Advanced search
Publication Cover
Molecular and Cellular Biology Volume 17, 1997 - Issue 12
Submit an article Journal homepage
14
Views
68
CrossRef citations to date
0
Altmetric
Research Article

The Saccharomyces cerevisiae Hap5p Homolog from Fission Yeast Reveals Two Conserved Domains That Are Essential for Assembly of Heterotetrameric CCAAT-Binding Factor

David S. McNabbDepartment of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts02139
,
Kelly A.-S. TsengDepartment of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts02139
&
Leonard GuarenteDepartment of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts02139Correspondence[email protected]
Pages 7008-7018 | Received 01 Jul 1997, Accepted 18 Sep 1997, Published online: 29 Mar 2023

Citations (68)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (5)

Ryuta Asada, Naomichi Takemata, Charles S. Hoffman, Kunihiro Ohta & Kouji Hirota. (2015) Antagonistic Controls of Chromatin and mRNA Start Site Selection by Tup Family Corepressors and the CCAAT-Binding Factor. Molecular and Cellular Biology 35:5, pages 847-855.
Read now
Kazuaki TAKUMA, Hokuto OHTSUKA, Kenko AZUMA, Hiroshi MURAKAMI & Hirofumi AIBA. (2013) The Fission Yeast php2 Mutant Displays a Lengthened Chronological Lifespan. Bioscience, Biotechnology, and Biochemistry 77:7, pages 1548-1555.
Read now
Shinjiro TANOUE, Ken-ichi KAMEI, Hideya GODA, Akimitsu TANAKA, Tetsuo KOBAYASHI, Norihiro TSUKAGOSHI & Masashi KATO. (2006) The Region in a Subunit of the Aspergillus CCAAT-Binding Protein Similar to the HAP4p-Recruiting Domain of Saccharomyces cerevisiae Hap5p Is Not Essential for Transcriptional Enhancement. Bioscience, Biotechnology, and Biochemistry 70:4, pages 782-787.
Read now
Akio NAKASHIMA, Masaru UENO, Takashi USHIMARU & Masahiro URITANI. (2002) Involvement of a CCAAT-binding Complex in the Expression of a Nitrogen-Starvation-Specific Gene, isp6 +, in Schizosaccharomyces pombe . Bioscience, Biotechnology, and Biochemistry 66:10, pages 2224-2227.
Read now
Stefan Steidl, Peter Papagiannopoulos, Olivier Litzka, Alex Andrianopoulos, Meryl A. Davis, Axel A. Brakhage & Michael J. Hynes. (1999) AnCF, the CCAAT Binding Complex of Aspergillus nidulans, Contains Products of the hapB,hapC, and hapE Genes and Is Required for Activation by the Pathway-Specific Regulatory Gene amdR. Molecular and Cellular Biology 19:1, pages 99-106.
Read now

Articles from other publishers (63)

Jingyi Li, Yanwei Sun, Feiyun Liu, Yao Zhou, Yunfeng Yan, Zhemin Zhou, Ping Wang & Shengmin Zhou. (2022) Increasing NADPH impairs fungal H2O2 resistance by perturbing transcriptional regulation of peroxiredoxin. Bioresources and Bioprocessing 9:1.
Crossref
Ryuta Asada & Kouji Hirota. (2022) Multi-Layered Regulations on the Chromatin Architectures: Establishing the Tight and Specific Responses of Fission Yeast fbp1 Gene Transcription. Biomolecules 12:11, pages 1642.
Crossref
Jin-Young Kim & Yong-Sun Bahn. (2022) Role of the Heme Activator Protein Complex in the Sexual Development of Cryptococcus neoformans. mSphere 7:3.
Crossref
Swathik Clarancia Peter, Naveenarani Murugan, Manoj Vadakkancherry Mohanan, Sarath Padmanabhan Thelakat Sasikumar, Dharshini Selvarajan, Ashwin Narayan Jayanarayanan, Suresha G. Shivalingamurthy, Mahadevaiah Chennappa, Valarmathi Ramanathan, Hemaprabha Govindakurup, Bakshi Ram & Appunu Chinnaswamy. (2020) Isolation, characterization and expression analysis of stress responsive plant nuclear transcriptional factor subunit (NF-YB2) from commercial Saccharum hybrid and wild relative Erianthus arundinaceus. 3 Biotech 10:7.
