13
Views
52
CrossRef citations to date
0
Altmetric
Research Article

A Novel DNA Binding Motif for Yeast Zinc Cluster Proteins: the Leu3p and Pdr3p Transcriptional Activators Recognize Everted Repeats

, &
Pages 6096-6102 | Received 03 Apr 1996, Accepted 07 Aug 1996, Published online: 29 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Nitnipa Soontorngun, Marc Larochelle, Simon Drouin, François Robert & Bernard Turcotte. (2007) Regulation of Gluconeogenesis in Saccharomyces cerevisiae Is Mediated by Activator and Repressor Functions of Rds2. Molecular and Cellular Biology 27:22, pages 7895-7905.
Read now
Marc Larochelle, Simon Drouin, François Robert & Bernard Turcotte. (2006) Oxidative Stress-Activated Zinc Cluster Protein Stb5 Has Dual Activator/Repressor Functions Required for Pentose Phosphate Pathway Regulation and NADPH Production. Molecular and Cellular Biology 26:17, pages 6690-6701.
Read now
Tatsuo ITO, Shuji TANI, Tomoyuki ITOH, Norihiro TSUKAGOSHI, Masashi KATO & Tetsuo KOBAYASHI. (2004) Mode of AmyR Binding to the CGGN8AGG Sequence in the Aspergillus oryzaetaaG2 Promoter. Bioscience, Biotechnology, and Biochemistry 68:9, pages 1906-1911.
Read now
Jeong-Ho Kim, Jeffrey Polish & Mark Johnston. (2003) Specificity and Regulation of DNA Binding by the Yeast Glucose Transporter Gene Repressor Rgt1. Molecular and Cellular Biology 23:15, pages 5208-5216.
Read now
Joseph Strauss, M. Isabel Muro-Pastor & Claudio Scazzocchio. (1998) The Regulator of Nitrate Assimilation in Ascomycetes Is a Dimer Which Binds a Nonrepeated, Asymmetrical Sequence. Molecular and Cellular Biology 18:3, pages 1339-1348.
Read now

Articles from other publishers (47)

Ekaterina Shelest. (2017) Transcription Factors in Fungi: TFome Dynamics, Three Major Families, and Dual-Specificity TFs. Frontiers in Genetics 8.
Crossref
Franziska Rabe, Denise Seitner, Lisa Bauer, Fernando Navarrete, Angelika Czedik‐Eysenberg, Fernando A. Rabanal & Armin Djamei. (2016) Phytohormone sensing in the biotrophic fungus Ustilago maydis – the dual role of the transcription factor Rss1 . Molecular Microbiology 102:2, pages 290-305.
Crossref
Najla Gasmi, Pierre-Etienne Jacques, Natalia Klimova, Xiao Guo, Alessandra Ricciardi, François Robert & Bernard Turcotte. (2014) The Switch from Fermentation to Respiration in Saccharomyces cerevisiae Is Regulated by the Ert1 Transcriptional Activator/Repressor . Genetics 198:2, pages 547-560.
Crossref
Damien J. Downes, Meryl A. Davis, Sara D. Kreutzberger, Brendan L. Taig & Richard B. Todd. (2013) Regulation of the NADP-glutamate dehydrogenase gene gdhA in Aspergillus nidulans by the Zn(II)2Cys6 transcription factor LeuB. Microbiology 159:Pt_12, pages 2467-2480.
Crossref
Gianna Cecchetto, Mariana Richero, Nathalie Oestreicher, María Isabel Muro-Pastor, Sergio Pantano & Claudio Scazzocchio. (2012) Mutations in the basic loop of the Zn binuclear cluster of the UaY transcriptional activator suppress mutations in the dimerisation domain. Fungal Genetics and Biology 49:9, pages 731-743.
Crossref
Z. Lewis Liu. 2012. Microbial Stress Tolerance for Biofuels. Microbial Stress Tolerance for Biofuels 1 28 .
Tibor Bedekovics, Hongqiao Li, Gabriella B. Gajdos & Grazia Isaya. (2011) Leucine Biosynthesis Regulates Cytoplasmic Iron-Sulfur Enzyme Biogenesis in an Atm1p-independent Manner. Journal of Biological Chemistry 286:47, pages 40878-40888.
