Advanced search
Publication Cover
Molecular and Cellular Biology Volume 17, 1997 - Issue 11
Submit an article Journal homepage
13
Views
23
CrossRef citations to date
0
Altmetric
Research Article

Proposed Mechanism for the Stabilization of Nuclear Receptor DNA Binding via Protein Dimerization

Guoqiang JiangEnvironmental Toxicology Graduate Program, University of California, Riverside, California92521
,
Una LeeEnvironmental Toxicology Graduate Program, University of California, Riverside, California92521
&
Frances M. SladekEnvironmental Toxicology Graduate Program, University of California, Riverside, California92521Correspondence[email protected]
Pages 6546-6554 | Received 18 Mar 1997, Accepted 26 Aug 1997, Published online: 29 Mar 2023

Citations (23)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Linh M. Vuong, Karthikeyani Chellappa, Joseph M. Dhahbi, Jonathan R. Deans, Bin Fang, Eugene Bolotin, Nina V. Titova, Nate P. Hoverter, Stephen R. Spindler, Marian L. Waterman & Frances M. Sladek. (2015) Differential Effects of Hepatocyte Nuclear Factor 4α Isoforms on Tumor Growth and T-Cell Factor 4/AP-1 Interactions in Human Colorectal Cancer Cells. Molecular and Cellular Biology 35:20, pages 3471-3490.
Read now
Ying Nie, Heng-Hong Li, Craig M. Bula & Xuan Liu. (2000) Stimulation of p53 DNA Binding by c-Abl Requires the p53 C Terminus and Tetramerization. Molecular and Cellular Biology 20:3, pages 741-748.
Read now
Yoon-Kwang Lee, Helen Dell, Dennis H. Dowhan, Margarita Hadzopoulou-Cladaras & David D. Moore. (2000) The Orphan Nuclear Receptor SHP Inhibits Hepatocyte Nuclear Factor 4 and Retinoid X Receptor Transactivation: Two Mechanisms for Repression. Molecular and Cellular Biology 20:1, pages 187-195.
Read now

Articles from other publishers (20)