Crossref
Ji Wang, Zeyang Jin, Mengjia Zhou, Yongjian Yu & Mingxiang Liang. (2020) Characterization of NF-Y transcription factor families in industrial rapeseed (Brassica napus L.) and identification of BnNF-YA3, which functions in the abiotic stress response. Industrial Crops and Products 148, pages 112253.
Crossref
Jung-Eun Kim, Hyejin Nam, Jiyeun Park, Gyung Ja Choi, Yin-Won Lee & Hokyoung Son. (2020) Characterization of the CCAAT-binding transcription factor complex in the plant pathogenic fungus Fusarium graminearum. Scientific Reports 10:1.
Crossref
Yinhe Mao & Changbin Chen. (2019) The Hap Complex in Yeasts: Structure, Assembly Mode, and Gene Regulation. Frontiers in Microbiology 10.
Crossref
Silvia Belluti, Valentina Semeghini, Valentina Basile, Giovanna Rigillo, Valentina Salsi, Filippo Genovese, Diletta Dolfini & Carol Imbriano. (2018) An autoregulatory loop controls the expression of the transcription factor NF-Y. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1861:5, pages 509-518.
Crossref
Antonin Thiébaut, Thierry Delaveau, Médine Benchouaia, Julia Boeri, Mathilde Garcia, Gaëlle Lelandais & Frédéric Devaux. (2017) The CCAAT-Binding Complex Controls Respiratory Gene Expression and Iron Homeostasis in Candida Glabrata. Scientific Reports 7:1.
Crossref
Peter Hortschansky, Hubertus Haas, Eva M. Huber, Michael Groll & Axel A. Brakhage. (2017) The CCAAT-binding complex (CBC) in Aspergillus species. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1860:5, pages 560-570.
Crossref
M. Bolotin-Fukuhara. (2017) Thirty years of the HAP2/3/4/5 complex. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1860:5, pages 543-559.
Crossref
Valentina Nardone, Antonio Chaves-Sanjuan & Marco Nardini. (2017) Structural determinants for NF-Y/DNA interaction at the CCAAT box. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1860:5, pages 571-580.
Crossref
Michal Eisenberg‐Bord & Maya Schuldiner. (2016) Ground control to major TOM: mitochondria–nucleus communication. The FEBS Journal 284:2, pages 196-210.
Crossref
Shan Li, Ka Li, Zheng Ju, Dongyan Cao, Daqi Fu, Hongliang Zhu, Benzhong Zhu & Yunbo Luo. (2016) Genome-wide analysis of tomato NF-Y factors and their role in fruit ripening. BMC Genomics 17:1.
Crossref
Ariane Brault, Charalampos Rallis, Vincent Normant, Jean-Michel Garant, Jürg Bähler & Simon Labbé. (2016) Php4 Is a Key Player for Iron Economy in Meiotic and Sporulating Cells. G3 Genes|Genomes|Genetics 6:10, pages 3077-3095.
Crossref
Saori Oda, Hiroya Yurimoto, Nobuhisa Nitta & Yasuyoshi Sakai. (2016) Unique C-terminal region of Hap3 is required for methanol-regulated gene expression in the methylotrophic yeast Candida boidinii. Microbiology 162:5, pages 898-907.
Crossref
Neha Malviya, Parul Jaiswal & Dinesh Yadav. (2016) Genome- wide characterization of Nuclear Factor Y (NF-Y) gene family of sorghum [Sorghum bicolor (L.) Moench]: a bioinformatics approach. Physiology and Molecular Biology of Plants 22:1, pages 33-49.
Crossref
Saori Oda, Hiroya Yurimoto, Nobuhisa Nitta, Yu Sasano & Yasuyoshi Sakai. (2015) Molecular Characterization of Hap Complex Components Responsible for Methanol-Inducible Gene Expression in the Methylotrophic Yeast Candida boidinii. Eukaryotic Cell 14:3, pages 278-285.
Crossref
Carolina Rípodas, Mélisse Castaingts, Joaquín Clúa, Flavio Blanco & María Eugenia Zanetti. (2015) Annotation, phylogeny and expression analysis of the nuclear factor Y gene families in common bean (Phaseolus vulgaris). Frontiers in Plant Science 5.
Crossref
Esma Ucisik-Akkaya, Janet K Leatherwood & Aaron M Neiman. (2014) A Genome-Wide Screen for Sporulation-Defective Mutants in Schizosaccharomyces pombe . G3 Genes|Genomes|Genetics 4:6, pages 1173-1182.
