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Research Article

Characterization of the Nuclear Export Signal of Human T-Cell Lymphotropic Virus Type 1 Rex Reveals that Nuclear Export Is Mediated by Position-Variable Hydrophobic Interactions

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Pages 5147-5155 | Received 05 Mar 1996, Accepted 07 Jun 1996, Published online: 29 Mar 2023

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Matthew E. Harris, Richard R. Gontarek, David Derse & Thomas J. Hope. (1998) Differential Requirements for Alternative Splicing and Nuclear Export Functions of Equine Infectious Anemia Virus Rev Protein. Molecular and Cellular Biology 18:7, pages 3889-3899.
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Yoshiyuki Hakata, Masami Yamada & Hisatoshi Shida. (2001) Rat CRM1 Is Responsible for the Poor Activity of Human T-Cell Leukemia Virus Type 1 Rex Protein in Rat Cells. Journal of Virology 75:23, pages 11515-11525.
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J. Hauber. 2001. Nuclear Export of Viral RNAs. Nuclear Export of Viral RNAs 55 76 .
Hal P. Bogerd, Heather L. Wiegand, Jin Yang & Bryan R. Cullen. (2000) Mutational Definition of Functional Domains within the Rev Homolog Encoded by Human Endogenous Retrovirus K. Journal of Virology 74:20, pages 9353-9361.
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Beric R. Henderson & Alexandra Eleftheriou. (2000) A Comparison of the Activity, Sequence Specificity, and CRM1-Dependence of Different Nuclear Export Signals. Experimental Cell Research 256:1, pages 213-224.
Crossref
Jørgen Kjems & Peter Askjaer. 2000. HIV-1: Molecular Biology and Pathogenesis Viral Mechanisms. HIV-1: Molecular Biology and Pathogenesis Viral Mechanisms 251 298 .
Sally G. Pasion & Susan L. Forsburg. (1999) Nuclear Localization of Schizosaccharomyces pombe Mcm2/Cdc19p Requires MCM Complex Assembly . Molecular Biology of the Cell 10:12, pages 4043-4057.
Crossref
Masaki Yamaga, Makoto Fujii, Hideaki Kamata, Hajime Hirata & Hitoshi Yagisawa. (1999) Phospholipase C-δ1 Contains a Functional Nuclear Export Signal Sequence. Journal of Biological Chemistry 274:40, pages 28537-28541.
Crossref
Peter Heger, Olaf Rosorius, Joachim Hauber & Roland H Stauber. (1999) Titration of cellular export factors, but not heteromultimerization, is the molecular mechanism of trans-dominant HTLV-1 Rex mutants. Oncogene 18:28, pages 4080-4090.
Crossref
William H. BiggsIIIIII, Jill Meisenhelder, Tony Hunter, Webster K. Cavenee & Karen C. Arden. (1999) Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proceedings of the National Academy of Sciences 96:13, pages 7421-7426.
Crossref
Mina Watanabe, Makoto Fukuda, Minoru Yoshida, Mitsuhiro Yanagida & Eisuke Nishida. (1999) Involvement of CRM1, a nuclear export receptor, in mRNA export in mammalian cells and fission yeast. Genes to Cells 4:5, pages 291-297.
Crossref
Thomas J. Hope. (1999) The Ins and Outs of HIV Rev. Archives of Biochemistry and Biophysics 365:2, pages 186-191.
Crossref
O. John Semmes, Lin Chen, Robert T. Sarisky, Zhigang Gao, Ling Zhong & S. Diane Hayward. (1998) Mta Has Properties of an RNA Export Protein and Increases Cytoplasmic Accumulation of Epstein-Barr Virus Replication Gene mRNA. Journal of Virology 72:12, pages 9526-9534.
Crossref
