Advanced search
Publication Cover
Molecular and Cellular Biology Volume 17, 1997 - Issue 5
Submit an article Journal homepage
5
Views
51
CrossRef citations to date
0
Altmetric
Research Article

Function of the c-Myc Antagonist Mad1 during a Molecular Switch from Proliferation to Differentiation

Constance M. CultraroNCI-Navy Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland20889-5105
,
Tamar BinoNCI-Navy Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland20889-5105
&
Shoshana SegalNCI-Navy Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland20889-5105;Uniformed Services University of the Health Sciences, Bethesda, Maryland20889-5105
Pages 2353-2359 | Received 20 Nov 1996, Accepted 28 Jan 1997, Published online: 29 Mar 2023

Citations (51)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (5)

Juan C. Acosta, Nuria Ferrándiz, Gabriel Bretones, Verónica Torrano, Rosa Blanco, Carlos Richard, Brenda O'Connell, John Sedivy, M. Dolores Delgado & Javier León. (2008) Myc Inhibits p27-Induced Erythroid Differentiation of Leukemia Cells by Repressing Erythroid Master Genes without Reversing p27-Mediated Cell Cycle Arrest. Molecular and Cellular Biology 28:24, pages 7286-7295.
Read now
Ming-Yue Li, Tak W. Lee, Anthony P.C. Yim & George G. Chen. (2006) Function of Pparγ and Its Ligands in Lung Cancer. Critical Reviews in Clinical Laboratory Sciences 43:2, pages 183-202.
Read now
Grant A. McArthur, Kevin P. Foley, Matthew L. Fero, Carl R. Walkley, Andrew J. Deans, James M. Roberts & Robert N. Eisenman. (2002) MAD1 and p27KIP1 Cooperate To Promote Terminal Differentiation of Granulocytes and To Inhibit Myc Expression and Cyclin E-CDK2 Activity. Molecular and Cellular Biology 22:9, pages 3014-3023.
Read now
Christophe Quéva, Grant A. McArthur, Brian M. Iritani & Robert N. Eisenman. (2001) Targeted Deletion of the S-Phase-Specific Myc Antagonist Mad3 Sensitizes Neuronal and Lymphoid Cells to Radiation-Induced Apoptosis. Molecular and Cellular Biology 21:3, pages 703-712.
Read now
Gonzalo Barrera-Hernandez, Constance M. Cultraro, Stefania Pianetti & Shoshana Segal. (2000) Mad1 Function Is Regulated through Elements within the Carboxy Terminus. Molecular and Cellular Biology 20:12, pages 4253-4264.
Read now

Articles from other publishers (46)

Feng Du, Dezuo Dong, Xiaodong Zhang & Jun Jia. (2021) MXD1 is a Potential Prognostic Biomarker and Correlated With Specific Molecular Change and Tumor Microenvironment Feature in Esophageal Squamous Cell Carcinoma. Technology in Cancer Research & Treatment 20, pages 153303382110521.
Crossref
Roberta ZiniChiara RossiRuggiero NorfoValentina PennucciGreta BarbieriSamantha RubertiSebastiano RontauroliSimona SalatiElisa BianchiRossella Manfredini. (2016) miR-382-5p Controls Hematopoietic Stem Cell Differentiation Through the Downregulation of MXD1 . Stem Cells and Development 25:19, pages 1433-1443.
Crossref
N. Bansal, G. David, E. Farias & S. Waxman. 2016. 113 135 .
Daniel Diolaiti, Lisa McFerrin, Patrick A. Carroll & Robert N. Eisenman. (2015) Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1849:5, pages 484-500.
Crossref
Bernhard Lüscher. (2012) MAD1 and its life as a MYC antagonist: An update. European Journal of Cell Biology 91:6-7, pages 506-514.
