Advanced search
Publication Cover
Molecular and Cellular Biology Volume 17, 1997 - Issue 12
Submit an article Journal homepage
4
Views
72
CrossRef citations to date
0
Altmetric
Research Article

POU Domain Transcription Factor brain 4 Confers Pancreatic α-Cell-Specific Expression of the Proglucagon Gene Through Interaction with a Novel Proximal Promoter G1 Element

Mehboob A. HussainLaboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, and Harvard Medical School, Boston, Massachusetts02114
,
John LeeLaboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, and Harvard Medical School, Boston, Massachusetts02114
,
Christopher P. MillerLaboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, and Harvard Medical School, Boston, Massachusetts02114
&
Joel F. HabenerLaboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, and Harvard Medical School, Boston, Massachusetts02114Correspondence[email protected].
Pages 7186-7194 | Received 10 Jun 1997, Accepted 09 Sep 1997, Published online: 29 Mar 2023

Citations (72)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Megumi C. Katoh, Yunshin Jung, Chioma M. Ugboma, Miki Shimbo, Akihiro Kuno, Walaa A. Basha, Takashi Kudo, Hisashi Oishi & Satoru Takahashi. (2018) MafB Is Critical for Glucagon Production and Secretion in Mouse Pancreatic α Cells In Vivo. Molecular and Cellular Biology 38:8.
Read now

Articles from other publishers (71)

Ying Chen, Jiajun Qiu, Yingwei Wu, Huan Jia, Yi Jiang, Mengda Jiang, Zhili Wang, Hai-Bin Sheng, Lingxiang Hu, Zhihua Zhang, Zhaoyan Wang, Yun Li, Zhiwu Huang & Hao Wu. (2022) Genetic findings of Sanger and nanopore single-molecule sequencing in patients with X-linked hearing loss and incomplete partition type III. Orphanet Journal of Rare Diseases 17:1.
Crossref
Daniel Oropeza, Valentina Cigliola, Agustín Romero, Simona Chera, Santiago A. Rodríguez-Seguí & Pedro L. Herrera. (2021) Stage-specific transcriptomic changes in pancreatic α-cells after massive β-cell loss. BMC Genomics 22:1.
Crossref
Daniel J. Drucker. 2016. Endocrinology: Adult and Pediatric. Endocrinology: Adult and Pediatric 586 597.e5 .
Matthias Hebrok & Michael S. German. 2016. Endocrinology: Adult and Pediatric. Endocrinology: Adult and Pediatric 517 526.e5 .
Ananta Poudel, Omid Savari, Zehra Tekin & Manami Hara. 2016. Pancreatic Islet Biology. Pancreatic Islet Biology 49 63 .
Guney Bademci, Akeem O Lasisi, Kemal O Yariz, Paola Montenegro, Ibis Menendez, Rodrigo Vinueza, Rosario Paredes, Germania Moreta, Asli Subasioglu, Susan Blanton, Suat Fitoz, Armagan Incesulu, Levent Sennaroglu & Mustafa Tekin. (2015) Novel domain-specific POU3F4 mutations are associated with X-linked deafness: examples from different populations. BMC Medical Genetics 16:1.
Crossref
Talitha van der Meulen & Mark O Huising. (2015) Role of transcription factors in the transdifferentiation of pancreatic islet cells. Journal of Molecular Endocrinology 54:2, pages R103-R117.
Crossref
Feng Li, Yutong Su, Yulong Cheng, Xiuli Jiang, Ying Peng, Yanli Li, Jieli Lu, Yanyun Gu, Changxian Zhang, Yanan Cao, Weiqing Wang & Guang Ning. (2015) Conditional Deletion of Men1 in the Pancreatic β-Cell Leads to Glucagon-Expressing Tumor Development. Endocrinology 156:1, pages 48-57.
Crossref
Mounia Heddad Masson, Caroline Poisson, Audrey Guérardel, Aline Mamin, Jacques Philippe & Yvan Gosmain. (2014) Foxa1 and Foxa2 Regulate α-Cell Differentiation, Glucagon Biosynthesis, and Secretion. Endocrinology 155:10, pages 3781-3792.
