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Research Article

2-Aminopurine Selectively Inhibits Splicing of Tumor Necrosis Factor Alpha mRNA

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Pages 2814-2822 | Received 01 Feb 1996, Accepted 11 Mar 1996, Published online: 29 Mar 2023

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Nayef Jarrous & Alexander Rouvinski. (2021) RNA polymerase III and antiviral innate immune response. Transcription 12:1, pages 1-11.
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Georg Stoecklin, Min Lu, Bernd Rattenbacher & Christoph Moroni. (2003) A Constitutive Decay Element Promotes Tumor Necrosis Factor Alpha mRNA Degradation via an AU-Rich Element-Independent Pathway. Molecular and Cellular Biology 23:10, pages 3506-3515.
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Articles from other publishers (32)

Raymond Kaempfer. (2023) Positive Regulation of Splicing of Cellular and Viral mRNA by Intragenic RNA Elements That Activate the Stress Kinase PKR, an Antiviral Mechanism. Genes 14:5, pages 974.
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Lise Sarah Namer, Alex Harwig, Stephan P. Heynen, Atze T. Das, Ben Berkhout & Raymond Kaempfer. (2023) HIV co-opts a cellular antiviral mechanism, activation of stress kinase PKR by its RNA, to enable splicing of rev/tat mRNA. Cell & Bioscience 13:1.
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Raymond Kaempfer, Lena Ilan, Smadar Cohen-Chalamish, Orli Turgeman, Lise Sarah Namer & Farhat Osman. (2019) Control of mRNA Splicing by Intragenic RNA Activators of Stress Signaling: Potential Implications for Human Disease. Frontiers in Genetics 10.
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Raymond Kaempfer, Lise Sarah Namer, Farhat Osman & Lena Ilan. (2018) Control of mRNA splicing by noncoding intragenic RNA elements that evoke a cellular stress response. The International Journal of Biochemistry & Cell Biology 105, pages 20-23.
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Lise Sarah Namer, Farhat Osman, Yona Banai, Benoît Masquida, Rodrigo Jung & Raymond Kaempfer. (2017) An Ancient Pseudoknot in TNF-α Pre-mRNA Activates PKR, Inducing eIF2α Phosphorylation that Potently Enhances Splicing. Cell Reports 20:1, pages 188-200.
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Lena Ilan, Farhat Osman, Lise Sarah Namer, Einav Eliahu, Smadar Cohen-Chalamish, Yitzhak Ben-Asouli, Yona Banai & Raymond Kaempfer. (2017) PKR activation and eIF2α phosphorylation mediate human globin mRNA splicing at spliceosome assembly. Cell Research 27:5, pages 688-704.
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San San Lin, Davy C.W. Lee, Anna H.Y. Law, Jun Wei Fang, Daniel T.T. Chua & Allan S.Y. Lau. (2010) A role for protein kinase PKR in the mediation of Epstein–Barr virus latent membrane protein-1-induced IL-6 and IL-10 expression. Cytokine 50:2, pages 210-219.
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José M. Leiro, Monica Varela, M. Carla Piazzon, Juan A. Arranz, Manuel Noya & Jesus Lamas. (2010) The anti-inflammatory activity of the polyphenol resveratrol may be partially related to inhibition of tumour necrosis factor-α (TNF-α) pre-mRNA splicing. Molecular Immunology 47:5, pages 1114-1120.
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Shehla Pervin, An H. Tran, Shaghayegh Zekavati, Jon M. Fukuto, Rajan Singh & Gautam Chaudhuri. (2008) Increased Susceptibility of Breast Cancer Cells to Stress Mediated Inhibition of Protein Synthesis. Cancer Research 68:12, pages 4862-4874.
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Shao-Chih Chiu & Ning-Sun Yang. (2007) Inhibition of Tumor Necrosis Factor-α through Selective Blockade of Pre-mRNA Splicing by Shikonin. Molecular Pharmacology 71:6, pages 1640-1645.
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Kristen L Shogren, Russell T Turner, Michael J Yaszemski & Avudaiappan Maran. (2006) Double-Stranded RNA-Dependent Protein Kinase Is Involved in 2-Methoxyestradiol-Mediated Cell Death of Osteosarcoma Cells. Journal of Bone and Mineral Research 22:1, pages 29-36.
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Toru Hosoi, Naomi Matsunami, Tomoko Nagahama, Yasunobu Okuma, Koichiro Ozawa, Tsuyoshi Takizawa & Yasuyuki Nomura. (2006) 2-Aminopurine inhibits leptin receptor signal transduction. European Journal of Pharmacology 553:1-3, pages 61-66.
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Lynn Martin, Sandeep C. Pingle, Daniel M. Hallam, Leonard P. Rybak & Vickram Ramkumar. (2006) Activation of the Adenosine A 3 Receptor in RAW 264.7 Cells Inhibits Lipopolysaccharide-Stimulated Tumor Necrosis Factor-α Release by Reducing Calcium-Dependent Activation of Nuclear Factor-κB and Extracellular Signal-Regulated Kinase 1/2 . Journal of Pharmacology and Experimental Therapeutics 316:1, pages 71-78.
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S. Kim-Schulze, T. Seki, G. Vlad, L. Scotto, J. Fan, P.C. Colombo, J. Liu, R. Cortesini & N. Suciu-Foca. (2006) Regulation of ILT3 Gene Expression by Processing of Precursor Transcripts in Human Endothelial Cells. American Journal of Transplantation 6:1, pages 76-82.
