Advanced search
Publication Cover
Molecular and Cellular Biology Volume 17, 1997 - Issue 11
Submit an article Journal homepage
9
Views
67
CrossRef citations to date
0
Altmetric
Research Article

Inhibition of trans-Retinoic Acid-Resistant Human Breast Cancer Cell Growth by Retinoid X Receptor-Selective Retinoids

Qiao Wu1 The Burnham Institute, La Jolla Cancer Research Center, La Jolla, California92037
,
Marcia I. Dawson2 Retinoid Program, SRI International, Menlo Park, California94025
,
Yun Zheng1 The Burnham Institute, La Jolla Cancer Research Center, La Jolla, California92037
,
Peter D. Hobbs2 Retinoid Program, SRI International, Menlo Park, California94025
,
Anissa Agadir1 The Burnham Institute, La Jolla Cancer Research Center, La Jolla, California92037
,
Ling Jong2 Retinoid Program, SRI International, Menlo Park, California94025
,
Yin Li1 The Burnham Institute, La Jolla Cancer Research Center, La Jolla, California92037
,
Ru Liu1 The Burnham Institute, La Jolla Cancer Research Center, La Jolla, California92037
,
Bingzhen Lin1 The Burnham Institute, La Jolla Cancer Research Center, La Jolla, California92037
&
Xiao-Kun Zhang1 The Burnham Institute, La Jolla Cancer Research Center, La Jolla, California92037Correspondence[email protected]
 show all
Pages 6598-6608 | Received 10 Mar 1997, Accepted 14 Aug 1997, Published online: 29 Mar 2023

Citations (67)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (8)

Matlola Bopape, Charlette Tiloke & Claudia Ntsapi. (2023) Moringa oleifera and Autophagy: Evidence from In Vitro Studies on Chaperone-Mediated Autophagy in HepG2 Cancer Cells. Nutrition and Cancer 75:10, pages 1822-1847.
Read now
Syng-Ook Lee, Xi Li, Shaheen Khan & Stephen Safe. (2011) Targeting NR4A1 (TR3) in cancer cells and tumors. Expert Opinion on Therapeutic Targets 15:2, pages 195-206.
Read now
Joana D Amaral, Susana Solá, Clifford J Steer & Cecília P Rodrigues. (2007) Function of nuclear steroid receptors in apoptosis: role of ursodeoxycholic acid. Expert Review of Endocrinology & Metabolism 2:4, pages 487-501.
Read now
Xiao-kun Zhang. (2007) Targeting Nur77 translocation. Expert Opinion on Therapeutic Targets 11:1, pages 69-79.
Read now
Xihua Cao, Wen Liu, Feng Lin, Hui Li, Siva Kumar Kolluri, Bingzhen Lin, Young-hoon Han, Marcia I. Dawson & Xiao-kun Zhang. (2004) Retinoid X Receptor Regulates Nur77/Thyroid Hormone Receptor 3-Dependent Apoptosis by Modulating Its Nuclear Export and Mitochondrial Targeting. Molecular and Cellular Biology 24:22, pages 9705-9725.
Read now
T. Tanaka, B. L. Dancheck, L. C. Trifiletti, R. E. Birnkrant, B. J. Taylor, S. H. Garfield, U. Thorgeirsson & L. M. De Luca. (2004) Altered Localization of Retinoid X Receptor α Coincides with Loss of Retinoid Responsiveness in Human Breast Cancer MDA-MB-231 Cells. Molecular and Cellular Biology 24:9, pages 3972-3982.
Read now
Siva Kumar Kolluri, Nathalie Bruey-Sedano, Xihua Cao, Bingzhen Lin, Feng Lin, Young-Hoon Han, Marcia I. Dawson & Xiao-kun Zhang. (2003) Mitogenic Effect of Orphan Receptor TR3 and Its Regulation by MEKK1 in Lung Cancer Cells. Molecular and Cellular Biology 23:23, pages 8651-8667.
