Advanced search
Publication Cover
Molecular and Cellular Biology Volume 16, 1996 - Issue 1
Submit an article Journal homepage
16
Views
124
CrossRef citations to date
0
Altmetric
Research Article

Differential Activation of the Ras/Extracellular-Signal-Regulated Protein Kinase Pathway Is Responsible for the Biological Consequences Induced by the Axl Receptor Tyrosine Kinase

Yih-Woei C. Fridell1 Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina27599-7295
,
Yan Jin1 Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina27599-7295
,
Lawrence A. Quilliam2 Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina27599-7295
,
Andreas Burchert1 Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina27599-7295
,
Patrick McCloskey3 Curriculum of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina27599-7295
,
Gwendolyn Spizz1 Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina27599-7295
,
Brian Varnum4 Amgen Corporation, Thousand Oaks, California91320
,
Channing Der2 Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina27599-7295
&
Edison T. Liu1 Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina27599-7295;3 Curriculum of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina27599-7295;5 Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina27599-7295Correspondence[email protected]
 show all
Pages 135-145 | Received 23 May 1995, Accepted 19 Oct 1995, Published online: 29 Mar 2023

Citations (124)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (13)

Aubhishek Zaman & Trever G Bivona. (2021) Targeting AXL in NSCLC. Lung Cancer: Targets and Therapy 12, pages 67-79.
Read now
Kary Y. F. Tsai, Kelsey M. Hirschi Budge, Sam Llavina, Taylor Davis, Matt Long, Abby Bennett, Beau Sitton, Juan A. Arroyo & Paul R. Reynolds. (2019) RAGE and AXL expression following secondhand smoke (SHS) exposure in mice. Experimental Lung Research 45:9-10, pages 297-309.
Read now
Afnan Abu-Thuraia, Rosemarie Gauthier, Rony Chidiac, Yoshinori Fukui, Robert A. Screaton, Jean-Philippe Gratton & Jean-François Côté. (2015) Axl Phosphorylates Elmo Scaffold Proteins To Promote Rac Activation and Cell Invasion. Molecular and Cellular Biology 35:1, pages 76-87.
Read now
Rachel MA Linger, Amy K Keating, H Shelton Earp & Douglas K Graham. (2010) Taking aim at Mer and Axl receptor tyrosine kinases as novel therapeutic targets in solid tumors. Expert Opinion on Therapeutic Targets 14:10, pages 1073-1090.
Read now
Pelle G. Lindqvist, Istwan Balogh & Björn Dahlbäck. (2010) Umbilical cord plasma levels of growth-arrest specific protein 6 in intrauterine growth restriction. Acta Obstetricia et Gynecologica Scandinavica 89:1, pages 22-26.
Read now
Vadim Budagian, Elena Bulanova, Zane Orinska, Erwin Duitman, Katja Brandt, Andreas Ludwig, Dieter Hartmann, Greg Lemke, Paul Saftig & Silvia Bulfone-Paus. (2005) Soluble Axl Is Generated by ADAM10-Dependent Cleavage and Associates with Gas6 in Mouse Serum. Molecular and Cellular Biology 25:21, pages 9324-9339.
Read now
Melissa P. Allen, Daniel A. Linseman, Hiroshi Udo, Mei Xu, Jerome B. Schaack, Brian Varnum, Eric R. Kandel, Kim A. Heidenreich & Margaret E. Wierman. (2002) Novel Mechanism for Gonadotropin-Releasing Hormone Neuronal Migration Involving Gas6/Ark Signaling to p38 Mitogen-Activated Protein Kinase. Molecular and Cellular Biology 22:2, pages 599-613.
Read now
Daniel Besser, Jacqueline F. Bromberg, James E. Darnell$suffix/text()$suffix/text() & Hidesaburo Hanafusa. (1999) A Single Amino Acid Substitution in the v-Eyk Intracellular Domain Results in Activation of Stat3 and Enhances Cellular Transformation. Molecular and Cellular Biology 19:2, pages 1401-1409.
Read now
Maria-Magdalena Georgescu, Kathrin H. Kirsch, Tomoyuki Shishido, Chen Zong & Hidesaburo Hanafusa. (1999) Biological Effects of c-Mer Receptor Tyrosine Kinase in Hematopoietic Cells Depend on the Grb2 Binding Site in the Receptor and Activation of NF-κB. Molecular and Cellular Biology 19:2, pages 1171-1181.
Read now
Francesca Walker, Akiko Kato, L. Jorge Gonez, Margaret L. Hibbs, Normand Pouliot, Alexander Levitzki & Antony W. Burgess. (1998) Activation of the Ras/Mitogen-Activated Protein Kinase Pathway by Kinase-Defective Epidermal Growth Factor Receptors Results in Cell Survival but Not Proliferation. Molecular and Cellular Biology 18:12, pages 7192-7204.
Read now
Sandro Goruppi, Elisabetta Ruaro, Brian Varnum & Claudio Schneider. (1997) Requirement of Phosphatidylinositol 3-Kinase-Dependent Pathway and Src for Gas6-Axl Mitogenic and Survival Activities in NIH 3T3 Fibroblasts. Molecular and Cellular Biology 17:8, pages 4442-4453.
Read now
Andreas Neubauer, Andreas Burchert, Carolyn Maiwald, Hans-JÜRgen Gruss, Stefan Serke, Dieter Huhn, Burghardt Wittig & Edison Liu. (1997) Recent Progress On the Role of Axl, A Receptor Tyrosine Kinase, in Malignant Transformation of Myeloid Leukemias. Leukemia & Lymphoma 25:1-2, pages 91-96.
