18
Views
80
CrossRef citations to date
0
Altmetric
Research Article

Interaction of the Interferon-Induced PKR Protein Kinase with Inhibitory Proteins P58IPK and Vaccinia Virus K3L Is Mediated by Unique Domains: Implications for Kinase Regulation

, , &
Pages 4172-4181 | Received 05 Mar 1996, Accepted 09 May 1996, Published online: 29 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Norina M. Tang, Marcus J. Korth, Michael Gale$suffix/text()$suffix/text(), Marlene Wambach, Sandy D. Der, Sudip K. Bandyopadhyay, Bryan R. G. Williams & Michael G. Katze. (1999) Inhibition of Double-Stranded RNA- and Tumor Necrosis Factor Alpha-Mediated Apoptosis by Tetratricopeptide Repeat Protein and Cochaperone P58IPK. Molecular and Cellular Biology 19:7, pages 4757-4765.
Read now
Patrick R. Romano, Fan Zhang, Seng-Lai Tan, Minerva T. Garcia-Barrio, Michael G. Katze, Thomas E. Dever & Alan G. Hinnebusch. (1998) Inhibition of Double-Stranded RNA-Dependent Protein Kinase PKR by Vaccinia Virus E3: Role of Complex Formation and the E3 N-Terminal Domain. Molecular and Cellular Biology 18:12, pages 7304-7316.
Read now
Michael Gale$suffix/text()$suffix/text(), Collin M. Blakely, Bart Kwieciszewski, Seng-Lai Tan, Michelle Dossett, Norina M. Tang, Marcus J. Korth, Stephen J. Polyak, David R. Gretch & Michael G. Katze. (1998) Control of PKR Protein Kinase by Hepatitis C Virus Nonstructural 5A Protein: Molecular Mechanisms of Kinase Regulation. Molecular and Cellular Biology 18:9, pages 5208-5218.
Read now
Seng-Lai Tan, Michael J. Gale$suffix/text()$suffix/text() & Michael G. Katze. (1998) Double-Stranded RNA-Independent Dimerization of Interferon-Induced Protein Kinase PKR and Inhibition of Dimerization by the Cellular P58IPK Inhibitor. Molecular and Cellular Biology 18:5, pages 2431-2443.
Read now
Michael Gale$suffix/text()$suffix/text(), Collin M. Blakely, Deborah A. Hopkins, Mark W. Melville, Marlene Wambach, Patrick R. Romano & Michael G. Katze. (1998) Regulation of Interferon-Induced Protein Kinase PKR: Modulation of P58IPK Inhibitory Function by a Novel Protein, P52rIPK. Molecular and Cellular Biology 18:2, pages 859-871.
Read now
Makiko Kawagishi-Kobayashi, Joshua B. Silverman, Tekly L. Ung & Thomas E. Dever. (1997) Regulation of the Protein Kinase PKR by the Vaccinia Virus Pseudosubstrate Inhibitor K3L Is Dependent on Residues Conserved between the K3L Protein and the PKR Substrate eIF2α. Molecular and Cellular Biology 17:7, pages 4146-4158.
Read now

Articles from other publishers (74)

Ki Seong Ko, Jae Yong Yoo, Kyung Hwa Kim, Bo Young Hwang, Bich Ngoc Vu, Young Eun Lee, Ha Na Choi, Yoo Na Lee, Jihee Yun, Ji Ye Park, Woo Sik Chung, Jong Chan Hong, Myeong Seon Jeong, Hyun Suk Jung, Su Kyoung Jung, Jeong Mee Park & Kyun Oh Lee. (2022) P58IPK facilitates plant recovery from ER stress by enhancing protein synthesis. Plant Biotechnology Reports 16:6, pages 665-681.
Crossref
Vladimir Lažetić & Emily R. Troemel. (2020) Conservation lost: host‐pathogen battles drive diversification and expansion of gene families. The FEBS Journal 288:18, pages 5289-5299.