Crossref
Z. Lewis Liu. (2011) Molecular mechanisms of yeast tolerance and in situ detoxification of lignocellulose hydrolysates. Applied Microbiology and Biotechnology 90:3, pages 809-825.
Crossref
Myriam Manente & Michel Ghislain. (2009) The lipid-translocating exporter family and membrane phospholipid homeostasis in yeast. FEMS Yeast Research 9:5, pages 673-687.
Crossref
Anders M. Näär & Jitendra K. Thakur. (2009) Nuclear receptor-like transcription factors in fungi. Genes & Development 23:4, pages 419-432.
Crossref
GALINA YU. KOVALEVA, GEORGII A. BAZYKIN, MICHAEL BRUDNO & MIKHAIL S. GELFAND. (2011) COMPARATIVE GENOMICS OF TRANSCRIPTIONAL REGULATION IN YEASTS AND ITS APPLICATION TO IDENTIFICATION OF A CANDIDATE ALPHA-ISOPROPYLMALATE TRANSPORTER. Journal of Bioinformatics and Computational Biology 04:05, pages 981-998.
Crossref
Sarah MacPherson, Marc Larochelle & Bernard Turcotte. (2006) A Fungal Family of Transcriptional Regulators: the Zinc Cluster Proteins. Microbiology and Molecular Biology Reviews 70:3, pages 583-604.
Crossref
Su-Wen Ho, Ghil Jona, Christina T. L. Chen, Mark Johnston & Michael Snyder. (2006) Linking DNA-binding proteins to their recognition sequences by using protein microarrays. Proceedings of the National Academy of Sciences 103:26, pages 9940-9945.
Crossref
Mary X. Fitzgerald, Jeannie R. Rojas, John M. Kim, Gunter B. Kohlhaw & Ronen Marmorstein. (2006) Structure of a Leu3-DNA Complex: Recognition of Everted CGG Half-Sites by a Zn2Cys6 Binuclear Cluster Protein. Structure 14:4, pages 725-735.
Crossref
Burkhard R Braun, Marco van het Hoog, Christophe d'Enfert, Mikhail Martchenko, Jan Dungan, Alan Kuo, Diane O Inglis, M. Andrew Uhl, Hervé Hogues, Matthew Berriman, Michael Lorenz, Anastasia Levitin, Ursula Oberholzer, Catherine Bachewich, Doreen Harcus, Anne Marcil, Daniel Dignard, Tatiana Iouk, Rosa Zito, Lionel Frangeul, Fredj Tekaia, Kim Rutherford, Edwin Wang, Carol A Munro, Steve Bates, Neil A Gow, Lois L Hoyer, Gerwald Köhler, Joachim Morschhäuser, George Newport, Sadri Znaidi, Martine Raymond, Bernard Turcotte, Gavin Sherlock, Maria Costanzo, Jan Ihmels, Judith Berman, Dominique Sanglard, Nina Agabian, Aaron P Mitchell, Alexander D Johnson, Malcolm Whiteway & André Nantel. (2005) A Human-Curated Annotation of the Candida albicans Genome. PLoS Genetics 1:1, pages e1.
Crossref
Sarah MacPherson, Bassel Akache, Sandra Weber, Xavier De Deken, Martine Raymond & Bernard Turcotte. (2005) Candida albicans Zinc Cluster Protein Upc2p Confers Resistance to Antifungal Drugs and Is an Activator of Ergosterol Biosynthetic Genes . Antimicrobial Agents and Chemotherapy 49:5, pages 1745-1752.
Crossref
Young-Jin Lee, Kyosuke Yamamoto, Hiroshi Hamamoto, Ryoji Nakaune & Tadaaki Hibi. (2005) A novel ABC transporter gene ABC2 involved in multidrug susceptibility but not pathogenicity in rice blast fungus, Magnaporthe grisea. Pesticide Biochemistry and Physiology 81:1, pages 13-23.
