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Molecular and Cellular Biology Volume 16, 1996 - Issue 7
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Research Article

The Extracellular Signal-Regulated Kinase Pathway Phosphorylates AML1, an Acute Myeloid Leukemia Gene Product, and Potentially Regulates Its Transactivation Ability

Tomoyuki Tanaka1 Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo113, Japan;2 Department of Transfusion Medicine and Immunohematology, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo113, Japan
,
Mineo Kurokawa1 Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo113, Japan;2 Department of Transfusion Medicine and Immunohematology, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo113, Japan
,
Kohjiro Ueki1 Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo113, Japan
,
Kozo Tanaka1 Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo113, Japan
,
Yoichi Imai1 Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo113, Japan
,
Kinuko Mitani1 Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo113, Japan
,
Kenji Okazaki3 Division of Molecular Genetics, Institute of Life Science, Kurume University, Kurume, Fukuoka830, Japan
,
Noriyuki Sagata3 Division of Molecular Genetics, Institute of Life Science, Kurume University, Kurume, Fukuoka830, Japan
,
Yoshio Yazaki1 Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo113, Japan
,
Yoichi Shibata2 Department of Transfusion Medicine and Immunohematology, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo113, Japan
,
Takashi Kadowaki1 Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo113, Japan
&
Hisamaru Hirai1 Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo113, JapanCorrespondence[email protected]
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Pages 3967-3979 | Received 11 Jan 1996, Accepted 03 Apr 1996, Published online: 29 Mar 2023

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Yan Chen, Lin Zhang, Lei Liu, Shixiu Sun, Xuyang Zhao, Yueyuan Wang, Yujie Zhang, Jun Du & Luo Gu. (2018) Rasip1 is a RUNX1 target gene and promotes migration of NSCLC cells. Cancer Management and Research 10, pages 4537-4552.
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Joseph R. Biggs, Luke F. Peterson, Youhong Zhang, Andrew S. Kraft & Dong-Er Zhang. (2006) AML1/RUNX1 Phosphorylation by Cyclin-Dependent Kinases Regulates the Degradation of AML1/RUNX1 by the Anaphase-Promoting Complex. Molecular and Cellular Biology 26:20, pages 7420-7429.
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Ramesh Sreeramaneni, Asif Chaudhry, Martin McMahon, Charles J. Sherr & Kazushi Inoue. (2005) Ras-Raf-Arf Signaling Critically Depends on the Dmp1 Transcription Factor. Molecular and Cellular Biology 25:1, pages 220-232.
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Kazuhiro Maki, Honoka Arai, Kazuo Waga, Ko Sasaki, Fumihiko Nakamura, Yoichi Imai, Mineo Kurokawa, Hisamaru Hirai & Kinuko Mitani. (2004) Leukemia-Related Transcription Factor TEL Is Negatively Regulated through Extracellular Signal-Regulated Kinase-Induced Phosphorylation. Molecular and Cellular Biology 24:8, pages 3227-3237.
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Yoichi Imai, Mineo Kurokawa, Yuko Yamaguchi, Koji Izutsu, Eriko Nitta, Kinuko Mitani, Masanobu Satake, Tetsuo Noda, Yoshiaki Ito & Hisamaru Hirai. (2004) The Corepressor mSin3A Regulates Phosphorylation-Induced Activation, Intranuclear Location, and Stability of AML1. Molecular and Cellular Biology 24:3, pages 1033-1043.
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Joëlle Michaud, Hamish S. Scott & Robert Escher. (2003) AML1 Interconnected Pathways of Leukemogenesis. Cancer Investigation 21:1, pages 105-136.
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Martha S. Petrovick, Scott W. Hiebert, Alan D. Friedman, Christopher J. Hetherington, Daniel G. Tenen & Dong-Er Zhang. (1998) Multiple Functional Domains of AML1: PU.1 and C/EBPα Synergize with Different Regions of AML1. Molecular and Cellular Biology 18:7, pages 3915-3925.