Crossref
Teresa Cesaro, Yohei Hayashi, Fabian Borghese, Didier Vertommen, Fanny Wavreil & Thomas Michiels. (2021) PKR activity modulation by phosphomimetic mutations of serine residues located three aminoacids upstream of double-stranded RNA binding motifs. Scientific Reports 11:1.
Crossref
Giulia Emanuelli, Nikou Nassehzadeh-Tabriz, Nick W. Morrell & Stefan J. Marciniak. (2020) The integrated stress response in pulmonary disease. European Respiratory Review 29:157, pages 200184.
Crossref
Yong Sun Lee, Nawapol Kunkeaw & Yeon‐Su Lee. (2019) Protein kinase R and its cellular regulators in cancer: An active player or a surveillant?. WIREs RNA 11:2.
Crossref
Jingxin Cao, Jessie Varga & Yvon Deschambault. (2020) Poxvirus encoded eIF2α homolog, K3 family proteins, is a key determinant of poxvirus host species specificity. Virology 541, pages 101-112.
Crossref
Nathan Meade, Stephen DiGiuseppe & Derek Walsh. (2018) Translational control during poxvirus infection. WIREs RNA 10:2.
Crossref
Keesha M. Matz, R. Marena Guzman & Alan G. Goodman. 2019. Nucleic Acid Sensing and Immunity - Part B. Nucleic Acid Sensing and Immunity - Part B 35 136 .
Die Wang, Nicole A. de Weerd, Belinda Willard, Galina Polekhina, Bryan R. G. Williams & Anthony J. Sadler. (2017) Auto-phosphorylation Represses Protein Kinase R Activity. Scientific Reports 7:1.
Crossref
Pengfei Jiang, Junge Wen, Hao Song, Xinyu Chen, Yan Sun, Xuexi Huo & Deli Zhang. (2013) Characterization of porcine P58IPK gene and its up-regulation after H1N1 or H3N2 influenza virus infection. Journal of Clinical Virology 58:1, pages 120-126.
Crossref
Jessica Tsalikis, David O. Croitoru, Dana J. Philpott & Stephen E. Girardin. (2013) Nutrient sensing and metabolic stress pathways in innate immunity. Cellular Microbiology, pages n/a-n/a.
Crossref
Bidhan Ch. Bera, K. Shanmugasundaram, Sanjay Barua, Taruna Anand, T. Riyesh, Rajesh K. Vaid, Nitin Virmani, Manish Bansal, Brihaspati N. Shukla, Praveen Malik & Raj K. Singh. (2012) Sequence and phylogenetic analysis of host-range (E3L, K3L, and C7L) and structural protein (B5R) genes of buffalopox virus isolates from buffalo, cattle, and human in India. Virus Genes 45:3, pages 488-498.
Crossref
Lucy E. Dalton, Eleanor Healey, James Irving & Stefan J. Marciniak. 2012. Protein Phosphorylation in Health and Disease. Protein Phosphorylation in Health and Disease 189 221 .
Maria Svärd, Ekaterina I. Biterova, Jean-Marie Bourhis & Jodie E. Guy. (2011) The Crystal Structure of the Human Co-Chaperone P58IPK. PLoS ONE 6:7, pages e22337.
Crossref
Jiahui Tao & Bingdong Sha. 2011. The Unfolded Protein Response and Cellular Stress, Part B. The Unfolded Protein Response and Cellular Stress, Part B 259 270 .
Zhenhong Guan, Di Liu, Shuofu Mi, Jie Zhang, Qinong Ye, Ming Wang, George F. Gao & Jinghua Yan. (2010) Interaction of Hsp40 with influenza virus M2 protein: implications for PKR signaling pathway. Protein & Cell 1:10, pages 944-955.
Crossref
J. A.L. Short. (2009) Viral evasion of interferon stimulated genes. Bioscience Horizons 2:2, pages 212-224.
Crossref
Alan G. Goodman, Jamie L. Fornek, Guruprasad R. Medigeshi, Lucy A. Perrone, Xinxia Peng, Matthew D. Dyer, Sean C. Proll, Sue E. Knoblaugh, Victoria S. Carter, Marcus J. Korth, Jay A. Nelson, Terrence M. Tumpey & Michael G. Katze. (2009) P58IPK: A Novel “CIHD” Member of the Host Innate Defense Response against Pathogenic Virus Infection. PLoS Pathogens 5:5, pages e1000438.