Crossref
R. Polotnianka, B. J. Monahan, M. J. Hynes & M. A. Davis. (2004) TamA interacts with LeuB, the homologue of Saccharomyces cerevisiae Leu3p, to regulate gdhA expression in Aspergillus nidulans. Molecular Genetics and Genomics 272:4, pages 452-459.
Crossref
Xavier De Deken & Martine Raymond. (2004) Constitutive Activation of the PDR16 Promoter in a Candida albicans Azole-Resistant Clinical Isolate Overexpressing CDR1 and CDR2 . Antimicrobial Agents and Chemotherapy 48:7, pages 2700-2703.
Crossref
Bassel Akache, Sarah MacPherson, Marc-André Sylvain & Bernard Turcotte. (2004) Complex Interplay Among Regulators of Drug Resistance Genes in Saccharomyces cerevisiae. Journal of Biological Chemistry 279:27, pages 27855-27860.
Crossref
Gunter B. Kohlhaw. (2003) Leucine Biosynthesis in Fungi: Entering Metabolism through the Back Door. Microbiology and Molecular Biology Reviews 67:1, pages 1-15.
Crossref
Ronen Marmorstein & Mary X. Fitzgerald. (2003) Modulation of DNA-binding domains for sequence-specific DNA recognition. Gene 304, pages 1-12.
Crossref
BETTINA E. BAUER, CHRISTOPH SCHÜLLER & KARL KUCHLER. 2003. ABC Proteins. ABC Proteins 295 316 .
Anu M. Idicula, Gregory L. Blatch, Terrance G. Cooper & Rosemary A. Dorrington. (2002) Binding and Activation by the Zinc Cluster Transcription Factors of Saccharomyces cerevisiae. Journal of Biological Chemistry 277:48, pages 45977-45983.
Crossref
Bassel Akache & Bernard Turcotte. (2002) New Regulators of Drug Sensitivity in the Family of Yeast Zinc Cluster Proteins. Journal of Biological Chemistry 277:24, pages 21254-21260.
Crossref
Karen Hellauer, Bassel Akache, Sarah MacPherson, Edith Sirard & Bernard Turcotte. (2002) Zinc Cluster Protein Rdr1p Is a Transcriptional Repressor of the PDR5 Gene Encoding a Multidrug Transporter. Journal of Biological Chemistry 277:20, pages 17671-17676.
Crossref
Dennis Gómez, Beatriz Cubero, Gianna Cecchetto & Claudio Scazzocchio. (2002) PrnA, a Zn2Cys6 activator with a unique DNA recognition mode, requires inducer for in vivo binding. Molecular Microbiology 44:2, pages 585-597.
Crossref
Bertrand Cahuzac, Rachel Cerdan, Béatrice Felenbok & Eric Guittet. (2001) The Solution Structure of an AlcR-DNA Complex Sheds Light onto the Unique Tight and Monomeric DNA Binding of a Zn2Cys6 Protein. Structure 9:9, pages 827-836.
Crossref
Hubert Wolfger, Yasmine M Mamnun & Karl Kuchler. (2001) Fungal ABC proteins: pleiotropic drug resistance, stress response and cellular detoxification. Research in Microbiology 152:3-4, pages 375-389.
Crossref
Duc-Thang Nguyên, Anne-Marie Alarco & Martine Raymond. (2001) Multiple Yap1p-binding Sites Mediate Induction of the Yeast Major Facilitator FLR1 Gene in Response to Drugs, Oxidants, and Alkylating Agents. Journal of Biological Chemistry 276:2, pages 1138-1145.
Crossref
Lute-Harm Zwiers & Maarten A De Waard. (2000) Characterization of the ABC Transporter Genes MgAtr1 and MgAtr2 from the Wheat Pathogen Mycosphaerella graminicola. Fungal Genetics and Biology 30:2, pages 115-125.
Crossref
Angela Hach, Thomas Hon & Li Zhang. (2000) The Coiled Coil Dimerization Element of the Yeast Transcriptional Activator Hap1, a Gal4 Family Member, Is Dispensable for DNA Binding but Differentially Affects Transcriptional Activation. Journal of Biological Chemistry 275:1, pages 248-254.