Read now
Shi-Yong Sun. (2002) Recent developments of retinoids as therapeutic agents. Expert Opinion on Therapeutic Patents 12:4, pages 529-542.
Read now

Articles from other publishers (59)

Qiong-Ying Hu, Jie Liu, Xiao-Kun Zhang, Wan-Ting Yang, Yu-Tian Tao, Ce Chen, Ye-He Qian, Jin-Shan Tang, Xin-Sheng Yao, Ying-He Xu & Jing-Hui Wang. (2023) Nur77 Serves as a Potential Prognostic Biomarker That Correlates with Immune Infiltration and May Act as a Good Target for Prostate adenocarcinoma. Molecules 28:3, pages 1238.
Crossref
Nisha Rani Dahiya, Boris A. Leibovitch, Rama Kadamb, Nidhi Bansal & Samuel Waxman. (2022) The Sin3A/MAD1 Complex, through Its PAH2 Domain, Acts as a Second Repressor of Retinoic Acid Receptor Beta Expression in Breast Cancer Cells. Cells 11:7, pages 1179.
Crossref
Baixue Li, Shi-Ying Cai & James L. Boyer. (2021) The role of the retinoid receptor, RAR/RXR heterodimer, in liver physiology. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1867:5, pages 166085.
Crossref
Tarek Ibrahim, Mahmoud N.El Rouby, El-Sayed A.M. Al-Sherbini, Amr H.El Noury & Mona E. Morsy. (2016) Photodecomposition, photomutagenicity and photocytotoxicity of retinyl palmitate under He–Ne laser photoirradiation and its effects on photodynamic therapy of cancer cells in vitro. Photodiagnosis and Photodynamic Therapy 13, pages 316-322.
Crossref
Lei Xie, Fuquan Jiang, Xindao Zhang, Gulimiran Alitongbieke, Xinlei Shi, MinJun Meng, Yiming Xu, Anshi Ren, Jing Wang, Lijun Cai, Yunxia Zhou, Yang Xu, Ying Su, Jie Liu, Zhiping Zeng, Guanghui Wang, Hu Zhou, Quan Cheng Chen & Xiao-kun Zhang. (2016) Honokiol sensitizes breast cancer cells to TNF-α induction of apoptosis by inhibiting Nur77 expression. British Journal of Pharmacology 173:2, pages 344-356.
Crossref
Sonja Khan, Deirdre Wall, Catherine Curran, John Newell, Michael J Kerin & Roisin M Dwyer. (2015) MicroRNA-10a is reduced in breast cancer and regulated in part through retinoic acid. BMC Cancer 15:1.
Crossref
Mani Roshan-Moniri, Michael Hsing, Miriam S. Butler, Artem Cherkasov & Paul S. Rennie. (2014) Orphan nuclear receptors as drug targets for the treatment of prostate and breast cancers. Cancer Treatment Reviews 40:10, pages 1137-1152.
Crossref
Xue-Jian Wang, Yu Duan, Zong-Tao Li, Jin-Hong Feng, Xiang-Po Pan, Xiu-Rong Zhang, Li-Hong Shi & Tao Zhang. (2014) Preparation and Antitumor Activity of a Tamibarotene-Furoxan Derivative. Asian Pacific Journal of Cancer Prevention 15:15, pages 6343-6347.
Crossref
Shauna N. Vasilatos, Tiffany A. Katz, Steffi Oesterreich, Yong Wan, Nancy E. Davidson & Yi Huang. (2013) Crosstalk between lysine-specific demethylase 1 (LSD1) and histone deacetylases mediates antineoplastic efficacy of HDAC inhibitors in human breast cancer cells. Carcinogenesis 34:6, pages 1196-1207.
Crossref
De-Fu Sun, Zu-Hua Gao, Hui-Ping Liu, Yi Yuan & Xian-Jun Qu. (2012) Sphingosine 1-phosphate antagonizes the effect of all-trans retinoic acid (ATRA) in a human colon cancer cell line by modulation of RARβ expression. Cancer Letters 319:2, pages 182-189.