Crossref
Lisa O. Roberts, Catherine L. Jopling, Richard J. Jackson & Anne E. Willis. 2009. Translational Control in Health and Disease. Translational Control in Health and Disease 313 367 .
Eun Joo SeoFurong LiuMakiko Kawagishi-KobayashiTekly L. UngChune CaoArvin C. Dar, Frank Sicheri & Thomas E. Dever. (2008) Protein kinase PKR mutants resistant to the poxvirus pseudosubstrate K3L protein. Proceedings of the National Academy of Sciences 105:44, pages 16894-16899.
Crossref
Jason T. Blackard, M. Tarek Shata, Norah J. Shire & Kenneth E. Sherman. (2007) Acute hepatitis C virus infection: A chronic problem. Hepatology 47:1, pages 321-331.
Crossref
Alan G. Goodman, Jennifer A. Smith, Siddharth Balachandran, Olivia Perwitasari, Sean C. Proll, Matthew J. Thomas, Marcus J. Korth, Glen N. Barber, Leslie A. Schiff & Michael G. Katze. (2007) The Cellular Protein P58 IPK Regulates Influenza Virus mRNA Translation and Replication through a PKR-Mediated Mechanism . Journal of Virology 81:5, pages 2221-2230.
Crossref
Zongdi Feng, Melissa Cerveny, Zhipeng Yan & Bin He. (2007) The VP35 Protein of Ebola Virus Inhibits the Antiviral Effect Mediated by Double-Stranded RNA-Dependent Protein Kinase PKR. Journal of Virology 81:1, pages 182-192.
Crossref
Natalie Strudwick & Martin Schröder. 2007. Systems Biology. Systems Biology 69 155 .
M. A. García, J. Gil, I. Ventoso, S. Guerra, E. Domingo, C. Rivas & M. Esteban. (2006) Impact of Protein Kinase PKR in Cell Biology: from Antiviral to Antiproliferative Action. Microbiology and Molecular Biology Reviews 70:4, pages 1032-1060.
Crossref
Morgan Hakki, Emily E. Marshall, Katherine L. De Niro & Adam P. Geballe. (2006) Binding and Nuclear Relocalization of Protein Kinase R by Human Cytomegalovirus TRS1. Journal of Virology 80:23, pages 11817-11826.
Crossref
John C. Kash, Alan G. Goodman, Marcus J. Korth & Michael G. Katze. (2006) Hijacking of the host-cell response and translational control during influenza virus infection. Virus Research 119:1, pages 111-120.
Crossref
Yoichi Hiasa, Jason T. Blackard, Wenyu Lin, Yoshitaka Kamegaya, Norio Horiike, Morikazu Onji, Emmett V. Schmidt & Raymond T. Chung. (2006) Cell-based models of sustained, interferon-sensitive hepatitis C virus genotype 1 replication. Journal of Virological Methods 132:1-2, pages 195-203.
Crossref
Ann M. Toth, Ping Zhang, Sonali Das, Cyril X. George & Charles E. Samuel. 2006. 369 434 .
Jye-Chian Hsiao, Che-Sheng Chung, Robert Drillien & Wen Chang. (2004) The cowpox virus host range gene, CP77, affects phosphorylation of eIF2 α and vaccinia viral translation in apoptotic HeLa cells. Virology 329:1, pages 199-212.
Crossref
Steven A Whitham & Yongzeng Wang. (2004) Roles for host factors in plant viral pathogenicity. Current Opinion in Plant Biology 7:4, pages 365-371.
Crossref
Yoichi Hiasa, Yoshitaka Kamegaya, Hideko Nuriya, Morikazu Onji, Michinori Kohara, Emmett V. Schmidt & Raymond T. Chung. (2003) Protein kinase R is increased and is functional in hepatitis C virus-related hepatocellular carcinoma. The American Journal of Gastroenterology 98:11, pages 2528-2534.
