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Research Article

Regulation of T-Cell Antigen Receptor Signalling by Syk Tyrosine Protein Kinase

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Pages 4434-4441 | Received 21 Jan 1997, Accepted 30 Apr 1997, Published online: 29 Mar 2023

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Vanessa Weis, Sebastian Königsberger, Susanne Amler, Jürgen Wienands & Friedemann Kiefer. (2017) Unperturbed Immune Function despite Mutation of C-Terminal Tyrosines in Syk Previously Implicated in Signaling and Activity Regulation. Molecular and Cellular Biology 37:21.
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Huaijian Guo, Mario-Ernesto Cruz-Munoz, Ning Wu, Michael Robbins & André Veillette. (2015) Immune Cell Inhibition by SLAMF7 Is Mediated by a Mechanism Requiring Src Kinases, CD45, and SHIP-1 That Is Defective in Multiple Myeloma Cells. Molecular and Cellular Biology 35:1, pages 41-51.
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Heuiran Lee, Jie Guo, Mengtao Li, Joong-Kook Choi, Maryann DeMaria, Michael Rosenzweig & Jae U. Jung. (1998) Identification of an Immunoreceptor Tyrosine-Based Activation Motif of K1 Transforming Protein of Kaposi’s Sarcoma-Associated Herpesvirus. Molecular and Cellular Biology 18:9, pages 5219-5228.
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Friedemann Kiefer, John Brumell, Nadia Al-Alawi, Sylvain Latour, Alec Cheng, André Veillette, Sergio Grinstein & Tony Pawson. (1998) The Syk Protein Tyrosine Kinase Is Essential for Fcγ Receptor Signaling in Macrophages and Neutrophils. Molecular and Cellular Biology 18:7, pages 4209-4220.
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Jane Wong, David Straus & Andrew C. Chan. (1998) Genetic Evidence of a Role for Lck in T-Cell Receptor Function Independent or Downstream of ZAP-70/Syk Protein Tyrosine Kinases. Molecular and Cellular Biology 18:5, pages 2855-2866.
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Young-Su Yi, Young-Jin Son, Chongsuk Ryou, Gi-Ho Sung, Jong-Hoon Kim & Jae Youl Cho. (2014) Functional Roles of Syk in Macrophage-Mediated Inflammatory Responses. Mediators of Inflammation 2014, pages 1-12.
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Craig E. Hughes, Uma Sinha, Anjali Pandey, Johannes A. Eble, Christopher A. O'Callaghan & Steve P. Watson. (2013) Critical Role for an Acidic Amino Acid Region in Platelet Signaling by the HemITAM (Hemi-immunoreceptor Tyrosine-based Activation Motif) Containing Receptor CLEC-2 (C-type Lectin Receptor-2). Journal of Biological Chemistry 288:7, pages 5127-5135.
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Jami L. Scheib, Chelsea S. Sullivan & Bruce D. Carter. (2012) Jedi-1 and MEGF10 Signal Engulfment of Apoptotic Neurons through the Tyrosine Kinase Syk. The Journal of Neuroscience 32:38, pages 13022-13031.
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Jeoung-Eun Park, David Cullins, Lillian Zalduondo, Stacey L. Barnett, Ae-Kyung Yi, Sandra Kleinau, John M. Stuart, Andrew H. Kang & Linda K. Myers. (2012) Molecular Basis for T Cell Response Induced by Altered Peptide Ligand of Type II Collagen. Journal of Biological Chemistry 287:23, pages 19765-19774.
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A K Chauhan & T L Moore. (2012) Immune complexes and late complement proteins trigger activation of Syk tyrosine kinase in human CD4+ T cells. Clinical and Experimental Immunology 167:2, pages 235-245.
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David G. T. Hesslein, Emil H. Palacios, Joseph C. Sun, Joshua N. Beilke, Susan R. Watson, Arthur Weiss & Lewis L. Lanier. (2011) Differential requirements for CD45 in NK-cell function reveal distinct roles for Syk-family kinases. Blood 117:11, pages 3087-3095.
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Chaim M. Roifman, Harjit Dadi, Raz Somech, Amit Nahum & Nigel Sharfe. (2010) Characterization of ζ-associated protein, 70 kd (ZAP70)–deficient human lymphocytes. Journal of Allergy and Clinical Immunology 126:6, pages 1226-1233.e1.