Read now
Kathryn E. Crosier & Philip S. Crosier. (1997) New insights into the control of cell growth; The role of the Axl family. Pathology 29:2, pages 131-135.
Read now

Articles from other publishers (111)

Sheena Bhalla & David E. Gerber. (2023) AXL Inhibitors: Status of Clinical Development. Current Oncology Reports 25:5, pages 521-529.
Crossref
Shingpan Chan, Yunong Zhang, Jie Wang, Qiuchun Yu, Xia Peng, Jian Zou, Licheng Zhou, Li Tan, Yunxin Duan, Yang Zhou, Hoon Hur, Jing Ai, Zhen Wang, Xiaomei Ren, Zhang Zhang & Ke Ding. (2022) Discovery of 3-Aminopyrazole Derivatives as New Potent and Orally Bioavailable AXL Inhibitors. Journal of Medicinal Chemistry 65:22, pages 15374-15390.
Crossref
Agata Poświata, Kamila Kozik, Marta Miączyńska & Daria Zdżalik-Bielecka. (2022) Endocytic trafficking of GAS6–AXL complexes is associated with sustained AKT activation. Cellular and Molecular Life Sciences 79:6.
Crossref
Anurima Majumder, Sina Hosseinian, Mia Stroud, Emma Adhikari, James J. Saller, Matthew A. Smith, Guolin Zhang, Shruti Agarwal, Marc Creixell, Benjamin S. Meyer, Fumi Kinose, Kiah Bowers, Bin Fang, Paul A. Stewart, Eric A. Welsh, Theresa A. Boyle, Aaron S. Meyer, John M. Koomen & Eric B. Haura. (2022) Integrated Proteomics-Based Physical and Functional Mapping of AXL Kinase Signaling Pathways and Inhibitors Define Its Role in Cell Migration. Molecular Cancer Research 20:4, pages 542-555.
Crossref
Marta Nyakas, Karianne Giller Fleten, Mads Haugland Haugen, Nikolai Engedal, Christina Sveen, Inger Nina Farstad, Vivi Ann Flørenes, Lina Prasmickaite, Gunhild Mari Mælandsmo & Kotryna Seip. (2022) AXL inhibition improves BRAF-targeted treatment in melanoma. Scientific Reports 12:1.
Crossref
Jia Z. Shen, Zhixin Qiu, Qiulian Wu, Guoxin Zhang, Rebecca Harris, Dahui Sun, Juha Rantala, William D. Barshop, Linjie Zhao, Deguan Lv, Kwang-Ai Won, James Wohlschlegel, Olle Sangfelt, Heike Laman, Jeremy N. Rich & Charles Spruck. (2022) A FBXO7/EYA2-SCFFBXW7 axis promotes AXL-mediated maintenance of mesenchymal and immune evasion phenotypes of cancer cells. Molecular Cell 82:6, pages 1123-1139.e8.
Crossref
Dan Yan, H. Shelton Earp, Deborah DeRyckere & Douglas K. Graham. (2021) Targeting MERTK and AXL in EGFR Mutant Non-Small Cell Lung Cancer. Cancers 13:22, pages 5639.
Crossref
Sean M. Post, Michael Andreeff, Courtney DiNardo, Joseph D. Khoury & Peter P. Ruvolo. (2021) TAM kinases as regulators of cell death. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1868:6, pages 118992.
Crossref
Hefeng Zhang, Xia Peng, Yang Dai, Jingwei Shao, Yinchun Ji, Yiming Sun, Bo Liu, Xu Cheng, Jing Ai & Wenhu Duan. (2021) Discovery of a Pyrimidinedione Derivative as a Potent and Orally Bioavailable Axl Inhibitor. Journal of Medicinal Chemistry 64:7, pages 3956-3975.
Crossref
Shengda Xie, Huiru Zhang, Zhenjie Liang, Xingmiao Yang & Ruibing Cao. (2021) AXL, an Important Host Factor for DENV and ZIKV Replication. Frontiers in Cellular and Infection Microbiology 11.
Crossref
Liwen Zhou & Glenn K. Matsushima. 2021. Signal Transduction in Cancer and Immunity. Signal Transduction in Cancer and Immunity 165 210 .
Nellie K. McDaniel, Mari Iida, Kwangok P. Nickel, Colin A. Longhurst, Samantha R. Fischbach, Tamara S. Rodems, Carlene A. Kranjac, Amber Y. Bo, Qianyun Luo, Meghan M. Gallagher, Noah B. Welke, Kaitlyn R. Mitchell, Alison E. Schulz, Jaimee C. Eckers, Rong Hu, Ravi Salgia, Seungpyo Hong, Justine Y. Bruce, Randall J. Kimple & Deric L. Wheeler. (2020) AXL Mediates Cetuximab and Radiation Resistance Through Tyrosine 821 and the c-ABL Kinase Pathway in Head and Neck Cancer. Clinical Cancer Research 26:16, pages 4349-4359.
Crossref
Mai Tanaka & Dietmar W. Siemann. (2020) Gas6/Axl Signaling Pathway in the Tumor Immune Microenvironment. Cancers 12:7, pages 1850.
Crossref
Laura Bonifacio, Michael Dodds, David Prohaska, Aaron Moss, Amato Giaccia, Ray Tabibiazar & Gail McIntyre. (2019) Target‐Mediated Drug Disposition Pharmacokinetic/Pharmacodynamic Model‐Informed Dose Selection for the First‐in‐Human Study of AVB‐S6‐500. Clinical and Translational Science 13:1, pages 204-211.
Crossref
Varsha Gadiyar, Gopi Patel & Viralkumar Davra. 2020. TAM Receptors in Health and Disease. TAM Receptors in Health and Disease 57 79 .
