Advanced search
Publication Cover
Molecular and Cellular Biology Volume 17, 1997 - Issue 5
Submit an article Journal homepage
9
Views
70
CrossRef citations to date
0
Altmetric
Research Article

Regulation of the Interleukin-2 CD28-Responsive Element by NF-ATp and Various NF-κB/Rel Transcription Factors

Sanjay B. MaggirwarDepartment of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey Medical Center, Hershey, Pennsylvania17033
,
Edward W. HarhajDepartment of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey Medical Center, Hershey, Pennsylvania17033
&
Shao-Cong SunDepartment of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey Medical Center, Hershey, Pennsylvania17033Correspondence[email protected]
Pages 2605-2614 | Received 11 Jul 1996, Accepted 19 Feb 1997, Published online: 29 Mar 2023

Citations (70)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (6)

Petra Ebner, Gijs A. Versteeg & Fumiyo Ikeda. (2017) Ubiquitin enzymes in the regulation of immune responses. Critical Reviews in Biochemistry and Molecular Biology 52:4, pages 425-460.
Read now
Bok Yun Kang, Shi-Chuen Miaw & I-Cheng Ho. (2005) ROG Negatively Regulates T-Cell Activation but Is Dispensable for Th-Cell Differentiation. Molecular and Cellular Biology 25:2, pages 554-562.
Read now
Emira Ayroldi, Ornella Zollo, Antonio Macchiarulo, Barbara Di Marco, Cristina Marchetti & Carlo Riccardi. (2002) Glucocorticoid-Induced Leucine Zipper Inhibits the Raf-Extracellular Signal-Regulated Kinase Pathway by Binding to Raf-1. Molecular and Cellular Biology 22:22, pages 7929-7941.
Read now
Jung-Hua Yeh, Patrick Lecine, Jacques A. Nunes, Salvatore Spicuglia, Pierre Ferrier, Daniel Olive & Jean Imbert. (2001) Novel CD28-Responsive Enhancer Activated by CREB/ATF and AP-1 Families in the Human Interleukin-2 Receptor α-Chain Locus. Molecular and Cellular Biology 21:14, pages 4515-4527.
Read now
Xin Lin, Alison O'Mahony, Yajun Mu, Romas Geleziunas & Warner C. Greene. (2000) Protein Kinase C-θ Participates in NF-κB Activation Induced by CD3-CD28 Costimulation through Selective Activation of IκB Kinase β. Molecular and Cellular Biology 20:8, pages 2933-2940.
Read now
Fernando Macián & Anjana Rao. (1999) Reciprocal Modulatory Interaction between Human Immunodeficiency Virus Type 1 Tat and Transcription Factor NFAT1. Molecular and Cellular Biology 19:5, pages 3645-3653.
Read now

Articles from other publishers (64)

Evrysthenis Vartholomatos, Stefania Mantziou, George A. Alexiou, Diamanto Lazari, Chrissa Sioka, Athanassios Kyritsis & Georgios S. Markopoulos. (2022) An NF-κB- and Therapy-Related Regulatory Network in Glioma: A Potential Mechanism of Action for Natural Antiglioma Agents. Biomedicines 10:5, pages 935.
Crossref
Romain Lévy, David Langlais, Vivien Béziat, Franck Rapaport, Geetha Rao, Tomi Lazarov, Mathieu Bourgey, Yu J. Zhou, Coralie Briand, Kunihiko Moriya, Fatima Ailal, Danielle T. Avery, Janet Markle, Ai Ing Lim, Masato Ogishi, Rui Yang, Simon Pelham, Mehdi Emam, Mélanie Migaud, Caroline Deswarte, Tanwir Habib, Luis R. Saraiva, Eman A. Moussa, Andrea Guennoun, Bertrand Boisson, Serkan Belkaya, Ruben Martinez-Barricarte, Jérémie Rosain, Aziz Belkadi, Sylvain Breton, Kathryn Payne, Ibtihal Benhsaien, Alessandro Plebani, Vassilios Lougaris, James P. Di Santo, Bénédicte Neven, Laurent Abel, Cindy S. Ma, Ahmed Aziz Bousfiha, Nico Marr, Jacinta Bustamante, Kang Liu, Philippe Gros, Frédéric Geissmann, Stuart G. Tangye, Jean-Laurent Casanova & Anne Puel. (2021) Inherited human c-Rel deficiency disrupts myeloid and lymphoid immunity to multiple infectious agents. Journal of Clinical Investigation 131:17.
