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Molecular and Cellular Biology Volume 17, 1997 - Issue 5
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Research Article

Ectopic TAL-1/SCL Expression in Phenotypically Normal or Leukemic Myeloid Precursors: Proliferative and Antiapoptotic Effects Coupled with a Differentiation Blockade

G. L. CondorelliKimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania19107-5541, and Department of Hematology-Oncology, Istituto Superiore di Sanità, 00161Rome, ItalyCorrespondence[email protected]
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A. TocciKimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania19107-5541, and Department of Hematology-Oncology, Istituto Superiore di Sanità, 00161Rome, Italy
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R. BottaKimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania19107-5541, and Department of Hematology-Oncology, Istituto Superiore di Sanità, 00161Rome, Italy
,
F. FacchianoKimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania19107-5541, and Department of Hematology-Oncology, Istituto Superiore di Sanità, 00161Rome, Italy
,
U. TestaKimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania19107-5541, and Department of Hematology-Oncology, Istituto Superiore di Sanità, 00161Rome, Italy
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L. VitelliKimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania19107-5541, and Department of Hematology-Oncology, Istituto Superiore di Sanità, 00161Rome, Italy
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M. ValtieriKimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania19107-5541, and Department of Hematology-Oncology, Istituto Superiore di Sanità, 00161Rome, Italy
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C. M. CroceKimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania19107-5541, and Department of Hematology-Oncology, Istituto Superiore di Sanità, 00161Rome, Italy
&
C. PeschleKimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania19107-5541, and Department of Hematology-Oncology, Istituto Superiore di Sanità, 00161Rome, Italy
 show all
Pages 2954-2969 | Received 09 Aug 1996, Accepted 05 Feb 1997, Published online: 29 Mar 2023

Citations (35)

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Soumyadeep Dey, David J. Curtis, Stephen M. Jane & Stephen J. Brandt. (2010) The TAL1/SCL Transcription Factor Regulates Cell Cycle Progression and Proliferation in Differentiating Murine Bone Marrow Monocyte Precursors. Molecular and Cellular Biology 30:9, pages 2181-2192.
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Anna H. Schuh, Alex J. Tipping, Allison J. Clark, Isla Hamlett, Boris Guyot, Francesco J. Iborra, Patrick Rodriguez, John Strouboulis, Tariq Enver, Paresh Vyas & Catherine Porcher. (2005) ETO-2 Associates with SCL in Erythroid Cells and Megakaryocytes and Provides Repressor Functions in Erythropoiesis. Molecular and Cellular Biology 25:23, pages 10235-10250.
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David B. Sykes & Mark P. Kamps. (2003) Estrogen-regulated Conditional Oncoproteins: Tools to Address Open Questions in Normal Myeloid Cell Function, Normal Myeloid Differentiation, and the Genetic Basis of Differentiation Arrest in Myeloid Leukemia. Leukemia & Lymphoma 44:7, pages 1131-1139.
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Luigi Vitelli, Gianluigi Condorelli, Valentina Lulli, Trang Hoang, Luisella Luchetti, Carlo M. Croce & Cesare Peschle. (2000) A Pentamer Transcriptional Complex Including tal-1 and Retinoblastoma Protein Downmodulates c-kit Expression in Normal Erythroblasts. Molecular and Cellular Biology 20:14, pages 5330-5342.
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Monica Florio, Maria-Clemencia Hernandez, Hui Yang, Hui-Kuo Shu, John L. Cleveland & Mark A. Israel. (1998) Id2 Promotes Apoptosis by a Novel Mechanism Independent of Dimerization to Basic Helix-Loop-Helix Factors. Molecular and Cellular Biology 18:9, pages 5435-5444.
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Articles from other publishers (30)