Crossref
Z Sun, X Cao, M-M Jiang, Y Qiu, H Zhou, L Chen, B Qin, H Wu, F Jiang, J Chen, J Liu, Y Dai, H-F Chen, Q-Y Hu, Z Wu, J-Z Zeng, X-S Yao & X-K Zhang. (2011) Inhibition of β-catenin signaling by nongenomic action of orphan nuclear receptor Nur77. Oncogene 31:21, pages 2653-2667.
Crossref
Özlem Darcansoy İşeri, Meltem Demirel Kars & Ufuk Gündüz. (2011) Two different docetaxel resistant MCF-7 sublines exhibited different gene expression pattern. Molecular Biology Reports 39:4, pages 3505-3516.
Crossref
Yi Huang, Shauna N. Vasilatos, Lamia Boric, Patrick G. Shaw & Nancy E. Davidson. (2011) Inhibitors of histone demethylation and histone deacetylation cooperate in regulating gene expression and inhibiting growth in human breast cancer cells. Breast Cancer Research and Treatment 131:3, pages 777-789.
Crossref
Donald J. AbrahamMarcia I. Dawson. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 369 546 .
Limin Liu, Fadila Derguini & Lorraine J. Gudas. (2009) Metabolism and regulation of gene expression by 4-oxoretinol versus all- trans retinoic acid in normal human mammary epithelial cells . Journal of Cellular Physiology 220:3, pages 771-779.
Crossref
Marcia I. Dawson, Mao Ye, Xihua Cao, Lulu Farhana, Qiong-Ying Hu, Yong Zhao, Li Ping Xu, Alice Kiselyuk, Ricardo G. Correa, Li Yang, Tingjun Hou, John C. Reed, Pamela Itkin-Ansari, Fred Levine, Michel F. Sanner, Joseph A. Fontana & Xiao-Kun Zhang. (2009) Derivation of a Retinoid X Receptor Scaffold from Peroxisome Proliferator-Activated Receptor γ Ligand 1-Di(1 H -indol-3-yl)methyl-4-trifluoromethylbenzene . ChemMedChem 4:7, pages 1106-1119.
Crossref
Yanyan Zhan, Xiping Du, Hangzi Chen, Jingjing Liu, Bixing Zhao, Danhong Huang, Guideng Li, Qingyan Xu, Mingqing Zhang, Bart C Weimer, Dong Chen, Zhe Cheng, Lianru Zhang, Qinxi Li, Shaowei Li, Zhonghui Zheng, Siyang Song, Yaojian Huang, Zhiyun Ye, Wenjin Su, Sheng-Cai Lin, Yuemao Shen & Qiao Wu. (2008) Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nature Chemical Biology 4:9, pages 548-556.
Crossref
Wen-xiu Zhao, Min Tian, Bi-xing Zhao, Gui-deng Li, Bo Liu, Yan-yan Zhan, Hang-zi Chen & Qiao Wu. (2007) Orphan Receptor TR3 Attenuates the p300-Induced Acetylation of Retinoid X Receptor-α. Molecular Endocrinology 21:12, pages 2877-2889.
Crossref
Hexin Chen, Huiping Zhang, Jishin Lee, Xiaohui Liang, Xinyan Wu, Tao Zhu, Pang-kuo Lo, Xiaokun Zhang & Saraswati Sukumar. (2007) HOXA5 Acts Directly Downstream of Retinoic Acid Receptor β and Contributes to Retinoic Acid–Induced Apoptosis and Growth Inhibition . Cancer Research 67:17, pages 8007-8013.
Crossref
Gregory S. Gorman, Lori Coward, Corenna Kerstner-Wood, Lea Cork, Izet M. Kapetanovic, Wayne J. Brouillette & Donald D. Muccio. (2007) In Vitro Metabolic Characterization, Phenotyping, and Kinetic Studies of 9cUAB30, a Retinoid X Receptor-Specific Retinoid. Drug Metabolism and Disposition 35:7, pages 1157-1164.