Crossref
Nadine Hein, Kan Jiang, Christian Cornelissen & Bernhard Lüscher. (2011) TGFβ1 enhances MAD1 expression and stimulates promoter-bound Pol II phosphorylation: basic functions of C/EBP, SP and SMAD3 transcription factors. BMC Molecular Biology 12:1.
Crossref
Guosheng Jiang, Ami Albihn, Tianhua Tang, Zhigang Tian & Marie Henriksson. (2008) Role of Myc in differentiation and apoptosis in HL60 cells after exposure to arsenic trioxide or all-trans retinoic acid. Leukemia Research 32:2, pages 297-307.
Crossref
María José Fernández-Nestosa, Pablo Hernández, Jorge B. Schvartzman & Dora B. Krimer. (2008) PU.1 is dispensable to block erythroid differentiation in Friend erythroleukemia cells. Leukemia Research 32:1, pages 121-130.
Crossref
Rajko Reljic. (2007) IFN- γ Therapy of Tuberculosis and Related Infections . Journal of Interferon & Cytokine Research 27:5, pages 353-364.
Crossref
Guosheng Jiang, Kehong Bi, Tianhua Tang, Junwei Wang, Yukun Zhang, Wei Zhang, Haiquan Ren, Houqiao Bai & Yunshan Wang. (2006) Down-regulation of TRRAP-dependent hTERT and TRRAP-independent CAD activation by Myc/Max contributes to the differentiation of HL60 cells after exposure to DMSO. International Immunopharmacology 6:7, pages 1204-1213.
Crossref
Anne Hultquist, Cihan Cetinkaya, Siqin Wu, Alina Castell, Anna Erlandsson & Lars-Gunnar Larsson. (2004) Mad 1 Inhibits Cell Growth and Proliferation but Does Not Promote Differentiation or Overall Survival in Human U-937 Monoblasts. Molecular Cancer Research 2:8, pages 464-476.
Crossref
Neelam V Shirsat & Sadaf A Shaikh. (2003) Overexpression of the immediate early gene fra-1 inhibits proliferation, induces apoptosis, and reduces tumourigenicity of c6 glioma cells. Experimental Cell Research 291:1, pages 91-100.
Crossref
Peter M. Siegel, Weiping Shu & Joan Massagué. (2003) Mad Upregulation and Id2 Repression Accompany Transforming Growth Factor (TGF)-β-mediated Epithelial Cell Growth Suppression. Journal of Biological Chemistry 278:37, pages 35444-35450.
Crossref
Devanand Sarkar, Magdalena Leszczyniecka, Dong-chul Kang, Irina V. Lebedeva, Kristoffer Valerie, Sonu Dhar, Tej K. Pandita & Paul B. Fisher. (2003) Down-regulation of Myc as a Potential Target for Growth Arrest Induced by Human Polynucleotide Phosphorylase (hPNPase) in Human Melanoma Cells. Journal of Biological Chemistry 278:27, pages 24542-24551.
Crossref
Richard Marcotte, Jing-Fang Qian, James Chen & Eugenia Wang. (2003) hMad4, c-Myc endogenous inhibitor, induces a replicative senescence-like state when overexpressed in human fibroblasts. Journal of Cellular Biochemistry 89:3, pages 576-588.
Crossref
Yukinori Ohta, Yuko Hamada, Norimitsu Saitoh & Kensei Katsuoka. (2002) Effect of the transcriptional repressor Mad1 on proliferation of human melanoma cells. Experimental Dermatology 11:5, pages 439-447.
Crossref
Barbara Hoffman, Arshad Amanullah, Marianna Shafarenko & Dan A Liebermann. (2002) The proto-oncogene c-myc in hematopoietic development and leukemogenesis. Oncogene 21:21, pages 3414-3421.
Crossref
Kimberly E. Fultz & Eugene W. Gerner. (2002) APC-dependent regulation of ornithine decarboxylase in human colon tumor cells. Molecular Carcinogenesis 34:1, pages 10-18.
