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Shun Xu, Haijiao Huang, Yu-ning Chen, Yun-ting Deng, Bing Zhang, Xing-dong Xiong, Yuan Yuan, Yanmei Zhu, Haiyong Huang, Luoyijun Xie & Xinguang Liu. (2016) DNA damage responsive miR-33b-3p promoted lung cancer cells survival and cisplatin resistance by targeting p21WAF1/CIP1. Cell Cycle 15:21, pages 2920-2930.
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Kotb Abdelmohsen, Subramanya Srikantan, Kumiko Tominaga, Min-Ju Kang, Yael Yaniv, Jennifer L. Martindale, Xiaoling Yang, Sung-Soo Park, Kevin G. Becker, Murugan Subramanian, Stuart Maudsley, Ashish Lal & Myriam Gorospe. (2012) Growth Inhibition by miR-519 via Multiple p21-Inducing Pathways. Molecular and Cellular Biology 32:13, pages 2530-2548.
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Yu-Chieh M. Wu & Michael A. O'Reilly. (2011) Bcl-XL Is the primary mediator of p21 protection against hyperoxia-induced cell death. Experimental Lung Research 37:2, pages 82-91.
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Jun Zhan, John B. Easton, Shile Huang, Ashutosh Mishra, Limin Xiao, Eilyn R. Lacy, Richard W. Kriwacki & Peter J. Houghton. (2007) Negative Regulation of ASK1 by p21Cip1 Involves a Small Domain That Includes Serine 98 That Is Phosphorylated by ASK1 In Vivo. Molecular and Cellular Biology 27:9, pages 3530-3541.
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Peggy Papeleu, Tamara Vanhaecke, Greetje Elaut, Mathieu Vinken, Tom Henkens, Sarah Snykers & Vera Rogiers. (2005) Differential Effects of Histone Deacetylase Inhibitors in Tumor and Normal Cells—What Is the Toxicological Relevance?. Critical Reviews in Toxicology 35:4, pages 363-378.
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Renald Blundell, David J. Harrison & Shirley O'Dea. (2004) p21Waf1/Cip1 REGULATES PROLIFERATION AND APOPTOSIS IN AIRWAY EPITHELIAL CELLS AND ALTERNATIVE FORMS HAVE ALTERED BINDING ACTIVITIES. Experimental Lung Research 30:6, pages 447-464.
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Jin-Mei Lai, Sulin Wu, Duen-Yi Huang & Zee-Fen Chang. (2002) Cytosolic Retention of Phosphorylated Extracellular Signal-Regulated Kinase and a Rho-Associated Kinase-Mediated Signal Impair Expression of p21Cip1/Waf1 in Phorbol 12-Myristate-13- Acetate-Induced Apoptotic Cells. Molecular and Cellular Biology 22:21, pages 7581-7592.
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Wengong Wang, Jinshui Fan, Xiaoling Yang, Stefanie Fürer-Galban, Isabel Lopez de Silanes, Cayetano von Kobbe, Jia Guo, Steve N. Georas, Fabienne Foufelle, D. Grahame Hardie, David Carling & Myriam Gorospe. (2002) AMP-Activated Kinase Regulates Cytoplasmic HuR. Molecular and Cellular Biology 22:10, pages 3425-3436.
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Wengong Wang, Henry Furneaux, Huiming Cheng, M. Craig Caldwell, Dorothy Hutter, Yusen Liu, Nikki Holbrook & Myriam Gorospe. (2000) HuR Regulates p21 mRNA Stabilization by UV Light. Molecular and Cellular Biology 20:3, pages 760-769.
Read now
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Myriam Gorospe, Xiantao Wang & Nikki J. Holbrook. (1998) p53-Dependent Elevation of p21Waf1 Expression by UV Light Is Mediated through mRNA Stabilization and Involves a Vanadate-Sensitive Regulatory System. Molecular and Cellular Biology 18:3, pages 1400-1407.
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Keitarou SUZUKI, Fumiko SHONO & Masaru UYEDA. (1998) Inhibition of Topoisomerases by Antitumor Prostaglandins.. Bioscience, Biotechnology, and Biochemistry 62:10, pages 2073-2075.
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N. YAMAGISHI, J. MIYAKOSHI and H. TAKEBE. (1997) Enhanced radiosensitivity by inhibition of nuclear factor kappaB activation in human malignant glioma cells. International Journal of Radiation Biology 72:2, pages 157-162.
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Articles from other publishers (123)
I-Ping Yang, Kwan-Ling Yip, Yu-Tang Chang, Yen-Cheng Chen, Ching-Wen Huang, Hsiang-Lin Tsai, Yung-Sung Yeh & Jaw-Yuan Wang. (2023) MicroRNAs as Predictive Biomarkers in Patients with Colorectal Cancer Receiving Chemotherapy or Chemoradiotherapy: A Narrative Literature Review. Cancers 15:5, pages 1358.
Crossref
Crossref
Chun-Ming Huang, Hsiang-Lin Tsai, Yen-Cheng Chen, Ching-Wen Huang, Ching-Chun Li, Wei-Chih Su, Tsung-Kun Chang, Yung-Sung Yeh, Po-Jung Chen, Ming-Yii Huang & Jaw-Yuan Wang. (2022) Role of non-coding RNAs in radiosensitivity of colorectal cancer: A narrative review. Frontiers in Oncology 12.
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Crossref
Satya Narayan, Asif Raza, Iqbal Mahmud, Nayeong Koo, Timothy J. Garrett, Mary E. Law, Brian K. Law & Arun K. Sharma. (2022) Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A. iScience 25:7, pages 104518.
