28
Views
58
CrossRef citations to date
0
Altmetric
Research Article

Binding of Eukaryotic Translation Initiation Factor 4E (eIF4E) to eIF4G Represses Translation of Uncapped mRNA

&
Pages 6876-6886 | Received 14 Jul 1997, Accepted 03 Sep 1997, Published online: 29 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Ka Young Hong, Seung Hwan Lee, Sohyun Gu, Eunah Kim, Sihyeon An, Junyoung Kwon, Jong-Bong Lee & Sung Key Jang. (2017) The bent conformation of poly(A)-binding protein induced by RNA-binding is required for its translational activation function. RNA Biology 14:3, pages 370-377.
Read now
Andrew Sobala & Gyorgy Hutvagner. (2013) Small RNAs derived from the 5′ end of tRNA can inhibit protein translation in human cells. RNA Biology 10:4, pages 553-563.
Read now
Chingakham Ranjit Singh, Ryosuke Watanabe, Wasimul Chowdhury, Hiroyuki Hiraishi, Marcelo J. Murai, Yasufumi Yamamoto, David Miles, Yuka Ikeda, Masayo Asano & Katsura Asano. (2012) Sequential Eukaryotic Translation Initiation Factor 5 (eIF5) Binding to the Charged Disordered Segments of eIF4G and eIF2β Stabilizes the 48S Preinitiation Complex and Promotes Its Shift to the Initiation Mode. Molecular and Cellular Biology 32:19, pages 3978-3989.
Read now
Hui He, Tobias von der Haar, C. Ranjit Singh, Miki Ii, Bin Li, Alan G. Hinnebusch, John E. G. McCarthy & Katsura Asano. (2003) The Yeast Eukaryotic Initiation Factor 4G (eIF4G) HEAT Domain Interacts with eIF1 and eIF5 and Is Involved in Stringent AUG Selection. Molecular and Cellular Biology 23:15, pages 5431-5445.
Read now
Maja Hemmings-Mieszczak, Thomas Hohn & Thomas Preiss. (2000) Termination and Peptide Release at the Upstream Open Reading Frame Are Required for Downstream Translation on Synthetic Shunt-Competent mRNA Leaders. Molecular and Cellular Biology 20:17, pages 6212-6223.
Read now
Gregory P. Cosentino, Tobias Schmelzle, Ashkan Haghighat, Stephen B. Helliwell, Michael N. Hall & Nahum Sonenberg. (2000) Eap1p, a Novel Eukaryotic Translation Initiation Factor 4E-Associated Protein in Saccharomyces cerevisiae. Molecular and Cellular Biology 20:13, pages 4604-4613.
Read now
Carrie L. Neff & Alan B. Sachs. (1999) Eukaryotic Translation Initiation Factors 4G and 4A from Saccharomyces cerevisiae Interact Physically and Functionally. Molecular and Cellular Biology 19:8, pages 5557-5564.
Read now

Articles from other publishers (51)

Mahabub Pasha Mohammad, Anna Smirnova, Stanislava Gunišová & Leoš Shivaya Valášek. (2021) eIF4G is retained on ribosomes elongating and terminating on short upstream ORFs to control reinitiation in yeast. Nucleic Acids Research 49:15, pages 8743-8756.
Crossref
Ebelechukwu C. Nwokoye, Eiman AlNaseem, Robert A. Crawford, Lydia M. Castelli, Martin D. Jennings, Christopher J. Kershaw & Graham D. Pavitt. (2021) Overlapping regions of Caf20 mediate its interactions with the mRNA-5′cap-binding protein eIF4E and with ribosomes. Scientific Reports 11:1.
Crossref
Ecem Esencan & Emre Seli. 2019. Human Reproductive and Prenatal Genetics. Human Reproductive and Prenatal Genetics 221 239 .
Astrid A. Glück, Eleonora Orlando, Dominic Leiser, Michaela Poliaková, Lluís Nisa, Aurélie Quintin, Jacopo Gavini, Deborah M. Stroka, Sabina Berezowska, Lukas Bubendorf, Andree Blaukat, Daniel M. Aebersold, Michaela Medová & Yitzhak Zimmer. (2018) Identification of a MET-eIF4G1 translational regulation axis that controls HIF-1α levels under hypoxia. Oncogene 37:30, pages 4181-4196.
Crossref
Pragyan Singh, Upasana Saha, Sunirmal Paira & Biswadip Das. (2018) Nuclear mRNA Surveillance Mechanisms: Function and Links to Human Disease. Journal of Molecular Biology 430:14, pages 1993-2013.