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Tomohiko Kanno, Yuka Kanno, Lin-Feng Chen, Eiko Ogawa, Woo-Young Kim & Yoshiaki Ito. (1998) Intrinsic Transcriptional Activation-Inhibition Domains of the Polyomavirus Enhancer Binding Protein 2/Core Binding Factor α Subunit Revealed in the Presence of the β Subunit. Molecular and Cellular Biology 18:5, pages 2444-2454.
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Jennifer J. Westendorf, Cindy M. Yamamoto, Noel Lenny, James R. Downing, Michael E. Selsted & Scott W. Hiebert. (1998) The t(8;21) Fusion Product, AML-1–ETO, Associates with C/EBP-α, Inhibits C/EBP-α-Dependent Transcription, and Blocks Granulocytic Differentiation. Molecular and Cellular Biology 18:1, pages 322-333.
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Yu-Wen Zhang, Suk-Chul Bae, Gang Huang, Yang-Xin Fu, Jie Lu, Mee-Young Ahn, Yuka Kanno, Tomohiko Kanno & Yoshiaki Ito. (1997) A Novel Transcript Encoding an N-Terminally Truncated AML1/PEBP2αB Protein Interferes with Transactivation and Blocks Granulocytic Differentiation of 32Dcl3 Myeloid Cells. Molecular and Cellular Biology 17:7, pages 4133-4145.
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Alan B. Cantor. 2016. Molecular and Cellular Biology of Platelet Formation. Molecular and Cellular Biology of Platelet Formation 61 91 .
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S Goyama, G Huang, M Kurokawa & J C Mulloy. (2014) Posttranslational modifications of RUNX1 as potential anticancer targets. Oncogene 34:27, pages 3483-3492.
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Crossref
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Giselle Sek Suan Nah, Boon-Hui Tay, Sydney Brenner, Motomi Osato & Byrappa Venkatesh. (2014) Characterization of the Runx Gene Family in a Jawless Vertebrate, the Japanese Lamprey (Lethenteron japonicum). PLoS ONE 9:11, pages e113445.
Crossref
Giselle Sek Suan Nah, Zhi Wei Lim, Boon-Hui Tay, Motomi Osato & Byrappa Venkatesh. (2014) Runx Family Genes in a Cartilaginous Fish, the Elephant Shark (Callorhinchus milii). PLoS ONE 9:4, pages e93816.
Crossref
Amanda M. SchmidtTao ZouRohan P. JoshiTheresa M. LeichnerMatthew A. PimentelConnie L. SommersTaku Kambayashi. (2013) Diacylglycerol Kinase ζ Limits the Generation of Natural Regulatory T Cells. Science Signaling 6:303.
Crossref
Linda Shyue Huey Chuang, Kosei Ito & Yoshiaki Ito. (2013) RUNX family: Regulation and diversification of roles through interacting proteins. International Journal of Cancer 132:6, pages 1260-1271.
Crossref
E Tijchon, J Havinga, F N van Leeuwen & B Scheijen. (2012) B-lineage transcription factors and cooperating gene lesions required for leukemia development. Leukemia 27:3, pages 541-552.
Crossref
E. N. Markova, N. V. Petrova, S. V. Razin & O. L. Kantidze. (2012) Transcription factor RUNX1. Molecular Biology 46:6, pages 755-767.
Crossref
Etienne De Braekeleer, Nathalie Douet-Guilbert, Frédéric Morel, Marie-Josée Le Bris, Audrey Basinko & Marc De Braekeleer. (2012) ETV6 fusion genes in hematological malignancies: A review. Leukemia Research 36:8, pages 945-961.
Crossref
Benjamin G. Neel & Nancy A. Speck. (2012) Tyrosyl phosphorylation toggles a Runx1 switch. Genes & Development 26:14, pages 1520-1526.