Crossref
Crossref
Libao Gong, Ti Wen, Zhi Li, Yizhe Wang, Jin Wang, Xiaofang Che, Yunpeng Liu & Xiujuan Qu. (2019) TNPO2 operates downstream of DYNC1I1 and promotes gastric cancer cell proliferation and inhibits apoptosis. Cancer Medicine 8:17, pages 7299-7312.
Crossref
Crossref
Al Bitar & Gali-Muhtasib. (2019) The Role of the Cyclin Dependent Kinase Inhibitor p21cip1/waf1 in Targeting Cancer: Molecular Mechanisms and Novel Therapeutics. Cancers 11:10, pages 1475.
Crossref
Crossref
Hyun-A. Seong & Hyunjung Ha. (2019) Thr55 phosphorylation of p21 by MPK38/MELK ameliorates defects in glucose, lipid, and energy metabolism in diet-induced obese mice. Cell Death & Disease 10:6.
Crossref
Crossref
Wing-Fu Lai. 2019. Delivery of Therapeutics for Biogerontological Interventions. Delivery of Therapeutics for Biogerontological Interventions
87
97
.
Xiaohui Jiang. (2018) Silencing of heart and neural crest derivatives expressed transcript 2 attenuates transforming growth factor‑β1‑enhanced apoptosis of human bronchial epithelial cells. Oncology Letters.
Crossref
Crossref
Masami Hayashi, Kayo Yoshida, Kohei Kitada, Akane Kizu, Daisuke Tachibana, Mitsuru Fukui, Takashi Morita & Masayasu Koyama. (2018) Low-dose irradiation of mouse embryos increases Smad-p21 pathway activity and preserves pluripotency. Journal of Assisted Reproduction and Genetics 35:6, pages 1061-1069.
Crossref
Crossref
Qiu Li, Xiu Li, Hao Tang, Bin Jiang, Yali Dou, Myriam Gorospe & Wengong Wang. (2017) NSUN2-Mediated m5C Methylation and METTL3/METTL14-Mediated m6A Methylation Cooperatively Enhance p21 Translation. Journal of Cellular Biochemistry 118:9, pages 2587-2598.
Crossref
Crossref
Alexandros G. Georgakilas, Olga A. Martin & William M. Bonner. (2017) p21: A Two-Faced Genome Guardian. Trends in Molecular Medicine 23:4, pages 310-319.
Crossref
Crossref
Deepti Saxena, Michael Spino, Fernando Tricta, John Connelly, Bernadette M. Cracchiolo, Axel-Rainer Hanauske, Darlene D’Alliessi Gandolfi, Michael B. Mathews, Jonathan Karn, Bart Holland, Myung Hee Park, Tsafi Pe’ery, Paul E. Palumbo & Hartmut M. Hanauske-Abel. (2016) Drug-Based Lead Discovery: The Novel Ablative Antiretroviral Profile of Deferiprone in HIV-1-Infected Cells and in HIV-Infected Treatment-Naive Subjects of a Double-Blind, Placebo-Controlled, Randomized Exploratory Trial. PLOS ONE 11:5, pages e0154842.
Crossref
Crossref
Lin Zheng, Yuqin Zhang, Yan Liu, Min Zhou, Yanxia Lu, Li Yuan, Chao Zhang, Min Hong, Shuang Wang & Xuenong Li. (2015) MiR-106b induces cell radioresistance via the PTEN/PI3K/AKT pathways and p21 in colorectal cancer. Journal of Translational Medicine 13:1.
Crossref
Crossref
Yun-Jeong Choe, Kyoung-Won Ko, Hyein Lee, Sun-Young Lee, Byung-Chul Kim & Ho-Shik Kim. (2016) PGA2-induced HO-1 attenuates G2M arrest by modulating GADD45α expression. Molecular & Cellular Toxicology 11:4, pages 465-474.
Crossref
Crossref
Kshaunis Misra, Subhabrata Paul & Rita Kundu. (2013) Induction of Apoptosis in G1/S Blocked HeLa Cells by R-Roscovitine: A Preliminary Study. Proceedings of the Zoological Society 67:2, pages 114-125.
Crossref
Crossref
Majid Safa, Kazem Mousavizadeh, Shekoofeh Noori, Arefeh Pourfathollah & Hamid Zand. (2014) cAMP protects acute promyelocytic leukemia cells from arsenic trioxide-induced caspase-3 activation and apoptosis. European Journal of Pharmacology 736, pages 115-123.
Crossref
Crossref
YUPING WANG, JIE CHEN, LIN WANG, YUJI HUANG, YE LENG & GUIYING WANG. (2013) Fangchinoline induces G0/G1 arrest by modulating the expression of CDKN1A and CCND2 in K562 human chronic myelogenous leukemia cells. Experimental and Therapeutic Medicine 5:4, pages 1105-1112.
Crossref
Crossref
Luca Mologni, Stefania Brussolo, Monica Ceccon & Carlo Gambacorti-Passerini. (2012) Synergistic Effects of Combined Wnt/KRAS Inhibition in Colorectal Cancer Cells. PLoS ONE 7:12, pages e51449.
Crossref
Crossref
V. S. Romanov, V. A. Pospelov & T. V. Pospelova. (2012) Cyclin-dependent kinase inhibitor p21Waf1: Contemporary view on its role in senescence and oncogenesis. Biochemistry (Moscow) 77:6, pages 575-584.
Crossref
Crossref
Catherine A. O'Brien, Antonija Kreso, Paul Ryan, Karin G. Hermans, Lianne Gibson, Yadong Wang, Andrew Tsatsanis, Steven Gallinger & John E. Dick. (2012) ID1 and ID3 Regulate the Self-Renewal Capacity of Human Colon Cancer-Initiating Cells through p21. Cancer Cell 21:6, pages 777-792.