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Benny K. W. Cheung, Davy C. W. Lee, James C. B. Li, Yu-Lung Lau & Allan S. Y. Lau. (2005) A Role for Double-Stranded RNA-Activated Protein Kinase PKR in Mycobacterium -Induced Cytokine Expression . The Journal of Immunology 175:11, pages 7218-7225.
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James C.B. Li, Davy C.W. Lee, Benny K.W. Cheung & Allan S.Y. Lau. (2005) Mechanisms for HIV Tat upregulation of IL-10 and other cytokine expression: Kinase signaling and PKR-mediated immune response. FEBS Letters 579:14, pages 3055-3062.
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Tsuyoshi Sugiyama, Megumi Fujita, Naoki Koide, Isamu Mori, Tomoaki Yoshida, Hiroshi Mori & Takashi Yokochi. (2004) 2-Aminopurine Inhibits Lipopolysaccharide-Induced Nitric Oxide Production by Preventing IFN-β Production. Microbiology and Immunology 48:12, pages 957-963.
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Richard T. Sawyer, Charles E. Parsons, Andrew P. Fontenot, Lisa A. Maier, May M. Gillespie, E. Brigitte Gottschall, Lori Silveira & Lee S. Newman. (2004) Beryllium-Induced Tumor Necrosis Factor-α Production by CD4 + T Cells Is Mediated by HLA-DP . American Journal of Respiratory Cell and Molecular Biology 31:1, pages 122-130.
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Linda Doerwald, Carla Onnekink, Siebe T. van Genesen, Wilfried W. de Jong & Nicolette H. Lubsen. (2003) Translational Thermotolerance Provided by Small Heat Shock Proteins Is Limited to Cap-dependent Initiation and Inhibited by 2-Aminopurine. Journal of Biological Chemistry 278:50, pages 49743-49750.
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Raymond Kaempfer. (2003) RNA sensors: novel regulators of gene expression. EMBO reports 4:11, pages 1043-1047.
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Shirley Huang, Li-Ke Qu, Andrew R Cuddihy, Rafik Ragheb, Yoichi Taya & Antonis E Koromilas. (2003) Protein kinase inhibitor 2-aminopurine overrides multiple genotoxic stress-induced cellular pathways to promote cell survival. Oncogene 22:24, pages 3721-3733.
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Julia Y Lee, Nahmah A Kim, Amy Sanford & Kathleen E Sullivan. (2003) Histone acetylation and chromatin conformation are regulated separately at the TNF-α promoter in monocytes and macrophages. Journal of Leukocyte Biology 73:6, pages 862-871.
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Liang Shi, Raj Kishore, Megan R. McMullen & Laura E. Nagy. (2002) Lipopolysaccharide stimulation of ERK1/2 increases TNF-α production via Egr-1. American Journal of Physiology-Cell Physiology 282:6, pages C1205-C1211.
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Yitzhak Ben-Asouli, Yona Banai, Yehuda Pel-Or, Alexei Shir & Raymond Kaempfer. (2002) Human Interferon-γ mRNA Autoregulates Its Translation through a Pseudoknot that Activates the Interferon-Inducible Protein Kinase PKR. Cell 108:2, pages 221-232.
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Gila Arad, Revital Levy, Dalia Hillman & Raymond Kaempfer. (2000) Superantigen antagonist protects against lethal shock and defines a new domain for T-cell activation. Nature Medicine 6:4, pages 414-421.
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Robert C. Newton & Carl P. Decicco. (1999) Therapeutic Potential and Strategies for Inhibiting Tumor Necrosis Factor-α. Journal of Medicinal Chemistry 42:13, pages 2295-2314.
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R. Todd Pickard, Beth A. Strifler, Ruth M. Kramer & John D. Sharp. (1999) Molecular Cloning of Two New Human Paralogs of 85-kDa Cytosolic Phospholipase A2. Journal of Biological Chemistry 274:13, pages 8823-8831.
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Min-Liang Wong & Yong-Ren Yen. (1998) Protein synthesis in pseudorabies virus-infected cells: decreased expression of protein kinase PKR, and effects of 2-aminopurine and adenine. Virus Research 56:2, pages 199-206.
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Yang Yang, Ju-Fay Chang, Jane R. Parnes & C. Garrison Fathman. (1998) T Cell Receptor (TCR) Engagement Leads to Activation-induced Splicing of  Tumor Necrosis Factor (TNF) Nuclear Pre-mRNA. Journal of Experimental Medicine 188:2, pages 247-254.
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Raymond Kaempfer. (1998) Cytokine and Interferon Research in Israel. Cytokine & Growth Factor Reviews 9:2, pages 99-108.
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Franck Amiot, Oréda Boussadia, Sylvaine Cases, Catherine Fitting, Mai Lebastard, Jean-Marc Cavaillon, Geneviève Milon & François Dautry. (1997) Mice heterozygous for a deletion of the tumor necrosis factor-α and lymphotoxin-α genes: biological importance of a nonlinear response of tumor necrosis factor-α to gene dosage. European Journal of Immunology 27:4, pages 1035-1042.
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Doron Aframian, Mark Katzenellenbogen, Gila Arad, Farhat Osman, Dror Sayar, Mali Ketzinel, Elimelech Deutsch & Raymond Kaempfer. (1996) Down-regulation of human tumor necrosis factor-β gene expression by cells with suppressive activity. Immunology Letters 54:2-3, pages 171-176.
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