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Molecular and Cellular Biology Volume 16, 1996 - Issue 3
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Research Article

Inhibition of Bcr Serine Kinase by Tyrosine Phosphorylation

Jiaxin Liu1 Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas
,
Yun Wu1 Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas
,
Guo Zhen Ma1 Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas
,
Dai Lu1 Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas
,
Leena Haataja2 Department of Pathology, Children’s Hospital of Los Angeles, Los Angeles, California
,
Nora Heisterkamp2 Department of Pathology, Children’s Hospital of Los Angeles, Los Angeles, California
,
John Groffen2 Department of Pathology, Children’s Hospital of Los Angeles, Los Angeles, California
&
Ralph B. Arlinghaus1 Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas
 show all
Pages 998-1005 | Received 18 Aug 1995, Accepted 29 Dec 1995, Published online: 29 Mar 2023

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G. Radziwill, R. A. Erdmann, U. Margelisch & K. Moelling. (2003) The Bcr Kinase Downregulates Ras Signaling by Phosphorylating AF-6 and Binding to Its PDZ Domain. Molecular and Cellular Biology 23:13, pages 4663-4672.
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Xiaowu Zhang, Ramesh Subrahmanyam, Ray Wong, Alec W. Gross & Ruibao Ren. (2001) The NH2-Terminal Coiled-Coil Domain and Tyrosine 177 Play Important Roles in Induction of a Myeloproliferative Disease in Mice by Bcr-Abl. Molecular and Cellular Biology 21:3, pages 840-853.
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Alec W. Gross, Xiaowu Zhang & Ruibao Ren. (1999) Bcr-Abl with an SH3 Deletion Retains the Ability To Induce a Myeloproliferative Disease in Mice, yet c-Abl Activated by an SH3 Deletion Induces Only Lymphoid Malignancy. Molecular and Cellular Biology 19:10, pages 6918-6928.
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Antoni Gayà, Fiorella Pirotto, Eduard Palou, Frank Autschbach, Victoria Del Pozo, Josepa Solé & Carles Sew-Pages. (1999) CD148, a New Membrane Tyrosine Phosphatase Involved in Leukocyte Function. Leukemia & Lymphoma 35:3-4, pages 237-243.
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Kenneth R. LaMontagne$suffix/text()$suffix/text(), Andrew J. Flint, B. Robert Franza$suffix/text()$suffix/text(), Ann Marie Pendergast & Nicholas K. Tonks. (1998) Protein Tyrosine Phosphatase 1B Antagonizes Signalling by Oncoprotein Tyrosine Kinase p210 bcr-abl In Vivo. Molecular and Cellular Biology 18:5, pages 2965-2975.
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X. Y. D. Guo, Jason Font Ana, Donald Kufe & Albert Deisserpth. (1998) Antagonistic Effects of ABL and BCRABL Proteins on Proliferation and the Response to Genotoxic Stress in Normal and Leukemic Myeloid Cells. Leukemia & Lymphoma 30:3-4, pages 225-235.
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Articles from other publishers (29)

