4
Views
56
CrossRef citations to date
0
Altmetric
Research Article

Efficient Repression of Endogenous Major Histocompatibility Complex Class II Expression through Dominant Negative CIITA Mutants Isolated by a Functional Selection Strategy

, , &
Pages 4249-4258 | Received 27 Jan 1997, Accepted 28 Apr 1997, Published online: 29 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Roberto Gambari. (2011) Recent patents on therapeutic applications of the transcription factor decoy approach. Expert Opinion on Therapeutic Patents 21:11, pages 1755-1771.
Read now
Michal Krawczyk, Krzysztof Masternak, Madeleine Zufferey, Emmanuèle Barras & Walter Reith. (2005) New Functions of the Major Histocompatibility Complex Class II-Specific Transcription Factor RFXANK Revealed by a High-Resolution Mutagenesis Study. Molecular and Cellular Biology 25:19, pages 8607-8618.
Read now
Marie Peretti, Jean Villard, Emmanuèle Barras, Madeleine Zufferey & Walter Reith. (2001) Expression of the Three Human Major Histocompatibility Complex Class II Isotypes Exhibits a Differential Dependence on the Transcription Factor RFXAP. Molecular and Cellular Biology 21:17, pages 5699-5709.
Read now
Sandra B. Hake, Krzysztof Masternak, Claudia Kammerbauer, Christian Janzen, Walter Reith & Viktor Steimle. (2000) CIITA Leucine-Rich Repeats Control Nuclear Localization, In Vivo Recruitment to the Major Histocompatibility Complex (MHC) Class II Enhanceosome, and MHC Class II Gene Transactivation. Molecular and Cellular Biology 20:20, pages 7716-7725.
Read now
Jonathan A. Harton & Jenny P.-Y. Ting. (2000) Class II Transactivator: Mastering the Art of Major Histocompatibility Complex Expression. Molecular and Cellular Biology 20:17, pages 6185-6194.
Read now
Jean Villard, Marie Peretti, Krzysztof Masternak, Emmanuèle Barras, Giuseppina Caretti, Roberto Mantovani & Walter Reith. (2000) A Functionally Essential Domain of RFX5 Mediates Activation of Major Histocompatibility Complex Class II Promoters by Promoting Cooperative Binding between RFX and NF-Y. Molecular and Cellular Biology 20:10, pages 3364-3376.
Read now
Androniki Kretsovali, Theodora Agalioti, Charalambos Spilianakis, Eleni Tzortzakaki, Menie Merika & Joseph Papamatheakis. (1998) Involvement of CREB Binding Protein in Expression of Major Histocompatibility Complex Class II Genes via Interaction with the Class II Transactivator. Molecular and Cellular Biology 18:11, pages 6777-6783.
Read now

Articles from other publishers (48)

Keisuke Ohta, Naoki Saka, Masayoshi Fukasawa & Machiko Nishio. (2023) Hazara orthonairovirus nucleoprotein facilitates viral cell-to-cell spread by modulating tight junction protein, claudin-1. Frontiers in Microbiology 14.
Crossref
Jorge Alfonso León Machado & Viktor Steimle. (2021) The MHC Class II Transactivator CIITA: Not (Quite) the Odd-One-Out Anymore among NLR Proteins. International Journal of Molecular Sciences 22:3, pages 1074.
Crossref
Anna Bruchez, Ky Sha, Joshua Johnson, Li Chen, Caroline Stefani, Hannah McConnellLea GaucherandRachel Prins, Kenneth A. Matreyek, Adam J. Hume, Elke Mühlberger, Emmett V. Schmidt, Gene G. Olinger, Lynda M. StuartAdam Lacy-Hulbert. (2020) MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses. Science 370:6513, pages 241-247.
Crossref
M L Palma, P Duangkhae, B Douradinha, I F T Viana, P O Rigato, R Dhalia, R B Mailliard, S M Barratt-Boyes, E J M Nascimento, T M Oshiro, A J da Silva Duarte & E T A Marques. (2017) Development of potent class II transactivator gene delivery systems capable of inducing de novo MHC II expression in human cells, in vitro and ex vivo. Gene Therapy 24:6, pages 342-352.
Crossref
Hideo Goto, Keisuke Ohta, Yusuke Matsumoto, Natsuko Yumine & Machiko Nishio. (2016) Evidence that Receptor Destruction by the Sendai Virus Hemagglutinin-Neuraminidase Protein Is Responsible for Homologous Interference. Journal of Virology 90:17, pages 7640-7646.
