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Molecular and Cellular Biology Volume 16, 1996 - Issue 10
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Research Article

Transformation by the Bmi-1 Oncoprotein Correlates with Its Subnuclear Localization but Not Its Transcriptional Suppression Activity

Kenneth J. Cohen1 Division of Pediatric Oncology, The Johns Hopkins Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland21205;2 Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland21205
,
Joseph S. Hanna1 Division of Pediatric Oncology, The Johns Hopkins Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland21205
,
Julia E. Prescott3 Program in Human Genetics and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland21205
&
Chi V. Dang1 Division of Pediatric Oncology, The Johns Hopkins Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland21205;3 Program in Human Genetics and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland21205;4 Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland21205Correspondence[email protected]
Pages 5527-5535 | Received 02 May 1996, Accepted 17 Jul 1996, Published online: 29 Mar 2023

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Jody A. Fromm, Sandra A. S. Johnson & Deborah L. Johnson. (2008) Epidermal Growth Factor Receptor 1 (EGFR1) and Its Variant EGFRvIII Regulate TATA-Binding Protein Expression through Distinct Pathways. Molecular and Cellular Biology 28:20, pages 6483-6495.
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Dmitri Wiederschain, Lin Chen, Brett Johnson, Kimberly Bettano, Dowdy Jackson, John Taraszka, Y. Karen Wang, Michael D. Jones, Michael Morrissey, James Deeds, Rebecca Mosher, Paul Fordjour, Christoph Lengauer & John D. Benson. (2007) Contribution of Polycomb Homologues Bmi-1 and Mel-18 to Medulloblastoma Pathogenesis. Molecular and Cellular Biology 27:13, pages 4968-4979.
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Ian F. G. King, Richard B. Emmons, Nicole J. Francis, Brigitte Wild, Jürg Müller, Robert E. Kingston & Chao-ting Wu. (2005) Analysis of a Polycomb Group Protein Defines Regions That Link Repressive Activity on Nucleosomal Templates to In Vivo Function. Molecular and Cellular Biology 25:15, pages 6578-6591.
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Koji Itahana, Ying Zou, Yoko Itahana, Jose-Luis Martinez, Christian Beausejour, Jacqueline J. L. Jacobs, Maarten van Lohuizen, Vimla Band, Judith Campisi & Goberdhan P. Dimri. (2003) Control of the Replicative Life Span of Human Fibroblasts by p16 and the Polycomb Protein Bmi-1. Molecular and Cellular Biology 23:1, pages 389-401.
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Sandra A. S. Johnson, Nihar Mandavia, Horng-Dar Wang & Deborah L. Johnson. (2000) Transcriptional Regulation of the TATA-Binding Protein by Ras Cellular Signaling. Molecular and Cellular Biology 20:14, pages 5000-5009.
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S. Kinnon & R. Fulton. (1999) Nucleotide Sequence Of The Feline Bmi-1 Coding Region. DNA Sequence 10:4-5, pages 335-338.
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David P. E. Satijn & Arie P. Otte. (1999) RING1 Interacts with Multiple Polycomb-Group Proteins and Displays Tumorigenic Activity. Molecular and Cellular Biology 19:1, pages 57-68.
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David P. E. Satijn, Daniel J. Olson, Johan van der Vlag, Karien M. Hamer, Caro Lambrechts, Hans Masselink, Marco J. Gunster, Richard G. A. B. Sewalt, Roel van Driel & Arie P. Otte. (1997) Interference with the Expression of a Novel Human Polycomb Protein, hPc2, Results in Cellular Transformation and Apoptosis. Molecular and Cellular Biology 17:10, pages 6076-6086.
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Brian C. Lewis, Hyunsuk Shim, Qing Li, Chyi Sun Wu, Linda A. Lee, Amit Maity & Chi V. Dang. (1997) Identification of Putative c-Myc-Responsive Genes: Characterization of rcl, a Novel Growth-Related Gene†. Molecular and Cellular Biology 17:9, pages 4967-4978.
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Oleg N. Denisenko & Karol Bomsztyk. (1997) The Product of the Murine Homolog of the Drosophila extra sex combs Gene Displays Transcriptional Repressor Activity. Molecular and Cellular Biology 17:8, pages 4707-4717.
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Marco J. Gunster, David P. Satijn, Karien M. Hamer, Jan L. den Blaauwen, Diederik de Bruijn, Mark J. Alkema, Maarten van Lohuizen, Roel van Driel & Arie P. Otte. (1997) Identification and Characterization of Interactions between the Vertebrate Polycomb-Group Protein BMI1 and Human Homologs of Polyhomeotic. Molecular and Cellular Biology 17:4, pages 2326-2335.
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Yong Han, Shengming Xu, Weimin Ye, Yang Wang, Xiangkai Zhang, Jiong Deng, Zhiyuan Zhang, Liu Liu & Shuli Liu. (2021) Targeting LSD1 suppresses stem cell-like properties and sensitizes head and neck squamous cell carcinoma to PD-1 blockade. Cell Death & Disease 12:11.
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Jun Yu, Yibo Wu, Hong Li, Hui Zhou, Cong Shen, Tingting Gao, Meng Lin, Xiuliang Dai, Jian Ou, Meiling Liu, Xiaoyan Huang, Bo Zheng & Fei Sun. (2021) BMI1 Drives Steroidogenesis Through Epigenetically Repressing the p38 MAPK Pathway. Frontiers in Cell and Developmental Biology 9.