Nellie K. McDaniel, Samantha R. Fischbach, Olivia J. Ondracek, Noah B. Welke, Mari Iida & Deric L. Wheeler. 2020. Improving the Therapeutic Ratio in Head and Neck Cancer. Improving the Therapeutic Ratio in Head and Neck Cancer 159 192 .
Markus Lauter, Anja Weber & Robert Torka. (2019) Targeting of the AXL receptor tyrosine kinase by small molecule inhibitor leads to AXL cell surface accumulation by impairing the ubiquitin-dependent receptor degradation. Cell Communication and Signaling 17:1.
Crossref
Chenjing Zhu, Yuquan Wei & Xiawei Wei. (2019) AXL receptor tyrosine kinase as a promising anti-cancer approach: functions, molecular mechanisms and clinical applications. Molecular Cancer 18:1.
Crossref
Chun-Yu Cho, Shih-Ying Chung, Shankung Lin, Jhy-Shrian Huang, Yen-Lin Chen, Shih-Sheng Jiang, Li-Chun Cheng, Tsu-Hsiang Kuo, Jong-Ding Lay, Ya-Yu Yang, Gi-Ming Lai & Shuang-En Chuang. (2019) PTBP1-mediated regulation of AXL mRNA stability plays a role in lung tumorigenesis. Scientific Reports 9:1.
Crossref
Chung-Kan Peng, Chin-Pyng Wu, Jr-Yu Lin, Shih-Chi Peng, Chien-Hsing Lee, Kun-Lun Huang & Chih-Hao Shen. (2019) Gas6/Axl signaling attenuates alveolar inflammation in ischemia-reperfusion-induced acute lung injury by up-regulating SOCS3-mediated pathway. PLOS ONE 14:7, pages e0219788.
Crossref
Kyeoung-Hwa Kim, Eun-Young Kim, Jung-Jae Ko & Kyung-Ah Lee. (2019) Gas6 is a reciprocal regulator of mitophagy during mammalian oocyte maturation. Scientific Reports 9:1.
Crossref
Seon Min Woo, Kyoung-jin Min, Seung Un Seo, Shin Kim, Peter Kubatka, Jong-Wook Park & Taeg Kyu Kwon. (2019) Axl Inhibitor R428 Enhances TRAIL-Mediated Apoptosis Through Downregulation of c-FLIP and Survivin Expression in Renal Carcinoma. International Journal of Molecular Sciences 20:13, pages 3253.
Crossref
David J. Pinato, Matthew W. Brown, Sebastian Trousil, Eric O. Aboagye, Jamie Beaumont, Hua Zhang, Helen M. Coley, Francesco A. Mauri & Rohini Sharma. (2019) Integrated analysis of multiple receptor tyrosine kinases identifies Axl as a therapeutic target and mediator of resistance to sorafenib in hepatocellular carcinoma. British Journal of Cancer 120:5, pages 512-521.
Crossref
Khuchtumur Bum-Erdene, Donghui Zhou, Giovanni Gonzalez-Gutierrez, Mona K. Ghozayel, Yubing Si, David Xu, Harlan E. Shannon, Barbara J. Bailey, Timothy W. Corson, Karen E. Pollok, Clark D. Wells & Samy O. Meroueh. (2019) Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD⋅Yap Protein-Protein Interaction. Cell Chemical Biology 26:3, pages 378-389.e13.
Crossref
Pei-Ling Hsu, Jonathan Jou & Shaw-Jenq Tsai. (2019) TYRO3: A potential therapeutic target in cancer. Experimental Biology and Medicine 244:2, pages 83-99.
Crossref
Guiling Wu, Zhiqiang Ma, Yicheng Cheng, Wei Hu, Chao Deng, Shuai Jiang, Tian Li, Fulin Chen & Yang Yang. (2018) Targeting Gas6/TAM in cancer cells and tumor microenvironment. Molecular Cancer 17:1.
Crossref
Martha Wium, Juliano Paccez & Luiz Zerbini. (2018) The Dual Role of TAM Receptors in Autoimmune Diseases and Cancer: An Overview. Cells 7:10, pages 166.
Crossref
Wenjing Li, Xiahui Xiong, Amro Abdalla, Salvador Alejo, Linyu Zhu, Fei Lu & Hong Sun. (2018) HGF-induced formation of the MET–AXL–ELMO2–DOCK180 complex promotes RAC1 activation, receptor clustering, and cancer cell migration and invasion. Journal of Biological Chemistry 293:40, pages 15397-15418.
Crossref
Selma Maacha, Jun Hong, Ariana von Lersner, Andries Zijlstra & Abbes Belkhiri. (2018) AXL Mediates Esophageal Adenocarcinoma Cell Invasion through Regulation of Extracellular Acidification and Lysosome Trafficking. Neoplasia 20:10, pages 1008-1022.
Crossref
Bridget Shafit-Zagardo, Ross C. Gruber & Juwen C. DuBois. (2018) The role of TAM family receptors and ligands in the nervous system: From development to pathobiology. Pharmacology & Therapeutics 188, pages 97-117.
Crossref
Yingying Shen, Xiguang Chen, Jun He, Duanfang Liao & Xuyu Zu. (2018) Axl inhibitors as novel cancer therapeutic agents. Life Sciences 198, pages 99-111.
Crossref
Guoan Zhang, Meng Wang, Hongli Zhao & Wen Cui. (2017) Function of Axl receptor tyrosine kinase in non-small cell lung cancer (Review). Oncology Letters.