Crossref
Zheng-jun Gao, Wen-ping Li, Xin-tao Mao, Tao Huang, Hao-li Wang, Yi-ning Li, Bao-qin Liu, Jiang-yan Zhong, Chai Renjie, Jin Jin & Yi-yuan Li. (2021) Single-nucleotide methylation specifically represses type I interferon in antiviral innate immunity. Journal of Experimental Medicine 218:3.
Crossref
Hongbo Hu & Shao-Cong Sun. (2016) Ubiquitin signaling in immune responses. Cell Research 26:4, pages 457-483.
Crossref
Frank Wolschendorf, Alberto Bosque, Takao Shishido, Alexandra Duverger, Jennifer Jones, Vicente Planelles & Olaf Kutsch. (2012) Kinase Control Prevents HIV-1 Reactivation in Spite of High Levels of Induced NF-κB Activity. Journal of Virology 86:8, pages 4548-4558.
Crossref
Wei Jin, Mikyoung Chang & Shao-Cong Sun. (2012) Peli: a family of signal-responsive E3 ubiquitin ligases mediating TLR signaling and T-cell tolerance. Cellular & Molecular Immunology 9:2, pages 113-122.
Crossref
Mikyoung Chang, Wei Jin, Jae-Hoon Chang, Yichuan Xiao, George C Brittain, Jiayi Yu, Xiaofei Zhou, Yi-Hong Wang, Xuhong Cheng, Pingwei Li, Brian A Rabinovich, Patrick Hwu & Shao-Cong Sun. (2011) The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity. Nature Immunology 12:10, pages 1002-1009.
Crossref
Nam-Sihk Lee, Laura Barber, Ali Kanchwala, Carter J. H. Childs, Yash P. Kataria, Marc A. Judson, Mark A. Mazer & Sergio Arce. (2011) Low Levels of NF-κB/p65 Mark Anergic CD4 + T Cells and Correlate with Disease Severity in Sarcoidosis . Clinical and Vaccine Immunology 18:2, pages 223-234.
Crossref
Nusrat Rahman, Graeme Stewart & Graham Jones. (2010) A role for the atopy‐associated gene PHF11 in T‐cell activation and viability . Immunology & Cell Biology 88:8, pages 817-824.
Crossref
Vincent Kam Wai Wong, Hua Zhou, Simon Shiu Fai Cheung, Ting Li & Liang Liu. (2009) Mechanistic study of saikosaponin-d (Ssd) on suppression of murine T lymphocyte activation. Journal of Cellular Biochemistry 107:2, pages 303-315.
Crossref
Jin Myung Choi, Hyun Jung Kim, Kwang Youl Lee, Hyun Jin Choi, Ik-Soo Lee & Bok Yun Kang. (2009) Increased IL-2 production in T cells by xanthohumol through enhanced NF-AT and AP-1 activity. International Immunopharmacology 9:1, pages 103-107.
Crossref
Emily Clarke, Nusrat Rahman, Natalie Page, Michael S. Rolph, Graeme J. Stewart & Graham J. Jones. (2008) Functional characterization of the atopy-associated gene PHF11. Journal of Allergy and Clinical Immunology 121:5, pages 1148-1154.e3.
Crossref
William E. AckermanIVIV, Taryn L.S. Summerfield, Dale D. Vandre, John M. Robinson & Douglas A. Kniss. (2008) Nuclear Factor-Kappa B Regulates Inducible Prostaglandin E Synthase Expression in Human Amnion Mesenchymal Cells1. Biology of Reproduction 78:1, pages 68-76.