Crossref
Nils Wierup, Frank Sundler & R Scott Heller. (2014) The islet ghrelin cell. Journal of Molecular Endocrinology 52:1, pages R35-R49.
Crossref
Thomas Parzefall, Shaked Shivatzki, Danielle R. Lenz, Birgit Rathkolb, Kathy Ushakov, Daphne Karfunkel, Yisgav Shapira, Michael Wolf, Manuela Mohr, Eckhard Wolf, Sibylle Sabrautzki, Martin Hrabé de Angelis, Moshe Frydman, Zippora Brownstein & Karen B. Avraham. (2013) Cytoplasmic Mislocalization of POU3F4 Due to Novel Mutations Leads to Deafness in Humans and Mice. Human Mutation 34:8, pages 1102-1110.
Crossref
Teresa L. Mastracci & Lori Sussel. (2012) The endocrine pancreas: insights into development, differentiation, and diabetes. Wiley Interdisciplinary Reviews: Developmental Biology 1:5, pages 609-628.
Crossref
N. C. Bramswig & K. H. Kaestner. (2011) Transcriptional regulation of α-cell differentiation. Diabetes, Obesity and Metabolism 13, pages 13-20.
Crossref
Yu-Ping Yang, Fabrizio Thorel, Daniel F. Boyer, Pedro L. Herrera & Christopher V.E. Wright. (2011) Context-specific α-to-β-cell reprogramming by forced Pdx1 expression. Genes & Development 25:16, pages 1680-1685.
Crossref
Masayuki Itoh, Yuji Takizawa, Sae Hanai, Shin Okazaki, Rie Miyata, Takeshi Inoue, Takumi Akashi, Masaharu Hayashi & Yu-ichi Goto. (2010) Partial loss of pancreas endocrine and exocrine cells of human ARX-null mutation: Consideration of pancreas differentiation. Differentiation 80:2-3, pages 118-122.
Crossref
Daniel J. Drucker. 2010. Endocrinology. Endocrinology 660 672 .
Matthias Hebrok & Michael S. German. 2010. Endocrinology. Endocrinology 592 602 .
George K. Gittes, Krishna Prasadan & Sidhartha Tulachan. 2010. Stem Cell Therapy for Diabetes. Stem Cell Therapy for Diabetes 3 40 .
Hee Keun LeeMee Hyun Song, Myengmo KangJung Tae LeeKyoung-Ah KongSu-Jin ChoiKyu Yup LeeHanka VenselaarGert VriendWon-Sang Lee, Hong-Joon Park, Taeg Kyu KwonJinwoong BokUn-Kyung Kim. (2009) Clinical and molecular characterizations of novel POU3F4 mutations reveal that DFN3 is due to null function of POU3F4 protein . Physiological Genomics 39:3, pages 195-201.
Crossref
José Ángel Díaz Pérez. (2009) Sistema neuroendocrino del páncreas y tracto gastrointestinal: origen y desarrollo. Endocrinología y Nutrición 56, pages 2-9.
Crossref
George K. Gittes. (2009) Developmental biology of the pancreas: A comprehensive review. Developmental Biology 326:1, pages 4-35.
Crossref
Juan Domínguez-BendalaJuan Domínguez-Bendala. 2009. Pancreatic Stem Cells. Pancreatic Stem Cells 11 33 .
Marie Best, Michael Carroll, Neil A. Hanley & Karen Piper Hanley. (2008) Embryonic stem cells to beta-cells by understanding pancreas development. Molecular and Cellular Endocrinology 288:1-2, pages 86-94.
Crossref
Yvan Gosmain, Isabelle Avril, Aline Mamin & Jacques Philippe. (2007) Pax-6 and c-Maf Functionally Interact with the α-Cell-specific DNA Element G1 in Vivo to Promote Glucagon Gene Expression. Journal of Biological Chemistry 282:48, pages 35024-35034.
Crossref
Mette Christine Jørgensen, Jonas Ahnfelt-Rønne, Jacob Hald, Ole D. Madsen, Palle Serup & Jacob Hecksher-Sørensen. (2007) An Illustrated Review of Early Pancreas Development in the Mouse. Endocrine Reviews 28:6, pages 685-705.
Crossref
Jesper Gromada, Isobel Franklin & Claes B. Wollheim. (2007) α-Cells of the Endocrine Pancreas: 35 Years of Research but the Enigma Remains. Endocrine Reviews 28:1, pages 84-116.