Crossref
Nick Arndt, Daniela Ross-Kaschitza, Artyom Kojukhov, Anton A. Komar & Michael Altmann. (2018) Properties of the ternary complex formed by yeast eIF4E, p20 and mRNA. Scientific Reports 8:1.
Crossref
Jared May, Philip Johnson, Huma Saleem & Anne E. Simon. (2017) A Sequence-Independent, Unstructured Internal Ribosome Entry Site Is Responsible for Internal Expression of the Coat Protein of Turnip Crinkle Virus. Journal of Virology 91:8.
Crossref
Satarupa Das & Biswadip Das. (2016) eIF4G—an integrator of mRNA metabolism?. FEMS Yeast Research 16:7, pages fow087.
Crossref
Thomas E Dever, Terri Goss Kinzy & Graham D Pavitt. (2016) Mechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae . Genetics 203:1, pages 65-107.
Crossref
Joseph Costello, Lydia M Castelli, William Rowe, Christopher J Kershaw, David Talavera, Sarah S Mohammad-Qureshi, Paul F G Sims, Christopher M Grant, Graham D Pavitt, Simon J Hubbard & Mark P Ashe. (2015) Global mRNA selection mechanisms for translation initiation. Genome Biology 16:1.
Crossref
Leena Sathe, Cheryl Bolinger, M. Amin-ul Mannan, Thomas E. Dever & Madhusudan Dey. (2015) Evidence That Base-pairing Interaction between Intron and mRNA Leader Sequences Inhibits Initiation of HAC1 mRNA Translation in Yeast. Journal of Biological Chemistry 290:36, pages 21821-21832.
Crossref
Amber Howard & Aric N. Rogers. (2014) Role of translation initiation factor 4G in lifespan regulation and age-related health. Ageing Research Reviews 13, pages 115-124.
Crossref
Yoram Zarai, Michael Margaliot & Tamir Tuller. (2013) Explicit Expression for the Steady-State Translation Rate in the Infinite-Dimensional Homogeneous Ribosome Flow Model. IEEE/ACM Transactions on Computational Biology and Bioinformatics 10:5, pages 1322-1328.
Crossref
Michael Margaliot & Tamir Tuller. (2013) Ribosome flow model with positive feedback. Journal of The Royal Society Interface 10:85, pages 20130267.
Crossref
Eun-Hee Park, Sarah E. Walker, Fujun Zhou, Joseph M. Lee, Vaishnavi Rajagopal, Jon R. Lorsch & Alan G. Hinnebusch. (2013) Yeast Eukaryotic Initiation Factor 4B (eIF4B) Enhances Complex Assembly between eIF4A and eIF4G in Vivo. Journal of Biological Chemistry 288:4, pages 2340-2354.
Crossref
Vaishnavi Rajagopal, Eun-Hee Park, Alan G. Hinnebusch & Jon R. Lorsch. (2012) Specific Domains in Yeast Translation Initiation Factor eIF4G Strongly Bias RNA Unwinding Activity of the eIF4F Complex toward Duplexes with 5′-Overhangs. Journal of Biological Chemistry 287:24, pages 20301-20312.
Crossref
Pavel Ivanov, Mohamed M. Emara, Judit Villen, Steven P. Gygi & Paul Anderson. (2011) Angiogenin-Induced tRNA Fragments Inhibit Translation Initiation. Molecular Cell 43:4, pages 613-623.
Crossref
Eun-Hee Park, Sarah E Walker, Joseph M Lee, Stefan Rothenburg, Jon R Lorsch & Alan G Hinnebusch. (2011) Multiple elements in the eIF4G1 N-terminus promote assembly of eIF4G1•PABP mRNPs in vivo . The EMBO Journal 30:2, pages 302-316.
Crossref
Sarah F. Mitchell, Sarah E. Walker, Vaishnavi Rajagopal, Colin Echeverría Aitken & Jon R. Lorsch. 2011. Ribosomes. Ribosomes 155 169 .
Frances M. Gratacós & Gary Brewer. (2010) The role of AUF1 in regulated mRNA decay. Wiley Interdisciplinary Reviews: RNA 1:3, pages 457-473.
Crossref
Sarah F. Mitchell, Sarah E. Walker, Mikkel A. Algire, Eun-Hee Park, Alan G. Hinnebusch & Jon R. Lorsch. (2010) The 5′-7-Methylguanosine Cap on Eukaryotic mRNAs Serves Both to Stimulate Canonical Translation Initiation and to Block an Alternative Pathway. Molecular Cell 39:6, pages 950-962.