Crossref
Jane Antony & Ruby Yun-Ju Huang. (2017) AXL-Driven EMT State as a Targetable Conduit in Cancer. Cancer Research 77:14, pages 3725-3732.
Crossref
Ghada Abboud-Jarrous, Shivam Priya, Avi Maimon, Stuart Fischman, Mayan Cohen-Elisha, Rakefet Czerninski & Tal Burstyn-Cohen. (2017) Protein S drives oral squamous cell carcinoma tumorigenicity through regulation of AXL. Oncotarget 8:8, pages 13986-14002.
Crossref
Carl M Gay, Kavitha Balaji & Lauren Averett Byers. (2017) Giving AXL the axe: targeting AXL in human malignancy. British Journal of Cancer 116:4, pages 415-423.
Crossref
Giridhar Mudduluru. 2017. Mechanisms of Molecular Carcinogenesis – Volume 1. Mechanisms of Molecular Carcinogenesis – Volume 1 39 60 .
Stanley G. Kimani, Sushil Kumar, Viralkumar Davra, Yun-Juan Chang, Canan Kasikara, Ke Geng, Wen-I Tsou, Shenyan Wang, Mainul Hoque, Andrej Boháč, Anita Lewis-Antes, Mariana S. De Lorenzo, Sergei V. Kotenko & Raymond B. Birge. (2016) Normalization of TAM post-receptor signaling reveals a cell invasive signature for Axl tyrosine kinase. Cell Communication and Signaling 14:1.
Crossref
Masakiyo Sakaguchi, Mami Yamamoto, Masashi Miyai, Tatsuo Maeda, Junichiro Hiruma, Hitoshi Murata, Rie Kinoshita, I Made Winarsa Ruma, Endy Widya Putranto, Yusuke Inoue, Shin Morizane, Nam-Ho Huh, Ryoji Tsuboi & Toshihiko Hibino. (2016) Identification of an S100A8 Receptor Neuroplastin-β and its Heterodimer Formation with EMMPRIN. Journal of Investigative Dermatology 136:11, pages 2240-2250.
Crossref
Pavel A. Levin, Rolf A. Brekken, Lauren Averett Byers, John V. Heymach & David E. Gerber. (2016) Axl Receptor Axis: A New Therapeutic Target in Lung Cancer. Journal of Thoracic Oncology 11:8, pages 1357-1362.
Crossref
Jacob J. Orme, Yong Du, Kamala Vanarsa, Jessica Mayeux, Li Li, Azza Mutwally, Cristina Arriens, Soyoun Min, Jack Hutcheson, Laurie S. Davis, Benjamin F. Chong, Anne B. Satterthwaite, Tianfu Wu & Chandra Mohan. (2016) Heightened cleavage of Axl receptor tyrosine kinase by ADAM metalloproteases may contribute to disease pathogenesis in SLE. Clinical Immunology 169, pages 58-68.
Crossref
D N Debruyne, N Bhatnagar, B Sharma, W Luther, N F Moore, N-K Cheung, N S Gray & R E George. (2015) ALK inhibitor resistance in ALKF1174L-driven neuroblastoma is associated with AXL activation and induction of EMT. Oncogene 35:28, pages 3681-3691.
Crossref
Matthew Brown, James R M Black, Rohini Sharma, Justin Stebbing & David J Pinato. (2016) Gene of the month: Axl . Journal of Clinical Pathology 69:5, pages 391-397.
Crossref
Chun-Yu Cho, Jhy-Shrian Huang, Shine-Gwo Shiah, Shih-Ying Chung, Jong-Ding Lay, Ya-Yu Yang, Gi-Ming Lai, Ann-Lii Cheng, Li-Tzong Chen & Shuang-En Chuang. (2016) Negative feedback regulation of AXL by miR-34a modulates apoptosis in lung cancer cells. RNA 22:2, pages 303-315.
Crossref
Caitlin D. May, Jeannine Garnett, XiaoYan Ma, Sharon M. Landers, Davis R. Ingram, Elizabeth G. Demicco, Ghadah A. Al Sannaa, Tona Vu, Lixia Han, Yi Zhang, Christine M. Kivlin, Svetlana Bolshakov, Azad Abul Kalam, Juehui Liu, Fuguo Zhou, Dominique Broccoli, Wei-Lien Wang, Alexander J. Lazar, Raphael E. Pollock, Dina Lev & Keila E. Torres. (2015) AXL is a potential therapeutic target in dedifferentiated and pleomorphic liposarcomas. BMC Cancer 15:1.
Crossref
H Yu, R Liu, B Ma, X Li, H-y Yen, Y Zhou, V Krasnoperov, Z Xia, X Zhang, A M Bove, M Buscarini, D Parekh, I S Gill, Q Liao, M Tretiakova, D Quinn, J Zhao & P S Gill. (2015) Axl receptor tyrosine kinase is a potential therapeutic target in renal cell carcinoma. British Journal of Cancer 113:4, pages 616-625.
Crossref
Rui Ji, Lingbin Meng, Qiutang Li & Qingxian Lu. (2014) TAM receptor deficiency affects adult hippocampal neurogenesis. Metabolic Brain Disease 30:3, pages 633-644.
Crossref
Greg Lemke. 2015. Receptor Tyrosine Kinases: Family and Subfamilies. Receptor Tyrosine Kinases: Family and Subfamilies 53 77 .
Haley Axelrod & Kenneth J. Pienta. (2014) Axl as a mediator of cellular growth and survival. Oncotarget 5:19, pages 8818-8852.