Crossref
Rajnish S. Dave & Roger J. Pomerantz. (2003) RNA interference: on the road to an alternate therapeutic strategy!. Reviews in Medical Virology 13:6, pages 373-385.
Crossref
Damla D Bilgin, Yule Liu, Michael Schiff & S.P Dinesh-Kumar. (2003) P58IPK, a Plant Ortholog of Double-Stranded RNA-Dependent Protein Kinase PKR Inhibitor, Functions in Viral Pathogenesis. Developmental Cell 4:5, pages 651-661.
Crossref
Ewan R.G. Main, Yong Xiong, Melanie J. Cocco, Luca D'Andrea & Lynne Regan. (2003) Design of Stable α-Helical Arrays from an Idealized TPR Motif. Structure 11:5, pages 497-508.
Crossref
Theresa A. Ramelot, John R. Cort, Adelinda A. Yee, Furong Liu, Michael B. Goshe, Aled M. Edwards, Richard D. Smith, Cheryl H. Arrowsmith, Thomas E. Dever & Michael A. Kennedy. (2002) Myxoma Virus Immunomodulatory Protein M156R is a Structural Mimic of Eukaryotic Translation Initiation Factor eIF2α. Journal of Molecular Biology 322:5, pages 943-954.
Crossref
Seng-Lai Tan, Semih U. Tareen, Mark W. Melville, Collin M. Blakely & Michael G. Katze. (2002) The Direct Binding of the Catalytic Subunit of Protein Phosphatase 1 to the PKR Protein Kinase Is Necessary but Not Sufficient for Inactivation and Disruption of Enzyme Dimer Formation. Journal of Biological Chemistry 277:39, pages 36109-36117.
Crossref
Arvin C Dar & Frank Sicheri. (2002) X-Ray Crystal Structure and Functional Analysis of Vaccinia Virus K3L Reveals Molecular Determinants for PKR Subversion and Substrate Recognition. Molecular Cell 10:2, pages 295-305.
Crossref
Adolfo García-Sastre. (2002) Mechanisms of inhibition of the host interferon α/β-mediated antiviral responses by viruses. Microbes and Infection 4:6, pages 647-655.
Crossref
Jan-Jong Hung, Che-Sheng Chung & Wen Chang. (2002) Molecular Chaperone Hsp90 Is Important for Vaccinia Virus Growth in Cells. Journal of Virology 76:3, pages 1379-1390.
Crossref
C. Jungwirth. 2002. 295 326 .
Lisa M. Parker, Ivo Fierro-Monti & Michael B. Mathews. (2001) Nuclear Factor 90 Is a Substrate and Regulator of the Eukaryotic Initiation Factor 2 Kinase Double-stranded RNA-activated Protein Kinase. Journal of Biological Chemistry 276:35, pages 32522-32530.
Crossref
Michael J. Clemens. 2001. Signaling Pathways for Translation. Signaling Pathways for Translation 57 89 .
Adolfo García-Sastre. (2001) Inhibition of Interferon-Mediated Antiviral Responses by Influenza A Viruses and Other Negative-Strand RNA Viruses. Virology 279:2, pages 375-384.
Crossref
Makiko Kawagishi-Kobayashi, Chune Cao, Jianming Lu, Keiko Ozato & Thomas E. Dever. (2000) Pseudosubstrate Inhibition of Protein Kinase PKR by Swine Pox Virus C8L Gene Product. Virology 276:2, pages 424-434.
Crossref
Michael GaleJr.Jr., Seng-Lai Tan & Michael G. Katze. (2000) Translational Control of Viral Gene Expression in Eukaryotes. Microbiology and Molecular Biology Reviews 64:2, pages 239-280.
Crossref
Jinjiao Guo & Ganes C. Sen. (2000) Characterization of the Interaction between the Interferon-Induced Protein P56 and the Int6 Protein Encoded by a Locus of Insertion of the Mouse Mammary Tumor Virus. Journal of Virology 74:4, pages 1892-1899.