Crossref
Mingxiang Liang, Xiangzhen Yin, Zhongyuan Lin, Qingsong Zheng, Guohong Liu & Gengmao Zhao. (2013) Identification and characterization of NF-Y transcription factor families in Canola (Brassica napus L.). Planta 239:1, pages 107-126.
Crossref
Po-Chen Hsu, Chun-Cheih Chao, Cheng-Yao Yang, Ya-Ling Ye, Fu-Chen Liu, Yung-Jen Chuang & Chung-Yu Lan. (2013) Diverse Hap43-Independent Functions of the Candida albicans CCAAT-Binding Complex. Eukaryotic Cell 12:6, pages 804-815.
Crossref
Tom Laloum, Stéphane De Mita, Pascal Gamas, Maël Baudin & Andreas Niebel. (2013) CCAAT-box binding transcription factors in plants: Y so many?. Trends in Plant Science 18:3, pages 157-166.
Crossref
Marco Antonio Leyva-González, Enrique Ibarra-Laclette, Alfredo Cruz-Ramírez & Luis Herrera-Estrella. (2012) Functional and Transcriptome Analysis Reveals an Acclimatization Strategy for Abiotic Stress Tolerance Mediated by Arabidopsis NF-YA Family Members. PLoS ONE 7:10, pages e48138.
Crossref
Philippe Vachon, Alexandre Mercier, Mehdi Jbel & Simon Labbé. (2012) The Monothiol Glutaredoxin Grx4 Exerts an Iron-Dependent Inhibitory Effect on Php4 Function. Eukaryotic Cell 11:6, pages 806-819.
Crossref
Mingxiang Liang, David Hole, Jixiang Wu, Tom Blake & Yajun Wu. (2011) Expression and functional analysis of NUCLEAR FACTOR-Y, subunit B genes in barley. Planta 235:4, pages 779-791.
Crossref
Shuanghe Cao, Roderick W. Kumimoto, Chamindika L. Siriwardana, Jan R. Risinger & Ben F. Holt. (2011) Identification and Characterization of NF-Y Transcription Factor Families in the Monocot Model Plant Brachypodium distachyon. PLoS ONE 6:6, pages e21805.
Crossref
Mehdi Jbel, Alexandre Mercier & Simon Labbé. (2011) Grx4 Monothiol Glutaredoxin Is Required for Iron Limitation-Dependent Inhibition of Fep1. Eukaryotic Cell 10:5, pages 629-645.
Crossref
Walter W Steiner, Peter A Davidow & Andrew T M Bagshaw. (2011) Important Characteristics of Sequence-Specific Recombination Hotspots in Schizosaccharomyces pombe . Genetics 187:2, pages 385-396.
Crossref
Po-Chen Hsu, Cheng-Yao Yang & Chung-Yu Lan. (2011) Candida albicans Hap43 Is a Repressor Induced under Low-Iron Conditions and Is Essential for Iron-Responsive Transcriptional Regulation and Virulence. Eukaryotic Cell 10:2, pages 207-225.
Crossref
K. Sybirna, N. Petryk, Y.-F. Zhou, A. Sibirny & M. Bolotin-Fukuhara. (2010) A novel Hansenula polymorpha transcriptional factor HpHAP4-B, able to functionally replace the S. cerevisiae HAP4 gene, contains an additional bZip motif. Yeast 27:11, pages 941-954.
Crossref
Alexandre Mercier & Simon Labbé. (2010) Iron-Dependent Remodeling of Fungal Metabolic Pathways Associated with Ferrichrome Biosynthesis. Applied and Environmental Microbiology 76:12, pages 3806-3817.
Crossref
Wayne P. Wahls & Mari K. Davidson. (2010) Discrete DNA sites regulate global distribution of meiotic recombination. Trends in Genetics 26:5, pages 202-208.
Crossref
Marcel Thön, Qusai Al Abdallah, Peter Hortschansky, Daniel H. Scharf, Martin Eisendle, Hubertus Haas & Axel A. Brakhage. (2010) The CCAAT-binding complex coordinates the oxidative stress response in eukaryotes. Nucleic Acids Research 38:4, pages 1098-1113.
Crossref
Alexandre Mercier & Simon Labbé. (2009) Both Php4 Function and Subcellular Localization Are Regulated by Iron via a Multistep Mechanism Involving the Glutaredoxin Grx4 and the Exportin Crm1. Journal of Biological Chemistry 284:30, pages 20249-20262.
