitman, Charles S. Morrow, Suzy V. Torti & Frank M. Torti. (2000) Coordinate Transcriptional and Translational Regulation of Ferritin in Response to Oxidative Stress. Molecular and Cellular Biology 20:16, pages 5818-5827.
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Hans A. Goldenberg & Premysl Ponka. (1997) Regulation of Mammalian Iron Metabolism: Current State and Need for Further Knowledge. Critical Reviews in Clinical Laboratory Sciences 34:6, pages 529-572.
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Articles from other publishers (42)

Yoshiaki Tsuji. (2023) Optimization of Biotinylated RNA or DNA Pull-Down Assays for Detection of Binding Proteins: Examples of IRP1, IRP2, HuR, AUF1, and Nrf2. International Journal of Molecular Sciences 24:4, pages 3604.
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Suzy V. Torti & Frank M. Torti. (2020) Iron and Cancer: 2020 Vision. Cancer Research 80:24, pages 5435-5448.
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J.J. Winzerling & D.Q.D. Pham. 2017. Reference Module in Life Sciences. Reference Module in Life Sciences.
Nikolaus Bresgen & Peter Eckl. (2015) Oxidative Stress and the Homeodynamics of Iron Metabolism. Biomolecules 5:2, pages 808-847.
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Shin-Jen Lin, Der-Yen Lee, Hao-Ching Wang, Shih-Ting Kang, Pung-Pung Hwang, Guang-Hsiung Kou, Ming-Fen Huang, Geen-Dong Chang & Chu-Fang Lo. (2015) White Spot Syndrome Virus Protein Kinase 1 Defeats the Host Cell's Iron-Withholding Defense Mechanism by Interacting with Host Ferritin. Journal of Virology 89:2, pages 1083-1093.
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Yunlong Tao, Qian Wu, Xin Guo, Zhuzhen Zhang, Yuanyuan Shen & Fudi Wang. (2014) MBD5 regulates iron metabolism via methylation-independent genomic targeting of Fth1 through KAT2A in mice . British Journal of Haematology 166:2, pages 279-291.
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Cole P. Anderson & Elizabeth A. Leibold. (2014) Mechanisms of iron metabolism in Caenorhabditis elegans. Frontiers in Pharmacology 5.
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Bo‐Wen Huang, Paul D. Ray, Kenta Iwasaki & Yoshiaki Tsuji. (2013) Transcriptional regulation of the human ferritin gene by coordinated regulation of Nrf2 and protein arginine methyltransferases PRMT1 and PRMT4. The FASEB Journal 27:9, pages 3763-3774.
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Wing-Hang Tong, Carole Sourbier, Gennady Kovtunovych, Suh Young Jeong, Manish Vira, Manik Ghosh, Vladimir Valera Romero, Rachid Sougrat, Sophie Vaulont, Benoit Viollet, Yeong-Sang Kim, Sunmin Lee, Jane Trepel, Ramaprasad Srinivasan, Gennady Bratslavsky, Youfeng Yang, W. Marston Linehan & Tracey A. Rouault. (2011) The Glycolytic Shift in Fumarate-Hydratase-Deficient Kidney Cancer Lowers AMPK Levels, Increases Anabolic Propensities and Lowers Cellular Iron Levels. Cancer Cell 20:3, pages 315-327.
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Kiros Hailemariam, Kenta Iwasaki, Bo-Wen Huang, Kensuke Sakamoto & Yoshiaki Tsuji. (2010) Transcriptional regulation of ferritin and antioxidant genes by HIPK2 under genotoxic stress. Journal of Cell Science 123:22, pages 3863-3871.
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Yuichi Ikegami, Kouichi Inukai, Kenta Imai, Yasushi Sakamoto, Hideki Katagiri, Susumu Kurihara, Takuya Awata & Shigehiro Katayama. (2009) Adiponectin Upregulates Ferritin Heavy Chain in Skeletal Muscle Cells. Diabetes 58:1, pages 61-70.
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Fan Zhang, Wei Wang, Yoshiaki Tsuji, Suzy V. Torti & Frank M. Torti. (2008) Post-transcriptional Modulation of Iron Homeostasis during p53-dependent Growth Arrest. Journal of Biological Chemistry 283:49, pages 33911-33918.