Crossref
Mayumi Yoshimi, Susumu Goyama, Masahito Kawazu, Masahiro Nakagawa, Motoshi Ichikawa, Yoichi Imai, Keiki Kumano, Takashi Asai, James C. Mulloy, Andrew S. Kraft, Tsuyoshi Takahashi, Naoki Shirafuji & Mineo Kurokawa. (2012) Multiple phosphorylation sites are important for RUNX1 activity in early hematopoiesis and T-cell differentiation. European Journal of Immunology 42:4, pages 1044-1050.
Crossref
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Crossref
Scott B. Ficarro, Yi Zhang, Marlene J. Carrasco-Alfonso, Brijesh Garg, Guillaume Adelmant, James T. Webber, C. John Luckey & Jarrod A. Marto. (2011) Online Nanoflow Multidimensional Fractionation for High Efficiency Phosphopeptide Analysis. Molecular & Cellular Proteomics 10:11, pages O111.011064.
Crossref
Lixin Wang, Joan S. Brugge & Kevin A. Janes. (2011) Intersection of FOXO- and RUNX1-mediated gene expression programs in single breast epithelial cells during morphogenesis and tumor progression. Proceedings of the National Academy of Sciences 108:40.
Crossref
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Crossref
Ji Hae Jun, Won-Joon Yoon, Sang-Beom Seo, Kyung-Mi Woo, Gwan-Shik Kim, Hyun-Mo Ryoo & Jeong-Hwa Baek. (2010) BMP2-activated Erk/MAP Kinase Stabilizes Runx2 by Increasing p300 Levels and Histone Acetyltransferase Activity. Journal of Biological Chemistry 285:47, pages 36410-36419.
Crossref
Lie Wang, Yumei Xiong & Rémy Bosselut. (2010) Tenuous paths in unexplored territory: From T cell receptor signaling to effector gene expression during thymocyte selection. Seminars in Immunology 22:5, pages 294-302.
Crossref
Won F. Wong, Megumi Nakazato, Toshio Watanabe, Kazuyoshi Kohu, Takehiro Ogata, Naomi Yoshida, Yusuke Sotomaru, Mamoru Ito, Kimi Araki, Janice Telfer, Manabu Fukumoto, Daisuke Suzuki, Takehito Sato, Katsuto Hozumi, Sonoko Habu & Masanobu Satake. (2010) Over-expression of Runx1 transcription factor impairs the development of thymocytes from the double-negative to double-positive stages. Immunology 130:2, pages 243-253.
Crossref
Ok-Jin Park, Hyun-Jung Kim, Kyung-Mi Woo, Jeong-Hwa Baek & Hyun-Mo Ryoo. (2010) FGF2-activated ERK Mitogen-activated Protein Kinase Enhances Runx2 Acetylation and Stabilization. Journal of Biological Chemistry 285:6, pages 3568-3574.
Crossref
Chunxi Ge, Guozhi Xiao, Di Jiang, Qian Yang, Nan E. Hatch, Hernan Roca & Renny T. Franceschi. (2009) Identification and Functional Characterization of ERK/MAPK Phosphorylation Sites in the Runx2 Transcription Factor. Journal of Biological Chemistry 284:47, pages 32533-32543.
Crossref
Christian R. Geest, Miranda Buitenhuis, Marian J. A. Groot KoerkampFrank C. P. HolstegeEdo Vellenga & Paul J. Coffer. (2009) Tight control of MEK-ERK activation is essential in regulating proliferation, survival, and cytokine production of CD34+-derived neutrophil progenitors. Blood 114:16, pages 3402-3412.
Crossref
Yu Shang, Xinghui Zhao, Xialian Xu, Hong Xin, Xueni Li, Yonggong Zhai, Dacheng He, Baoqing Jia, Wei Chen & Zhijie Chang. (2009) CHIP functions an E3 ubiquitin ligase of Runx1. Biochemical and Biophysical Research Communications 386:1, pages 242-246.