Crossref
Mehdi Jbel, Alexandre Mercier, Benoit Pelletier, Jude Beaudoin & Simon Labbé. (2009) Iron Activates In Vivo DNA Binding of Schizosaccharomyces pombe Transcription Factor Fep1 through Its Amino-Terminal Region . Eukaryotic Cell 8:4, pages 649-664.
Crossref
Nicholas SiefersKristen K. DangRoderick W. KumimotoWilliam Edwards BynumIVIVGregory TayroseBen F. HoltIIIIII. (2009) Tissue-Specific Expression Patterns of Arabidopsis NF-Y Transcription Factors Suggest Potential for Extensive Combinatorial Complexity    . Plant Physiology 149:2, pages 625-641.
Crossref
Alexandre Mercier, Stephen Watt, Jürg Bähler & Simon Labbé. (2008) Key Function for the CCAAT-Binding Factor Php4 To Regulate Gene Expression in Response to Iron Deficiency in Fission Yeast. Eukaryotic Cell 7:3, pages 493-508.
Crossref
Yongchao Zhao, Wei Shao, Huajiang Wei, Jiying Qiao, Ying Lu, Yimin Sun, Keith Mitchelson, Jing Cheng & Yuxiang Zhou. (2008) Development of a Novel Oligonucleotide Array-Based Transcription Factor Assay Platform for Genome-Wide Active Transcription Factor Profiling in Saccharomyces cerevisiae . Journal of Proteome Research 7:3, pages 1315-1325.
Crossref
Peter Hortschansky, Martin Eisendle, Qusai Al-Abdallah, André D Schmidt, Sebastian Bergmann, Marcel Thön, Olaf Kniemeyer, Beate Abt, Birgit Seeber, Ernst R Werner, Masashi Kato, Axel A Brakhage & Hubertus Haas. (2007) Interaction of HapX with the CCAAT-binding complex—a novel mechanism of gene regulation by iron. The EMBO Journal 26:13, pages 3157-3168.
Crossref
Simon Labbé, Benoit Pelletier & Alexandre Mercier. (2007) Iron homeostasis in the fission yeast Schizosaccharomyces pombe. BioMetals 20:3-4.
Crossref
Stephan Wenkel, Franziska Turck, Kamy Singer, Lionel Gissot, José Le Gourrierec, Alon Samach & George Coupland. (2006) CONSTANS and the CCAAT Box Binding Complex Share a Functionally Important Domain and Interact to Regulate Flowering of Arabidopsis . The Plant Cell 18:11, pages 2971-2984.
Crossref
Alexandre Mercier, Benoit Pelletier & Simon Labbé. (2006) A Transcription Factor Cascade Involving Fep1 and the CCAAT-Binding Factor Php4 Regulates Gene Expression in Response to Iron Deficiency in the Fission Yeast Schizosaccharomyces pombe . Eukaryotic Cell 5:11, pages 1866-1881.
Crossref
Soomin Park. (2006) Recombinant AtNF-YA, a subunit of theArabidopsis CCAAT-binding transcription factor, forms a protein-DNA complex with mammalian NF-YB and NF-YC. Journal of Plant Biology 49:4, pages 281-285.
Crossref
David S. McNabb & Inés Pinto. (2005) Assembly of the Hap2p/Hap3p/Hap4p/Hap5p-DNA Complex in Saccharomyces cerevisiae . Eukaryotic Cell 4:11, pages 1829-1839.
Crossref
Duncan C. Johnson, Kristin E. Cano, Erika C. Kroger & David S. McNabb. (2005) Novel Regulatory Function for the CCAAT-Binding Factor in Candida albicans . Eukaryotic Cell 4:10, pages 1662-1676.
Crossref
André Tüncher, Petra Spröte, Alexander Gehrke & Axel A. Brakhage. (2005) The CCAAT-binding Complex of Eukaryotes: Evolution of a Second NLS in the HapB Subunit of the Filamentous Fungus Aspergillus nidulans Despite Functional Conservation at the Molecular Level between Yeast, A.nidulans and Human. Journal of Molecular Biology 352:3, pages 517-533.
Crossref
K. Sybirna, B. Guiard, Y.F. Li, W.G. Bao, M. Bolotin-Fukuhara & A. Delahodde. (2004) A new Hansenula polymorpha HAP4 homologue which contains only the N-terminal conserved domain of the protein is fully functional in Saccharomyces cerevisiae. Current Genetics 47:3, pages 172-181.