Crossref
Hang-Zi Chen & Qiao Wu. (2007) A novel function of p53 in TR3-MDM2 cross-talk. Cell Research 17:4, pages 293-294.
Crossref
Bi-xing Zhao, Hang-zi Chen, Na-zi Lei, Gui-deng Li, Wen-xiu Zhao, Yan-yan Zhan, Bo Liu, Sheng-cai Lin & Qiao Wu. (2006) p53 mediates the negative regulation of MDM2 by orphan receptor TR3. The EMBO Journal 25:24, pages 5703-5715.
Crossref
U M Moll, N Marchenko & X-k Zhang. (2006) p53 and Nur77/TR3 – transcription factors that directly target mitochondria for cell death induction. Oncogene 25:34, pages 4725-4743.
Crossref
John L. Stebbins, Dawoon Jung, Marilisa Leone, Xiao-kun Zhang & Maurizio Pellecchia. (2006) A Structure-based Approach to Retinoid X Receptor-α Inhibition. Journal of Biological Chemistry 281:24, pages 16643-16648.
Crossref
Y-H Han, X Cao, B Lin, F Lin, S K Kolluri, J Stebbins, J C Reed, M I Dawson & X-k Zhang. (2006) Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt. Oncogene 25:21, pages 2974-2986.
Crossref
Kuk-Wha Lee, Liqun Ma, Xinmin Yan, Bingrong Liu, Xiao-kun Zhang & Pinchas Cohen. (2005) Rapid Apoptosis Induction by IGFBP-3 Involves an Insulin-like Growth Factor-independent Nucleomitochondrial Translocation of RXRα/Nur77. Journal of Biological Chemistry 280:17, pages 16942-16948.
Crossref
A Szanto, V Narkar, Q Shen, I P Uray, P J A Davies & L Nagy. (2004) Retinoid X receptors: X-ploring their (patho)physiological functions. Cell Death & Differentiation 11:S2, pages S126-S143.
Crossref
Xiao-Feng Lin, Bi-Xing Zhao, Hang-Zhi Chen, Xiao-Feng Ye, Chao-Yi Yang, Hai-Ying Zhou, Ming-Qing Zhang, Sheng-Cai Lin & Qiao Wu. (2004) RXRα acts as a carrier for TR3 nuclear export in a 9-cis retinoic acid-dependent manner in gastric cancer cells. Journal of Cell Science 117:23, pages 5609-5621.
Crossref
David L Crowe & Roshantha AS Chandraratna. (2004) A retinoid X receptor (RXR)-selective retinoid reveals that RXR-α is potentially a therapeutic target in breast cancer cell lines, and that it potentiates antiproliferative and apoptotic responses to peroxisome proliferator-activated receptor ligands. Breast Cancer Research 6:5.
Crossref
Xiao-feng Ye, Qiao Wu, Su Liu, Xiao-feng Lin, Bing Zhang, Jia-fa Wu, Jian-huai Cai, Ming-qing Zhang & Wen-jin Su. (2004) Distinct role and functional mode of TR3 and RARα in mediating ATRA-induced signalling pathway in breast and gastric cancer cells. The International Journal of Biochemistry & Cell Biology 36:1, pages 98-113.
Crossref
Shaija Samuel & Lori R. Bernstein. (2004) Adhesion, migration, transcriptional, interferon-inducible, and other signaling molecules newly implicated in cancer susceptibility and resistance of JB6 cells by cDNA microarray analyses. Molecular Carcinogenesis 39:1, pages 34-60.
Crossref
Francesca Scarlatti, Giusy Sala, Giulia Somenzi, Paola Signorelli, Nicoletta Sacchi & Riccardo Ghidoni. (2003) Resveratrol induces growth inhibition and apoptosis in metastatic breast cancer cells via de novo ceramide signaling. The FASEB Journal 17:15, pages 2339-2341.