Crossref
Lan Wang, Gang Huang, Xinyang Zhao, Megan A. Hatlen, Ly Vu, Fan Liu & Stephen D. Nimer. (2009) Post-translational modifications of Runx1 regulate its activity in the cell. Blood Cells, Molecules, and Diseases 43:1, pages 30-34.
Crossref
Christian R Geest & Paul J Coffer. (2009) MAPK signaling pathways in the regulation of hematopoiesis. Journal of Leukocyte Biology 86:2, pages 237-250.
Crossref
Nagarajan Selvamurugan, Emi Shimizu, Minnkyong Lee, Tong Liu, Hong Li & Nicola C. Partridge. (2009) Identification and characterization of Runx2 phosphorylation sites involved in matrix metalloproteinase-13 promoter activation. FEBS Letters 583:7, pages 1141-1146.
Crossref
Hee-Jun WeeDominic Chih-Cheng VoonSuk-Chul Bae & Yoshiaki Ito. (2008) PEBP2-β/CBF-β–dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis. Blood 112:9, pages 3777-3787.
Crossref
Masashi Tachibana, Chieko Tezuka, Sawako Muroi, Sogo Nishimoto, Takuo Katsumoto, Atsushi Nakajima, Issay Kitabayashi & Ichiro Taniuchi. (2008) Phosphorylation of Runx1 at Ser249, Ser266, and Ser276 is dispensable for bone marrow hematopoiesis and thymocyte differentiation. Biochemical and Biophysical Research Communications 368:3, pages 536-542.
Crossref
Xinyang Zhao, Vladimir Jankovic, Alexander Gural, Gang Huang, Animesh Pardanani, Silvia Menendez, Jin Zhang, Richard Dunne, Andrew Xiao, Hediye Erdjument-Bromage, C. David Allis, Paul Tempst & Stephen D. Nimer. (2008) Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity. Genes & Development 22:5, pages 640-653.
Crossref
Linsheng Zhang, Florence B. Fried, Hong Guo & Alan D. Friedman. (2008) Cyclin-dependent kinase phosphorylation of RUNX1/AML1 on 3 sites increases transactivation potency and stimulates cell proliferation. Blood 111:3, pages 1193-1200.
Crossref
C Bourgin-Hierle, S Gobert-Gosse, J Thérier, M-F Grasset & G Mouchiroud. (2007) Src-family kinases play an essential role in differentiation signaling downstream of macrophage colony-stimulating factor receptors mediating persistent phosphorylation of phospholipase C-γ2 and MAP kinases ERK1 and ERK2. Leukemia 22:1, pages 161-169.
Crossref
Daniel E. Johnson. (2008) Src family kinases and the MEK/ERK pathway in the regulation of myeloid differentiation and myeloid leukemogenesis. Advances in Enzyme Regulation 48:1, pages 98-112.
Crossref
Cherry Ee Lin Ng, Motomi Osato, Boon Hui Tay, Byrappa Venkatesh & Yoshiaki Ito. (2007) cDNA cloning of Runx family genes from the pufferfish (Fugu rubripes). Gene 399:2, pages 162-173.
Crossref
M B Miranda & D E Johnson. (2007) Signal transduction pathways that contribute to myeloid differentiation. Leukemia 21:7, pages 1363-1377.
Crossref
Suiquan Wang, Youhong Zhang, Juliana Soosairajah & Andrew S. Kraft. (2007) Regulation of RUNX1/AML1 during the G2/M transition. Leukemia Research 31:6, pages 839-851.
Crossref
M Nanjundan, F Zhang, R Schmandt, K Smith-McCune & G B Mills. (2006) Identification of a novel splice variant of AML1b in ovarian cancer patients conferring loss of wild-type tumor suppressive functions. Oncogene 26:18, pages 2574-2584.
Crossref
M Marzec, M Kasprzycka, X Liu, P N Raghunath, P Wlodarski & M A Wasik. (2006) Oncogenic tyrosine kinase NPM/ALK induces activation of the MEK/ERK signaling pathway independently of c-Raf. Oncogene 26:6, pages 813-821.
