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Molecular and Cellular Biology Volume 17, 1997 - Issue 5
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Research Article

Activation of Jak2 Catalytic Activity Requires Phosphorylation of Y1007 in the Kinase Activation Loop

Jian FengDepartment of Biochemistry, St. Jude Children’s Research Hospital, Memphis, Tennessee38105; Department of Biochemistry, University of Tennessee Medical School, Memphis, Tennessee38103; and Imperial Cancer Research Fund, LondonWC2A 3PX, United Kingdom
,
Bruce A. WitthuhnDepartment of Biochemistry, St. Jude Children’s Research Hospital, Memphis, Tennessee38105; Department of Biochemistry, University of Tennessee Medical School, Memphis, Tennessee38103; and Imperial Cancer Research Fund, LondonWC2A 3PX, United Kingdom
,
Tadashi MatsudaDepartment of Biochemistry, St. Jude Children’s Research Hospital, Memphis, Tennessee38105; Department of Biochemistry, University of Tennessee Medical School, Memphis, Tennessee38103; and Imperial Cancer Research Fund, LondonWC2A 3PX, United Kingdom
,
Franz KohlhuberDepartment of Biochemistry, St. Jude Children’s Research Hospital, Memphis, Tennessee38105; Department of Biochemistry, University of Tennessee Medical School, Memphis, Tennessee38103; and Imperial Cancer Research Fund, LondonWC2A 3PX, United Kingdom
,
Ian M. KerrDepartment of Biochemistry, St. Jude Children’s Research Hospital, Memphis, Tennessee38105; Department of Biochemistry, University of Tennessee Medical School, Memphis, Tennessee38103; and Imperial Cancer Research Fund, LondonWC2A 3PX, United Kingdom
&
James N. IhleDepartment of Biochemistry, St. Jude Children’s Research Hospital, Memphis, Tennessee38105; Department of Biochemistry, University of Tennessee Medical School, Memphis, Tennessee38103; and Imperial Cancer Research Fund, LondonWC2A 3PX, United KingdomCorrespondencejames.ihle @stjude.org
Pages 2497-2501 | Received 27 Dec 1996, Accepted 11 Feb 1997, Published online: 29 Mar 2023