Crossref
Clémence Feneyrolles, Aurélia Spenlinhauer, Léa Guiet, Bénédicte Fauvel, Bénédicte Daydé-Cazals, Pierre Warnault, Gwénaël Chevé & Aziz Yasri. (2014) Axl Kinase as a Key Target for Oncology: Focus on Small Molecule Inhibitors. Molecular Cancer Therapeutics 13:9, pages 2141-2148.
Crossref
Khanh-Quynh N. Nguyen, Wen-I Tsou, Daniel A. Calarese, Stanley G. Kimani, Sukhwinder Singh, Shelly Hsieh, Yongzhang Liu, Bin Lu, Yi Wu, Scott J. Garforth, Steve C. Almo, Sergei V. Kotenko & Raymond B. Birge. (2014) Overexpression of MERTK Receptor Tyrosine Kinase in Epithelial Cancer Cells Drives Efferocytosis in a Gain-of-Function Capacity. Journal of Biological Chemistry 289:37, pages 25737-25749.
Crossref
Wen-I Tsou, Khanh-Quynh N. Nguyen, Daniel A. Calarese, Scott J. Garforth, Anita L. Antes, Sergey V. Smirnov, Steve C. Almo, Raymond B. Birge & Sergei V. Kotenko. (2014) Receptor Tyrosine Kinases, TYRO3, AXL, and MER, Demonstrate Distinct Patterns and Complex Regulation of Ligand-induced Activation. Journal of Biological Chemistry 289:37, pages 25750-25763.
Crossref
Florian Beigel, Matthias Friedrich, Corina Probst, Karl Sotlar, Burkhard Göke, Julia Diegelmann & Stephan Brand. (2014) Oncostatin M Mediates STAT3-Dependent Intestinal Epithelial Restitution via Increased Cell Proliferation, Decreased Apoptosis and Upregulation of SERPIN Family Members. PLoS ONE 9:4, pages e93498.
Crossref
S. Salian-MehtaM. XuA. J. KnoxL. Plummer, D. SlavovM. TaylorS. BeversR. S. HodgesW. F. CrowleyJrJr & M. E. Wierman. (2014) Functional Consequences of AXL Sequence Variants in Hypogonadotropic Hypogonadism . The Journal of Clinical Endocrinology & Metabolism 99:4, pages 1452-1460.
Crossref
S. Laurance, M.N. Aghourian, Z. Jiva Lila, C.A. Lemarié & M.D. Blostein. (2014) Gas6‐induced tissue factor expression in endothelial cells is mediated through caveolin‐1–enriched microdomains. Journal of Thrombosis and Haemostasis 12:3, pages 395-408.
Crossref
Angela M. Pierce & Amy K. Keating. (2014) TAM receptor tyrosine kinases: Expression, disease and oncogenesis in the central nervous system. Brain Research 1542, pages 206-220.
Crossref
Kathleen N. O'GuinRoss C. GruberCedric S. RaineHillary M. GuzikBradford K. PoulosBridget Shafit-Zagardo. (2014) Gas6 Enhances Axonal Ensheathment by MBP + Membranous Processes in Human DRG/OL Promyelinating Co-Cultures . ASN Neuro 6:1, pages AN20130022.
Crossref
Masashi Ishikawa, Makoto Sonobe, Ei Nakayama, Masashi Kobayashi, Ryutaro Kikuchi, Jiro Kitamura, Naoto Imamura & Hiroshi Date. (2012) Higher Expression of Receptor Tyrosine Kinase Axl, and Differential Expression of its Ligand, Gas6, Predict Poor Survival in Lung Adenocarcinoma Patients. Annals of Surgical Oncology 20:S3, pages 467-476.
Crossref
T. N. Haase, M. Rasmussen, C. A. M. Jaksch, L. W. Gaarn, C. K. Petersen, N. Billestrup & J. H. Nielsen. (2013) Growth arrest specific protein (GAS) 6: a role in the regulation of proliferation and functional capacity of the perinatal rat beta cell. Diabetologia 56:4, pages 763-773.
Crossref
D J Pinato, F A Mauri, T Lloyd, V Vaira, C Casadio, R L Boldorini & R Sharma. (2013) The expression of Axl receptor tyrosine kinase influences the tumour phenotype and clinical outcome of patients with malignant pleural mesothelioma. British Journal of Cancer 108:3, pages 621-628.
Crossref
Jessica E. Brown, Meredith Krodel, Mauricio Pazos, Cary Lai & Anne L. Prieto. (2012) Cross-Phosphorylation, Signaling and Proliferative Functions of the Tyro3 and Axl Receptors in Rat2 Cells. PLoS ONE 7:5, pages e36800.
Crossref
Vyacheslav A. Korshunov. (2011) Axl-dependent signalling: a clinical update. Clinical Science 122:8, pages 361-368.
Crossref
Sandrine Laurance, Catherine A. Lemarié & Mark D. Blostein. (2012) Growth Arrest-Specific Gene 6 (gas6) and Vascular Hemostasis. Advances in Nutrition 3:2, pages 196-203.
Crossref
Alexis Mollard, Steven L. Warner, Lee T. Call, Mark L. Wade, Jared J. Bearss, Anupam Verma, Sunil Sharma, Hariprasad Vankayalapati & David J. Bearss. (2011) Design, Synthesis, and Biological Evaluation of a Series of Novel AXL Kinase Inhibitors. ACS Medicinal Chemistry Letters 2:12, pages 907-912.
Crossref
Maeva Dufies, Arnaud Jacquel, Nathalie Belhacene, Guillaume Robert, Thomas Cluzeau, Fréderic Luciano, Jill Patrice Cassuto, Sophie Raynaud & Patrick Auberger. (2011) Mechanisms of AXL overexpression and function in Imatinib-resistant chronic myeloid leukemia cells. Oncotarget 2:11, pages 874-885.