Crossref
Teija LT Aho, Jouko Sandholm, Katriina J Peltola, Yoshiaki Ito & Päivi J Koskinen. (2006) Pim-1 kinase phosphorylates RUNX family transcription factors and enhances their activity. BMC Cell Biology 7:1.
Crossref
Yukiko Aikawa, Lan Anh Nguyen, Kyoichi Isono, Nobuyuki Takakura, Yusuke Tagata, M Lienhard Schmitz, Haruhiko Koseki & Issay Kitabayashi. (2006) Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation. The EMBO Journal 25:17, pages 3955-3965.
Crossref
Virginie HamelinClaire LetourneuxPaul-Henri RomeoFrançoise PorteuMurielle Gaudry. (2006) Thrombopoietin regulates IEX-1 gene expression through ERK-induced AML1 phosphorylation. Blood 107:8, pages 3106-3113.
Crossref
Robert B. Lorsbach & James R. Downing. 2010. Childhood Leukemias. Childhood Leukemias 298 338 .
Suk-Chul Bae & Yong Hee Lee. (2006) Phosphorylation, acetylation and ubiquitination: The molecular basis of RUNX regulation. Gene 366:1, pages 58-66.
Crossref
Takefumi DOI. (2005) Transcription Factors Responsible for Megakaryocyte-specific Gene Expression巨核球・血小板系列の遺伝子発現に関与する転写因子. YAKUGAKU ZASSHI 125:9, pages 685-697.
Crossref
Joseph R. Biggs, Youhong Zhang, Luke F. Peterson, Marileila Garcia, Dong-Er Zhang & Andrew S. Kraft. (2005) Phosphorylation of AML1/RUNX1 Regulates Its Degradation and Nuclear Matrix Association. Molecular Cancer Research 3:7, pages 391-401.
Crossref
Karen Blyth, Ewan R. Cameron & James C. Neil. (2005) The runx genes: gain or loss of function in cancer. Nature Reviews Cancer 5:5, pages 376-387.
Crossref
Susumu GoyamaYuko YamaguchiYoichi ImaiMasahito KawazuMasahiro NakagawaTakashi AsaiKeiki KumanoKinuko MitaniSeishi OgawaShigeru ChibaMineo KurokawaHisamaru Hirai. (2004) The transcriptionally active form of AML1 is required for hematopoietic rescue of the AML1-deficient embryonic para-aortic splanchnopleural (P-Sp) region. Blood 104:12, pages 3558-3564.
Crossref
Youhong Zhang, Joseph R. Biggs & Andrew S. Kraft. (2004) Phorbol Ester Treatment of K562 Cells Regulates the Transcriptional Activity of AML1c through Phosphorylation. Journal of Biological Chemistry 279:51, pages 53116-53125.
Crossref
Michael Centrella, Sylvia Christakos & Thomas L. McCarthy. (2004) Skeletal hormones and the C/EBP and Runx transcription factors: interactions that integrate and redefine gene expression. Gene 342:1, pages 13-24.
Crossref
John W. Edmunds & Louis C. Mahadevan. (2004) MAP kinases as structural adaptors and enzymatic activators in transcription complexes. Journal of Cell Science 117:17, pages 3715-3723.
Crossref
Yoshiaki Ito. (2004) Oncogenic potential of the RUNX gene family: ‘Overview’. Oncogene 23:24, pages 4198-4208.
Crossref
Janice C. Telfer, Emmett E. Hedblom, Michele K. Anderson, Micheline N. Laurent & Ellen V. Rothenberg. (2004) Localization of the Domains in Runx Transcription Factors Required for the Repression of CD4 in Thymocytes. The Journal of Immunology 172:7, pages 4359-4370.