Crossref
Young-Chang Cho, Goo Yoon, Kwang Youl Lee, Hyun Jin Choi & Bok Yun Kang. (2007) Inhibition of Interleukin-2 Production by Myricetin in Mouse EL-4 T Cells. Archives of Pharmacal Research 30:9, pages 1075-1079.
Crossref
Diana Legarda-Addison & Adrian T. Ting. (2007) Negative Regulation of TCR Signaling by NF-κB2/p100. The Journal of Immunology 178:12, pages 7767-7778.
Crossref
Denise M. Ray, Kimberly M. Morse, Shannon P. Hilchey, Tatiana M. Garcia, Raymond E. Felgar, Sanjay B. Maggirwar, Richard P. Phipps & Steven H. Bernstein. (2006) The novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) induces apoptosis of human diffuse large B-cell lymphoma cells through a peroxisome proliferator-activated receptor γ-independent pathway. Experimental Hematology 34:9, pages 1201-1210.
Crossref
Carmen Sánchez-Valdepeñas, Angel G. Martín, Parameswaran Ramakrishnan, David Wallach & Manuel Fresno. (2006) NF-κB-Inducing Kinase Is Involved in the Activation of the CD28 Responsive Element through Phosphorylation of c-Rel and Regulation of Its Transactivating Activity. The Journal of Immunology 176:8, pages 4666-4674.
Crossref
Pei-Yun Chang & Shigeki Miyamoto. (2006) Nuclear Factor-κB Dimer Exchange Promotes a p21waf1/cip1 Superinduction Response in Human T Leukemic Cells. Molecular Cancer Research 4:2, pages 101-112.
Crossref
Susumu Nishiyama, Noriko Manabe, Yoshitsugu Kubota, Hiroaki Ohnishi, Akira Kitanaka, Michiaki Tokuda, Tomohiko Taminato, Toshihiko Ishida, Jiro Takahara & Terukazu Tanaka. (2005) Cyclosporin A inhibits the early phase of NF-κB/RelA activation induced by CD28 costimulatory signaling to reduce the IL-2 expression in human peripheral T cells. International Immunopharmacology 5:4, pages 699-710.
Crossref
Sebastian A. Mikolajczak, Bruce Y. Ma, Tetsuya Yoshida, Ryoko Yoshida, David J. Kelvin & Atsuo Ochi. (2004) The Modulation of CD40 Ligand Signaling by Transmembrane CD28 Splice Variant in Human T Cells. Journal of Experimental Medicine 199:7, pages 1025-1031.
Crossref
Bruce Y Ma, Sebastian A Mikolajczak, Tetsuya Yoshida, Ryoko Yoshida, David J Kelvin & Atsuo Ochi. (2004) CD28 T cell costimulatory receptor function is negatively regulated by N-linked carbohydrates. Biochemical and Biophysical Research Communications 317:1, pages 60-67.
Crossref
Nieves Márquez, Rocío Sancho, Antonio Macho, Marco A. Calzado, Bernd L. Fiebich & Eduardo Muñoz. (2004) Caffeic Acid Phenethyl Ester Inhibits T-Cell Activation by Targeting Both Nuclear Factor of Activated T-Cells and NF-κB Transcription Factors. Journal of Pharmacology and Experimental Therapeutics 308:3, pages 993-1001.
Crossref
Rocío Sancho, Antonio Macho, Laureano de La Vega, Marco A. Calzado, Bernd L. Fiebich, Giovanni Appendino & Eduardo Muñoz. (2004) Immunosuppressive Activity of Endovanilloids: N -Arachidonoyl-Dopamine Inhibits Activation of the NF-κB, NFAT, and Activator Protein 1 Signaling Pathways . The Journal of Immunology 172:4, pages 2341-2351.
Crossref
James L. Smith, Irene Collins, G.V.R. Chandramouli, Wayne G. Butscher, Elena Zaitseva, Wendy J. Freebern, Cynthia M. Haggerty, Victoria Doseeva & Kevin Gardner. (2003) Targeting Combinatorial Transcriptional Complex Assembly at Specific Modules within the Interleukin-2 Promoter by the Immunosuppressant SB203580. Journal of Biological Chemistry 278:42, pages 41034-41046.
