Advanced search
Publication Cover
Molecular and Cellular Biology Volume 16, 1996 - Issue 4
Submit an article Journal homepage
5
Views
67
CrossRef citations to date
0
Altmetric
Research Article

The Myeloid-Cell-Specific c-fes Promoter Is Regulated by Sp1, PU.1, and a Novel Transcription Factor

Ahlke Heydemann1 Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois60637
,
George Juang2 Department of Medicine, University of Chicago, Chicago, Illinois60637
,
Kathleen Hennessy2 Department of Medicine, University of Chicago, Chicago, Illinois60637;3 Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois60637
,
Michael S. Parmacek2 Department of Medicine, University of Chicago, Chicago, Illinois60637
&
M. Celeste Simon1 Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois60637;2 Department of Medicine, University of Chicago, Chicago, Illinois60637;3 Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois60637
Pages 1676-1686 | Received 18 Oct 1995, Accepted 21 Dec 1995, Published online: 29 Mar 2023

Citations (67)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Jynho Kim & Ricardo A. Feldman. (2002) Activated Fes Protein Tyrosine Kinase Induces Terminal Macrophage Differentiation of Myeloid Progenitors (U937 Cells) and Activation of the Transcription Factor PU.1. Molecular and Cellular Biology 22:6, pages 1903-1918.
Read now
Tokiko Nagamura-Inoue, Tomohiko Tamura & Keiko Ozato. (2001) Transcription Factors that Regulate Growth and Differentiation of Myeloid Cells. International Reviews of Immunology 20:1, pages 83-105.
Read now

Articles from other publishers (65)

Elisavet KaramanaviDavid G. McVey, Sander W. van der Laan, Paulina J. StanczykGavin E. MorrisYifan Wang, Wei YangKenneth Chan, Robin N. PostonJun LuoXinmiao Zhou, Peng GongPeter D. JonesJunjun CaoRenata B. Kostogrys, Tom R. Webb, Gerard Pasterkamp, Haojie Yu, Qingzhong Xiao, Peter A. GreerEmma J. StringerNilesh J. Samani & Shu Ye. (2022) The FES Gene at the 15q26 Coronary-Artery-Disease Locus Inhibits Atherosclerosis . Circulation Research 131:12, pages 1004-1017.
Crossref
Thomas E. Smithgall. 2021. Encyclopedia of Biological Chemistry III. Encyclopedia of Biological Chemistry III 358 363 .
Hemanth TummalaAmanda J. Walne, Findlay Bewicke-CopleyAlicia Ellison, Nikolas PontikosMaria G. Bridger, Ana Rio-Machin, Jasmin K. SidhuJun WangHenrik Hasle, Jude FitzgibbonTom VulliamyInderjeet Dokal. (2020) A frameshift variant in specificity protein 1 triggers superactivation of Sp1-mediated transcription in familial bone marrow failure. Proceedings of the National Academy of Sciences 117:29, pages 17151-17155.
Crossref
Jinhang Hu, Lufeng Zheng, Xiao Shen, Yan Zhang, Cheng Li & Tao Xi. (2017) MicroRNA-125b inhibits AML cells differentiation by directly targeting Fes. Gene 620, pages 1-9.
Crossref
Jason H. Rogers, Kristin S. Owens, Jeffrey Kurkewich, Nathan Klopfenstein, Sangeeta R. Iyer, M. Celeste Simon & Richard Dahl. (2016) E2A Antagonizes PU.1 Activity through Inhibition of DNA Binding. BioMed Research International 2016, pages 1-11.
Crossref
Helen M. Reid & B. Therese Kinsella. (2015) Prostacyclin receptors: Transcriptional regulation and novel signalling mechanisms. Prostaglandins & Other Lipid Mediators 121, pages 70-82.
Crossref
Giorgia Santilli, Elena Almarza, Christian Brendel, Uimook Choi, Chiara Beilin, Michael P Blundell, Sneha Haria, Kathryn L Parsley, Christine Kinnon, Harry L Malech, Juan A Bueren, Manuel Grez & Adrian J Thrasher. (2011) Biochemical Correction of X-CGD by a Novel Chimeric Promoter Regulating High Levels of Transgene Expression in Myeloid Cells. Molecular Therapy 19:1, pages 122-132.