Crossref
Crossref
Zhi-ming Wu, Chun Dai, Ying Huang, Cui-fang Zheng, Qiong-zhu Dong, Guan Wang, Xiao-wen Li, Xiao-fei Zhang, Bin Li & Gang Chen. (2011) Anti-cancer effects of p21WAF1/CIP1 transcriptional activation induced by dsRNAs in human hepatocellular carcinoma cell lines. Acta Pharmacologica Sinica 32:7, pages 939-946.
Crossref
Crossref
Jee-In Heo, Soo-Jin Oh, Yoon-Jung Kho, Jeong-Hyeon Kim, Hong-Joon Kang, Seong-Hoon Park, Hyun-Seok Kim, Jong-Yeon Shin, Min-Ju Kim, Sung Chan Kim, Jae-Bong Park, Jaebong Kim & Jae-Yong Lee. (2010) ERK mediates anti-apoptotic effect through phosphorylation and cytoplasmic localization of p21Waf1/Cip1/Sdi in response to DNA damage in normal human embryonic fibroblast (HEF) cells. Molecular Biology Reports 38:4, pages 2785-2791.
Crossref
Crossref
Joanna Boruc, Evelien Mylle, Maria Duda, Rebecca De Clercq, Stephane Rombauts, Danny Geelen, Pierre Hilson, Dirk Inzeݩ, Daniel Van Damme & Eugenia Russinova. (2010) Systematic Localization of the Arabidopsis Core Cell Cycle Proteins Reveals Novel Cell Division Complexes
. Plant Physiology 152:2, pages 553-565.
Crossref
Crossref
Sun-Young Lee, Ji-Hyun Ahn, Kyoung Won Ko, Jaetaek Kim, Seong Whan Jeong, In-Kyung Kim, Jin Kim & Ho-Shik Kim. (2010) Prostaglandin A2 activates intrinsic apoptotic pathway by direct interaction with mitochondria in HL-60 cells. Prostaglandins & Other Lipid Mediators 91:1-2, pages 30-37.
Crossref
Crossref
Yuki Kuwano, Imed-Eddine Gallouzi & Myriam Gorospe. 2010. Apoptosome. Apoptosome
203
220
.
Eun-Woo Lee, Min-Sik Lee, Suzanne Camus, Jaewang Ghim, Mi-Ran Yang, Wonkyung Oh, Nam-Chul Ha, David P Lane & Jaewhan Song. (2009) Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis. The EMBO Journal 28:14, pages 2100-2113.
Crossref
Crossref
Jared M. Whitson, Emily J. Noonan, Deepa Pookot, Robert F. Place & Rajvir Dahiya. (2009) Double stranded-RNA-mediated activation of P21 gene induced apoptosis and cell cycle arrest in renal cell carcinoma. International Journal of Cancer 125:2, pages 446-452.
Crossref
Crossref
Anke Doller, Josef Pfeilschifter & Wolfgang Eberhardt. (2008) Signalling pathways regulating nucleo-cytoplasmic shuttling of the mRNA-binding protein HuR. Cellular Signalling 20:12, pages 2165-2173.
Crossref
Crossref
P G Hemmati, G Normand, B Gillissen, J Wendt, B Dörken & P T Daniel. (2008) Cooperative effect of p21Cip1/WAF−1 and 14-3-3σ on cell cycle arrest and apoptosis induction by p14ARF. Oncogene 27:53, pages 6707-6719.
Crossref
Crossref
Simone Stark, Alexandra SchÜller, Marco Sifringer, Bettina Erstner, Felix Brehmer, Sven Weber, Rodica Altmann, Michael Obladen, Christoph BÜhrer & Ursula Felderhoff-Mueser. (2008) Suramin induces and enhances apoptosis in a model of hyperoxia-induced oligodendrocyte injury. Neurotoxicity Research 13:3-4, pages 197-207.
Crossref
Crossref
Elisa Sala, Luca Mologni, Silvia Truffa, Carlo Gaetano, Gideon E. Bollag & Carlo Gambacorti-Passerini. (2008) BRAF Silencing by Short Hairpin RNA or Chemical Blockade by PLX4032 Leads to Different Responses in Melanoma and Thyroid Carcinoma Cells. Molecular Cancer Research 6:5, pages 751-759.
Crossref
Crossref
Peter F. Vitiello, Rhonda J. Staversky, Peter C. Keng & Michael A. O'Reilly. (2008) PUMA inactivation protects against oxidative stress through p21/Bcl-XL inhibition of bax death. Free Radical Biology and Medicine 44:3, pages 367-374.
Crossref
Crossref
Antonio Brú, Carlos del Fresno, Alessandra Soares-Schanoski, Sonia Albertos, Isabel Brú, Amelia Porres, Eduardo Rollán-Landeras, Ana Dopazo, David Casero, Vanesa Gómez-Piña, Lourdes García, Francisco Arnalich, Rebeca Alvarez, Alexandro Rodríguez-Rojas, Pablo Fuentes-Prior & Eduardo López-Collazo. (2007) Position-dependent expression of GADD45α in rat brain tumours. Medical Oncology 24:4, pages 436-444.
Crossref
Crossref
Kazuhiro Tanaka, Takashi Sasayama, Katsu Mizukawa, Atsufumi Kawamura, Takeshi Kondoh, Kohkichi Hosoda, Toshiyoshi Fujiwara & Eiji Kohmura. (2007) Specific mTOR inhibitor rapamycin enhances cytotoxicity induced by alkylating agent 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea (ACNU) in human U251 malignant glioma cells. Journal of Neuro-Oncology 84:3, pages 233-244.
Crossref
Crossref
Ritu Aneja, Amr M. Ghaleb, Jun Zhou, Vincent W. Yang & Harish C. Joshi. (2007) p53 and p21 Determine the Sensitivity of Noscapine-Induced Apoptosis in Colon Cancer Cells. Cancer Research 67:8, pages 3862-3870.