Crossref
M. J. Korth & M. G. Katze. 2000. The Hepatitis C Viruses. The Hepatitis C Viruses 197 224 .
Ruorong Cai, Bruce Carpick, Rene F. Chun, Kuan-Teh Jeang & Bryan R.G. Williams. (2000) HIV-I TAT Inhibits PKR Activity by Both RNA-Dependent and RNA-Independent Mechanisms. Archives of Biochemistry and Biophysics 373:2, pages 361-367.
Crossref
Gregory L. Blatch & Michael Lässle. (1999) The tetratricopeptide repeat: a structural motif mediating protein-protein interactions. BioEssays 21:11, pages 932-939.
Crossref
Hirofumi Koga, Hiroaki Terasawa, Hiroyuki Nunoi, Koichiro Takeshige, Fuyuhiko Inagaki & Hideki Sumimoto. (1999) Tetratricopeptide Repeat (TPR) Motifs of p67 Participate in Interaction with the Small GTPase Rac and Activation of the Phagocyte NADPH Oxidase. Journal of Biological Chemistry 274:35, pages 25051-25060.
Crossref
Seng-Lai Tan & Michael G. Katze. (1999) The Emerging Role of the Interferon-Induced PKR Protein Kinase as an Apoptotic Effector: A New Face of Death?. Journal of Interferon & Cytokine Research 19:6, pages 543-554.
Crossref
Suhayl Dhib-Jalbut, Jane Xia, Himabindu Rangaviggula, Yu-Yan Fang & Terry Lee. (1999) Failure of Measles Virus to Activate Nuclear Factor-κB in Neuronal Cells: Implications on the Immune Response to Viral Infections in the Central Nervous System. The Journal of Immunology 162:7, pages 4024-4029.
Crossref
Brian M Cali, Sherry L Kuchma, Jonathan Latham & Philip Anderson. (1999) smg-7 Is Required for mRNA Surveillance in Caenorhabditis elegans. Genetics 151:2, pages 605-616.
Crossref
Wolfgang Schliebs, Jürgen Saidowsky, Bogos Agianian, Gabriele Dodt, Friedrich W. Herberg & Wolf-H. Kunau. (1999) Recombinant Human Peroxisomal Targeting Signal Receptor PEX5. Journal of Biological Chemistry 274:9, pages 5666-5673.
Crossref
Mark W. Melville, Seng-Lai Tan, Marlene Wambach, Jaewhan Song, Richard I. Morimoto & Michael G. Katze. (1999) The Cellular Inhibitor of the PKR Protein Kinase, P58IPK, Is an Influenza Virus-activated Co-chaperone That Modulates Heat Shock Protein 70 Activity. Journal of Biological Chemistry 274:6, pages 3797-3803.
Crossref
Olga Savinova, Bhavesh Joshi & Rosemary Jagus. (1999) Abnormal levels and minimal activity of the dsRNA-activated protein kinase, PKR, in breast carcinoma cells. The International Journal of Biochemistry & Cell Biology 31:1, pages 175-189.
Crossref
Rosemary Jagus, Bhavesh Joshi & Glen N Barber. (1999) PKR, apoptosis and cancer. The International Journal of Biochemistry & Cell Biology 31:1, pages 123-138.
Crossref
T.V. Sharp, F. Moonan, A. Romashko, B. Joshi, G.N. Barber & R. Jagus. (1998) The Vaccinia Virus E3L Gene Product Interacts with both the Regulatory and the Substrate Binding Regions of PKR: Implications for PKR Autoregulation. Virology 250:2, pages 302-315.
Crossref
SENG-LAI TAN & MICHAEL G. KATZE. (1998) Biochemical and Genetic Evidence for Complex Formation Between the Influenza A Virus NS1 Protein and the Interferon-induced PKR Protein Kinase. Journal of Interferon & Cytokine Research 18:9, pages 757-766.