Crossref
Anna Kolaczkowska & Andre Goffeau. (1999) Regulation of pleiotropic drug resistance in yeast. Drug Resistance Updates 2:6, pages 403-414.
Crossref
Dake Wang, Feng Zheng, Steen Holmberg & Gunter B. Kohlhaw. (1999) Yeast Transcriptional Regulator Leu3p. Journal of Biological Chemistry 274:27, pages 19017-19024.
Crossref
K.C. Ehrlich, B.G. Montalbano & J.W. Cary. (1999) Binding of the C6-zinc cluster protein, AFLR, to the promoters of aflatoxin pathway biosynthesis genes in Aspergillus parasiticus. Gene 230:2, pages 249-257.
Crossref
Driss Talibi & Martine Raymond. (1999) Isolation of a Putative Candida albicans Transcriptional Regulator Involved in Pleiotropic Drug Resistance by Functional Complementation of a pdr1 pdr3 Mutation in Saccharomyces cerevisiae . Journal of Bacteriology 181:1, pages 231-240.
Crossref
Yaël Mamane, Karen Hellauer, Marie-Hélène Rochon & Bernard Turcotte. (1998) A Linker Region of the Yeast Zinc Cluster Protein Leu3p Specifies Binding to Everted Repeat DNA. Journal of Biological Chemistry 273:29, pages 18556-18561.
Crossref
Josée Noël & Bernard Turcotte. (1998) Zinc Cluster Proteins Leu3p and Uga3p Recognize Highly Related but Distinct DNA Targets. Journal of Biological Chemistry 273:28, pages 17463-17468.
Crossref
Bénédicte BeckerAndré FellerMohamed El AlamiEvelyne DuboisAndré Piérard. (2002) A nonameric core sequence is required upstream of the LYS genes of Saccharomyces cerevisiae for Lys14p‐mediated activation and apparent repression by lysine . Molecular Microbiology 29:1, pages 151-163.
Crossref
Beatrice Cazelle, Anna Pokorska, Elizabeth Hull, Peter M. Green, Glyn Stanway & Claudio Scazzocchio. (1998) Sequence, exon-intron organization, transcription and mutational analysis of prnA, the gene encoding the transcriptional activator of the prn gene cluster in Aspergillus nidulans. Molecular Microbiology 28:2, pages 355-370.
Crossref
Kunchithapadam Swaminathan, Paul Flynn, Richard J. Reece & Ronen Marmorstein. (1997) Crystal structure of a PUT3–DNA complex reveals a novel mechanism for DMA recognition by a protein containing a Zn2Cys6 binuclear cluster. Nature Structural Biology 4:9, pages 751-759.
Crossref
John W.R. Schwabe & Daniela Rhodes. (1997) Linkers made to measure. Nature Structural Biology 4:9, pages 680-683.
Crossref
Lilyann Novak Frazer. (1997) One stop mycology. Mycological Research 101:9, pages 1145-1152.
Crossref
Hanspeter Rottensteiner, Arnoud J. Kal, Barbara Hamilton, Helmut Ruis & Henk F. Tabak. (1997) A Heterodimer of the Zn2Cys6 Transcription Factors Pip2p and Oaf1p Controls Induction of Genes Encoding Peroxisomal Proteins in Saccharomyces Cerevisiae. European Journal of Biochemistry 247:3, pages 776-783.
Crossref
Lilyann Novak Frazer. (1997) One stop mycology. Mycological Research 101:8, pages 1006-1024.
Crossref
Pascal Hoffmann & Alanna Schepartz. (1997) Evidence for induced DNA bending by the yeast zinc cluster protein PUT3. Bioorganic & Medicinal Chemistry Letters 7:15, pages 2049-2054.
Crossref
Richard B. Todd & Alex Andrianopoulos. (1997) Evolution of a Fungal Regulatory Gene Family: The Zn(II)2Cys6 Binuclear Cluster DNA Binding Motif. Fungal Genetics and Biology 21:3, pages 388-405.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.