Crossref
Hideo Goto, Hironobu Ihira, Keiichi Morishita, Mitsuki Tsuchiya, Keisuke Ohta, Natsuko Yumine, Masato Tsurudome & Machiko Nishio. (2015) Enhanced growth of influenza A virus by coinfection with human parainfluenza virus type 2. Medical Microbiology and Immunology 205:3, pages 209-218.
Crossref
Yves B. Beaulieu, Jorge A. Leon Machado, Sylvain Ethier, Luc Gaudreau & Viktor Steimle. (2016) Degradation, Promoter Recruitment and Transactivation Mediated by the Extreme N-Terminus of MHC Class II Transactivator CIITA Isoform III. PLOS ONE 11:2, pages e0148753.
Crossref
Anja Mottok, Bruce Woolcock, Fong Chun Chan, King Mong Tong, Lauren Chong, Pedro Farinha, Adèle Telenius, Elizabeth Chavez, Suvan Ramchandani, Marie Drake, Merrill Boyle, Susana Ben-Neriah, David W. Scott, Lisa M. Rimsza, Reiner Siebert, Randy D. Gascoyne & Christian Steidl. (2015) Genomic Alterations in CIITA Are Frequent in Primary Mediastinal Large B Cell Lymphoma and Are Associated with Diminished MHC Class II Expression. Cell Reports 13:7, pages 1418-1431.
Crossref
Susanne Englisch & Mathias Zink. 2015. Obsessive-Compulsive Symptoms in Schizophrenia. Obsessive-Compulsive Symptoms in Schizophrenia 179 202 .
Mathias Zink, Susanne Englisch & Andrea Schmitt. (2014) Antipsychotic treatment modulates glutamate transport and NMDA receptor expression. European Archives of Psychiatry and Clinical Neuroscience 264:S1, pages 67-82.
Crossref
Andreas Neerincx, Kristin Jakobshagen, Olaf Utermöhlen, Hildegard Büning, Viktor Steimle & Thomas A. Kufer. (2014) The N-Terminal Domain of NLRC5 Confers Transcriptional Activity for MHC Class I and II Gene Expression. The Journal of Immunology 193:6, pages 3090-3100.
Crossref
Tobias Ulbricht, Mohammad Alzrigat, Almut Horch, Nina Reuter, Anna von Mikecz, Viktor Steimle, Eberhard Schmitt, Oliver H. Krämer, Thomas Stamminger & Peter Hemmerich. (2012) PML promotes MHC class II gene expression by stabilizing the class II transactivator. Journal of Cell Biology 199:1, pages 49-63.
Crossref
Andreas Neerincx, Galaxia M. Rodriguez, Viktor Steimle & Thomas A. Kufer. (2012) NLRC5 Controls Basal MHC Class I Gene Expression in an MHC Enhanceosome-Dependent Manner. The Journal of Immunology 188:10, pages 4940-4950.
Crossref
Yannick Nizet, Laurent Gillet, Hélène Schroeder, Corinne Lecuivre, J. Louahed, J.-C. Renauld, Pierre Gianello & Alain Vanderplasschen. (2011) Antibody production by injection of living cells expressing non self antigens as cell surface type II transmembrane fusion protein. Journal of Immunological Methods 367:1-2, pages 70-77.
Crossref
Muriel M. Lemaire, Aurélie Vanhaudenarde, Yannick Nizet, Laure Dumoutier & Jean-Christophe Renauld. (2011) Induction of autoantibodies against mouse soluble proteins after immunization with living cells presenting the autoantigen at the cell surface in fusion with a human type 2 transmembrane protein. Journal of Immunological Methods 367:1-2, pages 56-62.
Crossref
Yong Xu, Jonathan A. Harton & Barbara D. Smith. (2008) CIITA Mediates Interferon-γ Repression of Collagen Transcription through Phosphorylation-dependent Interactions with Co-repressor Molecules. Journal of Biological Chemistry 283:3, pages 1243-1256.
Crossref
Laura Strähle, Jean-Baptiste Marq, Albert Brini, Stéphane Hausmann, Daniel Kolakofsky & Dominique Garcin. (2007) Activation of the Beta Interferon Promoter by Unnatural Sendai Virus Infection Requires RIG-I and Is Inhibited by Viral C Proteins. Journal of Virology 81:22, pages 12227-12237.
Crossref
Samuel Cordey & Laurent Roux. (2007) Further characterization of a paramyxovirus transcription initiation signal: search for required nucleotides upstream and importance of the N phase context. Journal of General Virology 88:5, pages 1555-1564.
Crossref
Jean-Baptiste Marq, Albert Brini, Daniel Kolakofsky & Dominique Garcin. (2007) Targeting of the Sendai Virus C Protein to the Plasma Membrane via a Peptide-Only Membrane Anchor. Journal of Virology 81:7, pages 3187-3197.