George M. Burslem, Anna Reister Schultz, Daniel P. Bondeson, Christopher A. Eide, Samantha L. Savage Stevens, Brian J. Druker & Craig M. Crews. (2019) Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-Mediated Targeted Protein Degradation. Cancer Research 79:18, pages 4744-4753.
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Camille Malouf & Katrin Ottersbach. (2017) Molecular processes involved in B cell acute lymphoblastic leukaemia. Cellular and Molecular Life Sciences 75:3, pages 417-446.
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Pedro Alves Bezerra Morais, Renata Dalmaschio Daltoé & Heberth de Paula. (2016) Opening the door to the development of novel Abl kinase inhibitors. Future Medicinal Chemistry 8:17, pages 2143-2165.
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Isabella Haberbosch, Anahita Rafiei, Claudia Oancea, Oliver Gerhart Ottmann, Martin Ruthardt & Afsar Ali Mian. (2016) BCR: a new target in resistance mediated by BCR/ABL-315I?. Genes & Cancer 7:1-2, pages 36-46.
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Anahita Rafiei, Afsar Ali Mian, Claudia Döring, Anna Metodieva, Claudia Oancea, Frederic B. Thalheimer, Martin Leo Hansmann, Oliver Gerhard Ottmann & Martin Ruthardt. (2015) The Functional Interplay Between the t(9;22)-Associated Fusion Proteins BCR/ABL and ABL/BCR in Philadelphia Chromosome-Positive Acute Lymphatic Leukemia. PLOS Genetics 11:4, pages e1005144.
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A-Reum Park, Daeyoung Oh, So-Hee Lim, Jeonghoon Choi, Jeonghee Moon, Dae-Yeol Yu, Sung Goo Park, Nora Heisterkamp, Eunjoon Kim, Pyung-Keun Myung & Jae-Ran Lee. (2012) Regulation of dendritic arborization by BCR Rac1 GTPase-activating protein, a new substrate of protein tyrosine phosphatase receptor T. Journal of Cell Science.
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A Samanta, B Perazzona, S Chakraborty, X Sun, H Modi, R Bhatia, W Priebe & R Arlinghaus. (2010) Janus kinase 2 regulates Bcr–Abl signaling in chronic myeloid leukemia. Leukemia 25:3, pages 463-472.
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B Perazzona, H Lin, T Sun, Y Wang & R Arlinghaus. (2007) Kinase domain mutants of Bcr enhance Bcr-Abl oncogenic effects. Oncogene 27:15, pages 2208-2214.
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Stephane WongOwen N. Witte. (2004) The BCR-ABL Story: Bench to Bedside and Back. Annual Review of Immunology 22:1, pages 247-306.
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Hiroshi Katayama, Kaori Sasai, Hidehiko Kawai, Zhi-Min Yuan, Jolanta Bondaruk, Fumio Suzuki, Satoshi Fujii, Ralph B Arlinghaus, Bogdan A Czerniak & Subrata Sen. (2003) Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53. Nature Genetics 36:1, pages 55-62.
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Ralph Arlinghaus & Tong Sun. 2004. Molecular Targeting and Signal Transduction. Molecular Targeting and Signal Transduction 239 270 .
Asit K Chakraborty & Salil K Das. (2003) Molecular cloning and characterization of the guinea pig cholinephosphotransferase gene. Biochemical and Biophysical Research Communications 312:4, pages 1104-1110.
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Tong Sun & Ralph B. Arlinghaus. (2003) Preparation and Application of Polyclonal and Monoclonal Sequence‐Specific Anti‐Phosphoamino Acid Antibodies. Current Protocols in Protein Science 34:1.
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Hanno Steen, Minerva Fernandez, Saghi Ghaffari, Akhilesh Pandey & Matthias Mann. (2003) Phosphotyrosine Mapping in Bcr/Abl Oncoprotein Using Phosphotyrosine-specific Immonium Ion Scanning. Molecular & Cellular Proteomics 2:3, pages 138-145.
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Richard A Van Etten. (2002) Studying the pathogenesis of BCR–ABL+ leukemia in mice. Oncogene 21:56, pages 8643-8651.
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Ralph B Arlinghaus. (2002) Bcr: a negative regulator of the Bcr-Abl oncoprotein in leukemia. Oncogene 21:56, pages 8560-8567.
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Aparajita Ghosh, Jacqueline Akech, Shyamali Mukherjee & Salil K Das. (2002) Differential expression of cholinephosphotransferase in normal and cancerous human mammary epithelial cells. Biochemical and Biophysical Research Communications 297:4, pages 1043-1048.
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Ming Tan, Tong Jing, Keng-Hsueh Lan, Christopher L Neal, Ping Li, Sangkyou Lee, Dexing Fang, Yoichi Nagata, Jiaxin Liu, Ralph Arlinghaus, Mien-Chie Hung & Dihua Yu. (2002) Phosphorylation on Tyrosine-15 of p34Cdc2 by ErbB2 Inhibits p34Cdc2 Activation and Is Involved in Resistance to Taxol-Induced Apoptosis. Molecular Cell 9:5, pages 993-1004.
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Feng Lin, Giuseppe Monaco, Tong Sun, Jiaxin Liu, Hui Lin, Clifton Stephens, John Belmont & Ralph B Arlinghaus. (2001) BCR gene expression blocks Bcr-Abl induced pathogenicity in a mouse model. Oncogene 20:15, pages 1873-1881.
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Yoshiro Maru. (2001) Molecular Biology of Chronic Myeloid Leukemia. International Journal of Hematology 73:3, pages 308-322.
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Katharina Pachmann, Shourong Zhao, Thomas Schenk, Hagop Kantarjian, Adel K. El-Naggar, Michael J. Siciliano, Jie-Qiang Guo, Ralph B. Arlinghaus & Michael Andreeff. (2001) Expression of bcr-abl mRNA in individual chronic myelogenous leukaemia cells as determined by in situ amplification . British Journal of Haematology 112:3, pages 749-759.
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Tong Sun, Martin Campbell, William Gordon & Ralph B. Arlinghaus. (2001) Preparation and application of antibodies to phosphoamino acid sequences. Biopolymers 60:1, pages 61-75.
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Michael W. N. DeiningerJohn M. GoldmanJunia V. Melo. (2000) The molecular biology of chronic myeloid leukemia. Blood 96:10, pages 3343-3356.
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Michael W. N. DeiningerJohn M. GoldmanJunia V. Melo. (2000) The molecular biology of chronic myeloid leukemia. Blood 96:10, pages 3343-3356.
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E Laurent, M Talpaz, M Wetzler & R Kurzrock. (2000) Cytoplasmic and nuclear localization of the 130 and 160 kDa Bcr proteins. Leukemia 14:11, pages 1892-1897.
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Victoria del Pozo, Fiorella Pirotto, Blanca Cárdaba, Isabel Cortegano, Soledad Gallardo, Marta Rojo, Ignacio Arrieta, Esther Aceituno, Pilar Palomino, Antoni Gaya & Carlos Lahoz. (2000) Expression on human eosinophils of CD148: a membrane tyrosine phosphatase. Implications in the effector function of eosinophils. Journal of Leukocyte Biology 68:1, pages 31-37.
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Yun Wu, Guozhen Ma, Dai Lu, Feng Lin, Hong-Ji Xu, Jiaxin Liu & Ralph B Arlinghaus. (1999) Bcr: a negative regulator of the Bcr-Abl oncoprotein. Oncogene 18:31, pages 4416-4424.
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Paris A Skourides, Samanthi A Perera & Ruibao Ren. (1999) Polarized distribution of Bcr-Abl in migrating myeloid cells and co-localization of Bcr-Abl and its target proteins. Oncogene 18:5, pages 1165-1176.
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Jianze Li & Thomas E. Smithgall. (1996) Co-expression with BCR Induces Activation of the FES Tyrosine Kinase and Phosphorylation of Specific N-terminal BCR Tyrosine Residues. Journal of Biological Chemistry 271:51, pages 32930-32936.
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