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Molecular and Cellular Biology Volume 16, 1996 - Issue 2
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Research Article

Transcriptional Down Regulation of the nov Proto-Oncogene in Fibroblasts Transformed by p60v-src

Glen Scholz1 Laboratory of Molecular Oncology, The Rockefeller University, New York, New York10021
,
Cecile Martinerie2 Laboratoire d’Oncologie Virale et Moleculaire, Institut Curie, 91405Orsay Cedex, France
,
Bernard Perbal2 Laboratoire d’Oncologie Virale et Moleculaire, Institut Curie, 91405Orsay Cedex, France;3 Unité de Formation à la Recherche de Biochimie, Université Paris 7-D, Diderot, Paris, France
&
Hidesaburo Hanafusa1 Laboratory of Molecular Oncology, The Rockefeller University, New York, New York10021
Pages 481-486 | Received 22 Aug 1995, Accepted 01 Nov 1995, Published online: 29 Mar 2023

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Tamara L. McLeod, John F. Bechberger & Christian C. G. Naus. (2001) Determination of a Potential Role of the CCN Family of Growth Regulators in Connexin43 Transfected C6 Glioma Cells. Cell Communication & Adhesion 8:4-6, pages 441-445.
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Alexander M. Babic, Chih-Chiun Chen & Lester F. Lau. (1999) Fisp12/Mouse Connective Tissue Growth Factor Mediates Endothelial Cell Adhesion and Migration through Integrin αvβ3, Promotes Endothelial Cell Survival, and Induces Angiogenesis In Vivo. Molecular and Cellular Biology 19:4, pages 2958-2966.
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Rong Zhang, Lidia Averboukh, Weimin Zhu, Hong Zhang, Hakryul Jo, Peter J. Dempsey, Robert J. Coffey, Arthur B. Pardee & Peng Liang. (1998) Identification of rCop-1, a New Member of the CCN Protein Family, as a Negative Regulator for Cell Transformation. Molecular and Cellular Biology 18:10, pages 6131-6141.
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Articles from other publishers (61)