Crossref
Jing Chen, Christopher S Kremer & Timothy P Bender. (2002) A Myb dependent pathway maintains Friend murine erythroleukemia cells in an immature and proliferating state. Oncogene 21:12, pages 1859-1869.
Crossref
Christa Cerni, Barbara Skrzypek, Nikita Popov, Soleman Sasgary, Gerlinde Schmidt, Lars-Gunnar Larsson, Bernhard Lüscher & Marie Henriksson. (2002) Repression of in vivo growth of Myc/Ras transformed tumor cells by Mad1. Oncogene 21:3, pages 447-459.
Crossref
V. Carrie Bromleigh & Leonard P. Freedman. 2002. Steroid Hormones and Cell Cycle Regulation. Steroid Hormones and Cell Cycle Regulation 147 171 .
Philippe Kastner & Susan Chan. (2001) Function of RARα during the maturation of neutrophils. Oncogene 20:49, pages 7178-7185.
Crossref
Joseph C Poole, Lucy G Andrews & Trygve O Tollefsbol. (2001) Activity, function, and gene regulation of the catalytic subunit of telomerase (hTERT). Gene 269:1-2, pages 1-12.
Crossref
Tehila Hyman, Chana Rothmann, Adi Heller, Zvi Malik & Samuel Salzberg. (2001) Structural characterization of erythroid and megakaryocytic differentiation in Friend erythroleukemia cells. Experimental Hematology 29:5, pages 563-571.
Crossref
F Öberg, S Wu, F Bahram, K Nilsson & L-G Larsson. (2001) Cytokine-induced restoration of differentiation and cell cycle arrest in v-Myc transformed U-937 monoblasts correlates with reduced Myc activity. Leukemia 15:2, pages 217-227.
Crossref
Carla GrandoriShaun M. CowleyLeonard P. JamesRobert N. Eisenman. (2000) The Myc/Max/Mad Network and the Transcriptional Control of Cell Behavior. Annual Review of Cell and Developmental Biology 16:1, pages 653-699.
Crossref
Maria Teresa Bejarano, Ami Albihn, Tobias Cornvik, Susanne Osterdahl Brijker, Charlotte Asker, Lyda M. Osorio & Marie Henriksson. (2000) Inhibition of Cell Growth and Apoptosis by Inducible Expression of the Transcriptional Repressor Mad1. Experimental Cell Research 260:1, pages 61-72.
Crossref
Ertesvag, Blomhoff, Beiske & Naderi. (2000) Co-Induction of Mad1 and c-Myc in Activated Normal B Lymphocytes. Scandinavian Journal of Immunology 51:6, pages 565-570.
Crossref
AC Ward, DM Loeb, AA Soede-Bobok, IP Touw & AD Friedman. (2000) Regulation of granulopoiesis by transcription factors and cytokine signals. Leukemia 14:6, pages 973-990.
Crossref
Bernd Pulverer, Anette Sommer, Grant A. McArthur, Robert N. Eisenman & Bernhard L�scher. (2000) Analysis of Myc/Max/Mad network members in adipogenesis: Inhibition of the proliferative burst and differentiation by ectopically expressed Mad1. Journal of Cellular Physiology 183:3, pages 399-410.
Crossref
Stefanie Gehring, Sabine Rottmann, Annette R. Menkel, Jürgen Mertsching, Anja Krippner-Heidenreich & Bernhard Lüscher. (2000) Inhibition of Proliferation and Apoptosis by the Transcriptional Repressor Mad1. Journal of Biological Chemistry 275:14, pages 10413-10420.
Crossref
S. Gagandeep, Michael Ott, Perry D. Nisen, Ronald A. DePinho & Sanjeev Gupta. (2000) Overexpression of Mad transcription factor inhibits proliferation of cultured human hepatocellular carcinoma cells along with tumor formation in immunodeficient animals. The Journal of Gene Medicine 2:2, pages 117-127.