Crossref
Ryosuke Watanabe, Marcelo Jun Murai, Chingakham Ranjit Singh, Stephanie Fox, Miki Ii & Katsura Asano. (2010) The Eukaryotic Initiation Factor (eIF) 4G HEAT Domain Promotes Translation Re-initiation in Yeast Both Dependent on and Independent of eIF4A mRNA Helicase. Journal of Biological Chemistry 285:29, pages 21922-21933.
Crossref
Xiaobing ZuoJinbu WangPing YuDan EylerHuan XuMary R. StarichDavid M. TiedeAnne E. SimonWojciech KasprzakCharles D. SchwietersBruce A. Shapiro & Yun-Xing Wang. (2010) Solution structure of the cap-independent translational enhancer and ribosome-binding element in the 3 ′ UTR of turnip crinkle virus . Proceedings of the National Academy of Sciences 107:4, pages 1385-1390.
Crossref
Chingakham Ranjit Singh, Tsuyoshi Udagawa, Bumjun Lee, Sarah Wassink, Hui He, Yasufumi Yamamoto, James T. Anderson, Graham D. Pavitt & Katsura Asano. (2007) Change in Nutritional Status Modulates the Abundance of Critical Pre-initiation Intermediate Complexes During Translation Initiation in Vivo. Journal of Molecular Biology 370:2, pages 315-330.
Crossref
Christiane Jünemann, Yutong Song, Gergis Bassili, Dagmar Goergen, Jura Henke & Michael Niepmann. (2007) Picornavirus Internal Ribosome Entry Site Elements Can Stimulate Translation of Upstream Genes. Journal of Biological Chemistry 282:1, pages 132-141.
Crossref
Bumjun Lee, Tsuyoshi Udagawa, Chingakham Ranjit Singh & Katsura Asano. 2007. Translation Initiation: Extract Systems and Molecular Genetics. Translation Initiation: Extract Systems and Molecular Genetics 105 137 .
Aurélie M. Rakotondrafara, Charlotta Polacek, Eva Harris & W. Allen Miller. (2006) Oscillating kissing stem–loop interactions mediate 5′ scanning-dependent translation by a viral 3′-cap-independent translation element. RNA 12:10, pages 1893-1906.
Crossref
R. Grzela, L. Strokovska, J.-P. Andrieu, B. Dublet, W. Zagorski & J. Chroboczek. (2006) Potyvirus terminal protein VPg, effector of host eukaryotic initiation factor eIF4E. Biochimie 88:7, pages 887-896.
Crossref
Muhammad M. Karim, Yuri V. Svitkin, Avak Kahvejian, Gregory De Crescenzo, Mauro Costa-Mattioli & Nahum Sonenberg. (2006) A mechanism of translational repression by competition of Paip2 with eIF4G for poly(A) binding protein (PABP) binding. Proceedings of the National Academy of Sciences 103:25, pages 9494-9499.
Crossref
Dianna Edgil, Charlotta Polacek & Eva Harris. (2006) Dengue Virus Utilizes a Novel Strategy for Translation Initiation When Cap-Dependent Translation Is Inhibited. Journal of Virology 80:6, pages 2976-2986.
Crossref
Federica Piccioni, Vincenzo Zappavigna & Arturo C. Verrotti. (2005) Translational regulation during oogenesis and early development: The cap-poly(A) tail relationship. Comptes Rendus Biologies 328:10-11, pages 863-881.
Crossref
John D. Gross, Nathan J. Moerke, Tobias von der Haar, Alexey A. Lugovskoy, Alan B. Sachs, John E.G. McCarthy & Gerhard Wagner. (2003) Ribosome Loading onto the mRNA Cap Is Driven by Conformational Coupling between eIF4G and eIF4E. Cell 115:6, pages 739-750.
Crossref
Thomas Preiss & Matthias W. Hentze. (2003) Starting the protein synthesis machine: eukaryotic translation initiation. BioEssays 25:12, pages 1201-1211.
Crossref
Jong-Jin Han & Gynheung An. (2003) Flower-preferential poly(A) binding (PAB) protein gene from rice. Plant Science 165:1, pages 103-112.
Crossref
JULIE BARON-BENHAMOU, PURI FORTES, TOSHIFUMI INADA, THOMAS PREISS & MATTHIAS W. HENTZE. (2003) The interaction of the cap-binding complex (CBC) with eIF4G is dispensable for translation in yeast. RNA 9:6, pages 654-662.