T. Hoang, J.A. Lambert & R. Martin. 2016. Hematopoiesis. Hematopoiesis 163 204 .
Julie LacombeGorazd KroslMathieu TremblayBastien GerbyRichard MartinPeter D. Aplan, Sebastien LemieuxTrang Hoang. (2013) Genetic interaction between Kit and Scl. Blood 122:7, pages 1150-1161.
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Fan Li, Lin Zhang, Chunxue Li, Bing Ni, Yuzhang Wu, Ying Huang, Guangjun Zhang, Li Wang, Anping Zhang, Yujun He, Tao Fu, Weidong Tong & Baohua Liu. (2010) Adenovirus-mediated stem cell leukemia gene transfer induces rescue of interstitial cells of Cajal in ICC-loss mice. International Journal of Colorectal Disease 25:5, pages 557-566.
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Kim U. Birkenkamp, Abdelkader Essafi, Kristan E. van der Vos, Marco da Costa, Rosaline C.-Y. Hui, Frank Holstege, Leo Koenderman, Eric W.-F. Lam & Paul J. Coffer. (2007) FOXO3a Induces Differentiation of Bcr-Abl-transformed Cells through Transcriptional Down-regulation of Id1. Journal of Biological Chemistry 282:4, pages 2211-2220.
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J A Shank-Calvo, K Draheim, M Bhasin & M A Kelliher. (2006) p16Ink4a or p19Arf loss contributes to Tal1-induced leukemogenesis in mice. Oncogene 25:21, pages 3023-3031.
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S Demontis, C Rigo, S Piccinin, M Mizzau, M Sonego, M Fabris, C Brancolini & R Maestro. (2005) Twist is substrate for caspase cleavage and proteasome-mediated degradation. Cell Death & Differentiation 13:2, pages 335-345.
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Yanjia Zhang, Kimberly J. Payne, Yuhua Zhu, Mary A. Price, Yasmin K. Parrish, Ewa Zielinska, Lora W. Barsky & Gay M. Crooks. (2009) SCL Expression at Critical Points in Human Hematopoietic Lineage Commitment . STEM CELLS 23:6, pages 852-860.
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Miranda BuitenhuisHanneke W. M. van DeutekomLiesbeth P. VerhagenAnders CastorSten Eirik W. JacobsenJan-Willem J. LammersLeo KoendermanPaul J. Coffer. (2005) Differential regulation of granulopoiesis by the basic helix-loop-helix transcriptional inhibitors Id1 and Id2. Blood 105:11, pages 4272-4281.
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Atsushi KunisatoShigeru ChibaToshiki SaitoKeiki KumanoEtsuko Nakagami-YamaguchiTomoyuki YamaguchiHisamaru Hirai. (2004) Stem cell leukemia protein directs hematopoietic stem cell fate. Blood 103:9, pages 3336-3341.
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Emmanuel RavetDamien ReynaudMonique TiteuxBrigitte IzacSerge FichelsonPaul-Henri RoméoAnne Dubart-KupperschmittFrançoise Pflumio. (2004) Characterization of DNA-binding-dependent and -independent functions of SCL/TAL1 during human erythropoiesis. Blood 103:9, pages 3326-3335.
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Eric Lécuyer & Trang Hoang. (2004) SCL: From the origin of hematopoiesis to stem cells and leukemia. Experimental Hematology 32:1, pages 11-24.
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Anders Hansson, Christina Manetopoulos, Jan-Ingvar Jönsson & Håkan Axelson. (2003) The basic helix–loop–helix transcription factor TAL1/SCL inhibits the expression of the p16INK4A and pTα genes. Biochemical and Biophysical Research Communications 312:4, pages 1073-1081.
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A Zeuner, A Eramo, U Testa, N Felli, E Pelosi, G Mariani, S M Srinivasula, E S Alnemri, G Condorelli, C Peschle & R De Maria. (2003) Control of erythroid cell production via caspase-mediated cleavage of transcription factor SCL/Tal-1. Cell Death & Differentiation 10:8, pages 905-913.
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Catherine Labbaye, Maria Teresa Quaranta, Alfredo Pagliuca, Stefania Militi, Jonathan D Licht, Ugo Testa & Cesare Peschle. (2002) PLZF induces megakaryocytic development, activates Tpo receptor expression and interacts with GATA1 protein. Oncogene 21:43, pages 6669-6679.
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Nicolas GoardonAnnette SchuhIman HajarXiaoqian MaHélène JouaultElaine DzierzakPaul-Henri RoméoLeı̈la Maouche-Chrétien. (2002) Ectopic expression of TAL-1 protein in Ly-6E.1-htal-1transgenic mice induces defects in B- and T-lymphoid differentiation. Blood 100:2, pages 491-500.