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Hua Wang, Zixuan Hu, Jun Wu, Yukun Mei, Qian Zhang, Hengwei Zhang, Dengshun Miao & Wen Sun. (2019) Sirt1 Promotes Osteogenic Differentiation and Increases Alveolar Bone Mass via Bmi1 Activation in Mice. Journal of Bone and Mineral Research 34:6, pages 1169-1181.
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Soumyajit Banerjee Mustafi, Nicolas Aznar, Shailendra Kumar Dhar Dwivedi, Prabir Kumar Chakraborty, Rumki Basak, Priyabrata Mukherjee, Pradipta Ghosh & Resham Bhattacharya. (2016) Mitochondrial BMI1 maintains bioenergetic homeostasis in cells. The FASEB Journal 30:12, pages 4042-4055.
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Felicia Gray, Hyo Je Cho, Shirish Shukla, Shihan He, Ashley Harris, Bohdan Boytsov, Łukasz Jaremko, Mariusz Jaremko, Borries Demeler, Elizabeth R. Lawlor, Jolanta Grembecka & Tomasz Cierpicki. (2016) BMI1 regulates PRC1 architecture and activity through homo- and hetero-oligomerization. Nature Communications 7:1.
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Xichao Zhou, Xiuliang Dai, Xuan Wu, Ji Ji, Andrew Karaplis, David Goltzman, Xiangjiao Yang & Dengshun Miao. (2016) Overexpression of Bmi1 in Lymphocytes Stimulates Skeletogenesis by Improving the Osteogenic Microenvironment. Scientific Reports 6:1.
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Resham Bhattacharya, Soumyajit Banerjee Mustafi, Mark Street, Anindya Dey & Shailendra Kumar Dhar Dwivedi. (2015) Bmi-1: At the crossroads of physiological and pathological biology. Genes & Diseases 2:3, pages 225-239.
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Sivaprakasam Balasubramanian, Tiffany M. Scharadin, Bingshe Han, Wen Xu & Richard L. Eckert. (2015) The Bmi-1 helix–turn and ring finger domains are required for Bmi-1 antagonism of (−) epigallocatechin-3-gallate suppression of skin cancer cell survival. Cellular Signalling 27:7, pages 1336-1344.
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F Wei, D Ojo, X Lin, N Wong, L He, J Yan, S Xu, P Major & D Tang. (2014) BMI1 attenuates etoposide-induced G2/M checkpoints via reducing ATM activation. Oncogene 34:23, pages 3063-3075.
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Fenggang Yu, Wen-son Hsieh, Fredrik Petersson, Henry Yang, Yingying Li, Chunwei Li, Soon Wah Low, Jing Liu, Yan Yan, De-Yun Wang & Kwok Seng Loh. (2014) Malignant cells derived from 3T3 fibroblast feeder layer in cell culture for nasopharyngeal carcinoma. Experimental Cell Research 322:1, pages 193-201.
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Bonnie Choy, Santhoshi Bandla, Yinglin Xia, Dongfeng Tan, Arjun Pennathur, James D Luketich, Tony E Godfrey, Jeffrey H Peters, Jun Sun & Zhongren Zhou. (2012) Clinicopathologic characteristics of high expression of Bmi-1 in esophageal adenocarcinoma and squamous cell carcinoma. BMC Gastroenterology 12:1.
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Maria Kouzmina, Valtteri Häyry, Junnu Leikola, Caj Haglund, Tom Böhling, Virve Koljonen & Jaana Hagström. (2012) BMI1 expression identifies subtypes of Merkel cell carcinoma. Virchows Archiv 461:6, pages 647-653.
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Carolina Prezioso & Valerio Orlando. (2011) Polycomb proteins in mammalian cell differentiation and plasticity. FEBS Letters 585:13, pages 2067-2077.
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Richard L. Eckert, Gautam Adhikary, Ellen A. Rorke, Yap Ching Chew & Sivaprakasam Balasubramanian. (2011) Polycomb Group Proteins Are Key Regulators of Keratinocyte Function. Journal of Investigative Dermatology 131:2, pages 295-301.
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Ajay K Yadav, Anagh A Sahasrabuddhe, Manjari Dimri, Prashant V Bommi, Rachana Sainger & Goberdhan P Dimri. (2010) Deletion analysis of BMI1 oncoprotein identifies its negative regulatory domain. Molecular Cancer 9:1.
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Reuben H. Kim, Mark B. Lieberman, Rachel Lee, Ki-Hyuk Shin, Shebli Mehrazarin, Ju-Eun Oh, No-Hee Park & Mo K. Kang. (2010) Bmi-1 extends the life span of normal human oral keratinocytes by inhibiting the TGF-β signaling. Experimental Cell Research 316:16, pages 2600-2608.
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Jie Zhang & Kevin D. Sarge. (2009) Identification of a polymorphism in the RING finger of human Bmi-1 that causes its degradation by the ubiquitin-proteasome system. FEBS Letters 583:6, pages 960-964.
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Dengshun MiaoHanyi Su, Bin He, Jianjun GaoQingwen XiaMin Zhu, Zhen Gu, David GoltzmanAndrew C. Karaplis. (2008) Severe growth retardation and early lethality in mice lacking the nuclear localization sequence and C-terminus of PTH-related protein. Proceedings of the National Academy of Sciences 105:51, pages 20309-20314.
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Shiqing Zhang, Dexue Li, Enzhong Li, Lan Li, Junjun Wang, Changyong Wang, Jingyan Lu & Xueming Zhang. (2008) Expression localization of Bmi1 in mice testis. Molecular and Cellular Endocrinology 287:1-2, pages 47-56.
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