Crossref
Yong Xu, Jessica McDonald, Emily Perloff, Giovanna Butticè, Barbara M. Schreiber & Barbara D. Smith. (2007) Collagen and major histocompatibility class II expression in mesenchymal cells from CIITA hypomorphic mice. Molecular Immunology 44:7, pages 1709-1721.
Crossref
Isabelle Cognet, Florence Guilhot, Mélanie Gabriac, Sylvie Chevalier, Younes Chouikh, Alexandra Herman-Bert, Angélique Guay-Giroux, Sophie Corneau, Giovanni Magistrelli, Greg C. Elson, Hugues Gascan & Jean-François Gauchat. (2005) Cardiotrophin-like cytokine labelling using Bir A biotin ligase: A sensitive tool to study receptor expression by immune and non-immune cells. Journal of Immunological Methods 301:1-2, pages 53-65.
Crossref
Sven K. Tschoeke & Lyle L. Moldawer. (2005) Human leukocyte antigen expression in sepsis: What have we learned?*. Critical Care Medicine 33:1, pages 236.
Crossref
Michal Krawczyk, Nicolas Peyraud, Natalia Rybtsova, Krzysztof Masternak, Philipp Bucher, Emmanuèle Barras & Walter Reith. (2004) Long Distance Control of MHC Class II Expression by Multiple Distal Enhancers Regulated by Regulatory Factor X Complex and CIITA. The Journal of Immunology 173:10, pages 6200-6210.
Crossref
Yong Xu, Lin Wang, Giovanna Butticè, Pritam K. Sengupta & Barbara D. Smith. (2004) Major Histocompatibility Class II Transactivator (CIITA) Mediates Repression of Collagen (COL1A2) Transcription by Interferon γ (IFN-γ). Journal of Biological Chemistry 279:40, pages 41319-41332.
Crossref
Dominique Garcin, Jean-Baptiste Marq, Fréderic Iseni, Stephen Martin & Daniel Kolakofsky. (2004) A Short Peptide at the Amino Terminus of the Sendai Virus C Protein Acts as an Independent Element That Induces STAT1 Instability. Journal of Virology 78:16, pages 8799-8811.
Crossref
G. Quinn, R. Bower, G. Dos-Santos Cruz, M. Giovino, Y. Xu, C. Patience & H.-J. Schuurman. (2003) Structural and functional characteristics of a dominant-negative isoform of porcine MHC class II transactivator. European Journal of Immunogenetics 30:4, pages 259-270.
Crossref
Dominique Garcin, Jean-Baptiste Marq, Stephen Goodbourn & Daniel Kolakofsky. (2003) The Amino-Terminal Extensions of the Longer Sendai Virus C Proteins Modulate pY701-Stat1 and Bulk Stat1 Levels Independently of Interferon Signaling. Journal of Virology 77:4, pages 2321-2329.
Crossref
Krzysztof Masternak, Nicolas Peyraud, Michal Krawczyk, Emmanuèle Barras & Walter Reith. (2003) Chromatin remodeling and extragenic transcription at the MHC class II locus control region. Nature Immunology 4:2, pages 132-137.
Crossref
Frédéric Iseni, Dominique Garcin, Machiko Nishio, Nancy Kedersha, Paul Anderson & Daniel Kolakofsky. (2002) Sendai virus trailer RNA binds TIAR, a cellular protein involved in virus-induced apoptosis. The EMBO Journal 21:19, pages 5141-5150.
Crossref
Séverine Bontron, Nathalie Lin-Marq & Michel Strubin. (2002) Hepatitis B Virus X Protein Associated with UV-DDB1 Induces Cell Death in the Nucleus and Is Functionally Antagonized by UV-DDB2. Journal of Biological Chemistry 277:41, pages 38847-38854.
Crossref
Pritam K. Sengupta, John Fargo & Barbara D. Smith. (2002) The RFX Family Interacts at the Collagen (COL1A2) Start Site and Represses Transcription. Journal of Biological Chemistry 277:28, pages 24926-24937.
Crossref
J�r�me Guicheux, Gaby Palmer, Biserka Relic, Fran�oise Mezin, Joseph Caverzasio, Pierre Apostolides, Jean-Fran�ois Gauchat, Cem Gabay & Pierre-Andr� Guerne. (2002) Primary human articular chondrocytes, dedifferentiated chondrocytes, and synoviocytes exhibit differential responsiveness to interleukin-4: Correlation with the expression pattern of the common receptor gamma chain. Journal of Cellular Physiology 192:1, pages 93-101.