Crossref
Patrick Collombat, Jacob Hecksher-Sørensen, Palle Serup & Ahmed Mansouri. (2006) Specifying pancreatic endocrine cell fates. Mechanisms of Development 123:7, pages 501-512.
Crossref
J. Michael Rukstalis, Mariano Ubeda, Megan V. Johnson & Joel F. Habener. (2006) Transcription Factor Snail Modulates Hormone Expression in Established Endocrine Pancreatic Cell Lines. Endocrinology 147:6, pages 2997-3006.
Crossref
Tao Liu, Donald R. Branch & Tianru Jin. (2006) Pbx1 is a co-factor for Cdx-2 in regulating proglucagon gene expression in pancreatic A cells. Molecular and Cellular Endocrinology 249:1-2, pages 140-149.
Crossref
Jamie L. Volinic, Jee H. Lee, Kazuhiro Eto, Varinderpal Kaur & Melissa K. Thomas. (2006) Overexpression of the Coactivator Bridge-1 Results in Insulin Deficiency and Diabetes. Molecular Endocrinology 20:1, pages 167-182.
Crossref
Daniel J. Drucker. 2006. Physiology of the Gastrointestinal Tract. Physiology of the Gastrointestinal Tract 161 181 .
Kristen A. LANTZKlaus H. KAESTNER. (2005) Winged-helix transcription factors and pancreatic development. Clinical Science 108:3, pages 195-204.
Crossref
Catherine S. Lee, Newman J. Sund, Rüdiger Behr, Pedro L. Herrera & Klaus H. Kaestner. (2005) Foxa2 is required for the differentiation of pancreatic α-cells. Developmental Biology 278:2, pages 484-495.
Crossref
Grace Flock, Xiemin Cao & Daniel J. Drucker. (2005) Pdx-1 Is Not Sufficient for Repression of Proglucagon Gene Transcription in Islet or Enteroendocrine Cells. Endocrinology 146:1, pages 441-449.
Crossref
R Scott Heller, Doris A Stoffers, Aihua Liu, Andreas Schedl, E.Bryan CrenshawIIIIII, Ole D Madsen & Palle Serup. (2004) The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity. Developmental Biology 268:1, pages 123-134.
Crossref
N. Wierup, S. Yang, R. J. McEvilly, H. Mulder & F. Sundler. (2016) Ghrelin Is Expressed in a Novel Endocrine Cell Type in Developing Rat Islets and Inhibits Insulin Secretion from INS-1 (832/13) Cells. Journal of Histochemistry & Cytochemistry 52:3, pages 301-310.
Crossref
Patrick Collombat, Ahmed Mansouri, Jacob Hecksher-Sørensen, Palle Serup, Jens Krull, Gerard Gradwohl & Peter Gruss. (2003) Opposing actions of Arx and Pax4 in endocrine pancreas development. Genes & Development 17:20, pages 2591-2603.
Crossref
Laurie L. Baggio & Daniel J. Drucker. 2003. International Textbook of Diabetes Mellitus. International Textbook of Diabetes Mellitus.
Xiemin Cao, Grace Flock, Caroline Choi, David M. Irwin & Daniel J. Drucker. (2003) Aberrant Regulation of Human Intestinal Proglucagon Gene Expression in the NCI-H716 Cell Line. Endocrinology 144:5, pages 2025-2033.
Crossref
Andreea Ianus, George G. Holz, Neil D. Theise & Mehboob A. Hussain. (2003) In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. Journal of Clinical Investigation 111:6, pages 843-850.
Crossref
Andreea Ianus, George G. Holz, Neil D. Theise & Mehboob A. Hussain. (2003) In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. Journal of Clinical Investigation 111:6, pages 843-850.
Crossref
D.G. Burrin, B. Stoll & X. Guan. (2003) Glucagon-like peptide 2 function in domestic animals. Domestic Animal Endocrinology 24:2, pages 103-122.
Crossref
Denny K.Y. Trinh, Kai Zhang, Moazzem Hossain, Patricia L. Brubaker & Daniel J. Drucker. (2003) Pax-6 Activates Endogenous Proglucagon Gene Expression in the Rodent Gastrointestinal Epithelium. Diabetes 52:2, pages 425-433.
