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Molecular and Cellular Biology Volume 16, 1996 - Issue 6
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Research Article

Base Pairing at the 5′ Splice Site with U1 Small Nuclear RNA Promotes Splicing of the Upstream Intron but May Be Dispensable for Splicing of the Downstream Intron

Dong-Youn HwangDepartment of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania15261
&
Justus B. CohenDepartment of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania15261Correspondence[email protected]
Pages 3012-3022 | Received 26 Jan 1996, Accepted 15 Mar 1996, Published online: 29 Mar 2023

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Read on this site (3)

Oren Ram, Schraga Schwartz & Gil Ast. (2008) Multifactorial Interplay Controls the Splicing Profile of Alu-Derived Exons. Molecular and Cellular Biology 28:10, pages 3513-3525.
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Anand Gersappe & David J. Pintel. (1999) CA- and Purine-Rich Elements Form a Novel Bipartite Exon Enhancer Which Governs Inclusion of the Minute Virus of Mice NS2-Specific Exon in Both Singly and Doubly Spliced mRNAs. Molecular and Cellular Biology 19:1, pages 364-375.
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Dong-Youn Hwang & Justus B. Cohen. (1997) U1 Small Nuclear RNA-Promoted Exon Selection Requires a Minimal Distance between the Position of U1 Binding and the 3′ Splice Site across the Exon. Molecular and Cellular Biology 17:12, pages 7099-7107.
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Articles from other publishers (14)

Andrew M Jobbins, Sébastien Campagne, Robert Weinmeister, Christian M Lucas, Alison R Gosliga, Antoine Clery, Li Chen, Lucy P Eperon, Mark J Hodson, Andrew J Hudson, Frédéric H T Allain & Ian C Eperon. (2021) Exon‐independent recruitment of SRSF1 is mediated by U1 snRNP stem‐loop 3. The EMBO Journal 41:1.
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Ainhoa Martínez-Pizarro, Maja Dembic, Belén Pérez, Brage S. Andresen & Lourdes R. Desviat. (2018) Intronic PAH gene mutations cause a splicing defect by a novel mechanism involving U1snRNP binding downstream of the 5’ splice site. PLOS Genetics 14:4, pages e1007360.
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Nicole Eger, Laura Schoppe, Susanne Schuster, Ulrich Laufs & Jes-Niels Boeckel. 2018. Circular RNAs. Circular RNAs 41 52 .
Olga L. Gurvich, Therese M. Tuohy, Michael T. Howard, Richard S. Finkel, Livija Medne, Christine B. Anderson, Robert B. Weiss, Steve D. Wilton & Kevin M. Flanigan. (2008) DMD pseudoexon mutations: splicing efficiency, phenotype, and potential therapy . Annals of Neurology 63:1, pages 81-89.
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Koji Yamanegi, Shuang Tang & Zhi-Ming Zheng. (2005) Kaposi's Sarcoma-Associated Herpesvirus K8β Is Derived from a Spliced Intermediate of K8 Pre-mRNA and Antagonizes K8α (K-bZIP) To Induce p21 and p53 and Blocks K8α-CDK2 Interaction. Journal of Virology 79:22, pages 14207-14221.
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Jana Královičová, Sophie Houngninou-Molango, Angela Krämer & Igor Vořechovský. (2004) Branch site haplotypes that control alternative splicing. Human Molecular Genetics 13:24, pages 3189-3202.
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IDO CARMEL, SAAR TAL, IDA VIG & GIL AST. (2004) Comparative analysis detects dependencies among the 5′ splice-site positions. RNA 10:5, pages 828-840.
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Zhi-Ming Zheng. (2004) Regulation of alternative RNA splicing by exon definition and exon sequences in viral and mammalian gene expression. Journal of Biomedical Science 11:3, pages 278-294.
Crossref
Zhi-Ming Zheng, Mingfang Tao, Koji Yamanegi, Sohrab Bodaghi & Wei Xiao. (2004) Splicing of a Cap-proximal Human Papillomavirus 16 E6E7 Intron Promotes E7 Expression, but can be Restrained by Distance of the Intron from its RNA 5′ Cap. Journal of Molecular Biology 337:5, pages 1091-1108.
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Ivo Melčák, Štěpánka Melčáková, Vojtěch Kopsky, Jaromı́ra Večeřová & Ivan Raška. (2001) Prespliceosomal Assembly on Microinjected Precursor mRNA Takes Place in Nuclear Speckles. Molecular Biology of the Cell 12:2, pages 393-406.
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Zhi-Ming Zheng, Eric S. Reid & Carl C. Baker. (2000) Utilization of the Bovine Papillomavirus Type 1 Late-Stage-Specific Nucleotide 3605 3′ Splice Site Is Modulated by a Novel Exonic Bipartite Regulator but Not by an Intronic Purine-Rich Element. Journal of Virology 74:22, pages 10612-10622.
Crossref
A.F. Muro, A. Iaconcig & F.E. Baralle. (1998) Regulation of the fibronectin EDA exon alternative splicing. Cooperative role of the exonic enhancer element and the 5′ splicing site. FEBS Letters 437:1-2, pages 137-141.
Crossref
D Y HwangJ B Cohen. (1997) A splicing enhancer in the 3'-terminal c-H-ras exon influences mRNA abundance and transforming activity. Journal of Virology 71:9, pages 6416-6426.
Crossref
C. J. Coolidge, R. J. Seely & J. G. Patton. (1997) Functional analysis of the polypyrimidine tract in pre-mRNA splicing. Nucleic Acids Research 25:4, pages 888-896.
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