Crossref
Yuko Yamaguchi, Mineo Kurokawa, Yoichi Imai, Koji Izutsu, Takashi Asai, Motoshi Ichikawa, Go Yamamoto, Eriko Nitta, Tetsuya Yamagata, Kazuki Sasaki, Kinuko Mitani, Seishi Ogawa, Shigeru Chiba & Hisamaru Hirai. (2004) AML1 Is Functionally Regulated through p300-mediated Acetylation on Specific Lysine Residues. Journal of Biological Chemistry 279:15, pages 15630-15638.
Crossref
Florence Bernardin-Fried, Tanawan Kummalue, Suzanne Leijen, Michael I. Collector, Katya Ravid & Alan D. Friedman. (2004) AML1/RUNX1 Increases During G1 to S Cell Cycle Progression Independent of Cytokine-dependent Phosphorylation and Induces Cyclin D3 Gene Expression. Journal of Biological Chemistry 279:15, pages 15678-15687.
Crossref
Shen-Hsi Yang, Andrew D. Sharrocks & Alan J. Whitmarsh. (2003) Transcriptional regulation by the MAP kinase signaling cascades. Gene 320, pages 3-21.
Crossref
Mineo Kurokawa & Hisamaru Hirai. (2003) Role of AML1/Runx1 in the pathogenesis of hematological malignancies. Cancer Science 94:10, pages 841-846.
Crossref
Leonidas C. Platanias. (2003) Map kinase signaling pathways and hematologic malignancies. Blood 101:12, pages 4667-4679.
Crossref
Chaoxiang Shui, Thomas C Spelsberg, B Lawrence Riggs & Sundeep Khosla. (2003) Changes in Runx2/Cbfa1 Expression and Activity During Osteoblastic Differentiation of Human Bone Marrow Stromal Cells. Journal of Bone and Mineral Research 18:2, pages 213-221.
Crossref
D. A. Hume & S. R. Himes. 2003. The Macrophage as Therapeutic Target. The Macrophage as Therapeutic Target 11 40 .
Ichiro Taniuchi, Motomi Osato, Takeshi Egawa, Mary Jean Sunshine, Suk-Chul Bae, Toshihisa Komori, Yoshiaki Ito & Dan R. Littman. (2002) Differential Requirements for Runx Proteins in CD4 Repression and Epigenetic Silencing during T Lymphocyte Development. Cell 111:5, pages 621-633.
Crossref
Honoka Arai, Kazuhiro Maki, Kazuo Waga, Ko Sasaki, Yuichi Nakamura, Yoichi Imai, Mineo Kurokawa, Hisamaru Hirai & Kinuko Mitani. (2002) Functional regulation of TEL by p38-induced phosphorylation. Biochemical and Biophysical Research Communications 299:1, pages 116-125.
Crossref
Hee‐Jun Wee, Gang Huang, Katsuya Shigesada & Yoshiaki Ito. (2002) Serine phosphorylation of RUNX2 with novel potential functions as negative regulatory mechanisms. EMBO reports 3:10, pages 967-974.
Crossref
Lindsay C. Spender, Georgina H. Cornish, Alexandra Sullivan & Paul J. Farrell. (2002) Expression of Transcription Factor AML-2 (RUNX3, CBFα-3) Is Induced by Epstein-Barr Virus EBNA-2 and Correlates with the B-Cell Activation Phenotype. Journal of Virology 76:10, pages 4919-4927.
Crossref
Naoki Kimura, Makiko Takizawa, Keisuke Okita, Osamu Natori, Katsuhide Igarashi, Masaya Ueno, Kin-ichi Nakashima, Ikuo Nobuhisa & Tetsuya Taga. (2002) Identification of a novel transcription factor, ELYS, expressed predominantly in mouse foetal haematopoietic tissues. Genes to Cells 7:4, pages 435-446.
Crossref
David G Skalnik. (2002) Transcriptional mechanisms regulating myeloid-specific genes. Gene 284:1-2, pages 1-21.
Crossref
Jonathan D Licht. (2001) AML1 and the AML1-ETO fusion protein in the pathogenesis of t(8;21) AML. Oncogene 20:40, pages 5660-5679.