Crossref
Crossref
Kotb Abdelmohsen, Rudolf PullmannJr.Jr., Ashish Lal, Hyeon Ho Kim, Stefanie Galban, Xiaoling Yang, Justin D. Blethrow, Mark Walker, Jonathan Shubert, David A. Gillespie, Henry Furneaux & Myriam Gorospe. (2007) Phosphorylation of HuR by Chk2 Regulates SIRT1 Expression. Molecular Cell 25:4, pages 543-557.
Crossref
Crossref
Rohit R. Sharma, T. S. Ravikumar, Derreck Raimo & Weng-Lang Yang. (2005) Induction of p21WAF1 Expression Protects HT29 Colon Cancer Cells From Apoptosis Induced by Cryoinjury. Annals of Surgical Oncology 12:9, pages 743-752.
Crossref
Crossref
Yoshimi Arima, Masayuki Nitta, Shinji Kuninaka, Dongwei Zhang, Toshiyoshi Fujiwara, Yoichi Taya, Mitsuyoshi Nakao & Hideyuki Saya. (2005) Transcriptional Blockade Induces p53-dependent Apoptosis Associated with Translocation of p53 to Mitochondria. Journal of Biological Chemistry 280:19, pages 19166-19176.
Crossref
Crossref
Michael A. O'Reilly. (2005)
Redox Activation of p21
Cip1/WAF1/Sdi1
: A Multifunctional Regulator of Cell Survival and Death
. Antioxidants & Redox Signaling 7:1-2, pages 108-118.
Crossref
Crossref
Xueli Fan, Yingwang Liu & Jason J. Chen. (2005) Down-regulation of p21 contributes to apoptosis induced by HPV E6 in human mammary epithelial cells. Apoptosis 10:1, pages 63-73.
Crossref
Crossref
Xiaoling Yang, Wengong Wang, Jinshui Fan, Ashish Lal, Dongmei Yang, Heping Cheng & Myriam Gorospe. (2004) Prostaglandin A2-mediated Stabilization of p21 mRNA through an ERK-dependent Pathway Requiring the RNA-binding Protein HuR. Journal of Biological Chemistry 279:47, pages 49298-49306.
Crossref
Crossref
James I. Geller, Kinga Szekely-Szucs, Istvan Petak, Belinda Doyle & Janet A. Houghton. (2004) P21Cip1 Is a Critical Mediator of the Cytotoxic Action of Thymidylate Synthase Inhibitors in Colorectal Carcinoma Cells. Cancer Research 64:17, pages 6296-6303.
Crossref
Crossref
Nidhi S. Undevia, Delbert R. Dorscheid, Bertha A. Marroquin, Wendy L. Gugliotta, Roberta Tse & Steven R. White. (2004) Smad and p38-MAPK signaling mediates apoptotic effects of transforming growth factor-β1 in human airway epithelial cells. American Journal of Physiology-Lung Cellular and Molecular Physiology 287:3, pages L515-L524.
Crossref
Crossref
Peter M. Price, Judit Megyesi & Robert L. Safirstein. (2004) Cell cycle regulation: Repair and regeneration in acute renal failure. Kidney International 66:2, pages 509-514.
Crossref
Crossref
Maria M. Facchinetti, Adriana De Siervi, Doreen Toskos & Adrian M. Senderowicz. (2004) UCN-01-Induced Cell Cycle Arrest Requires the Transcriptional Induction of p21waf1/cip1 by Activation of Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase/Extracellular Signal-Regulated Kinase Pathway. Cancer Research 64:10, pages 3629-3637.
Crossref
Crossref
Marc B. Hershenson. (2004)
p21
Waf1/Cip1
and the prevention of oxidative stress
. American Journal of Physiology-Lung Cellular and Molecular Physiology 286:3, pages L502-L505.
Crossref
Crossref
Wook Kim, Seunghyi Kook, Dae Joong Kim, Carmen Teodorof & Woo Keun Song. (2004) The 31-kDa Caspase-generated Cleavage Product of p130 Functions as a Transcriptional Repressor of E2A in Apoptotic Cells. Journal of Biological Chemistry 279:9, pages 8333-8342.
Crossref
Crossref
Sung-Kwon Moon, Sun-Young Jung, Yung-Hyun Choi, Young-Choon Lee, Cam Patterson & Cheorl-Ho Kim. (2004) PDTC, metal chelating compound, induces G1 phase cell cycle arrest in vascular smooth muscle cells through inducing p21Cip1 expression: Involvement of p38 mitogen activated protein kinase. Journal of Cellular Physiology 198:2, pages 310-323.
Crossref
Crossref
Adriana De Siervi, Maria Marinissen, Jessica Diggs, Xiao-Fan Wang, Gilles Pages & Adrian Senderowicz. (2004) Transcriptional Activation of p21waf1/cip1 by Alkylphospholipids. Cancer Research 64:2, pages 743-750.
Crossref
Crossref
Yoshikazu MIWA, Yoji TABA, Megumi MIYAGI & Toshiyuki SASAGURI. (2004) Physiology and pharmacology of the prostaglandin J2 family.. Folia Pharmacologica Japonica 123:1, pages 34-40.
Crossref
Crossref
Michael A. O'Reilly, Richard H. Watkins, Rhonda J. Staversky & William M. Maniscalco. (2003)
Induced p21
Cip1
in premature baboons with CLD: implications for alveolar hypoplasia
. American Journal of Physiology-Lung Cellular and Molecular Physiology 285:4, pages L964-L971.
Crossref
Crossref
Peter M Price, Judit Megyesi & Robert L Safirstein. (2003) Cell cycle regulation: repair and regeneration in acute renal failure. Seminars in Nephrology 23:5, pages 449-459.