Crossref
Yukifumi Uesono & Akio Toh-e. (2002) Transient Inhibition of Translation Initiation by Osmotic Stress. Journal of Biological Chemistry 277:16, pages 13848-13855.
Crossref
Sung Key Jang & Eckard Wimmer. 2002. RNA Binding Proteins. RNA Binding Proteins 1 33 .
Kianoush Khaleghpour, Yuri V Svitkin, Andrew W Craig, Christine T DeMaria, Rahul C Deo, Stephen K Burley & Nahum Sonenberg. (2001) Translational Repression by a Novel Partner of Human Poly(A) Binding Protein, Paip2. Molecular Cell 7:1, pages 205-216.
Crossref
Angelica V Timofeeva, Natalia A Skrypina, Larissa P Savochkina & Robert Sh Beabealashvilli. (2000) Size distribution of the urokinase mRNA decay intermediates in different tissues and cell lines. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1517:1, pages 33-45.
Crossref
Mary C. Schaad, Robert J. Anderberg & James C. Carrington. (2000) Strain-Specific Interaction of the Tobacco Etch Virus NIa Protein with the Translation Initiation Factor eIF4E in the Yeast Two-Hybrid System. Virology 273:2, pages 300-306.
Crossref
Eric Winstall, Martin Sadowski, Uwe Kühn, Elmar Wahle & Alan B. Sachs. (2000) The Saccharomyces cerevisiae RNA-binding Protein Rbp29 Functions in Cytoplasmic mRNA Metabolism. Journal of Biological Chemistry 275:29, pages 21817-21826.
Crossref
Puri Fortes, Toshifumi Inada, Thomas Preiss, Matthias W. Hentze, Iain W. Mattaj & Alan B. Sachs. (2000) The Yeast Nuclear Cap Binding Complex Can Interact with Translation Factor eIF4G and Mediate Translation Initiation. Molecular Cell 6:1, pages 191-196.
Crossref
Justin T Brown, Xianmei Yang & Arlen W Johnson. (2000) Inhibition of mRNA Turnover in Yeast by an xrn1 Mutation Enhances the Requirement for eIF4E Binding to eIF4G and for Proper Capping of Transcripts by Ceg1p . Genetics 155:1, pages 31-42.
Crossref
Diana Dominguez, Michael Altmann, Jörg Benz, Ulrich Baumann & Hans Trachsel. (1999) Interaction of Translation Initiation Factor eIF4G with eIF4A in the Yeast Saccharomyces cerevisiae. Journal of Biological Chemistry 274:38, pages 26720-26726.
Crossref
Panda E.C. Hershey, Sarah M. McWhirter, John D. Gross, Gerhard Wagner, Tom Alber & Alan B. Sachs. (1999) The Cap-binding Protein eIF4E Promotes Folding of a Functional Domain of Yeast Translation Initiation Factor eIF4G1. Journal of Biological Chemistry 274:30, pages 21297-21304.
Crossref
Joseph Marcotrigiano, Anne-Claude Gingras, Nahum Sonenberg & Stephen K Burley. (1999) Cap-Dependent Translation Initiation in Eukaryotes Is Regulated by a Molecular Mimic of eIF4G. Molecular Cell 3:6, pages 707-716.
Crossref
Christopher S. Fraser, Virginia M. Pain & Simon J. Morley. (1999) The Association of Initiation Factor 4F with Poly(A)-binding Protein Is Enhanced in Serum-stimulated Xenopus Kidney Cells. Journal of Biological Chemistry 274:1, pages 196-204.
Crossref
John E. G. McCarthy. (1998) Posttranscriptional Control of Gene Expression in Yeast. Microbiology and Molecular Biology Reviews 62:4, pages 1492-1553.
Crossref
Immo E. Scheffler, Bernard J. de la Cruz & Susana Prieto. (1998) Control of mRNA turnover as a mechanism of glucose repression in Saccharomyces cerevisiae. The International Journal of Biochemistry & Cell Biology 30:11, pages 1175-1193.
Crossref
Sandra E. Wells, Paul E. Hillner, Ronald D. Vale & Alan B. Sachs. (1998) Circularization of mRNA by Eukaryotic Translation Initiation Factors. Molecular Cell 2:1, pages 135-140.
Crossref
Daniel R. Gallie, Hanh Le, Robert L. Tanguay & Karen S. Browning. (1998) Translation initiation factors are differentially regulated in cereals during development and following heat shock. The Plant Journal 14:6, pages 715-722.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.