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Research Article

The Immediate-Early Gene Product Egr-1 Regulates the Human Interleukin-2 Receptor β-Chain Promoter through Noncanonical Egr and Sp1 Binding Sites

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Pages 3714-3722 | Received 19 Aug 1996, Accepted 08 Apr 1997, Published online: 29 Mar 2023

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Zheng Wu, Hyoung-Pyo Kim, Hai-Hui Xue, Hong Liu, Keji Zhao & Warren J. Leonard. (2005) Interleukin-21 Receptor Gene Induction in Human T Cells Is Mediated by T-Cell Receptor-Induced Sp1 Activity. Molecular and Cellular Biology 25:22, pages 9741-9752.
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Paul R. Mittelstadt & Jonathan D. Ashwell. (1998) Cyclosporin A-Sensitive Transcription Factor Egr-3 Regulates Fas Ligand Expression. Molecular and Cellular Biology 18:7, pages 3744-3751.
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Articles from other publishers (66)

Muntasir Billah, Adiba Naz, Rashed Noor, Ravinay Bhindi & Levon M. Khachigian. (2023) Early Growth Response-1: Friend or Foe in the Heart?. Heart, Lung and Circulation 32:5, pages e23-e35.
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Luca PaciniSilvia SuffrediniDonatella PontiRaffaele CoppiniGiacomo FratiGiuseppe RagonaElisabetta CerbaiAntonella Calogero. (2013) Altered calcium regulation in isolated cardiomyocytes from Egr-1 knock-out mice . Canadian Journal of Physiology and Pharmacology 91:12, pages 1135-1142.
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Jifeng Zhang, Yuan Zhang, Tingwan Sun, Fang Guo, Shengping Huang, Menisha Chandalia, Nicola Abate, Daping Fan, Hong-Bo Xin, Y. Eugene Chen & Mingui Fu. (2013) Dietary obesity-induced Egr-1 in adipocytes facilitates energy storage via suppression of FOXC2. Scientific Reports 3:1.
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E. M. Kuklina. (2013) Molecular mechanisms of T-cell anergy. Biochemistry (Moscow) 78:2, pages 144-156.
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Wei Liao, Jian-Xin Lin & Warren J. Leonard. (2013) Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy. Immunity 38:1, pages 13-25.
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Serene Keilani, Samira Chandwani, Georgia Dolios, Alexey Bogush, Heike Beck, Antonis K. Hatzopoulos, Gadiparthi N. Rao, Elizabeth A. Thomas, Rong Wang & Michelle E. Ehrlich. (2012) Egr-1 Induces DARPP-32 Expression in Striatal Medium Spiny Neurons via a Conserved Intragenic Element. The Journal of Neuroscience 32:20, pages 6808-6818.
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Ning Shen, Yue Shao, Shan-Shan Lai, Long Qiao, Run-Lin Yang, Bin Xue, Fei-Yan Pan, Hua-Qun Chen & Chao-Jun Li. (2011) GGPPS, a New EGR-1 Target Gene, Reactivates ERK 1/2 Signaling through Increasing Ras Prenylation. The American Journal of Pathology 179:6, pages 2740-2750.
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Feng Fang, Kohtaro Ooka, Swati Bhattachyya, Jun Wei, Minghua Wu, Pan Du, Simon Lin, Francesco Del Galdo, Carol A. Feghali-Bostwick & John Varga. (2011) The Early Growth Response Gene Egr2 (Alias Krox20) Is a Novel Transcriptional Target of Transforming Growth Factor-β that Is Up-Regulated in Systemic Sclerosis and Mediates Profibrotic Responses. The American Journal of Pathology 178:5, pages 2077-2090.
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Ning Shen, Tao Gong, Jian-Dong Wang, Fan-Li Meng, Long Qiao, Run-Lin Yang, Bin Xue, Fei-Yan Pan, Xiao-Jun Zhou, Hua-Qun Chen, Wen Ning & Chao-Jun Li. (2011) Cigarette Smoke–Induced Pulmonary Inflammatory Responses Are Mediated by EGR-1/GGPPS/MAPK Signaling. The American Journal of Pathology 178:1, pages 110-118.
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N. Fukuda. (2010) Cigarette smoking induces vascular proliferative disease through the activation of Egr-1. Cardiovascular Research 88:2, pages 207-208.
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Elvira Bailón, Margarita Cueto-Sola, Pilar Utrilla, María Elena Rodríguez-Cabezas, Natividad Garrido-Mesa, Antonio Zarzuelo, Jordi Xaus, Julio Gálvez & Mònica Comalada. (2010) Butyrate in vitro immune-modulatory effects might be mediated through a proliferation-related induction of apoptosis. Immunobiology 215:11, pages 863-873.
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Frédéric Bouchard, Simon D. Bélanger, Katherine Biron-Pain & Yves St-Pierre. (2010) EGR-1 activation by EGF inhibits MMP-9 expression and lymphoma growth. Blood 116:5, pages 759-766.
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Diana Gómez-Martín, Mariana Díaz-Zamudio, Miguel Galindo-Campos & Jorge Alcocer-Varela. (2010) Early growth response transcription factors and the modulation of immune response. Autoimmunity Reviews 9:6, pages 454-458.
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Chi-Tan Hu, Tsu-Yao Chang, Chuan-Chu Cheng, Chun-Shan Liu, Jia-Ru Wu, Ming-Che Li & Wen-Sheng Wu. (2010) Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b. FEBS Journal 277:5, pages 1202-1218.
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Lu Xue, Hongling Qiu, Jian Ma, Mingxiong Guo & Wenxin Li. (2010) ZNF300, a recently identified human transcription factor, activates the human IL-2Rβ promoter through the overlapping ZNF300/EGR1 binding site. Cellular and Molecular Biology Letters 15:4.
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Michael Lohoff, Marco Giaisi, Rebecca Köhler, Bärbel Casper, Peter H. Krammer & Min Li-Weber. (2010) Early Growth Response Protein-1 (Egr-1) Is Preferentially Expressed in T Helper Type 2 (Th2) Cells and Is Involved in Acute Transcription of the Th2 Cytokine Interleukin-4. Journal of Biological Chemistry 285:3, pages 1643-1652.
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Hyun-Jin Shin, Jee-Boong Lee, Sung-Hwan Park, Jun Chang & Chang-Woo Lee. (2009) T-bet expression is regulated by EGR1-mediated signaling in activated T cells. Clinical Immunology 131:3, pages 385-394.
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