Crossref
P Burda, P Laslo & T Stopka. (2010) The role of PU.1 and GATA-1 transcription factors during normal and leukemogenic hematopoiesis. Leukemia 24:7, pages 1249-1257.
Crossref
Jonathan M. Shaffer & Thomas E. Smithgall. (2009) Promoter methylation blocks FES protein-tyrosine kinase gene expression in colorectal cancer. Genes, Chromosomes and Cancer 48:3, pages 272-284.
Crossref
Elizebeth C. Turner & B. Therese Kinsella. (2009) Transcriptional Regulation of the Human Prostacyclin Receptor Gene Is Dependent on Sp1, PU.1 and Oct-1 in Megakaryocytes and Endothelial Cells. Journal of Molecular Biology 386:3, pages 579-597.
Crossref
Richard Dahl, Sangeeta R. Iyer, Kristin S. Owens, Dorothy D. Cuylear & M. Celeste Simon. (2007) The Transcriptional Repressor GFI-1 Antagonizes PU.1 Activity through Protein-Protein Interaction. Journal of Biological Chemistry 282:9, pages 6473-6483.
Crossref
S. A. Gross, J. H. Zheng, A. T. Le, P. J. Kerzic & R. D. Irons. (2006) PU.1 phosphorylation correlates with hydroquinone-induced alterations in myeloid differentiation and cytokine-dependent clonogenic response in human CD34+ hematopoietic progenitor cells. Cell Biology and Toxicology 22:4, pages 229-241.
Crossref
J K Mangan, R V Tantravahi, S G Rane & E P Reddy. (2006) Granulocyte colony-stimulating factor-induced upregulation of Jak3 transcription during granulocytic differentiation is mediated by the cooperative action of Sp1 and Stat3. Oncogene 25:17, pages 2489-2499.
Crossref
Ying Wang, Rebecca M. Baron, Guangli Zhu, Myungsoo Joo, John W. Christman, Eric S. Silverman, Mark A. Perrella, Richard J. Riese & Manuela Cernadas. (2006) PU.1 Regulates Cathepsin S Expression in Professional APCs. The Journal of Immunology 176:1, pages 275-283.
Crossref
Padraic G. P. O'Malley, Shirley M. Sangster, Salma A. Abdelmagid, Stephen L. Bearne & Catherine K. L. Too. (2005) Characterization of a novel, cytokine-inducible carboxypeptidase D isoform in haematopoietic tumour cells. Biochemical Journal 390:3, pages 665-673.
Crossref
James K. ManganSushil G. RaneAnthony D. KangArshad AmanullahBrian C. WongE. Premkumar Reddy. (2004) Mechanisms associated with IL-6–induced up-regulation of Jak3 and its role in monocytic differentiation. Blood 103:11, pages 4093-4101.
Crossref
Michael Rehli, Hans-Helmut Niller, Christoph Ammon, Sabine Langmann, Lucia Schwarzfischer, Reinhard Andreesen & Stefan W. Krause. (2003) Transcriptional Regulation of CHI3L1, a Marker Gene for Late Stages of Macrophage Differentiation. Journal of Biological Chemistry 278:45, pages 44058-44067.
Crossref
Satoshi Hirose, Hirofumi Nishizumi & Hitoshi Sakano. (2003) Pub, a novel PU.1 binding protein, regulates the transcriptional activity of PU.1. Biochemical and Biophysical Research Communications 311:2, pages 351-360.
Crossref
Ann Dekoninck, Claire Calomme, Séverine Nizet, Yvan de Launoit, Arsène Burny, Jacques Ghysdael & Carine Van Lint. (2003) Identification and characterization of a PU.1/Spi-B binding site in the bovine leukemia virus long terminal repeat. Oncogene 22:19, pages 2882-2896.
Crossref
Paula D. Ladd, David M. WilsonIIIIII, Mark R. Kelley & David G. Skalnik. (2003) Identification of the human HEX1/hExo1 gene promoter and characterization of elements responsible for promoter activity. DNA Repair 2:2, pages 187-198.