Crossref
Nagarajan Selvamurugan, Regina J. Brown & Nicola C. Partridge. (2000) Regulation of collagenase-3 gene expression in osteoblastic and non-osteoblastic cell lines. Journal of Cellular Biochemistry 79:2, pages 182-190.
Crossref
James R Downing, Masakazu Higuchi, Noel Lenny & Allen Eng-Juh Yeoh. (2000) Alterations of the AML1 transcription factor in human leukemia. Seminars in Cell & Developmental Biology 11:5, pages 347-360.
Crossref
Thomas L. McCarthy, Changhua Ji, Yun Chen, Kenneth K. Kim, Masayoshi Imagawa, Yoshiaki Ito & Michael Centrella. (2000) Runt Domain Factor (Runx)-dependent Effects on CCAAT/ Enhancer-binding Protein δ Expression and Activity in Osteoblasts. Journal of Biological Chemistry 275:28, pages 21746-21753.
Crossref
S Kanto, N Chiba, Y Tanaka, S Fujita, M Endo, N Kamada, K Yoshikawa, A Fukuzaki, S Orikasa, T Watanabe & M Satake. (2000) The PEBP2β/CBFβ-SMMHC chimeric protein is localized both in the cell membrane and nuclear subfractions of leukemic cells carrying chromosomal inversion 16. Leukemia 14:7, pages 1253-1259.
Crossref
AC Ward, DM Loeb, AA Soede-Bobok, IP Touw & AD Friedman. (2000) Regulation of granulopoiesis by transcription factors and cytokine signals. Leukemia 14:6, pages 973-990.
Crossref
Guglielmina Chimienti, Mauro Alaibac, Franco Marzullo, Antonio Carbone & Gabriella Pepe. (2000) The Expression Pattern of the AML1 Gene in Non-Hodgkin's B-Cell Lymphomas and Normal B Lymphocytes. Blood Cells, Molecules, and Diseases 26:3, pages 186-192.
Crossref
Yoshihide Mitani, Syed H. E. Zaidi, Pascale Dufourcq, Karen Thompson & Marlene Rabinovitch. (2000) Nitric oxide reduces vascular smooth muscle cell elastase activity through cGMP‐mediated suppression of ERK phosphorylation and AML1B nuclear partitioning. The FASEB Journal 14:5, pages 805-814.
Crossref
Nagarajan Selvamurugan, Malini R. Pulumati, Darren R. Tyson & Nicola C. Partridge. (2000) Parathyroid Hormone Regulation of the Rat Collagenase-3 Promoter by Protein Kinase A-dependent Transactivation of Core Binding Factor α1. Journal of Biological Chemistry 275:7, pages 5037-5042.
Crossref
Guozhi Xiao, Di Jiang, Peedikayil Thomas, M.Douglas Benson, Kunliang Guan, Gerard Karsenty & Renny T. Franceschi. (2000) MAPK Pathways Activate and Phosphorylate the Osteoblast-specific Transcription Factor, Cbfa1. Journal of Biological Chemistry 275:6, pages 4453-4459.
Crossref
David K. Strom, John Nip, Jennifer J. Westendorf, Bryan Linggi, Bart Lutterbach, James R. Downing, Noel Lenny & Scott W. Hiebert. (2000) Expression of the AML-1 Oncogene Shortens the G1Phase of the Cell Cycle. Journal of Biological Chemistry 275:5, pages 3438-3445.
Crossref
Yu-Wen Zhang, Natsuo Yasui, Naoki Kakazu, Tatsuo Abe, Kenzo Takada, Shosuke Imai, Motohiko Sato, Shintaro Nomura, Takahiro Ochi, Shigeharu Okuzumi, Hiroshi Nogami, Toshiro Nagai, Hirohumi Ohashi & Yoshiaki Ito. (2000) PEBP2αA/CBFA1 mutations in Japanese cleidocranial dysplasia patients. Gene 244:1-2, pages 21-28.