Crossref
Michael J Gale, Jr, Marcus J Korth & Michael G Katze. (1998) Repression of the PKR protein kinase by the hepatitis C virus NS5A protein: a potential mechanism of interferon resistance. Clinical and Diagnostic Virology 10:2-3, pages 157-162.
Crossref
Seng-Lai Tan & Michael G Katze. (1998) Using Genetic Means to Dissect Homologous and Heterologous Protein–Protein Interactions of PKR, the Interferon-Induced Protein Kinase. Methods 15:3, pages 207-223.
Crossref
William L Kelley. (1998) The J-domain family and the recruitment of chaperone power. Trends in Biochemical Sciences 23:6, pages 222-227.
Crossref
Michael GaleJr.Jr. & Michael G Katze. (1998) Molecular Mechanisms of Interferon Resistance Mediated by Viral-Directed Inhibition of PKR, the Interferon-Induced Protein Kinase. Pharmacology & Therapeutics 78:1, pages 29-46.
Crossref
Juan Ortı́n. (1998) Multiple Levels of Posttranscriptional Regulation of Influenza Virus Gene Expression. Seminars in Virology 8:4, pages 335-342.
Crossref
C. E. Samuel. 1998. Reoviruses II. Reoviruses II 125 145 .
Tyson V. Sharp, J. Eric Witzel & Rosemary Jagus. (1997) Homologous Regions of the alpha Subunit of Eukaryotic Translational Initiation Factor 2 (eIF2alpha) and the Vaccinia Virus K3L Gene Product Interact with the Same Domain within the dsRNA-Activated Protein Kinase (PKR). European Journal of Biochemistry 250:1, pages 85-91.
Crossref
Rosanna Rende-Fournier, Laura G. Ortega, Cyril X. George & Charles E. Samuel. (1997) Interaction of the Human Protein Kinase PKR with the Mouse PKR Homolog Occurs via the N-Terminal Region of PKR and Does Not Inactivate Autophosphorylation Activity of Mouse PKR. Virology 238:2, pages 410-423.
Crossref
MICHAEL J. CLEMENS & ANDROULLA ELIA. (1997) The Double-Stranded RNA-Dependent Protein Kinase PKR: Structure and Function. Journal of Interferon & Cytokine Research 17:9, pages 503-524.
Crossref
Michael J. GaleJr.Jr., Marcus J. Korth, Norina M. Tang, Seng-Lai Tan, Deborah A. Hopkins, Thomas E. Dever, Stephen J. Polyak, David R. Gretch & Michael G. Katze. (1997) Evidence That Hepatitis C Virus Resistance to Interferon Is Mediated through Repression of the PKR Protein Kinase by the Nonstructural 5A Protein. Virology 230:2, pages 217-227.
Crossref
Michael GaleJr.Jr. & Michael G. Katze. (1997) What Happens Inside Lentivirus or Influenza Virus Infected Cells: Insights into Regulation of Cellular and Viral Protein Synthesis. Methods 11:4, pages 383-401.
Crossref
Mark W. Melville, William J. Hansen, Brian C. Freeman, William J. Welch & Michael G. Katze. (1997) The molecular chaperone hsp40 regulates the activity of P58 IPK , the cellular inhibitor of PKR . Proceedings of the National Academy of Sciences 94:1, pages 97-102.
Crossref
Norina M. Tang, Catherine Y. Ho & Michael G. Katze. (1996) The 58-kDa Cellular Inhibitor of the Double Stranded RNA-dependent Protein Kinase Requires the Tetratricopeptide Repeat 6 and DnaJ Motifs to Stimulate Protein Synthesis in Vivo. Journal of Biological Chemistry 271:45, pages 28660-28666.
Crossref
Andrew.W.B. Craig, Gregory P. Cosentino, Olivier Donzé & Nahum Sonenberg. (1996) The Kinase Insert Domain of Interferon-induced Protein Kinase PKR Is Required for Activity but Not for Interaction with the Pseudosubstrate K3L. Journal of Biological Chemistry 271:40, pages 24526-24533.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.