Crossref
Scott A. Crist, Thomas S. Griffith & Timothy L. Ratliff. (2003) Structure/Function Analysis of the Murine CD95L Promoter Reveals the Identification of a Novel Transcriptional Repressor and Functional CD28 Response Element. Journal of Biological Chemistry 278:38, pages 35950-35958.
Crossref
Ye Zheng, Monika Vig, Jesse Lyons, Luk Van Parijs & Amer A. Beg. (2003) Combined Deficiency of p50 and cRel in CD4+ T Cells Reveals an Essential Requirement for Nuclear Factor κB in Regulating Mature T Cell Survival and In Vivo Function. Journal of Experimental Medicine 197:7, pages 861-874.
Crossref
Sonia Sharma, Nathalie Grandvaux, Yael Mamane, Pierre Genin, Nazli Azimi, Thomas Waldmann & John Hiscott. (2002) Regulation of IFN Regulatory Factor 4 Expression in Human T Cell Leukemia Virus-I-Transformed T Cells. The Journal of Immunology 169:6, pages 3120-3130.
Crossref
Lawrence P. Kane, Joseph Lin & Arthur Weiss. (2002) It's all Rel-ative: NF-κB and CD28 costimulation of T-cell activation. Trends in Immunology 23:8, pages 413-420.
Crossref
Xu-Yu Zhou, Yumi Yashiro-Ohtani, Masakiyo Nakahira, Woong Ryeon Park, Ryo Abe, Toshiyuki Hamaoka, Mayumi Naramura, Hua Gu & Hiromi Fujiwara. (2002) Molecular Mechanisms Underlying Differential Contribution of CD28 Versus Non-CD28 Costimulatory Molecules to IL-2 Promoter Activation. The Journal of Immunology 168:8, pages 3847-3854.
Crossref
Noah IsakovAmnon Altman. (2002) Protein Kinase Cθ in T Cell Activation. Annual Review of Immunology 20:1, pages 761-794.
Crossref
Haruo HanawaYong MaSebastian A. MikolajczakMatthew L. CharlesTetsuya YoshidaRyoko YoshidaCraig A. StrathdeeDavid W. LitchfieldAtsuo Ochi. (2002) A novel costimulatory signaling in human T lymphocytes by a splice variant of CD28. Blood 99:6, pages 2138-2145.
Crossref
Clara Abraham & Jim Miller. (2001) Molecular Mechanisms of IL-2 Gene Regulation Following Costimulation Through LFA-1. The Journal of Immunology 167:9, pages 5193-5201.
Crossref
Emira AyroldiGraziella MiglioratiStefano BruscoliCristina MarchettiOrnella ZolloLorenza CannarileFrancesca D'AdamioCarlo Riccardi. (2001) Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor κB. Blood 98:3, pages 743-753.
Crossref
Esther González, Carmen Punzón, Manuel González & Manuel Fresno. (2001) HIV-1 Tat Inhibits IL-2 Gene Transcription Through Qualitative and Quantitative Alterations of the Cooperative Rel/AP1 Complex Bound to the CD28RE/AP1 Composite Element of the IL-2 Promoter. The Journal of Immunology 166:7, pages 4560-4569.
Crossref
Kun Bi & Amnon Altman. (2001) Membrane lipid microdomains and the role of PKCθ in T cell activation. Seminars in Immunology 13:2, pages 139-146.
Crossref
Francesc Marti, Anja Krause, Nicholas H. Post, Clay Lyddane, Bo Dupont, Michel Sadelain & Philip D. King. (2001) Negative-Feedback Regulation of CD28 Costimulation by a Novel Mitogen-Activated Protein Kinase Phosphatase, MKP6 . The Journal of Immunology 166:1, pages 197-206.