Crossref
Anupam Verma, Steven L. Warner, Hariprasad Vankayalapati, David J. Bearss & Sunil Sharma. (2011) Targeting Axl and Mer Kinases in Cancer. Molecular Cancer Therapeutics 10:10, pages 1763-1773.
Crossref
Xianzhou Song, Hua Wang, Craig D. Logsdon, Asif Rashid, Jason B. Fleming, James L. Abbruzzese, Henry F. Gomez, Douglas B. Evans & Huamin Wang. (2011) Overexpression of receptor tyrosine kinase Axl promotes tumor cell invasion and survival in pancreatic ductal adenocarcinoma. Cancer 117:4, pages 734-743.
Crossref
Yusuke Shiozawa, Elisabeth A. Pedersen, Lalit R. Patel, Anne M. Ziegler, Aaron M. Havens, Younghun Jung, Jingcheng Wang, Stephanie Zalucha, Robert D. Loberg, Kenneth J. Pienta & Russell S. Taichman. (2010) GAS6/AXL Axis Regulates Prostate Cancer Invasion, Proliferation, and Survival in the Bone Marrow Niche. Neoplasia 12:2, pages 116-IN4.
Crossref
Giridhar Mudduluru, Peter Vajkoczy & Heike Allgayer. (2010) Myeloid Zinc Finger 1 Induces Migration, Invasion, and In vivo Metastasis through Axl Gene Expression in Solid Cancer . Molecular Cancer Research 8:2, pages 159-169.
Crossref
Lin Pao-Chun, Perry M. Chan, Wing Chan & Ed Manser. (2009) Cytoplasmic ACK1 Interaction with Multiple Receptor Tyrosine Kinases Is Mediated by Grb2. Journal of Biological Chemistry 284:50, pages 34954-34963.
Crossref
Angela Pierce, Brian Bliesner, Mei Xu, Sheila Nielsen-Preiss, Greg Lemke, Stuart Tobet & Margaret E. Wierman. (2008) Axl and Tyro3 Modulate Female Reproduction by Influencing Gonadotropin-Releasing Hormone Neuron Survival and Migration. Molecular Endocrinology 22:11, pages 2481-2495.
Crossref
K-Y Tai, Y-S Shieh, C-S Lee, S-G Shiah & C-W Wu. (2008) Axl promotes cell invasion by inducing MMP-9 activity through activation of NF-κB and Brg-1. Oncogene 27:29, pages 4044-4055.
Crossref
Jason G. Weinger, Pouyan Gohari, Ying Yan, Jonathan M. Backer, Brian Varnum & Bridget Shafit-Zagardo. (2008) In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation. Journal of Neurochemistry 106:1, pages 134-146.
Crossref
Megan E. CavetElaine M. SmolockOktay H. OzturkCameron WorldJinjiang PangAtsushi KonishiBradford C. Berk. (2008) Gas6–Axl Receptor Signaling Is Regulated by Glucose in Vascular Smooth Muscle Cells. Arteriosclerosis, Thrombosis, and Vascular Biology 28:5, pages 886-891.
Crossref
Lola Bellido‐Martín & Pablo García de Frutos. 2008. Vitamin K. Vitamin K 185 209 .
Rachel M.A. Linger, Amy K. Keating, H. Shelton Earp & Douglas K. Graham. 2008. 35 83 .
Jong-Ding Lay, Chih-Chen Hong, Jhy-Shrian Huang, Ya-Yu Yang, Chung-Yi Pao, Ching-Hang Liu, Yi-Pin Lai, Gi-Ming Lai, Ann-Lii Cheng, Ih-Jen Su & Shuang-En Chuang. (2007) Sulfasalazine Suppresses Drug Resistance and Invasiveness of Lung Adenocarcinoma Cells Expressing AXL. Cancer Research 67:8, pages 3878-3887.
Crossref
Stephan Brand, Julia Dambacher, Florian Beigel, Kathrin Zitzmann, Malte H. J. Heeg, Thomas S. Weiss, Thomas Prüfer, Torsten Olszak, Christian J. Steib, Martin Storr, Burkhard Göke, Helmut Diepolder, Manfred Bilzer, Wolfgang E. Thasler & Christoph J. Auernhammer. (2007) IL-22-mediated liver cell regeneration is abrogated by SOCS-1/3 overexpression in vitro. American Journal of Physiology-Gastrointestinal and Liver Physiology 292:4, pages G1019-G1028.
Crossref
Georgina D.M. CollettAndrew P. SageJohn Paul KirtonM. Yvonne AlexanderAndrew P. GilmoreAnn E. Canfield. (2007) Axl/Phosphatidylinositol 3-Kinase Signaling Inhibits Mineral Deposition by Vascular Smooth Muscle Cells. Circulation Research 100:4, pages 502-509.
Crossref
Tateo Sawabu, Hiroshi Seno, Tomoko Kawashima, Akihisa Fukuda, Yoshito Uenoyama, Mayumi Kawada, Naoki Kanda, Akira Sekikawa, Hirokazu Fukui, Motoko Yanagita, Hiroshi Yoshibayashi, Seiji Satoh, Yoshiharu Sakai, Toru Nakano & Tsutomu Chiba. (2007) Growth arrest-specific gene 6 and Axl signaling enhances gastric cancer cell survival via Akt pathway. Molecular Carcinogenesis 46:2, pages 155-164.