Crossref
Crossref
Yana Schavinsky-Khrapunsky, Mahmoud Huleihel, Mordechai Aboud & Amram Torgeman. (2003) Role of protein kinase C and the Sp1-p53 complex in activation of p21WAF-1 expression by 12-O-tetradecanoylphorbol-13-acetate in human T cells. Oncogene 22:34, pages 5315-5324.
Crossref
Crossref
Takumi Satoh, Megumi Baba, Daisaku Nakatsuka, Yasuyuki Ishikawa, Hiroyuki Aburatani, Kyoji Furuta, Toshihisa Ishikawa, Hiroshi Hatanaka, Masaaki Suzuki & Yasuyoshi Watanabe. (2003) Role of heme oxygenase-1 protein in the neuroprotective effects of cyclopentenone prostaglandin derivatives under oxidative stress. European Journal of Neuroscience 17:11, pages 2249-2255.
Crossref
Crossref
Jae-Won Soh, Yun-Sil Lee & I. Bernard Weinstein. (2003) Effects of regulatory domains of specific isoforms of protein kinase C on growth control and apoptosis in MCF-7 breast cancer cells. Journal of Experimental Therapeutics and Oncology 3:3, pages 115-126.
Crossref
Crossref
Y. Schavinsky-Khrapunsky, M. Huleihel, M. Aboud & A. Torgeman. (2003) TPA activates p21WAF-1 promoter in human T-cells through its second most upstream Sp1 site. Biochemical and Biophysical Research Communications 304:4, pages 696-700.
Crossref
Crossref
Olivier Coqueret. (2003) New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment?. Trends in Cell Biology 13:2, pages 65-70.
Crossref
Crossref
Katharina M. Detjen, Derek Murphy, Martina Welzel, Katrin Farwig, Bertram Wiedenmann & Stefan Rosewicz. (2003) Downregulation of p21waf/cip-1 mediates apoptosis of human hepatocellular carcinoma cells in response to interferon-γ. Experimental Cell Research 282:2, pages 78-89.
Crossref
Crossref
W. Andrew Yeudall & Katharine H. Wrighton. 2003. Head and Neck Cancer. Head and Neck Cancer
101
116
.
Luis A. Martinez, Jun Yang, Elba S. Vazquez, María del Carmen Rodriguez-Vargas, Matilde Olive, Jer-Tsong Hsieh, Christopher J. Logothetis & Nora M. Navone. (2002) p21 modulates threshold of apoptosis induced by DNA-damage and growth factor withdrawal in prostate cancer cells. Carcinogenesis 23:8, pages 1289-1296.
Crossref
Crossref
Naoki Hagimoto, Kazuyoshi Kuwano, Ichiro Inoshima, Michihiro Yoshimi, Norio Nakamura, Masaki Fujita, Takashige Maeyama & Nobuyuki Hara. (2002) TGF-β1 as an Enhancer of Fas-Mediated Apoptosis of Lung Epithelial Cells. The Journal of Immunology 168:12, pages 6470-6478.
Crossref
Crossref
Ying Li, Donald Dowbenko & Laurence A. Lasky. (2002) AKT/PKB Phosphorylation of p21Cip/WAF1 Enhances Protein Stability of p21Cip/WAF1 and Promotes Cell Survival. Journal of Biological Chemistry 277:13, pages 11352-11361.
Crossref
Crossref
Kaoru Kobayashi, Chieko Terada & Ikuyo Tsukamoto. (2002) Methotrexate-induced apoptosis in hepatocytes after partial hepatectomy. European Journal of Pharmacology 438:1-2, pages 19-24.
Crossref
Crossref
Georgina Westwood, Benjamin C Dibling, Darren Cuthbert-Heavens & Susan A Burchill. (2002) Basic fibroblast growth factor (bFGF)-induced cell death is mediated through a caspase-dependent and p53-independent cell death receptor pathway. Oncogene 21:5, pages 809-824.
Crossref
Crossref
Sonia Y. Archer & Richard A. Hodin. 2002. Wiley Encyclopedia of Molecular Medicine. Wiley Encyclopedia of Molecular Medicine.
Nicole Baptiste, Philip Friedlander, Xinbin Chen & Carol Prives. (2002) The proline-rich domain of p53 is required for cooperation with anti-neoplastic agents to promote apoptosis of tumor cells. Oncogene 21:1, pages 9-21.
Crossref
Crossref
Claudia M. Hattinger, Aart G. Jochemsen, Hans J. Tanke & Roeland W. Dirks. (2016) Induction of p21 mRNA Synthesis After Short-wavelength UV Light Visualized in Individual Cells by RNA FISH. Journal of Histochemistry & Cytochemistry 50:1, pages 81-89.
Crossref
Crossref
Takumi Satoh, Ryuzo Shingai, Kyoji Furuta, Masaaki Suzuki & Yasuyoshi Watanabe. 2002. Strategic Medical Science Against Brain Attack. Strategic Medical Science Against Brain Attack
78
93
.
Paola Inguaggiato, Luis Gonzalez-Michaca, Anthony J. Croatt, Jill J. Haggard, Jawed Alam & Karl A. Nath. (2001) Cellular overexpression of heme oxygenase-1 up-regulates p21 and confers resistance to apoptosis. Kidney International 60:6, pages 2181-2191.
Crossref
Crossref
Yangxin Fu, Helmut Sies & Xin Gen Lei. (2001) Opposite Roles of Selenium-dependent Glutathione Peroxidase-1 in Superoxide Generator Diquat- and Peroxynitrite-induced Apoptosis and Signaling. Journal of Biological Chemistry 276:46, pages 43004-43009.