Crossref
Toufic Renno, Anne Wilson, Caroline Dunkel, Isabelle Coste, Karine Maisnier-Patin, Amélie Benoit de Coignac, Jean-Pierre Aubry, Rosemary K. Lees, Jean-Yves Bonnefoy, H. Robson MacDonald & Jean-François Gauchat. (2002) A Role for CD147 in Thymic Development. The Journal of Immunology 168:10, pages 4946-4950.
Crossref
Krzysztof Masternak & Walter Reith. (2002) Promoter-specific functions of CIITA and the MHC class II enhanceosome in transcriptional activation. The EMBO Journal 21:6, pages 1379-1388.
Crossref
Yves Stauffer, Samuel Marguerat, Françoise Meylan, Catherine Ucla, Natalie Sutkowski, Brigitte Huber, Thierry Pelet & Bernard Conrad. (2001) Interferon-α-Induced Endogenous Superantigen. Immunity 15:4, pages 591-601.
Crossref
Nathalie Lin-Marq, Séverine Bontron, Olivier Leupin & Michel Strubin. (2001) Hepatitis B Virus X Protein Interferes with Cell Viability through Interaction with the p127-kDa UV-Damaged DNA-Binding Protein. Virology 287:2, pages 266-274.
Crossref
Salomé Landmann, Annick Mühlethaler-Mottet, Luca Bernasconi, Tobias Suter, Jean-Marc Waldburger, Krzysztof Masternak, Jean-François Arrighi, Conrad Hauser, Adriano Fontana & Walter Reith. (2001) Maturation of Dendritic Cells Is Accompanied by Rapid Transcriptional Silencing of Class II Transactivator (Ciita) Expression. Journal of Experimental Medicine 194:4, pages 379-392.
Crossref
Androniki Kretsovali, Charalambos Spilianakis, Andreas Dimakopoulos, Takis Makatounakis & Joseph Papamatheakis. (2001) Self-association of Class II Transactivator Correlates with Its Intracellular Localization and Transactivation. Journal of Biological Chemistry 276:34, pages 32191-32197.
Crossref
Satoshi Kanazawa & B. Matija Peterlin. (2001) Combinations of dominant-negative class II transactivator, p300 or CDK9 proteins block the expression of MHC II genes. International Immunology 13:7, pages 951-958.
Crossref
Walter ReithBernard Mach. (2001) The Bare Lymphocyte Syndrome and the Regulation of MHC Expression. Annual Review of Immunology 19:1, pages 331-373.
Crossref
Johanne Poudrier, Pierre Graber, Suzanne Herren, Claude Berney, Denise Gretener, Marie H. Kosco-Vilbois & Jean-François Gauchat. (2000) A novel monoclonal antibody, C41, reveals IL-13Rα1 expression by murine germinal center B cells and follicular dendritic cells. European Journal of Immunology 30:11, pages 3157-3164.
Crossref
Krzysztof Masternak, Annick Muhlethaler-Mottet, Jean Villard, Madeleine Zufferey, Viktor Steimle & Walter Reith. (2000) CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complex. Genes & Development 14:9, pages 1156-1166.
Crossref
Mohammed Saifuddin, Kenneth A. Roebuck, Cheong-hee Chang, Jenny P. Y. Ting & Gregory T. Spear. (2000) Cutting Edge: Activation of HIV-1 Transcription by the MHC Class II Transactivator. The Journal of Immunology 164:8, pages 3941-3945.
Crossref
Joseph D Fontes, Satoshi Kanazawa, Nada Nekrep & B.Matija Peterlin. (1999) The class II transactivator CIITA is a transcriptional integrator. Microbes and Infection 1:11, pages 863-869.
Crossref
Yulong Han, Z-H. Lucy Zhou & Richard M. Ransohoff. (1999) TNF-α Suppresses IFN-γ-Induced MHC Class II Expression in HT1080 Cells by Destabilizing Class II trans -Activator mRNA . The Journal of Immunology 163:3, pages 1435-1440.
Crossref
Jean Villard, Annick Muhlethaler-Mottet, Séverine Bontron, Bernard Mach & Walter Reith. (1999) CIITA-induced occupation of MHC class II promoters is independent of the cooperative stabilization of the promoter-bound multi-protein complexes. International Immunology 11:3, pages 461-469.
Crossref
Angelos Constantinou, Daniela Gunz, Elizabeth Evans, Philippe Lalle, Paul A. Bates, Richard D. Wood & Stuart G. Clarkson. (1999) Conserved Residues of Human XPG Protein Important for Nuclease Activity and Function in Nucleotide Excision Repair. Journal of Biological Chemistry 274:9, pages 5637-5648.
Crossref
Luc Alain Otten, Viktor Steimle, Séverine Bontron & Bernard Mach. (1998) Quantitative control of MHC class II expression by the transactivator CIITA. European Journal of Immunology 28:2, pages 473-478.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.