Jeffrey L. Hansen & Barak A. Cohen. (2022) A quantitative metric of pioneer activity reveals that HNF4A has stronger in vivo pioneer activity than FOXA1. Genome Biology 23:1.
Crossref
Jeffrey L Hansen, Kaiser J Loell & Barak A Cohen. (2022) A test of the pioneer factor hypothesis using ectopic liver gene activation. eLife 11.
Crossref
Fengwei Li, Chun Song, Youming Zhang & Dalei Wu. (2021) Structural overview and perspectives of the nuclear receptors, a major family as the direct targets for<?A3B2 ACK?>small-molecule drugs. Acta Biochimica et Biophysica Sinica 54:1, pages 12-24.
Crossref
Mei Yang, Jingyu Chen & Wei Wei. (2021) Dimerization of glucocorticoid receptors and its role in inflammation and immune responses. Pharmacological Research 166, pages 105334.
Crossref
Puja Singh, Shu-Ping Tung, Eun Hee Han, In-Kyu Lee & Young-In Chi. (2019) Dimerization defective MODY mutations of hepatocyte nuclear factor 4α. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 814, pages 1-6.
Crossref
Laurent Bianchetti, Bianca Wassmer, Audrey Defosset, Anna Smertina, Marion L. Tiberti, Roland H. Stote & Annick Dejaegere. (2018) Alternative dimerization interfaces in the glucocorticoid receptor-α ligand binding domain. Biochimica et Biophysica Acta (BBA) - General Subjects 1862:8, pages 1810-1825.
Crossref
Vikas Chandra, Pengxiang Huang, Nalini Potluri, Dalei Wu, Youngchang Kim & Fraydoon Rastinejad. (2013) Multidomain integration in the structure of the HNF-4α nuclear receptor complex. Nature 495:7441, pages 394-398.
Crossref
Fridtjof Weltmeier & Juergen Borlak. (2011) A High Resolution Genome-Wide Scan of HNF4α Recognition Sites Infers a Regulatory Gene Network in Colon Cancer. PLoS ONE 6:7, pages e21667.
Crossref
Eugene Bolotin, Hailing Liao, Tuong Chi Ta, Chuhu Yang, Wendy Hwang-Verslues, Jane R. Evans, Tao Jiang & Frances M. Sladek. (2010) Integrated approach for the identification of human hepatocyte nuclear factor 4α target genes using protein binding microarrays. Hepatology 51:2, pages 642-653.
Crossref
Yea Huey Chang, Tin Yun Ho, Chieh Hsi Wu, Chien Yu Chen, Hung Jin Huang, Fuu Jen Tsai, Chang Hai Tsai & Calvin Yu Chian Chen. (2009) Study of AMP-Activated Protein Kinase Agonists by Structure-Based Drug Designing. Advanced Materials Research 79-82, pages 2187-2190.
Crossref
Christopher W. Rowley, Lora J. Staloch, Joyce K. Divine, Sean P. McCaul & Theodore C. Simon. (2006) Mechanisms of mutual functional interactions between HNF-4α and HNF-1α revealed by mutations that cause maturity onset diabetes of the young. American Journal of Physiology-Gastrointestinal and Liver Physiology 290:3, pages G466-G475.
Crossref
Anca D. Petrescu, Rachel Hertz, Jacob Bar-Tana, Friedhelm Schroeder & Ann B. Kier. (2005) Role of Regulatory F-domain in Hepatocyte Nuclear Factor-4α Ligand Specificity. Journal of Biological Chemistry 280:17, pages 16714-16727.
Crossref
Yoko Shimamoto, Junji Ishida, Kazuyuki Yamagata, Tomoko Saito, Hideki Kato, Toshiki Matsuoka, Keiko Hirota, Hiroaki Daitoku, Masaomi Nangaku, Kazuya Yamagata, Hiroshi Fujii, Jun Takeda & Akiyoshi Fukamizu. (2004) Inhibitory Effect of the Small Heterodimer Partner on Hepatocyte Nuclear Factor-4 Mediates Bile Acid-induced Repression of the Human Angiotensinogen Gene. Journal of Biological Chemistry 279:9, pages 7770-7776.
Crossref
Qin Ning, Sophia Lakatoo, Mingfeng Liu, Weiming Yang, Zhimo Wang, M. James Phillips & Gary A. Levy. (2003) Induction of Prothrombinase fgl2 by the Nucleocapsid Protein of Virulent Mouse Hepatitis Virus Is Dependent on Host Hepatic Nuclear Factor-4α. Journal of Biological Chemistry 278:18, pages 15541-15549.
Crossref
Hongtao Guo, Junping Wei, Yusuke Inoue, Frank J. Gonzalez & Paul C. Kuo. (2003) Serine/threonine phosphorylation regulates HNF-4α-dependent redox-mediated iNOS expression in hepatocytes. American Journal of Physiology-Cell Physiology 284:4, pages C1090-C1099.
Crossref
Vincent Laudet & Hinrich Gronemeyer. 2002. The Nuclear Receptor FactsBook. The Nuclear Receptor FactsBook 238 247 .
Frances M. Sladek & Shawn D. Seidel. 2001. Nuclear Receptors and Genetic Disease. Nuclear Receptors and Genetic Disease 309 361 .
Andrew A. Bogan, Qing Dallas-Yang, Michael D. RuseJrJr, Yutaka Maeda, Guoqiang Jiang, Luviminda Nepomuceno, Thomas S. Scanlan, Fred E. Cohen & Frances M. Sladek. (2000) Analysis of protein dimerization and ligand binding of orphan receptor HNF4α. Journal of Molecular Biology 302:4, pages 831-851.
Crossref
B. Laine, J. Eeckhoute, L. Suaud, I. Briche, H. Furuta, G.I. Bell & P. Formstecher. (2000) Functional properties of the R154X HNF-4α protein generated by a mutation associated with maturity-onset diabetes of the young, type 1. FEBS Letters 479:1-2, pages 41-45.
Crossref
Helen Dell & Margarita Hadzopoulou-Cladaras. (1999) CREB-binding Protein Is a Transcriptional Coactivator for Hepatocyte Nuclear Factor-4 and Enhances Apolipoprotein Gene Expression. Journal of Biological Chemistry 274:13, pages 9013-9021.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.