Crossref
Crossref
Thomas R. Berton, Amy Pavone & Susan M. Fischer. (2001) Ultraviolet-B Irradiation Alters the Cell Cycle Machinery in Murine Epidermis In Vivo. Journal of Investigative Dermatology 117:5, pages 1171-1178.
Crossref
Crossref
Debasis Chattopadhyay, Mrinal K. Ghosh, Asoke Mal & Marian L. Harter. (2001) Inactivation of p21 by E1A Leads to the Induction of Apoptosis in DNA-Damaged Cells. Journal of Virology 75:20, pages 9844-9856.
Crossref
Crossref
Lan F. Qin & Irene O.L. Ng. (2001) Exogenous expression of p21WAF1/CIP1 exerts cell growth inhibition and enhances sensitivity to cisplatin in hepatoma cells. Cancer Letters 172:1, pages 7-15.
Crossref
Crossref
Makoto Saegusa, Daisuke Machida B.Isao Okayasu. (2001) Possible associations among expression of p14ARF, p16INK4a, p21WAF1/CIP1, p27KIP1, and p53 accumulation and the balance of apoptosis and cell proliferation in ovarian carcinomas. Cancer 92:5, pages 1177-1189.
Crossref
Crossref
Tamara Glaser, Bettina Wagenknecht & Michael Weller. (2001) Identification of p21 as a target of cycloheximide-mediated facilitation of CD95-mediated apoptosis in human malignant glioma cells. Oncogene 20:35, pages 4757-4767.
Crossref
Crossref
Kaoru Kobayashi & Ikuyo Tsukamoto. (2001) Prolonged Jun N-terminal kinase (JNK) activation and the upregulation of p53 and p21WAF1/CIP1 preceded apoptosis in hepatocytes after partial hepatectomy and cisplatin. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1537:1, pages 79-88.
Crossref
Crossref
M Wallace, P J Coates, E G Wright & K L Ball. (2001) Differential post-translational modification of the tumour suppressor proteins Rb and p53 modulate the rates of radiation-induced apoptosis in vivo. Oncogene 20:28, pages 3597-3608.
Crossref
Crossref
Mojgan Mahyar-Roemer & Klaus Roemer. (2001) p21 Waf1/Cip1 can protect human colon carcinoma cells against p53-dependent and p53-independent apoptosis induced by natural chemopreventive and therapeutic agents. Oncogene 20:26, pages 3387-3398.
Crossref
Crossref
Christie P. Fanton, Martin McMahon & Russell O. Pieper. (2001) Dual Growth Arrest Pathways in Astrocytes and Astrocytic Tumors in Response to Raf-1 Activation. Journal of Biological Chemistry 276:22, pages 18871-18877.
Crossref
Crossref
Magdalena Leszczyniecka, Terry Roberts, Paul Dent, Steven Grant & Paul B Fisher. (2001) Differentiation therapy of human cancer: basic science and clinical applications. Pharmacology & Therapeutics 90:2-3, pages 105-156.
Crossref
Crossref
Y. Gazitt, S.V. Reddy, O. Alcantara, J. Yang & D.H. Boldt. (2001) A new molecular role for iron in regulation of cell cycling and differentiation of HL-60 human leukemia cells: Iron is required for transcription of p21(WAF1/CIP1) in cells induced by phorbol myristate acetate. Journal of Cellular Physiology 187:1, pages 124-135.
Crossref
Crossref
M.K. Kang & M.-H. Park. (2016) Conversion of Normal To Malignant Phenotype: Telomere Shortening, Telomerase Activation, and Genomic Instability During Immortalization of Human Oral Keratinocytes. Critical Reviews in Oral Biology & Medicine 12:1, pages 38-54.
Crossref
Crossref
H. Lincet, L. Poulain, J.S. Remy, E. Deslandes, F. Duigou, P. Gauduchon & C. Staedel. (2000) The p21 cip1/waf1 cyclin-dependent kinase inhibitor enhances the cytotoxic effect of cisplatin in human ovarian carcinoma cells. Cancer Letters 161:1, pages 17-26.
Crossref
Crossref
Zinaida Bezvenyuk, Tiina Suuronen, Antero Salminen & Victor Solovyan. (2000) Protective effect of suramin against cell death in rat cerebellar granular neurons and mouse neuroblastoma cells. Neuroscience Letters 292:2, pages 111-114.
Crossref
Crossref
Shi-Yong Sun, Ping Yue & Reuben Lotan. (2000) Implication of multiple mechanisms in apoptosis induced by the synthetic retinoid CD437 in human prostate carcinoma cells. Oncogene 19:39, pages 4513-4522.
Crossref
Crossref
Ying Hua Jin, Kye Jin Yoo, You Hui Lee & Seung Ki Lee. (2000) Caspase 3-mediated Cleavage of p21 Associated with the Cyclin A-Cyclin-dependent Kinase 2 Complex Is a Prerequisite for Apoptosis in SK-HEP-1 Cells. Journal of Biological Chemistry 275:39, pages 30256-30263.
Crossref
Crossref
Takumi Satoh, Kyoji Furuta, Keiichiro Tomokiyo, Daisaku Nakatsuka, Motoki Tanikawa, Makoto Nakanishi, Maki Miura, Shuuitsu Tanaka, Tetsuro Koike, Hiroshi Hatanaka, Kazuyoshi Ikuta, Masaaki Suzuki & Yasuyoshi Watanabe. (2002) Facilitatory Roles of Novel Compounds Designed from Cyclopentenone Prostaglandins on Neurite Outgrowth-Promoting Activities of Nerve Growth Factor. Journal of Neurochemistry 75:3, pages 1092-1102.