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Sajid Rashid, Nousheen Bibi, Zahida Parveen & Shagufta Shafique. (2015) Inhibition of Janus kinases by tyrosine phosphorylation inhibitor, Tyrphostin AG-490. Journal of Biomolecular Structure and Dynamics 33:11, pages 2368-2379.
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Roy J Duhé. (2013) Redox regulation of Janus kinase. JAK-STAT 2:4.
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Ping-Hung Chen, Fan-Ching Chien, Sue-Ping Lee, Woan-Eng Chan, I-Hsuan Lin, Chun-Shan Liu, Fang-Jen Lee, Jiann-Shiun Lai, Peilin Chen, Hsin-Fang yang-yen & Jeffrey Yen. (2012) Identification of a novel function of the clathrin-coated structure at the plasma membrane in facilitating GM-CSF receptor-mediated activation of JAK2. Cell Cycle 11:19, pages 3611-3626.
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Scott A. Robertson, Rositsa I. Koleva, Lawrence S. Argetsinger, Christin Carter-Su, Jarrod A. Marto, Edward P. Feener & Martin G. Myers$suffix/text()$suffix/text(). (2009) Regulation of Jak2 Function by Phosphorylation of Tyr317 and Tyr637 during Cytokine Signaling. Molecular and Cellular Biology 29:12, pages 3367-3378.
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Hanyin Cheng, Jeremy A. Ross, Jeffrey A. Frost & Robert A. Kirken. (2008) Phosphorylation of Human Jak3 at Tyrosines 904 and 939 Positively Regulates Its Activity. Molecular and Cellular Biology 28:7, pages 2271-2282.
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Megumi Funakoshi-Tago, Stéphane Pelletier, Hiroshi Moritake, Evan Parganas & James N. Ihle. (2008) Jak2 FERM Domain Interaction with the Erythropoietin Receptor Regulates Jak2 Kinase Activity. Molecular and Cellular Biology 28:5, pages 1792-1801.
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Jason H. Kurzer, Pipsa Saharinen, Olli Silvennoinen & Christin Carter-Su. (2006) Binding of SH2-B Family Members within a Potential Negative Regulatory Region Maintains JAK2 in an Active State. Molecular and Cellular Biology 26:17, pages 6381-6394.
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Anna M. Mazurkiewicz-Munoz, Lawrence S. Argetsinger, Jean-Louis K. Kouadio, Allan Stensballe, Ole N. Jensen, Joel M. Cline & Christin Carter-Su. (2006) Phosphorylation of JAK2 at Serine 523: a Negative Regulator of JAK2 That Is Stimulated by GrowthHormone and Epidermal Growth Factor. Molecular and Cellular Biology 26:11, pages 4052-4062.
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Ryoko Ishida-Takahashi, Felicia Rosario, Yusong Gong, Keely Kopp, Zlatina Stancheva, Xiaohong Chen, Edward P. Feener & Martin G. Myers$suffix/text()$suffix/text(). (2006) Phosphorylation of Jak2 on Ser523 InhibitsJak2-Dependent Leptin ReceptorSignaling. Molecular and Cellular Biology 26:11, pages 4063-4073.
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Edward P. Feener, Felicia Rosario, Sarah L. Dunn, Zlatina Stancheva & Martin G. Myers$suffix/text()$suffix/text(). (2004) Tyrosine Phosphorylation of Jak2 in the JH2 Domain Inhibits Cytokine Signaling. Molecular and Cellular Biology 24:11, pages 4968-4978.
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Lawrence S. Argetsinger, Jean-Louis K. Kouadio, Hanno Steen, Allan Stensballe, Ole N. Jensen & Christin Carter-Su. (2004) Autophosphorylation of JAK2 on Tyrosines 221 and 570 Regulates Its Activity. Molecular and Cellular Biology 24:11, pages 4955-4967.
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Stéphane Pelletier, François Duhamel, Philippe Coulombe, Michel R. Popoff & Sylvain Meloche. (2003) Rho Family GTPases Are Required for Activation of Jak/STAT Signaling by G Protein-Coupled Receptors. Molecular and Cellular Biology 23:4, pages 1316-1333.
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Nick Carpino, Ryuji Kobayashi, Heesuk Zang, Yutaka Takahashi, Shiann-Tarrng Jou, Jian Feng, Hideaki Nakajima & James N. Ihle. (2002) Identification, cDNA Cloning, and Targeted Deletion of p70, a Novel, Ubiquitously Expressed SH3 Domain-Containing Protein. Molecular and Cellular Biology 22:21, pages 7491-7500.
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Daniela Ungureanu, Pipsa Saharinen, Ilkka Junttila, Douglas J. Hilton & Olli Silvennoinen. (2002) Regulation of Jak2 through the Ubiquitin-Proteasome Pathway Involves Phosphorylation of Jak2 on Y1007 and Interaction with SOCS-1. Molecular and Cellular Biology 22:10, pages 3316-3326.
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T Kindler, RG Meyer & T Fischer. (2002) BCR-ABL as a target for novel therapeutic interventions. Expert Opinion on Therapeutic Targets 6:1, pages 85-101.
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Liangyou Rui, David R. Gunter, James Herrington & Christin Carter-Su. (2000) Differential Binding to and Regulation of JAK2 by the SH2 Domain and N-Terminal Region of SH2-Bβ. Molecular and Cellular Biology 20:9, pages 3168-3177.
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Pipsa Saharinen, Kati Takaluoma & Olli Silvennoinen. (2000) Regulation of the Jak2 Tyrosine Kinase by Its Pseudokinase Domain. Molecular and Cellular Biology 20:10, pages 3387-3395.
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Min Chen, Alan Cheng, Fabio Candotti, Yong-Jie Zhou, Anka Hymel, Anders Fasth, Luigi D. Notarangelo & John J. O'Shea. (2000) Complex Effects of Naturally Occurring Mutations in the JAK3 Pseudokinase Domain: Evidence for Interactions between the Kinase and Pseudokinase Domains. Molecular and Cellular Biology 20:3, pages 947-956.
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Markus H. Heim. (1999) The Jak-Stat Pathway: Cytokine Signalling from the Receptor to the Nucleus. Journal of Receptors and Signal Transduction 19:1-4, pages 75-120.
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Masahiko Hibi & Toshio Hirano. (1998) Signal TransductionThrough Cytokine Receptors. International Reviews of Immunology 17:1-4, pages 75-102.
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Liangyou Rui, Lawrence S. Mathews, Kikuko Hotta, Thomas A. Gustafson & Christin Carter-Su. (1997) Identification of SH2-Bβ as a Substrate of the Tyrosine Kinase JAK2 Involved in Growth Hormone Signaling. Molecular and Cellular Biology 17:11, pages 6633-6644.
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