Crossref
Stephan Brand, Florian Beigel, Torsten Olszak, Kathrin Zitzmann, Sören T. Eichhorst, Jan-Michel Otte, Helmut Diepolder, Andreas Marquardt, Wolfgang Jagla, Andreas Popp, Stéphane Leclair, Karin Herrmann, Julia Seiderer, Thomas Ochsenkühn, Burkhard Göke, Christoph J. Auernhammer & Julia Dambacher. (2006) IL-22 is increased in active Crohn’s disease and promotes proinflammatory gene expression and intestinal epithelial cell migration. American Journal of Physiology-Gastrointestinal and Liver Physiology 290:4, pages G827-G838.
Crossref
Stephan Brand, Torsten Olszak, Florian Beigel, Joachim Diebold, Jan-Michel Otte, Soeren T. Eichhorst, Burkhard Göke & Julia Dambacher. (2006) Cell differentiation dependent expressed CCR6 mediates ERK-1/2, SAPK/JNK, and Akt signaling resulting in proliferation and migration of colorectal cancer cells. Journal of Cellular Biochemistry 97:4, pages 709-723.
Crossref
Stephan Brand, Florian Beigel, Torsten Olszak, Kathrin Zitzmann, Sören T. Eichhorst, Jan-Michel Otte, Joachim Diebold, Helmut Diepolder, Barbara Adler, Christoph J. Auernhammer, Burkhard Göke & Julia Dambacher. (2005) IL-28A and IL-29 mediate antiproliferative and antiviral signals in intestinal epithelial cells and murine CMV infection increases colonic IL-28A expression. American Journal of Physiology-Gastrointestinal and Liver Physiology 289:5, pages G960-G968.
Crossref
Sassan Hafizi, Anna Gustafsson, Jonas Stenhoff & Björn Dahlbäck. (2005) The Ran binding protein RanBPM interacts with Axl and Sky receptor tyrosine kinases. The International Journal of Biochemistry & Cell Biology 37:11, pages 2344-2356.
Crossref
Stephan Brand, Julia Dambacher, Florian Beigel, Torsten Olszak, Joachim Diebold, Jan-Michel Otte, Burkhard Göke & Sören T. Eichhorst. (2005) CXCR4 and CXCL12 are inversely expressed in colorectal cancer cells and modulate cancer cell migration, invasion and MMP-9 activation. Experimental Cell Research 310:1, pages 117-130.
Crossref
Istvan BaloghSassan HafiziJonas StenhoffKarin HanssonBjörn Dahlbäck. (2005) Analysis of Gas6 in Human Platelets and Plasma. Arteriosclerosis, Thrombosis, and Vascular Biology 25:6, pages 1280-1286.
Crossref
P. Valverde, M.S. Obin & A. Taylor. (2004) Role of Gas6/Axl signaling in lens epithelial cell proliferation and survival. Experimental Eye Research 78:1, pages 27-37.
Crossref
W.S. Sun, J. Fujimoto & T. Tamaya. (2003) Coexpression of growth arrest-specific gene 6 and receptor tyrosine kinases Axl and Sky in human uterine endometrial cancers. Annals of Oncology 14:6, pages 898-906.
Crossref
Georgina CollettAlan WoodM. Yvonne AlexanderBrian C. VarnumRaymond P. Boot-HandfordVasken OhanianJacqueline OhanianYih-Woei FridellAnn E. Canfield. (2003) Receptor Tyrosine Kinase Axl Modulates the Osteogenic Differentiation of Pericytes. Circulation Research 92:10, pages 1123-1129.
Crossref
Sassan Hafizi, Filiz Alindri, Roger Karlsson & Björn Dahlbäck. (2002) Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin. Biochemical and Biophysical Research Communications 299:5, pages 793-800.
Crossref
Takako Sasaki, Pjotr G. Knyazev, Yuri Cheburkin, Walter Göhring, Dominic Tisi, Axel Ullrich, Rupert Timpl & Erhard Hohenester. (2002) Crystal Structure of a C-terminal Fragment of Growth Arrest-specific Protein Gas6. Journal of Biological Chemistry 277:46, pages 44164-44170.
Crossref
Melissa P. Allen, Mei Xu, Daniel A. Linseman, John E. Pawlowski, Gary M. Bokoch, Kim A. Heidenreich & Margaret E. Wierman. (2002) Adhesion-related Kinase Repression of Gonadotropin-releasing Hormone Gene Expression Requires Rac Activation of the Extracellular Signal-regulated Kinase Pathway. Journal of Biological Chemistry 277:41, pages 38133-38140.
Crossref
Katherine L. Guttridge, J. Christopher Luft, Thomas L. Dawson, Eva Kozlowska, Nupam P. Mahajan, Brian Varnum & H. Shelton Earp. (2002) Mer Receptor Tyrosine Kinase Signaling. Journal of Biological Chemistry 277:27, pages 24057-24066.
Crossref
Dominador J. Manalo & Alice Y.-C. Liu. (2001) Resolution, Detection, and Characterization of Redox Conformers of Human HSF1. Journal of Biological Chemistry 276:26, pages 23554-23561.
Crossref
Kristen C. Hart, Scott C. Robertson & Daniel J. Donoghue. (2001) Identification of Tyrosine Residues in Constitutively Activated Fibroblast Growth Factor Receptor 3 Involved in Mitogenesis, Stat Activation, and Phosphatidylinositol 3-Kinase Activation. Molecular Biology of the Cell 12:4, pages 931-942.
Crossref
A Wimmel, D Glitz, A Kraus, J Roeder & M Schuermann. (2001) Axl receptor tyrosine kinase expression in human lung cancer cell lines correlates with cellular adhesion. European Journal of Cancer 37:17, pages 2264-2274.