Crossref
Crossref
Richard A. Steinman & Daniel E. Johnson. (2000) p21WAF1 Prevents Down-modulation of the Apoptotic Inhibitor Protein c-IAP1 and Inhibits Leukemic Apoptosis. Molecular Medicine 6:9, pages 736-749.
Crossref
Crossref
Yanjun Lu, Masaaki Tatsuka, Hiraku Takebe & Takashi Yagi. (2000) Involvement of cyclin-dependent kinases in doxorubicin-induced apoptosis in human tumor cells. Molecular Carcinogenesis 29:1, pages 1-7.
Crossref
Crossref
Ralph Schuette & Margot C. LaPointe. (2000) Phorbol ester stimulates cyclooxygenase-2 expression and prostanoid production in cardiac myocytes. American Journal of Physiology-Heart and Circulatory Physiology 279:2, pages H719-H725.
Crossref
Crossref
P. J. Moos, K. Edes & F. A. Fitzpatrick. (2000) Inactivation of wild-type p53 tumor suppressor by electrophilic prostaglandins. Proceedings of the National Academy of Sciences 97:16, pages 9215-9220.
Crossref
Crossref
. (2000) Acute renal failure. III. The role of growth factors in the process of renal regeneration and repair. American Journal of Physiology-Renal Physiology 279:1, pages F3-F11.
Crossref
Crossref
G.Paolo Dotto. (2000) p21WAF1/Cip1: more than a break to the cell cycle?. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1471:1, pages M43-M56.
Crossref
Crossref
Edward Rubenstein. (2000) Biologic Effects of and Clinical Disorders Caused by Nonprotein Amino Acids. Medicine 79:2, pages 80-89.
Crossref
Crossref
Geng Hui Zhu, Benjamin Chun Yu Wong, Eric D. Slosberg, Margaret C. Eggo, Chi Kong Ching, Siu Tsan Yuen, Kam Chuen Lai, Jae Won Soh, I.Bernard Weinstein & Shiu Kum Lam. (2000) Overexpression of protein kinase C-β1 isoenzyme suppresses indomethacin-induced apoptosis in gastric epithelial cells. Gastroenterology 118:3, pages 507-514.
Crossref
Crossref
Shi-Qiong Xu & Wafik S. El-Deiry. (2000) p21WAF1/CIP1 Inhibits Initiator Caspase Cleavage by TRAIL Death Receptor DR4. Biochemical and Biophysical Research Communications 269:1, pages 179-190.
Crossref
Crossref
J.C. Seegers, A.M. Joubert, A. Panzer, M.L. Lottering, C.A. Jordan, F. Joubert, J.L. Maree, P. Bianchi, M. de Kock & W.C.A. Gelderblom. (2000) Fumonisin B1influenced the effects of arachidonic acid, prostaglandins E2 and A2 on cell cycle progression, apoptosis induction, tyrosine- and CDC2-kinase activity in oesophageal cancer cells. Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) 62:2, pages 75-84.
Crossref
Crossref
Delphine Javelaud, Juana Wietzerbin, Olivier Delattre & Françoise Besançon. (2000) Induction of p21Waf1/Cip1 by TNFα requires NF-κB activity and antagonizes apoptosis in Ewing tumor cells. Oncogene 19:1, pages 61-68.
Crossref
Crossref
Jeremy Hughes, Paul Brown & Stuart J. Shankland. (1999)
Cyclin kinase inhibitor p21
CIP1/WAF1
limits interstitial cell proliferation following ureteric obstruction
. American Journal of Physiology-Renal Physiology 277:6, pages F948-F956.
Crossref
Crossref
Janice Ciacci-Zanella, Melissa Stone, Gail Henderson & Clinton Jones. (1999) The Latency-Related Gene of Bovine Herpesvirus 1 Inhibits Programmed Cell Death. Journal of Virology 73:12, pages 9734-9740.
Crossref
Crossref
Jennifer L. Nargi, Rajiv R. Ratan & Diane E. Griffin. (1999) p53-Independent Inhibition of Proliferation and p21Waf1/Cip1-Modulated Induction of Cell Death by the Antioxidants N-acetylcysteine and Vitamin E. Neoplasia 1:6, pages 544-556.
Crossref
Crossref
Radu Marches, Robert Hsueh & Jonathan W. Uhr. (1999)
Cancer dormancy and cell signaling: Induction of p21
waf1
initiated by membrane IgM engagement increases survival of B lymphoma cells
. Proceedings of the National Academy of Sciences 96:15, pages 8711-8715.
Crossref
Crossref
Klara Megyeri, Klara Berencsi, Thanos D. Halazonetis, George C. Prendergast, Giorgia Gri, Stanley A. Plotkin, Giovanni Rovera & Eva Gönczöl. (1999) Involvement of a p53-Dependent Pathway in Rubella Virus-Induced Apoptosis. Virology 259:1, pages 74-84.
Crossref
Crossref
Jaime F. Modiano, Michelle G. Ritt, John Wojcieszyn & Roger SmithIiiIii. (1999) Growth Arrest of Melanoma Cells Is Differentially Regulated by Contact Inhibition and Serum Deprivation. DNA and Cell Biology 18:5, pages 357-367.
Crossref
Crossref
Tetsuo Akimoto, Jinsil Seong, Nancy R Hunter, Lara Buchmiller, Kathy Mason & Luka Milas. (1999) Association of increased radiocurability of murine carcinomas with low constitutive expression of p21WAF1/CIP1 protein. International Journal of Radiation Oncology*Biology*Physics 44:2, pages 413-419.
Crossref
Crossref
Yingcai Wang, Giovanni Blandino & David Givol. (1999) Induced p21waf expression in H1299 cell line promotes cell senescence and protects against cytotoxic effect of radiation and doxorubicin. Oncogene 18:16, pages 2643-2649.