Crossref
Lawrence P. Kane, Pietro G. Andres, Kimberly C. Howland, Abul K. Abbas & Arthur Weiss. (2001) Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not TH2 cytokines. Nature Immunology 2:1, pages 37-44.
Crossref
Carlo Riccardi, Stefano Bruscoli, Emira Ayroldi, Massimiliano Agostini & Graziella Migliorati. 2001. Progress in Basic and Clinical Immunology. Progress in Basic and Clinical Immunology 31 39 .
Andrea Denk, Thomas Wirth & Bernd Baumann. (2000) NF-κB transcription factors: critical regulators of hematopoiesis and neuronal survival. Cytokine & Growth Factor Reviews 11:4, pages 303-320.
Crossref
Edgar Serfling, Friederike Berberich-Siebelt, Sergei Chuvpilo, Eriks Jankevics, Stefan Klein-Hessling, Thomas Twardzik & Andris Avots. (2000) The role of NF-AT transcription factors in T cell activation and differentiation11We dedicate this review to Prof. Dr. Rigomar Rieger (Gatersleben), a great scientist and man, on the occasion of his 70th birthday. One of us (E.S.) had the pleasure of working in his department.. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1498:1, pages 1-18.
Crossref
Joel MachadoJrJr, Paula C Fernandez, Ina Baumann & Dirk A.E Dobbelaere. (2000) Characterisation of NF-κB complexes in Theileria parva-transformed T cells. Microbes and Infection 2:11, pages 1311-1320.
Crossref
Ahmad Pazirandeh, Yintong Xue, Sam Okret & Mikael Jondal. (2000) Glucocorticoid Resistance in Thymocytes from Mice Expressing a T Cell Receptor Transgene. Biochemical and Biophysical Research Communications 276:1, pages 189-196.
Crossref
Isis Rivera-Walsh, Mary Ellen Cvijic, Gutian Xiao & Shao-Cong Sun. (2000) The NF-κB Signaling Pathway Is Not Required for Fas Ligand Gene Induction but Mediates Protection from Activation-induced Cell Death. Journal of Biological Chemistry 275:33, pages 25222-25230.
Crossref
Laurie H. Glimcher & Kenneth M. Murphy. (2000) Lineage commitment in the immune system: the T helper lymphocyte grows up. Genes & Development 14:14, pages 1693-1711.
Crossref
Nolwenn Coudronniere, Martin Villalba, Nathan Englund & Amnon Altman. (2000) NF-κB activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-θ. Proceedings of the National Academy of Sciences 97:7, pages 3394-3399.
Crossref
Sanjay B. Maggirwar, Servio Ramirez, Ning Tong, Harris A. Gelbard & Stephen Dewhurst. (2001) Functional Interplay Between Nuclear Factor-κB and c-Jun Integrated by Coactivator p300 Determines the Survival of Nerve Growth Factor-Dependent PC12 Cells. Journal of Neurochemistry 74:2, pages 527-539.
Crossref
Catherine Shang, Joanne Attema, Dimitrios Cakouros, Peter N. Cockerill & M. Frances Shannon. (1999) Nuclear factor of activated T cells contributes to the function of the CD28 response region of the granulocyte macrophage-colony stimulating factor promoter. International Immunology 11:12, pages 1945-1956.
Crossref
Azem Civil, Irma Rensink, Lucien A. Aarden & Cornelis L. Verweij. (1999) Functional Disparity of Distinct CD28 Response Elements toward Mitogenic Responses. Journal of Biological Chemistry 274:48, pages 34369-34374.
Crossref
Henry K. Wong, Gary M. Kammer, Greg Dennis & George C. Tsokos. (1999) Abnormal NF-κB Activity in T Lymphocytes from Patients with Systemic Lupus Erythematosus Is Associated with Decreased p65-RelA Protein Expression . The Journal of Immunology 163:3, pages 1682-1689.
Crossref
Nan Fang & Gary A. Koretzky. (1999) SLP-76 and Vav Function in Separate, but Overlapping Pathways to Augment Interleukin-2 Promoter Activity. Journal of Biological Chemistry 274:23, pages 16206-16212.