Crossref
Yoshiaki Ito. (1999) Molecular basis of tissue-specific gene expression mediated by the Runt domain transcription factor PEBP2/CBF. Genes to Cells 4:12, pages 685-696.
Crossref
James R. Downing. (1999) THE AML1-ETO CHIMAERIC TRANSCRIPTION FACTOR IN ACUTE MYELOID LEUKAEMIA: BIOLOGY AND CLINICAL SIGNIFICANCE. British Journal of Haematology 106:2, pages 296-308.
Crossref
Xiao-Feng Le, Yoram Groner, Steve M. Kornblau, Yun Gu, Walter N. Hittelman, Ditsa Levanon, Kapil Mehta, Ralph B. Arlinghaus & Kun-Sang Chang. (1999) Regulation of AML2/CBFA3 in Hematopoietic Cells through the Retinoic Acid Receptor α-Dependent Signaling Pathway. Journal of Biological Chemistry 274:31, pages 21651-21658.
Crossref
H Matsushita, M Kizaki, H Kobayashi, A Muto & Y Ikeda. (1999) Induction of apoptosis in myeloid leukaemic cells by ribozymes targeted against AML1/MTG8. British Journal of Cancer 79:9-10, pages 1325-1331.
Crossref
D Porte, J Tuckermann, M Becker, B Baumann, S Teurich, T Higgins, M J Owen, M Schorpp-Kistner & P Angel. (1999) Both AP-1 and Cbfa1-like factors are required for the induction of interstitial collagenase by parathyroid hormone. Oncogene 18:3, pages 667-678.
Crossref
Guozhi Xiao, Dian Wang, M. Douglas Benson, Gerard Karsenty & Renny T. Franceschi. (1998) Role of the α2-Integrin in Osteoblast-specific Gene Expression and Activation of the Osf2 Transcription Factor. Journal of Biological Chemistry 273:49, pages 32988-32994.
Crossref
Nagarajan Selvamurugan, Wan-Yin Chou, A. Terrece Pearman, Malini R. Pulumati & Nicola C. Partridge. (1998) Parathyroid Hormone Regulates the Rat Collagenase-3 Promoter in Osteoblastic Cells through the Cooperative Interaction of the Activator Protein-1 Site and the runt Domain Binding Sequence. Journal of Biological Chemistry 273:17, pages 10647-10657.
Crossref
Kozo TanakaTomoyuki TanakaMineo KurokawaYoichi ImaiSeishi OgawaKinuko MitaniYoshio YazakiHisamaru Hirai. (1998) The AML1/ETO(MTG8) and AML1/Evi-1 Leukemia-Associated Chimeric Oncoproteins Accumulate PEBP2β(CBFβ) in the Nucleus More Efficiently Than Wild-Type AML1. Blood 91:5, pages 1688-1699.
Crossref
Kozo TanakaTomoyuki TanakaMineo KurokawaYoichi ImaiSeishi OgawaKinuko MitaniYoshio YazakiHisamaru Hirai. (1998) The AML1/ETO(MTG8) and AML1/Evi-1 Leukemia-Associated Chimeric Oncoproteins Accumulate PEBP2β(CBFβ) in the Nucleus More Efficiently Than Wild-Type AML1. Blood 91:5, pages 1688-1699.
Crossref
Timothy S. Lewis, Paul S. Shapiro & Natalie G. Ahn. 1998. 49 139 .
Daniel G. TenenRobert HromasJonathan D. LichtDong-Er Zhang. (1997) Transcription Factors, Normal Myeloid Development, and Leukemia. Blood 90:2, pages 489-519.
Crossref
Daniel G. TenenRobert HromasJonathan D. LichtDong-Er Zhang. (1997) Transcription Factors, Normal Myeloid Development, and Leukemia. Blood 90:2, pages 489-519.
Crossref
Yoshiaki Ito & Suk-Chul Bae. 1997. Oncogenes as Transcriptional Regulators. Oncogenes as Transcriptional Regulators 107 132 .

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