Crossref
Crossref
Masahiro Ohtani, Hiroshi Isozaki, Keizo Fujii, Eiji Nomura, Masami Niki, Hideaki Mabuchi, Kanji Nishiguchi, Masao Toyoda, Takashi Ishibashi & Nobuhiko Tanigawa. (1999) Impact of the expression of cyclin-dependent kinase inhibitor p27Kip1 and apoptosis in tumor cells on the overall survival of patients with non-Early stage gastric carcinoma. Cancer 85:8, pages 1711-1718.
Crossref
Crossref
Takumi Satoh, Kyoji Furuta, Masaaki Suzuki & Yasuyoshi Watanabe. (1999) Prostaglandin J2and Its Metabolites Promote Neurite Outgrowth Induced by Nerve Growth Factor in PC12 Cells. Biochemical and Biophysical Research Communications 258:1, pages 50-53.
Crossref
Crossref
Kumiko Iwao & Ikuyo Tsukamoto. (1999) Quercetin inhibited DNA synthesis and induced apoptosis associated with increase in c-fos mRNA level and the upregulation of p21WAF1CIP1 mRNA and protein expression during liver regeneration after partial hepatectomy. Biochimica et Biophysica Acta (BBA) - General Subjects 1427:1, pages 112-120.
Crossref
Crossref
Béatrice Eymin, Monika Haugg, Nathalie Droin, Olivier Sordet, Marie-Thérèse Dimanche-Boitrel & Eric Solary. (1999) p27Kip1 induces drug resistance by preventing apoptosis upstream of cytochrome c release and procaspase-3 activation in leukemic cells. Oncogene 18:7, pages 1411-1418.
Crossref
Crossref
Hirofumi Yamamoto, Jae-Won Soh, Haim Shirin, Wang-Qiu Xing, Jin TE Lim, Yao Yao, Eric Slosberg, Naohiro Tomita, Ira Schieren & I Bernard Weinstein. (1999) Comparative effects of overexpression of p27Kip1 and p21Cip1/Waf1 on growth and differentiation in human colon carcinoma cells. Oncogene 18:1, pages 103-115.
Crossref
Crossref
Ryo Nishikawa & Masao Matsutani. (1998) Immunohistochemical analysis of p53 and p21WAF1/Cip1 expression in primary intracranial germ cell tumors. Neurosurgical Focus 5:1, pages E4.
Crossref
Crossref
Jianhui Zhu, Wenjing Zhou, Jieyuan Jiang & Xinbin Chen. (1998) Identification of a Novel p53 Functional Domain That Is Necessary for Mediating Apoptosis. Journal of Biological Chemistry 273:21, pages 13030-13036.
Crossref
Crossref
Fumio Kondo, Yoichi Kondo, Marvin Gómez-Vargas & Norio Ogawa. (1998) Indomethacin inhibits delayed DNA fragmentation of hippocampal CA1 pyramidal neurons after transient forebrain ischemia in gerbils. Brain Research 791:1-2, pages 352-356.
Crossref
Crossref
Yalin Jiang & Alan G. Porter. (1998) Prevention of Tumor Necrosis Factor (TNF)-Mediated Induction of p21WAF1/CIP1Sensitizes MCF-7 Carcinoma Cells to TNF-Induced Apoptosis. Biochemical and Biophysical Research Communications 245:3, pages 691-697.
Crossref
Crossref
Bodo Levkau, Hidenori Koyama, Elaine W Raines, Bruce E Clurman, Barbara Herren, Kim Orth, James M Roberts & Russell Ross. (1998) Cleavage of p21Cip1/Waf1 and p27Kip1 Mediates Apoptosis in Endothelial Cells through Activation of Cdk2: Role of a Caspase Cascade. Molecular Cell 1:4, pages 553-563.
Crossref
Crossref
Nicholas J. Donato & Margot Perez. (1998) Tumor Necrosis Factor-induced Apoptosis Stimulates p53 Accumulation and p21WAF1 Proteolysis in ME-180 Cells. Journal of Biological Chemistry 273:9, pages 5067-5072.
Crossref
Crossref
Helen H. Cha, Erin J. Cram, Edward C. Wang, Art J. Huang, Herbert G. Kasler & Gary L. Firestone. (1998) Glucocorticoids Stimulate p21 Gene Expression by Targeting Multiple Transcriptional Elements within a Steroid Responsive Region of the p21 Promoter in Rat Hepatoma Cells. Journal of Biological Chemistry 273:4, pages 1998-2007.
Crossref
Crossref
Andrei L. Gartel & Angela L. Tyner. 1998. Inhibitors of Cell Growth. Inhibitors of Cell Growth
43
71
.
W. S. El-Deiry. 1998. Cyclin Dependent Kinase (CDK) Inhibitors. Cyclin Dependent Kinase (CDK) Inhibitors
121
137
.
Y. Alan Wang, Ari Elson & Philip Leder. (1997)
Loss of
p
21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in
atm
-deficient mice
. Proceedings of the National Academy of Sciences 94:26, pages 14590-14595.
Crossref
Crossref
Rebecca Chinery, Jeffrey A. Brockman, Mark O. Peeler, Yu Shyr, R. Daniel Beauchamp & Robert J. Coffey. (1997) Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: A p53-independent induction of p21WAF1/CIP1 via C/EBPβ. Nature Medicine 3:11, pages 1233-1241.
Crossref
Crossref
Satya Narayan, Asif Raza, Iqbal Mahmud, Nayeong Koo, Timothy Garrett, Mary E. Law, Brian K. Law & Arun K. Sharma. (2021) Sensitization of FOLFOX-Resistant Colorectal Cancer Cells via the Modulation of a Novel Pathway Involving Protein Phosphatase 2A. SSRN Electronic Journal.
Crossref
Crossref