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Shin Kawamata, Changchun Du, Kaijun Li & Catherine Lavau. (2002) Overexpression of the Notch target genes Hes in vivo induces lymphoid and myeloid alterations. Oncogene 21:24, pages 3855-3863.
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Jun Lu & Steven R. Sloan. (2002) The Basic Helix–Loop–Helix Domain of the E47 Transcription Factor Requires Other Protein Regions for Full DNA Binding Activity. Biochemical and Biophysical Research Communications 290:5, pages 1521-1528.
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Carol Beadling, Anna Cereseto, Wen Fan, Mayumi Naramura & Kendall A Smith. (2001) Cytokine response gene 8 (CR8) regulates the cell cycle G1-S phase transition and promotes cellular survival. Oncogene 20:14, pages 1771-1783.
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HN Crans & KM Sakamoto. (2001) Transcription factors and translocations in lymphoid and myeloid leukemia. Leukemia 15:3, pages 313-331.
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J. R. Caceres‐Cortes, G. Krosl, N. Tessier, P. Hugo & T. Hoang. (2009) Steel Factor Sustains SCL Expression and the Survival of Purified CD34 + Bone Marrow Cells in the Absence of Detectable Cell Differentiation . STEM CELLS 19:1, pages 59-70.
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Christine Courtes, Nathalie Lecointe, Laurent Le Cam, Florence Baudoin, Claude Sardet & Danièle Mathieu-Mahul. (2000) Erythroid-specific Inhibition of the tal-1 Intragenic Promoter Is Due to Binding of a Repressor to a Novel Silencer. Journal of Biological Chemistry 275:2, pages 949-958.
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L.M Barton, B Göttgens & A.R Green. (1999) The stem cell leukaemia (SCL) gene: a critical regulator of haemopoietic and vascular development. The International Journal of Biochemistry & Cell Biology 31:10, pages 1193-1207.
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C. Glenn BegleyAnthony R. Green. (1999) The SCL Gene: From Case Report to Critical Hematopoietic Regulator. Blood 93:9, pages 2760-2770.
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C. Glenn BegleyAnthony R. Green. (1999) The SCL Gene: From Case Report to Critical Hematopoietic Regulator. Blood 93:9, pages 2760-2770.
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Richard Ferrier, Romain Nougarede, Sandrine Doucet, Brigitte Kahn-Perles, Jean Imbert & Danièle Mathieu-Mahul. (1999) Physical interaction of the bHLH LYL1 protein and NF-κB1 p105. Oncogene 18:4, pages 995-1005.
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Ernst-Otto Bockamp, Jeremy L. Fordham, Berthold Göttgens, Adelle M. Murrell, Maria-José Sanchez & Anthony R. Green. (1998) Transcriptional Regulation of the Stem Cell Leukemia Gene by PU.1 and Elf-1. Journal of Biological Chemistry 273:44, pages 29032-29042.
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Santini Scappini Gozzini Grossi Villa, Ronco, Douillet, Pouillart Bernabei Rossi Ferrini. (2001) Butyrate‐stable monosaccharide derivatives induce maturation and apoptosis in human acute myeloid leukaemia cells. British Journal of Haematology 101:3, pages 529-538.
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Ngaire J. ElwoodHelen ZogosDaniel S. PereiraJohn E. DickC. Glenn Begley. (1998) Enhanced Megakaryocyte and Erythroid Development From Normal Human CD34+ Cells: Consequence of Enforced Expression of SCL. Blood 91:10, pages 3756-3765.
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Ngaire J. ElwoodHelen ZogosDaniel S. PereiraJohn E. DickC. Glenn Begley. (1998) Enhanced Megakaryocyte and Erythroid Development From Normal Human CD34+ Cells: Consequence of Enforced Expression of SCL. Blood 91:10, pages 3756-3765.
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Richard W. Deed, Michelle Jasiok & John D. Norton. (1998) Lymphoid-specific Expression of the Id3 Gene in Hematopoietic Cells. Journal of Biological Chemistry 273:14, pages 8278-8286.
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