Peter Heger, Olaf Rosorius, Claudia Koch, Georg Casari, Ralph Grassmann & Joachim Hauber. (1998) Multimer Formation Is Not Essential for Nuclear Export of Human T-Cell Leukemia Virus Type 1 Rextrans-Activator Protein. Journal of Virology 72:11, pages 8659-8668.
Crossref
Victoria W. PollardMichael H. Malim. (1998) THE HIV-1 REV PROTEIN. Annual Review of Microbiology 52:1, pages 491-532.
Crossref
Yoshiyuki Hakata, Tomoe Umemoto, Shuzo Matsushita & Hisatoshi Shida. (1998) Involvement of Human CRM1 (Exportin 1) in the Export and Multimerization of the Rex Protein of Human T-Cell Leukemia Virus Type 1. Journal of Virology 72:8, pages 6602-6607.
Crossref
Péter Csermely, Tamás Schnaider, Csaba So″ti, Zoltán Prohászka & Gábor Nardai. (1998) The 90-kDa Molecular Chaperone Family. Pharmacology & Therapeutics 79:2, pages 129-168.
Crossref
Salme Taagepera, David McDonald, Jonathan E. Loeb, Laura L. Whitaker, Anita K. McElroy, Jean Y. J. Wang & Thomas J. Hope. (1998) Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase. Proceedings of the National Academy of Sciences 95:13, pages 7457-7462.
Crossref
Peter Askjaer & Jørgen Kjems. (1998) Mapping of Multiple RNA Binding Sites of Human T-cell Lymphotropic Virus Type I Rex Protein within 5′- and 3′-Rex Response Elements. Journal of Biological Chemistry 273:19, pages 11463-11471.
Crossref
Wendy E. Mears & Stephen A. Rice. (1998) The Herpes Simplex Virus Immediate-Early Protein ICP27 Shuttles between Nucleus and Cytoplasm. Virology 242:1, pages 128-137.
Crossref
Ming Jie Zhang & Andrew I. Dayton. (1998) Tolerance of Diverse Amino Acid Substitutions at Conserved Positions in the Nuclear Export Signal (NES) of HIV-1 Rev. Biochemical and Biophysical Research Communications 243:1, pages 113-116.
Crossref
Amy E. Pasquinelli, Maureen A. Powers, Elsebet Lund, Douglass Forbes & James E. Dahlberg. (1997) Inhibition of mRNA export in vertebrate cells by nuclear export signal conjugates. Proceedings of the National Academy of Sciences 94:26, pages 14394-14399.
Crossref
Makoto Fukuda, Isamu Gotoh, Makoto Adachi, Yukiko Gotoh & Eisuke Nishida. (1997) A Novel Regulatory Mechanism in the Mitogen-activated Protein (MAP) Kinase Cascade. Journal of Biological Chemistry 272:51, pages 32642-32648.
Crossref
Makoto Fukuda, Shiro Asano, Takahiro Nakamura, Makoto Adachi, Minoru Yoshida, Mitsuhiro Yanagida & Eisuke Nishida. (1997) CRM1 is responsible for intracellular transport mediated by the nuclear export signal. Nature 390:6657, pages 308-311.
Crossref
David A. Nix & Mary C. Beckerle. (1997) Nuclear–Cytoplasmic Shuttling of the Focal Contact Protein, Zyxin: A Potential Mechanism for Communication between Sites of Cell Adhesion and the Nucleus. Journal of Cell Biology 138:5, pages 1139-1147.
Crossref
Juli D Klemm, Chan R Beals & Gerald R Crabtree. (1997) Rapid targeting of nuclear proteins to the cytoplasm. Current Biology 7:9, pages 638-644.
Crossref
Thomas J. Hope. (1997) Viral RNA export. Chemistry & Biology 4:5, pages 335-344.
Crossref
Margaret S Lee & Pamela A Silver. (1997) RNA movement between the nucleus and the cytoplasm. Current Opinion in Genetics & Development 7:2, pages 212-219.
Crossref
Zsuzsanna Kiss-László & Thomas Hohn. (1996) Pararetro- and retrovirus RNA: splicing and the control of nuclear export. Trends in Microbiology 4:12, pages 480-485.
Crossref

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