Crossref
Tue Nguyen, Jayne E Hocker, Wayne Thomas, Stewart A Smith, Murray D Norris, Michelle Haber, Belamy Cheung & Glenn M Marshall. (2003) Combined RARα- and RXR-specific ligands overcome N-myc-associated retinoid resistance in neuroblastoma cells. Biochemical and Biophysical Research Communications 302:3, pages 462-468.
Crossref
Xiao-Feng Ye. (2003) Degradation of retinoid X receptor α by TPA through proteasome pathway in gastric cancer cells. World Journal of Gastroenterology 9:9, pages 1915.
Crossref
Qifeng Yang, Takeo Sakurai & Kennichi Kakudo. (2002) Retinoid, Retinoic Acid Receptor β and Breast Cancer. Breast Cancer Research and Treatment 76:2, pages 167-173.
Crossref
Qiao Wu, Zheng-ming Chen & Wen-jin Su. (2002) Anticancer effect of retinoic acid via AP-1 activity repression is mediated by retinoic acid receptor α and β in gastric cancer cells. The International Journal of Biochemistry & Cell Biology 34:9, pages 1102-1114.
Crossref
Naiyer A. RizviJohn L. MarshallElizabeth NessMichael J. HawkinsCraig KesslerHelena JacobsWayne D. BrenckmanJrJrJin S. LeeWilliam PetrosWaun K. HongJonathan M. Kurie. (2002) Initial Clinical Trial of Oral TAC-101, a Novel Retinoic Acid Receptor-Alpha Selective Retinoid, in Patients With Advanced Cancer. Journal of Clinical Oncology 20:16, pages 3522-3532.
Crossref
Feng Lin, Siva Kumar Kolluri, Guo-quan Chen & Xiao-kun Zhang. (2002) Regulation of Retinoic Acid-induced Inhibition of AP-1 Activity by Orphan Receptor Chicken Ovalbumin Upstream Promoter-Transcription Factor. Journal of Biological Chemistry 277:24, pages 21414-21422.
Crossref
Guo-quan Chen, Bingzhen Lin, Marcia I. Dawson & Xiao-kun Zhang. (2002) Nicotine modulates the effects of retinoids on growth inhibition and RAR? expression in lung cancer cells. International Journal of Cancer 99:2, pages 171-178.
Crossref
Su Liu. (2002) Induction of apoptosis by TPA and VP-16 is through translocation of TR3. World Journal of Gastroenterology 8:3, pages 446.
Crossref
Maria I. Arenas, Juan Alfaro & Ricardo Paniagua. 2002. Molecular Pathology, Colorectal Carcinoma, and Prostate Carcinoma. Molecular Pathology, Colorectal Carcinoma, and Prostate Carcinoma 399 408 .
Su Liu, Qiao Wu & Zheng-Ming Chen and Wen-Jin Su. (2001) The effect pathway of retinoic acid through regulation of retinoic acid receptor α in gastric cancer cells. World Journal of Gastroenterology 7:5, pages 662.
Crossref
Arthur C.-K. Chung & Austin J. Cooney. 2001. Nuclear Receptors and Genetic Disease. Nuclear Receptors and Genetic Disease 245 295 .
Hui WangXuan ZhengFrederick G. BehmManohar Ratnam. (2000) Differentiation-independent retinoid induction of folate receptor type β, a potential tumor target in myeloid leukemia. Blood 96:10, pages 3529-3536.
Crossref
Hui WangXuan ZhengFrederick G. BehmManohar Ratnam. (2000) Differentiation-independent retinoid induction of folate receptor type β, a potential tumor target in myeloid leukemia. Blood 96:10, pages 3529-3536.
Crossref
Hui LiSiva Kumar KolluriJian GuMarcia I. DawsonXihua CaoPeter D. HobbsBingzhen LinGuo-quen ChenJiang-song LuFeng LinZhihua XieJoseph A. FontanaJohn C. ReedXiao-kun Zhang. (2000) Cytochrome c Release and Apoptosis Induced by Mitochondrial Targeting of Nuclear Orphan Receptor TR3. Science 289:5482, pages 1159-1164.