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Elizabeth L. MackenzieKenta IwasakiYoshiaki Tsuji. (2008) Intracellular Iron Transport and Storage: From Molecular Mechanisms to Health Implications. Antioxidants & Redox Signaling 10:6, pages 997-1030.
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Elizabeth L. MackenzieYoshiaki Tsuji. (2008) Elevated intracellular calcium increases ferritin H expression through an NFAT-independent post-transcriptional mechanism involving mRNA stabilization. Biochemical Journal 411:1, pages 107-113.
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Wan Seok Yang & Brent R. Stockwell. (2008) Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells. Chemistry & Biology 15:3, pages 234-245.
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Kenta Iwasaki, Kiros Hailemariam & Yoshiaki Tsuji. (2007) PIAS3 Interacts with ATF1 and Regulates the Human Ferritin H Gene through an Antioxidant-responsive Element. Journal of Biological Chemistry 282:31, pages 22335-22343.
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Holly L. Prentice, Christopher J.D. Tonkin, Louisa Caamano & William P. Sisk. (2007) High level expression of proteins using sequences from the ferritin heavy chain gene locus. Journal of Biotechnology 128:1, pages 50-60.
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Maria Concetta Faniello, Annalisa Fregola, Antonia Nisticò, Barbara Quaresima, Telma Crugliano, Raffaella Faraonio, Pasquale Puzzonia, Francesco Baudi, Giuseppe Parlato, Giovanni Cuda, Giovanni Morrone, Salvatore Venuta & Francesco Costanzo. (2006) Detection and functional analysis of an SNP in the promoter of the human ferritin H gene that modulates the gene expression. Gene 377, pages 1-5.
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Jamie E. Jennings-Gee, Yoshiaki Tsuji, E. Christine Pietsch, Elizabeth Moran, J.S. Mymryk, Frank M. Torti & Suzy V. Torti. (2006) Coordinate Inhibition of Cytokine-mediated Induction of Ferritin H, Manganese Superoxide Dismutase, and Interleukin-6 by the Adenovirus E1A Oncogene. Journal of Biological Chemistry 281:24, pages 16428-16435.
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Yoshiaki Tsuji. (2005) JunD activates transcription of the human ferritin H gene through an antioxidant response element during oxidative stress. Oncogene 24:51, pages 7567-7578.
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J.J. Winzerling & D.Q.-D. Pham. 2005. Comprehensive Molecular Insect Science. Comprehensive Molecular Insect Science 341 356 .
Dawn L. Geiser, Carrie A. Chavez, Roberto Flores-Munguia, Joy J. Winzerling & Daphne Q.-D. Pham. (2003) Aedes aegypti ferritin. A cytotoxic protector against iron and oxidative challenge?. European Journal of Biochemistry 270:18, pages 3667-3674.
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John Wilkinson IV, E.Christine Pietsch, Suzy V Torti & Frank M Torti. (2003) Ferritin regulation by oxidants and chemopreventive xenobiotics. Advances in Enzyme Regulation 43:1, pages 135-151.
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Yong-Chul Kim, Yoshimi Yamaguchi, Norihiko Kondo, Hiroshi Masutani & Junji Yodoi. (2003) Thioredoxin-dependent redox regulation of the antioxidant responsive element (ARE) in electrophile response. Oncogene 22:12, pages 1860-1865.
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E. Christine Pietsch, Jefferson Y. Chan, Frank M. Torti & Suzy V. Torti. (2003) Nrf2 Mediates the Induction of Ferritin H in Response to Xenobiotics and Cancer Chemopreventive Dithiolethiones. Journal of Biological Chemistry 278:4, pages 2361-2369.
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D.Q.-D. Pham, J.J. Shaffer, C.A. Chavez & P.L. Douglass. (2003) Identification and mapping of the promoter for the gene encoding the ferritin heavy-chain homologue of the yellow fever mosquito Aedes aegypti. Insect Biochemistry and Molecular Biology 33:1, pages 51-62.