Crossref
Hong Shen-Li, Rónán C. O'Hagan, Harry HouJr.Jr., James W. HornerIIII, Han-Woong Lee & Ronald A. DePinho. (2000) Essential role for Max in early embryonic growth and development. Genes & Development 14:1, pages 17-22.
Crossref
Neelam V. Shirsat. (1999) HMBA inhibits growth and induces differentiation of astrocytes from neonatal rat brain. NeuroReport 10:18, pages 3755-3758.
Crossref
Matthias Knödel, Andreas W. Kuss, Dirk Lindemann, Ingolf Berberich & Anneliese Schimpl. (1999) Reversal of Blimp-1-mediated apoptosis by A1, a member of the Bcl-2 family. European Journal of Immunology 29:9, pages 2988-2998.
Crossref
Fuad BahramSiqin WuFredrik ÖbergBernhard LüscherLars-Gunnar Larsson. (1999) Posttranslational Regulation of Myc Function in Response to Phorbol Ester/Interferon-γ–Induced Differentiation of v-Myc–Transformed U-937 Monoblasts. Blood 93:11, pages 3900-3912.
Crossref
Fuad BahramSiqin WuFredrik ÖbergBernhard LüscherLars-Gunnar Larsson. (1999) Posttranslational Regulation of Myc Function in Response to Phorbol Ester/Interferon-γ–Induced Differentiation of v-Myc–Transformed U-937 Monoblasts. Blood 93:11, pages 3900-3912.
Crossref
Craig S. Newman & Paul A. Krieg. (1999) Alternative splicing and embryonic expression of theXenopus mad4 bHLH gene. Developmental Dynamics 215:2, pages 170-178.
Crossref
Daitoku Sakamuro & George C Prendergast. (1999) New Myc-interacting proteins: a second Myc network emerges. Oncogene 18:19, pages 2942-2954.
Crossref
Kevin P Foley & Robert N Eisenman. (1999) Two MAD tails: what the recent knockouts of Mad1 and Mxi1 tell us about the MYC/MAX/MAD network. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1423:3, pages M37-M47.
Crossref
Arunangsu Dey, Leopold Kim & Wei Li. (1999) Gamma interferon induces expression of Mad1 gene in macrophage, which inhibits colony-stimulating factor-1-dependent mitogenesis. Journal of Cellular Biochemistry 72:2, pages 232-241.
Crossref
George P. Studzinski & Lawrence E. Harrison. 1999. 1 58 .
Soheil Naderi & Heidi Kiil Blomhoff. (1999) Mad1 expression in the absence of differentiation: Effect of cAMP on the B-lymphoid cell line Reh. Journal of Cellular Physiology 178:1, pages 76-84.
Crossref
Edward V. Prochownik, Linette Eagle Grove, Debra Deubler, Xiao Lin Zhu, Robert A. Stephenson, L. Ralph Rohr, Xiaoying Yin & Arthur R. Brothman. (1998) Commonly occurring loss and mutation of theMXI1 gene in prostate cancer. Genes, Chromosomes and Cancer 22:4, pages 295-304.
Crossref
T. BRUUN, A. K. KRISTOFFERSEN, H. ROLLAG, S. BECK & M. DEGRÉ. (1998) Herpes simplex virus type 1 inhibits in vitro differentiation and selected functions of human blood-derived monocytes . APMIS 106:7-12, pages 1194-1203.
Crossref
G.A. MCARTHUR, C.D. LAHERTY, C. QUEVA, P.J. HURLIN, L. LOO, L. JAMES, C. GRANDORI, P. GALLANT, Y. SHIIO, W.C. HOKANSON, A.C. BUSH, P.F. CHENG, Q.A. LAWRENCE, B. PULVERER, P.J. KOSKINEN, K.P. FOLEY, D.E. AYER & R.N. EISENMAN. (1998) The Mad Protein Family Links Transcriptional Repression to Cell Differentiation. Cold Spring Harbor Symposia on Quantitative Biology 63:0, pages 423-434.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.