Crossref
Marcia I Dawson, Ling Jong, Peter D Hobbs, Dongmei Xiao, Kai-Chia Feng, Wan-ru Chao, Chin Pan, Joseph A Fontana & Xiao-kun Zhang. (2000) 4-[3-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoic acid and heterocyclic-bridged analogues are novel retinoic acid receptor subtype and retinoid X receptor α agonists. Bioorganic & Medicinal Chemistry Letters 10:12, pages 1311-1313.
Crossref
Marcia I Dawson, Peter D Hobbs, Ling Jong, Dongmei Xiao, Wan-ru Chao, Chin Pan & Xiao-kun Zhang. (2000) sp2-bridged diaryl retinoids: Effects of bridge-region substitution on retinoid x receptor (RXR) selectivity. Bioorganic & Medicinal Chemistry Letters 10:12, pages 1307-1310.
Crossref
Sejal H Desai, Goran Boskovic, Linda Eastham, Marcia Dawson & Richard M Niles. (2000) Effect of receptor-selective retinoids on growth and differentiation pathways in mouse melanoma cells. Biochemical Pharmacology 59:10, pages 1265-1275.
Crossref
Hakim Bouterfa, Thomas Picht, Daniel Ke, Christian Herbold, Elizabeth Noll, Peter McL. Black, Klaus Roosen & Jörg C. Tonn. (2000) Retinoids Inhibit Human Glioma Cell Proliferation and Migration in Primary Cell Cultures But Not in Established Cell Lines. Neurosurgery 46:2, pages 419-430.
Crossref
S. Toma, P. Raffo & L. Isnardi. 2000. Vitamin A and Retinoids: An Update of Biological Aspects and Clinical Applications. Vitamin A and Retinoids: An Update of Biological Aspects and Clinical Applications 209 219 .
M. I. Dawson, X. Zhang, P. D. Hobbs & L. Jong. 2000. Vitamin A and Retinoids: An Update of Biological Aspects and Clinical Applications. Vitamin A and Retinoids: An Update of Biological Aspects and Clinical Applications 161 196 .
Yong Li, Michele A. Glozak, Susan M. Smith & Melissa B. Rogers. (1999) The Expression and Activity of D-Type Cyclins in F9 Embryonal Carcinoma Cells: Modulation of Growth by RXR-Selective Retinoids. Experimental Cell Research 253:2, pages 372-384.
Crossref
Sonja M. Schneider, Martin Offterdinger, Heinz Huber & Thomas W. Grunt. (1999) Involvement of nuclear steroid/thyroid/retinoid receptors and of protein kinases in the regulation of growth and of c‐erbB and retinoic acid receptor expression in MCF‐7 breast cancer cells. Breast Cancer Research and Treatment 58:2, pages 171-181.
Crossref
Vincent Giguère. (1999) Orphan Nuclear Receptors: From Gene to Function*. Endocrine Reviews 20:5, pages 689-725.
Crossref
B. Harvat & A. M. Jetten. 1999. Retinoids. Retinoids 239 276 .
F. Javier Piedrafita & M. Pfahl. 1999. Retinoids. Retinoids 153 184 .
Guizhong Liu, Min Wu, Giovanni Levi & Nicoletta Ferrari. (1998) Inhibition of cancer cell growth by all-trans retinoic acid and its analog N-(4-hydroxyphenyl) retinamide: a possible mechanism of actionvia regulation of retinoid receptors expression. International Journal of Cancer 78:2, pages 248-254.
Crossref
Ru Liu, Shinichi Takayama, Yun Zheng, Barbara Froesch, Guo-quan Chen, Xin Zhang, John C. Reed & Xiao-kun Zhang. (1998) Interaction of BAG-1 with Retinoic Acid Receptor and Its Inhibition of Retinoic Acid-induced Apoptosis in Cancer Cells. Journal of Biological Chemistry 273:27, pages 16985-16992.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.