Crossref
Thomas S. BushMichele St. CoeurKaren K. ResendesAlan G. Rosmarin. (2003) GA-binding protein (GABP) and Sp1 are required, along with retinoid receptors, to mediate retinoic acid responsiveness of CD18 (β2 leukocyte integrin): a novel mechanism of transcriptional regulation in myeloid cells. Blood 101:1, pages 311-317.
Crossref
Barbara Timblin, Michael Rehli & Randal A Skidgel. (2002) Structural characterization of the human carboxypeptidase D gene and its promoter. International Immunopharmacology 2:13-14, pages 1907-1917.
Crossref
David R. Greaves & Siamon Gordon. (2002) Macrophage-Specific Gene Expression: Current Paradigms and Future Challenges. International Journal of Hematology 76:1, pages 6-15.
Crossref
Alan D Friedman. (2002) Transcriptional regulation of granulocyte and monocyte development. Oncogene 21:21, pages 3377-3390.
Crossref
Peter Greer. (2002) Closing in on the biological functions of fps/fes and fer. Nature Reviews Molecular Cell Biology 3:4, pages 278-289.
Crossref
Kyung-Nam Kang, Mirang Kim, Kwang-Min Pae & Seung-Taek Lee. (2002) Characterization of the 5′-flanking region of the human PTK6 gene. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1574:3, pages 365-369.
Crossref
Timothy R. Hughes, Tengku S. Tengku-Muhammad, Scott A. Irvine & Dipak P. Ramji. (2002) A Novel Role of Sp1 and Sp3 in the Interferon-γ-mediated Suppression of Macrophage Lipoprotein Lipase Gene Transcription. Journal of Biological Chemistry 277:13, pages 11097-11106.
Crossref
David G Skalnik. (2002) Transcriptional mechanisms regulating myeloid-specific genes. Gene 284:1-2, pages 1-21.
Crossref
Jingqiu Li, Michael Rehli, Barbara Timblin, Fulong Tan, Stefan W. Krause & Randal A. Skidgel. (2002) Structure of the human carboxypeptidase M gene. Identification of a proximal GC-rich promoter and a unique distal promoter that consists of repetitive elements. Gene 284:1-2, pages 189-202.
Crossref
Daniel R Barreda & Miodrag Belosevic. (2001) Transcriptional regulation of hemopoiesis. Developmental & Comparative Immunology 25:8-9, pages 763-789.
Crossref
Peter Keller, Jennifer L. Payne, Gabi Tremml, Peter A. Greer, Mirella Gaboli, Pier P. Pandolfi & Monica Bessler. (2001) Fes-Cre Targets Phosphatidylinositol Glycan Class a (Piga) Inactivation to Hematopoietic Stem Cells in the Bone Marrow. Journal of Experimental Medicine 194:5, pages 581-590.
Crossref
Javier Hernández-Torres, Mónica Yunta & Pedro A. Lazo. (2001) Differential Cooperation between Regulatory Sequences Required for Human CD53 Gene Expression. Journal of Biological Chemistry 276:38, pages 35405-35413.
Crossref
Piotr Rieske & JaganM.R. Pongubala. (2001) AKT Induces Transcriptional Activity of PU.1 through Phosphorylation-mediated Modifications within Its Transactivation Domain. Journal of Biological Chemistry 276:11, pages 8460-8468.
Crossref
Victor I Sementchenko & Dennis K Watson. (2001) Ets target genes: past, present and future. Oncogene 19:55, pages 6533-6548.
Crossref
Ahlke HeydemannSoren WarmingCynthia ClendeninKirsten SigristJ. Peter HjorthM. Celeste Simon. (2000) A minimal c-fes cassette directs myeloid-specific expression in transgenic mice. Blood 96:9, pages 3040-3048.
Crossref
Ahlke HeydemannSoren WarmingCynthia ClendeninKirsten SigristJ. Peter HjorthM. Celeste Simon. (2000) A minimal c-fes cassette directs myeloid-specific expression in transgenic mice. Blood 96:9, pages 3040-3048.