Crossref
Zuyao Ni, Younes Anini, Xianjun Fang, Gordon Mills, Patricia L Brubaker & Tianru Jin. (2003) Transcriptional Activation of the Proglucagon Gene by Lithium and β-Catenin in Intestinal Endocrine L Cells. Journal of Biological Chemistry 278:2, pages 1380-1387.
Crossref
Maria E. Wilson, David Scheel & Michael S. German. (2003) Gene expression cascades in pancreatic development. Mechanisms of Development 120:1, pages 65-80.
Crossref
Grace Flock & Daniel J. Drucker. (2002) Pax-2 Activates the Proglucagon Gene Promoter But Is Not Essential for Proglucagon Gene Expression or Development of Proglucagon-Producing Cell Lineages in the Murine Pancreas or Intestine. Molecular Endocrinology 16:10, pages 2349-2359.
Crossref
Elizabeth J. Abraham, Colin A. Leech, Julia C. Lin, Henryk Zulewski & Joel F. Habener. (2002) Insulinotropic Hormone Glucagon-Like Peptide-1 Differentiation of Human Pancreatic Islet-Derived Progenitor Cells into Insulin-Producing Cells. Endocrinology 143:8, pages 3152-3161.
Crossref
Maria E. Wilson, Julie A. Kalamaras & Michael S. German. (2002) Expression pattern of IAPP and prohormone convertase 1/3 reveals a distinctive set of endocrine cells in the embryonic pancreas. Mechanisms of Development 115:1-2, pages 171-176.
Crossref
Hideto Kojima, Takaaki Nakamura, Yukihiro Fujita, Akio Kishi, Mineko Fujimiya, Syu Yamada, Motoi Kudo, Yoshihiko Nishio, Hiroshi Maegawa, Masakazu Haneda, Hitoshi Yasuda, Itaru Kojima, Masaharu Seno, Norman C.W. Wong, Ryuichi Kikkawa & Atsunori Kashiwagi. (2002) Combined Expression of Pancreatic Duodenal Homeobox 1 and Islet Factor 1 Induces Immature Enterocytes to Produce Insulin. Diabetes 51:5, pages 1398-1408.
Crossref
Mehboob A. Hussain, Christopher P. Miller & Joel F. Habener. (2002) Brn-4 Transcription Factor Expression Targeted to the Early Developing Mouse Pancreas Induces Ectopic Glucagon Gene Expression in Insulin-producing β Cells. Journal of Biological Chemistry 277:18, pages 16028-16032.
Crossref
Benoit R. Gauthier, Valerie M. Schwitzgebel, Maia Zaiko, Aline Mamin, Beate Ritz-Laser & Jacques Philippe. (2002) Hepatic Nuclear Factor-3 (HNF-3 or Foxa2) Regulates Glucagon Gene Transcription by Binding to the G1 and G2 Promoter Elements. Molecular Endocrinology 16:1, pages 170-183.
Crossref
Sven Schinner, Claudia Dellas, Margit Schröder, Cynthia A. Heinlein, Chawnshang Chang, Janina Fischer & Willhart Knepel. (2002) Repression of Glucagon Gene Transcription by Peroxisome Proliferator-activated Receptor γ through Inhibition of Pax6 Transcriptional Activity. Journal of Biological Chemistry 277:3, pages 1941-1948.
Crossref
Timothy J. Kieffer, Mehboob A. Hussain & Joel F. Habener. 2011. Comprehensive Physiology. Comprehensive Physiology 197 265 .
Roland Stein. 2011. Comprehensive Physiology. Comprehensive Physiology 25 47 .
Nathalie Planque, Laurence Leconte, Frédéric M. Coquelle, Sofia Benkhelifa, Patrick Martin, Marie-Paule Felder-Schmittbuhl & Simon Saule. (2001) Interaction of Maf Transcription Factors with Pax-6 Results in Synergistic Activation of the Glucagon Promoter. Journal of Biological Chemistry 276:38, pages 35751-35760.
Crossref
Bogi Andersen & Michael G. Rosenfeld. (2001) POU Domain Factors in the Neuroendocrine System: Lessons from Developmental Biology Provide Insights into Human Disease*. Endocrine Reviews 22:1, pages 2-35.