Crossref
Alexander Kel, Olga Kel-Margoulis, Vladimir Babenko & Edgar Wingender. (1999) Recognition of NFATp/AP-1 composite elements within genes induced upon the activation of immune cells. Journal of Molecular Biology 288:3, pages 353-376.
Crossref
Xin Lin, Emmett T CunninghamJr.Jr., Yajun Mu, Romas Geleziunas & Warner C Greene. (1999) The Proto-Oncogene Cot Kinase Participates in CD3/CD28 Induction of NF-κB Acting through the NF-κB-Inducing Kinase and IκB Kinases. Immunity 10:2, pages 271-280.
Crossref
Sanjay B. Maggirwar, Patrick D. Sarmiere, Stephen Dewhurst & Robert S. Freeman. (1998) Nerve Growth Factor-Dependent Activation of NF-κB Contributes to Survival of Sympathetic Neurons. The Journal of Neuroscience 18:24, pages 10356-10365.
Crossref
Esteban S. Masuda, Ryu Imamura, Yoshiharu Amasaki, Kenichi Arai & Naoko Arai. (1998) Signalling into the T-Cell Nucleus. Cellular Signalling 10:9, pages 599-611.
Crossref
Min-Ying ZhangEdward W. HarhajLaurie BellShao-Cong SunBarbara A. Miller. (1998) Bcl-3 Expression and Nuclear Translocation Are Induced by Granulocyte-Macrophage Colony-Stimulating Factor and Erythropoietin in Proliferating Human Erythroid Precursors. Blood 92:4, pages 1225-1234.
Crossref
Min-Ying ZhangEdward W. HarhajLaurie BellShao-Cong SunBarbara A. Miller. (1998) Bcl-3 Expression and Nuclear Translocation Are Induced by Granulocyte-Macrophage Colony-Stimulating Factor and Erythropoietin in Proliferating Human Erythroid Precursors. Blood 92:4, pages 1225-1234.
Crossref
Isis Rivera, Edward W. Harhaj & Shao-Cong Sun. (1998) Involvement of NF-AT in Type I Human T-cell Leukemia Virus Tax-mediated Fas Ligand Promoter Transactivation. Journal of Biological Chemistry 273:35, pages 22382-22388.
Crossref
Margaret E Ginn-Pease & Ronald L Whisler. (1998) Redox Signals and NF-κB Activation in T Cells. Free Radical Biology and Medicine 25:3, pages 346-361.
Crossref
Deborah R. New, Sanjay B. Maggirwar, Leon G. Epstein, Stephen Dewhurst & Harris A. Gelbard. (1998) HIV-1 Tat Induces Neuronal Death via Tumor Necrosis Factor-α and Activation of Non-N-methyl-d-aspartate Receptors by a NFκB-Independent Mechanism. Journal of Biological Chemistry 273:28, pages 17852-17858.
Crossref
Min-Ying ZhangShao-Cong SunLaurie BellBarbara A. Miller. (1998) NF-κB Transcription Factors Are Involved in Normal Erythropoiesis. Blood 91:11, pages 4136-4144.
Crossref
Min-Ying ZhangShao-Cong SunLaurie BellBarbara A. Miller. (1998) NF-κB Transcription Factors Are Involved in Normal Erythropoiesis. Blood 91:11, pages 4136-4144.
Crossref
Steve Gerondakis, Raelene Grumont, Ian Rourke & Mathis Grossmann. (1998) The regulation and roles of Rel/NF-κB transcription factors during lymphocyte activation. Current Opinion in Immunology 10:3, pages 353-359.
Crossref
Suneet Agarwal & Anjana Rao. (1998) Long-range transcriptional regulation of cytokine gene expression. Current Opinion in Immunology 10:3, pages 345-352.
Crossref
James I. HealyChristopher C. Goodnow. (1998) POSITIVE VERSUS NEGATIVE SIGNALING BY LYMPHOCYTE ANTIGEN RECEPTORS. Annual Review of Immunology 16:1, pages 645-670.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.