Crossref
Arati Khanna-GuptaTheresa ZibelloCarl SimkevichAlan G. RosmarinNancy Berliner. (2000) Sp1 and C/EBP are necessary to activate the lactoferrin gene promoter during myeloid differentiation. Blood 95:12, pages 3734-3741.
Crossref
Arati Khanna-GuptaTheresa ZibelloCarl SimkevichAlan G. RosmarinNancy Berliner. (2000) Sp1 and C/EBP are necessary to activate the lactoferrin gene promoter during myeloid differentiation. Blood 95:12, pages 3734-3741.
Crossref
AC Ward, DM Loeb, AA Soede-Bobok, IP Touw & AD Friedman. (2000) Regulation of granulopoiesis by transcription factors and cytokine signals. Leukemia 14:6, pages 973-990.
Crossref
Michael Rehli, Alexander Poltorak, Lucia Schwarzfischer, Stefan W. Krause, Reinhard Andreesen & Bruce Beutler. (2000) PU.1 and Interferon Consensus Sequence-binding Protein Regulate the Myeloid Expression of the Human Toll-like Receptor 4 Gene. Journal of Biological Chemistry 275:13, pages 9773-9781.
Crossref
Sridhar Rao, Lee Ann Garrett-Sinha, Jung Yoon & M. Celeste Simon. (1999) The Ets Factors PU.1 and Spi-B Regulate the Transcriptionin Vivo of P2Y10, a Lymphoid Restricted Heptahelical Receptor. Journal of Biological Chemistry 274:48, pages 34245-34252.
Crossref
Shu-ichi Hashimoto, Hirofumi Nishizumi, Reiko Hayashi, Akio Tsuboi, Fumikiyo Nagawa, Toshitada Takemori & Hitoshi Sakano. (1999) Prf, a novel Ets family protein that binds to the PU.1 binding motif, is specifically expressed in restricted stages of B cell development. International Immunology 11:9, pages 1423-1429.
Crossref
Kui Shin VooDavid G. Skalnik. (1999) Elf-1 and PU.1 Induce Expression of gp91phox Via a Promoter Element Mutated in a Subset of Chronic Granulomatous Disease Patients. Blood 93:10, pages 3512-3520.
Crossref
Sridhar Rao, Amy Matsumura, Jung Yoon & M. Celeste Simon. (1999) SPI-B Activates Transcription via a Unique Proline, Serine, and Threonine Domain and Exhibits DNA Binding Affinity Differences from PU.1. Journal of Biological Chemistry 274:16, pages 11115-11124.
Crossref
Jorge Lloberas, Concepció Soler & Antonio Celada. (1999) The key role of PU.1/SPI-1 in B cells, myeloid cells and macrophages. Immunology Today 20:4, pages 184-189.
Crossref
Xuemei Ou, Jonathan Pollock, Mary C. Dinauer, Elisabeth Gharehbaghi-Schnell & David G. Skalnik. (1999) Identification and Functional Characterization of the Murine Rac2 Gene Promoter. DNA and Cell Biology 18:3, pages 253-263.
Crossref
Brian S. Egan, Kirk B. Lane & Virginia L. Shepherd. (1999) PU.1 and USF Are Required for Macrophage-specific Mannose Receptor Promoter Activity. Journal of Biological Chemistry 274:13, pages 9098-9107.
Crossref
Michael Rehli, Agnieszka Lichanska, A. Ian Cassady, Michael C. Ostrowski & David A. Hume. (1999) TFEC Is a Macrophage-Restricted Member of the Microphthalmia-TFE Subfamily of Basic Helix-Loop-Helix Leucine Zipper Transcription Factors. The Journal of Immunology 162:3, pages 1559-1565.
Crossref
Giorgio Berton. (1999) Tyrosine kinases in neutrophils. Current Opinion in Hematology 6:1, pages 51.
Crossref
Issarang Nuchprayoon, Jing Shang, Carl P. Simkevich, Menglin Luo, Alan G. Rosmarin & Alan D. Friedman. (1999) An Enhancer Located between the Neutrophil Elastase and Proteinase 3 Promoters Is Activated by Sp1 and an Ets Factor. Journal of Biological Chemistry 274:2, pages 1085-1091.