Crossref
Antonella Franchini, Carol Imbriano, Elisa Peruzzi, Roberto Mantovani & Enzo Ottaviani. (2005) Expression of the CCAAT-binding factor NF-Y in Caenorhabditis elegans. Journal of Molecular Histology 36:1, pages 139-145.
Crossref
Jelena Djurovic & Milena Stevanovic. (2004) Structural and functional characterization of the human SOX14 promoter. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1680:1, pages 53-59.
Crossref
M. Lévesque-Lemay, D. Albani, D. Aldcorn, J. Hammerlindl, W. Keller & L. S. Robert. (2003) Expression of CCAAT-binding factor antisense transcripts in reproductive tissues affects plant fertility. Plant Cell Reports 21:8, pages 804-808.
Crossref
Akimitsu Tanaka, Masashi Kato, Takashi Nagase, Tetsuo Kobayashi & Norihiro Tsukagoshi. (2002) Isolation of genes encoding novel transcription factors which interact with the Hap complex from Aspergillus species. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1576:1-2, pages 176-182.
Crossref
Giuliana Gusmaroli, Chiara Tonelli & Roberto Mantovani. (2002) Regulation of novel members of the Arabidopsis thaliana CCAAT-binding nuclear factor Y subunits. Gene 283:1-2, pages 41-48.
Crossref
Rozmin T K Janoo, Lori A Neely, Burkhard R Braun, Simon K Whitehall & Charles S Hoffman. (2001) Transcriptional Regulators of the Schizosaccharomyces pombe fbp1 Gene Include Two Redundant Tup1p-like Corepressors and the CCAAT Binding Factor Activation Complex . Genetics 157:3, pages 1205-1215.
Crossref
Giuliana Gusmaroli, Chiara Tonelli & Roberto Mantovani. (2001) Regulation of the CCAAT-Binding NF-Y subunits in Arabidopsis thaliana. Gene 264:2, pages 173-185.
Crossref
Norihiro Tsukagoshi, Tetsuo Kobayashi & Masashi Kato. (2001) Regulation of the amylolytic and (hemi-)cellulolytic genes in aspergilli. The Journal of General and Applied Microbiology 47:1, pages 1-19.
Crossref
Hitomi Sakurai & Akira Ishihama. (2001) Transcription organization and mRNA levels of the genes for all 12 subunits of the fission yeast RNA polymerase II. Genes to Cells 6:1, pages 25-36.
Crossref
Qianghua Hu & Sankar N. Maity. (2000) Stable Expression of a Dominant Negative Mutant of CCAAT Binding Factor/NF-Y in Mouse Fibroblast Cells Resulting in Retardation of Cell Growth and Inhibition of Transcription of Various Cellular Genes. Journal of Biological Chemistry 275:6, pages 4435-4444.
Crossref
Roberto Mantovani. (1999) The molecular biology of the CCAAT-binding factor NF-Y. Gene 239:1, pages 15-27.
Crossref
A.A. Brakhage, A. Andrianopoulos, M. Kato, S. Steidl, M.A. Davis, N. Tsukagoshi & M.J. Hynes. (1999) HAP-Like CCAAT-Binding Complexes in Filamentous Fungi: Implications for Biotechnology. Fungal Genetics and Biology 27:2-3, pages 243-252.
Crossref
D. Bourgarel, C.-C. Nguyen & M. Bolotin-Fukuhara. (1999) HAP4, the glucose-repressed regulated subunit of the HAP transcriptional complex involved in the fermentation-respiration shift, has a functional homologue in the respiratory yeast Kluyveromyces lactis. Molecular Microbiology 31:4, pages 1205-1215.
Crossref
Chiara Liberati, Alberto di Silvio, Sergio Ottolenghi & Roberto Mantovani. (1999) NF-Y binding to twin CCAAT boxes: role of Q-rich domains and histone fold helices 1 1Edited by M. Yaniv. Journal of Molecular Biology 285:4, pages 1441-1455.
Crossref
Sherry L. Spinelli, Harmit S. Malik, Sandra A. Consaul & Eric M. Phizicky. (1998) A functional homolog of a yeast tRNA splicing enzyme is conserved in higher eukaryotes and in Escherichia coli . Proceedings of the National Academy of Sciences 95:24, pages 14136-14141.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.