Crossref
Melissa P. Allen, Mei Xu, Chan Zeng, Stuart A. Tobet & Margaret E. Wierman. (2000) Myocyte Enhancer Factors-2B and -2C Are Required for Adhesion Related Kinase Repression of Neuronal Gonadotropin Releasing Hormone Gene Expression. Journal of Biological Chemistry 275:50, pages 39662-39670.
Crossref
Sandro Goruppi, Elisabetta Ruaro, Brian Varnum & Claudio Schneider. (1999) Gas6-mediated survival in NIH3T3 cells activates stress signalling cascade and is independent of Ras. Oncogene 18:29, pages 4224-4236.
Crossref
Melissa P. Allen, Chan Zeng, Kristina Schneider, Xiaoyan Xiong, Mary Kay Meintzer, Paola Bellosta, Claudio Basilico, Brian Varnum, Kim A. Heidenreich & Margaret E. Wierman. (1999) Growth Arrest-Specific Gene 6 (Gas6)/Adhesion Related Kinase (Ark) Signaling Promotes Gonadotropin-Releasing Hormone Neuronal Survival via Extracellular Signal-Regulated Kinase (ERK) and Akt. Molecular Endocrinology 13:2, pages 191-201.
Crossref
E. TAKAHASHI & B.C. BERK. (1998) MAP kinases and vascular smooth muscle function. Acta Physiologica Scandinavica 164:4, pages 611-621.
Crossref
Ann-Ping Tsou, Keh-Ming Wu, Ten-Yen Tsen, Chin-Wen Chi, Jen-Hwey Chiu, Wing-Yiu Lui, Cheng-Po Hu, Chungming Chang, Chen-Kung Chou & Shih-Feng Tsai. (1998) Parallel Hybridization Analysis of Multiple Protein Kinase Genes: Identification of Gene Expression Patterns Characteristic of Human Hepatocellular Carcinoma. Genomics 50:3, pages 331-340.
Crossref
Cora Maucher, Eva M Weissinger, Elisabeth Kremmer, Manuela Baccarini, Kasia Procyk, Darren W Henderson, Linda Wolff, Walter Kolch, Bernd Kaspers, J.Frederic Mushinski & Harald Mischak. (1998) Activation of bcl-2 suppressible 40 and 44 kDa p38-like kinases during apoptosis of early and late B lymphocytic cell lines. FEBS Letters 427:1, pages 29-35.
Crossref
Gian Carlo AvanziMargherita GallicchioFlavia BottarelLoretta GammaitoniGiuliana CavalloniDonatella BuonfiglioManuela BragardoGiorgio BellomoEmanuele AlbanoRoberto FantozziGiovanni GarbarinoBrian VarnumMassimo AgliettaGiuseppe SaglioUmberto DianzaniChiara Dianzani. (1998) GAS6 Inhibits Granulocyte Adhesion to Endothelial Cells. Blood 91:7, pages 2334-2340.
Crossref
Gian Carlo AvanziMargherita GallicchioFlavia BottarelLoretta GammaitoniGiuliana CavalloniDonatella BuonfiglioManuela BragardoGiorgio BellomoEmanuele AlbanoRoberto FantozziGiovanni GarbarinoBrian VarnumMassimo AgliettaGiuseppe SaglioUmberto DianzaniChiara Dianzani. (1998) GAS6 Inhibits Granulocyte Adhesion to Endothelial Cells. Blood 91:7, pages 2334-2340.
Crossref
Yih-Woei C. Fridell, Jacy VillaJr.Jr., Eyal C. Attar & Edison T. Liu. (1998) GAS6 Induces Axl-mediated Chemotaxis of Vascular Smooth Muscle Cells. Journal of Biological Chemistry 273:12, pages 7123-7126.
Crossref
Pat McCloskey, Yih-Woei Fridell, Eyal Attar, Jacy Villa, Yan Jin, Brian Varnum & Edison T. Liu. (1997) GAS6 Mediates Adhesion of Cells Expressing the Receptor Tyrosine Kinase Axl. Journal of Biological Chemistry 272:37, pages 23285-23291.
Crossref
Bradford C. BerkMarshall A. Corson. (1997) Angiotensin II Signal Transduction in Vascular Smooth Muscle. Circulation Research 80:5, pages 607-616.
Crossref
Robin Hesketh. 1997. The Oncogene & Tumour Suppressor Gene Factsbook. The Oncogene & Tumour Suppressor Gene Factsbook 86 88 .
Q K ZhangS BoastK de los SantosM BegemannS P Goff. (1996) Transforming activity of retroviral genomes encoding Gag-Axl fusion proteins. Journal of Virology 70:11, pages 8089-8097.
Crossref
Jacqueline S. Biscardi, Fabienne Denhez, Georg F. Buehler, David A. Chesnutt, Steven C. Baragona, John P. O'Bryan, Channing J. Der, James J. Fiordalisi, Daniel W. Fults & Patricia F. Maness. (1996) rek, a Gene Expressed in Retina and Brain, Encodes a Receptor Tyrosine Kinase of the Axl/Tyro3 Family. Journal of Biological Chemistry 271:46, pages 29049-29059.
Crossref
Lei Ling, Dennis Templeton & Hsing-Jien Kung. (1996) Identification of the Major Autophosphorylation Sites of Nyk/Mer, an NCAM-related Receptor Tyrosine Kinase. Journal of Biological Chemistry 271:31, pages 18355-18362.
Crossref
John P. O'Bryan, Carol B. Martin, Zhou Songyang, Lewis C. Cantley & Channing J. Der. (1996) Binding Specificity and Mutational Analysis of the Phosphotyrosine Binding Domain of the Brain-specific Adaptor Protein ShcC. Journal of Biological Chemistry 271:20, pages 11787-11791.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.