Crossref
Martin Hauses, Ralf R. Tönjes & Manuel Grez. (1998) The Transcription Factor Sp1 Regulates the Myeloid-specific Expression of the Human Hematopoietic Cell Kinase (HCK) Gene through Binding to Two Adjacent GC Boxes within the HCK Promoter-Proximal Region. Journal of Biological Chemistry 273:48, pages 31844-31852.
Crossref
Alexander G. Bassuk, Kevin P. Barton, Roshani T. Anandappa, Min M. Lu & Jeffrey M. Leiden. (1998) Expression Pattern of the Ets-related Transcription Factor Elf-1. Molecular Medicine 4:6, pages 392-401.
Crossref
Alan G. Rosmarin, Menglin Luo, David G. Caprio, Jing Shang & Carl P. Simkevich. (1998) Sp1 Cooperates with the ets Transcription Factor, GABP, to Activate the CD18 (β2 Leukocyte Integrin) Promoter. Journal of Biological Chemistry 273:21, pages 13097-13103.
Crossref
Han Ying, Ju-Fay Chang & Jane R. Parnes. (1998) PU.1/Spi-1 Is Essential for the B Cell-Specific Activity of the Mouse CD72 Promoter. The Journal of Immunology 160:5, pages 2287-2296.
Crossref
Ian L. Ross, Xie Yue, Michael C. Ostrowski & David A. Hume. (1998) Interaction between PU.1 and Another Ets Family Transcription Factor Promotes Macrophage-specific Basal Transcription Initiation. Journal of Biological Chemistry 273:12, pages 6662-6669.
Crossref
Robert C. Fisher & Edward W. Scott. (2009) Role of PU.1 in Hematopoiesis. STEM CELLS 16:1, pages 25-37.
Crossref
Ahlke Heydemann, James H. Boehmler & M. Celeste Simon. (1997) Expression of Two Myeloid Cell-specific Genes Requires the Novel Transcription Factor, c-fes Expression Factor. Journal of Biological Chemistry 272:47, pages 29527-29537.
Crossref
Chunyan Zhang, Paul Gadue, Edward Scott, Michael Atchison & Mortimer Poncz. (1997) Activation of the Megakaryocyte-specific Gene Platelet Basic Protein (PBP) by the Ets Family Factor PU.1. Journal of Biological Chemistry 272:42, pages 26236-26246.
Crossref
Daniel G. TenenRobert HromasJonathan D. LichtDong-Er Zhang. (1997) Transcription Factors, Normal Myeloid Development, and Leukemia. Blood 90:2, pages 489-519.
Crossref
Daniel G. TenenRobert HromasJonathan D. LichtDong-Er Zhang. (1997) Transcription Factors, Normal Myeloid Development, and Leukemia. Blood 90:2, pages 489-519.
Crossref
A G BassukR T AnandappaJ M Leiden. (1997) Physical interactions between Ets and NF-kappaB/NFAT proteins play an important role in their cooperative activation of the human immunodeficiency virus enhancer in T cells. Journal of Virology 71:5, pages 3563-3573.
Crossref
Eva Sjøttem, Cecilie Andersen & Terje Johansen. (1997) Structural and functional analyses of DNA bending induced by Sp1 family transcription factors 1 1Edited by T. Richmond. Journal of Molecular Biology 267:3, pages 490-504.
Crossref
Shingo INOUE, Masayuki TANAKA, Motohiro HORIUCHI, Naotaka ISHIGURO & Morikazu SHINAGAWA. (1997) Characterization of the Bovine Prion Protein Gene: The Expression Requires Interaction between the Promoter and Intron.. Journal of Veterinary Medical Science 59:3, pages 175-183.
Crossref
Alexander G. Bassuk & Jeffrey M. Leiden. 1997. Advances in Immunology Volume 64. Advances in Immunology Volume 64 65 104 .
Robin Hesketh. 1997. The Oncogene & Tumour Suppressor Gene Factsbook. The Oncogene & Tumour Suppressor Gene Factsbook 190 194 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.