Crossref
Haiyan Wang, Pierre Maechler, Beate Ritz-Laser, Kerstin A. Hagenfeldt, Hisamitsu Ishihara, Jacques Philippe & Claes B. Wollheim. (2001) Pdx1 Level Defines Pancreatic Gene Expression Pattern and Cell Lineage Differentiation. Journal of Biological Chemistry 276:27, pages 25279-25286.
Crossref
Tianru Jin & Huiqin Li. (2001) POU Homeodomain Protein OCT1 Is Implicated in the Expression of the Caudal-related Homeobox Gene Cdx-2. Journal of Biological Chemistry 276:18, pages 14752-14758.
Crossref
Willchart Knepel. 2001. Molecular Basis of Pancreas Development and Function. Molecular Basis of Pancreas Development and Function 67 89 .
Kevin Gerrish, Susan Samaras, Michelle A. Cissell, Christopher V.E. Wright & Roland Stein. 2001. Molecular Basis of Pancreas Development and Function. Molecular Basis of Pancreas Development and Function 275 287 .
Anne David, Daniel Stone, Rachel L. Cowen, Maria G. Castro & Pedro R. Lowenstein. 2001. Transgenic Models in Endocrinology. Transgenic Models in Endocrinology 195 232 .
Paula Y. P. Lam & Xandra O. Breakefield. (2000) Hybrid vector designs to control the delivery, fate and expression of transgenes. The Journal of Gene Medicine 2:6, pages 395-408.
Crossref
Stephan Herzig, Laszlo Füzesi & Willhart Knepel. (2000) Heterodimeric Pbx-Prep1 Homeodomain Protein Binding to the Glucagon Gene Restricting Transcription in a Cell Type-dependent Manner. Journal of Biological Chemistry 275:36, pages 27989-27999.
Crossref
Hans Baumeister & Wolfgang Meyerhof. (2000) The POU Domain Transcription Factor Tst-1 Activates Somatostatin Receptor 1 Gene Expression in Pancreatic β-Cells. Journal of Biological Chemistry 275:37, pages 28882-28887.
Crossref
Rafal Grzeskowiak, Jasmin Amin, Elke Oetjen & Willhart Knepel. (2000) Insulin Responsiveness of the Glucagon Gene Conferred by Interactions between Proximal Promoter and More Distal Enhancer-like Elements Involving the Paired-domain Transcription Factor Pax6. Journal of Biological Chemistry 275:39, pages 30037-30045.
Crossref
Timothy James KiefferJoel Francis Habener. (1999) The Glucagon-Like Peptides. Endocrine Reviews 20:6, pages 876-913.
Crossref
Min Nian, Daniel J. Drucker & David Irwin. (1999) Divergent regulation of human and rat proglucagon gene promoters in vivo. American Journal of Physiology-Gastrointestinal and Liver Physiology 277:4, pages G829-G837.
Crossref
Mehboob A. Hussain & Joel F. Habener. (1999) Glucagon Gene Transcription Activation Mediated by Synergistic Interactions of pax-6 and cdx-2 with the p300 Co-activator. Journal of Biological Chemistry 274:41, pages 28950-28957.
Crossref
Frank Gellert Andersen, R.Scott Heller, Helle Vestergård Petersen, Jan Jensen, Ole Dragsbaek Madsen & Palle Serup. (1999) Pax6 and Cdx2/3 form a functional complex on the rat glucagon gene promoter G1-element. FEBS Letters 445:2-3, pages 306-310.
Crossref
Petra T. Schwartz & Mario Vallejo. (1998) Differential Regulation of Basal and Cyclic Adenosine 3′,5′-Monophosphate-Induced Somatostatin Gene Transcription in Neural Cells by DNA Control Elements That Bind Homeodomain Proteins. Molecular Endocrinology 12:9, pages 1280-1293.
Crossref
R.Scott Heller, Doris A. Stoffers, Mehboob A. Hussain, Christopher P. Miller & Joel F. Habener. (1998) Misexpression of the pancreatic homeodomain protein IDX-1 by the Hoxa-4 promoter associated with agenesis of the cecum. Gastroenterology 115:2, pages 381-387.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.