Bernard Perbal. (2023) Time has come to address the spatiotemporal combinatorial model for CCN proteins biological activitites by spatial transcriptomics and genome wide association studies. Journal of Cell Communication and Signaling 17:1, pages 1-3.
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Alexander Peidl, Bernard Perbal & Andrew Leask. (2019) Yin/Yang expression of CCN family members: Transforming growth factor beta 1, via ALK5/FAK/MEK, induces CCN1 and CCN2, yet suppresses CCN3, expression in human dermal fibroblasts. PLOS ONE 14:6, pages e0218178.
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Tammy Y. Carter, Swetha Gadwala, Ashish B. Chougule, Anh P. N. Bui, Alex C. Sanders, Raghothama Chaerkady, Nathaly Cormier, Robert N. Cole & Jeffrey H. Thomas. (2019) Actomyosin contraction during cellularization is regulated in part by Src64 control of Actin 5C protein levels. genesis, pages e23297.
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Indranil Chattopadhyay, Jianmin Wang, Maochun Qin, Lingqiu Gao, Renae Holtz, Robert L. Vessella, Robert W. Leach & Irwin H. Gelman. (2016) Src promotes castration-recurrent prostate cancer through androgen receptor-dependent canonical and non-canonical transcriptional signatures. Oncotarget 8:6, pages 10324-10347.
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JUAN YAO, YAGUANG WENG, SHUJUAN YAN, MENGYI HOU, HAO WANG, QIONG SHI & GUOWEI ZUO. (2015) NOV inhibits proliferation while promoting apoptosis and migration in osteosarcoma cell lines through p38/MAPK and JNK/MAPK pathways. Oncology Reports 34:4, pages 2011-2021.
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X. J. Liao, L. Li, Z. Y. Zhang, Y. Long, B. Yang, G. R. Ruan, Y. Su, H. S. Ai, W. C. Zhang, W. Y. Deng, S. J. Xiao, J. Ren, N. S. Ding & L. S. Huang. (2015) Susceptibility loci for umbilical hernia in swine detected by genome-wide association. Russian Journal of Genetics 51:10, pages 1000-1006.
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Bernard Perbal. (2013) CCN proteins: A centralized communication network. Journal of Cell Communication and Signaling 7:3, pages 169-177.
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Byung-Whi Kong, Jeong Yoon Lee, Walter G Bottje, Kentu Lassiter, Jonghyuk Lee & Douglas N Foster. (2011) Genome-wide differential gene expression in immortalized DF-1 chicken embryo fibroblast cell line. BMC Genomics 12:1.
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L. Kular, J. Pakradouni, P. Kitabgi, M. Laurent & C. Martinerie. (2011) The CCN family: A new class of inflammation modulators?. Biochimie 93:3, pages 377-388.
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Bart M Maślikowski, Benjamin D Néel, Ying Wu, Lizhen Wang, Natalie A Rodrigues, Germain Gillet & Pierre-André Bédard. (2010) Cellular processes of v-Src transformation revealed by gene profiling of primary cells - Implications for human cancer. BMC Cancer 10:1.
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Bernard Perbal, Noureddine Lazar, Diana Zambelli, Jose Antonio Lopez-Guerrero, Antonio Llombart-Bosch, Katia Scotlandi & Piero Picci. (2009) Prognostic relevance of CCN3 in Ewing sarcoma. Human Pathology 40:10, pages 1479-1486.
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Wun Chey Sin, John F. Bechberger, Walter J. Rushlow & Christian C. Naus. (2008) Dose-dependent differential upregulation of CCN1/Cyr61 and CCN3/NOV by the gap junction protein Connexin43 in glioma cells. Journal of Cellular Biochemistry 103:6, pages 1772-1782.
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Yahao Bu & Irwin H. Gelman. (2007) v-Src-mediated Down-regulation of SSeCKS Metastasis Suppressor Gene Promoter by the Recruitment of HDAC1 into a USF1-Sp1-Sp3 Complex. Journal of Biological Chemistry 282:37, pages 26725-26739.
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A.M. Bleau, N. Planque, N. Lazar, D. Zambelli, A. Ori, T. Quan, G. Fisher, K. Scotlandi & B. Perbal. (2007) Antiproliferative activity of CCN3: Involvement of the C-terminal module and post-translational regulation. Journal of Cellular Biochemistry 101:6, pages 1475-1491.
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Kathryn Masker, Alicia Golden, Christian J. Gaffney, Virginia Mazack, William F. Schwindinger, Weizhou Zhang, Lu-Hai Wang, David J. Carey & Marius Sudol. (2007) Transcriptional profile of Rous Sarcoma Virus transformed chicken embryo fibroblasts reveals new signaling targets of viral-src. Virology 364:1, pages 10-20.
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Bernard Perbal. (2006) NOV story: the way to CCN3. Cell Communication and Signaling 4:1.
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Chang Long Li, Philippe Coullin, Alain Bernheim, Véronique Joliot, Charles Auffray, Rima Zoroob & Bernard Perbal. (2006) Integration of Myeloblastosis Associated Virus proviral sequences occurs in the vicinity of genes encoding signaling proteins and regulators of cell proliferation. Cell Communication and Signaling 4:1.
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Lynn McCallumSusan PriceNathalie PlanqueBernard PerbalAndrew PierceAnthony D. WhettonAlexandra E. Irvine. (2006) A novel mechanism for BCR-ABL action: stimulated secretion of CCN3 is involved in growth and differentiation regulation. Blood 108:5, pages 1716-1723.
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Runping Gao & David R. Brigstock. (2005) Connective Tissue Growth Factor (CCN2) in Rat Pancreatic Stellate Cell Function: Integrin α5β1 as a Novel CCN2 Receptor. Gastroenterology 129:3, pages 1019-1030.
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Stefania Benini, Bernard Perbal, Diana Zambelli, Mario Paolo Colombo, Maria Cristina Manara, Massimo Serra, Mariella Parenza, Vincent Martinez, Piero Picci & Katia Scotlandi. (2005) In Ewing's sarcoma CCN3(NOV) inhibits proliferation while promoting migration and invasion of the same cell type. Oncogene 24:27, pages 4349-4361.
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Cristiane G. Lin, Chih-Chiun Chen, Shr-Jeng Leu, Tatiana M. Grzeszkiewicz & Lester F. Lau. (2005) Integrin-dependent Functions of the Angiogenic Inducer NOV (CCN3). Journal of Biological Chemistry 280:9, pages 8229-8237.
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Alexandra Gellhaus, Xuesen Dong, Sven Propson, Karen Maass, Ludger Klein-Hitpass, Mark Kibschull, Otto Traub, Klaus Willecke, Bernard Perbal, Stephen J. Lye & Elke Winterhager. (2004) Connexin43 Interacts with NOV. Journal of Biological Chemistry 279:35, pages 36931-36942.
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Dong Xie, Dong Yin, He-Jing Wang, Gen-Tao Liu, Robert Elashoff, Keith Black & H. Phillip Koeffler. (2004) Levels of Expression of CYR61 and CTGF Are Prognostic for Tumor Progression and Survival of Individuals with Gliomas . Clinical Cancer Research 10:6, pages 2072-2081.
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Dong Xie, Dong Yin, Xiangjun Tong, James O’Kelly, Akio Mori, Carl Miller, Keith Black, Dorina Gui, Johathan W. Said & H. Phillip Koeffler. (2004) Cyr61 Is Overexpressed in Gliomas and Involved in Integrin-Linked Kinase-Mediated Akt and β-Catenin-TCF/Lef Signaling Pathways. Cancer Research 64:6, pages 1987-1996.
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M. Laurent, C. Martinerie, H. Thibout, M. P. Hoffman, F. Verrecchia, Y. Le Bouc, A. Mauviel & H. K. Kleinman. (2003) NOVH increases MMP3 expression and cell migration in glioblastoma cells via a PDGFR‐α‐dependent mechanism. The FASEB Journal 17:13, pages 1-23.
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Cristiane G. Lin, Shr-Jeng Leu, Ningyu Chen, Christopher M. Tebeau, Shao-Xia Lin, Cho-Yau Yeung & Lester F. Lau. (2003) CCN3 (NOV) Is a Novel Angiogenic Regulator of the CCN Protein Family. Journal of Biological Chemistry 278:26, pages 24200-24208.
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S Tanaka. (2003) Human WISP1v, a member of the CCN family, is associated with invasive cholangiocarcinoma. Hepatology 37:5, pages 1122-1129.
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Jérôme Lafont, Maryvonne Laurent, Hélène Thibout, François Lallemand, Yves Le Bouc, Azeddine Atfi & Cécile Martinerie. (2002) The Expression of novH in Adrenocortical Cells Is Down-regulated by TGFβ1 through c-Jun in a Smad-independent Manner. Journal of Biological Chemistry 277:43, pages 41220-41229.
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Kiho Cho, Lee Adamson, Jae-Hak Park, Ronen Zipkin & David Greenhalgh. (2002) Identification of Truncated Form of Mouse HAX-1s Gene (HAX-1xs) and Characterization of Its Expression in Small Intestine and Thymus of Mice After Burn Injury. Shock 18:3, pages 223-229.
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Bernard Perbal. (2002) Les protéines CCN : quand multimodulaire rime avec multifonctionnel. médecine/sciences 18:6-7, pages 745-756.
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