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Douglas M Templeton & Ying Liu. (2003) Genetic regulation of cell function in response to iron overload or chelation. Biochimica et Biophysica Acta (BBA) - General Subjects 1619:2, pages 113-124.
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Kiyoko Kato & Norio Wake. 2003. Cell and Molecular Biology of Endometrial Carcinoma. Cell and Molecular Biology of Endometrial Carcinoma 207 218 .
Paolo Arosio & Sonia Levi. (2002) Ferritin, iron homeostasis, and oxidative damage1,2 1Guest Editor: Mario Comporti 2This article is part of a series of reviews on “Iron and Cellular Redox Status.” The full list of papers may be found on the homepage of the journal.. Free Radical Biology and Medicine 33:4, pages 457-463.
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Frank M. TortiSuzy V. Torti. (2002) Regulation of ferritin genes and protein. Blood 99:10, pages 3505-3516.
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Kiyoko Kato, Shinji Horiuchi, Akira Takahashi, Yousuke Ueoka, Takahiro Arima, Takao Matsuda, Hidenori Kato, Jun-ichi Nishida, Yusaku Nakabeppu & Norio Wake. (2002) Contribution of Estrogen Receptor α to Oncogenic K-Ras-mediated NIH3T3 Cell Transformation and Its Implication for Escape from Senescence by Modulating the p53 Pathway. Journal of Biological Chemistry 277:13, pages 11217-11224.
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Or KakhlonYosef GruenbaumZvi Ioav Cabantchik. (2001) Repression of ferritin expression increases the labile iron pool, oxidative stress, and short-term growth of human erythroleukemia cells. Blood 97:9, pages 2863-2871.
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Kouichi Orino, Yoshiaki Tsuji, Frank M. Torti & Suzy V. Torti. (1999) Adenovirus E1A blocks oxidant-dependent ferritin induction and sensitizes cells to pro-oxidant cytotoxicity. FEBS Letters 461:3, pages 334-338.
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Daphne Q.-D. Pham, Joy J. Winzerling, Mark S. Dodson & John H. Law. (1999) Transcriptional control is relevant in the modulation of mosquito ferritin synthesis by iron. European Journal of Biochemistry 266:1, pages 236-240.
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Yoshiaki Tsuji, Elizabeth Moran, Suzy V. Torti & Frank M. Torti. (1999) Transcriptional Regulation of the Mouse Ferritin H Gene. Journal of Biological Chemistry 274:11, pages 7501-7507.
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Linda M. Facchini & Linda Z. Penn. (1998) The molecular role of Myc in growth and transformation: recent discoveries lead to new insights. The FASEB Journal 12:9, pages 633-651.
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Yoshiaki Tsuji, Suzy V. Torti & Frank M. Torti. (1998) Activation of the Ferritin H Enhancer, FER-1, by the Cooperative Action of Members of the AP1 and Sp1 Transcription Factor Families. Journal of Biological Chemistry 273:5, pages 2984-2992.
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D R Richardson. (1997) Potential of iron chelators as effective antiproliferative agents. Canadian Journal of Physiology and Pharmacology 75:10-11, pages 1164-1180.
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Maria Assunta Bevilacqua, Maria Concetta Faniello, Barbara Quaresima, Maria Teresa Tiano, Paola Giuliano, Antonio Feliciello, Vittorio Enrico Avvedimento, Filiberto Cimino & Francesco Costanzo. (1997) A Common Mechanism Underlying the E1A Repression and the cAMP Stimulation of the H Ferritin Transcription. Journal of Biological Chemistry 272:33, pages 20736-20741.
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C Moroz, H Bessler, M Katz, I Zahavi, H Salman & M Djaldetti. (1997) Elevated serum ferritin level in acute myocardial infarction. Biomedicine & Pharmacotherapy 51:3, pages 126-130.
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Paul Rucker, Frank M. Torti & Suzy V. Torti. (1996) Role of H and L Subunits in Mouse Ferritin. Journal of Biological Chemistry 271:52, pages 33352-33357.
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Pauline M. Harrison & Paolo Arosio. (1996) The ferritins: molecular properties, iron storage function and cellular regulation. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1275:3, pages 161-203.
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