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Christine Dierks, Francisco Adrian, Paul Fisch, Hong Ma, Helga Maurer, Dieter Herchenbach, Christine Ulrike Forster, Clara Sprissler, Guoxun Liu, Sabine Rottmann, Gui-Rong Guo, Zirlik Katja, Hendrik Veelken & Markus Warmuth. (2010) The ITK-SYK Fusion Oncogene Induces a T-Cell Lymphoproliferative Disease in Mice Mimicking Human Disease. Cancer Research 70:15, pages 6193-6204.
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Farnaz Fallah-Arani, Edina Schweighoffer, Lesley Vanes & Victor L. J. Tybulewicz. (2008) Redundant role for Zap70 in B cell development and activation. European Journal of Immunology 38:6, pages 1721-1733.
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Juan Zhang, Katsuhiro Suzuki, Tomohiro Hitomi & Reuben P. Siraganian. (2007) TOM1L1 Is a Lyn Substrate Involved in FcϵRI Signaling in Mast Cells. Journal of Biological Chemistry 282:52, pages 37669-37677.
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Shannon M. Grande, Gregory Bannish, Ezequiel M. Fuentes-Panana, Elad Katz & John G. Monroe. (2007) Tonic B-cell and viral ITAM signaling: context is everything. Immunological Reviews 218:1, pages 214-234.
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Karl D. Mack, Melissa Von Goetz, Monica Lin, Marina Venegas, Jerry Barnhart, Yan Lu, Betty Lamar, Robert Stull, Christopher Silvin, Pamela Owings, Fong-Yih Bih & Arie Abo. (2005) Functional identification of kinases essential for T-cell activation through a genetic suppression screen. Immunology Letters 96:1, pages 129-145.
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Lisa A. Pitcher & Nicolai S.C. van Oers. (2003) T-cell receptor signal transmission: who gives an ITAM?. Trends in Immunology 24:10, pages 554-560.
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Koichiro Maeno, Kiyonao Sada, Shinkou Kyo, S. M. Shahjahan Miah, Keiko Kawauchi-Kamata, Xiujuan Qu, Yuhong Shi & Hirohei Yamamura. (2003) Adaptor Protein 3BP2 Is a Potential Ligand of Src Homology 2 and 3 Domains of Lyn Protein-tyrosine Kinase. Journal of Biological Chemistry 278:27, pages 24912-24920.
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Sylvain Latour, Romain Roncagalli, Riyan Chen, Marcin Bakinowski, Xiaochu Shi, Pamela L. Schwartzberg, Dominique Davidson & André Veillette. (2003) Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation. Nature Cell Biology 5:2, pages 149-154.
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Bernard Malissen. (2003) An evolutionary and structural perspective on T cell antigen receptor function. Immunological Reviews 191:1, pages 7-27.
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Lisa A. Pitcher, Jennifer A. Young, Meredith A. Mathis, Philip C. Wrage, Beatrix Bartók & Nicolai S. C. Van Oers. (2003) The formation and functions of the 21- and 23-kDa tyrosine-phosphorylated TCR ζ subunits. Immunological Reviews 191:1, pages 47-61.
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Sylvain Latour, Gerald Gish, Cheryl D. Helgason, R. Keith Humphries, Tony Pawson & André Veillette. (2001) Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product. Nature Immunology 2:8, pages 681-690.
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Sylvain Latour & André Veillette. (2001) Proximal protein tyrosine kinases in immunoreceptor signaling. Current Opinion in Immunology 13:3, pages 299-306.
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Haiyan Ma, Thomas M. Yankee, Jianjie Hu, David J. Asai, Marietta L. Harrison & Robert L. Geahlen. (2001) Visualization of Syk-Antigen Receptor Interactions Using Green Fluorescent Protein: Differential Roles for Syk and Lyn in the Regulation of Receptor Capping and Internalization. The Journal of Immunology 166:3, pages 1507-1516.
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Hiroki Tabata, Takako Matsuoka, Fumio Endo, Yasuharu Nishimura & Sho Matsushita. (2000) Ligation of HLA-DR Molecules on B Cells Induces Enhanced Expression of IgM Heavy Chain Genes in Association with Syk Activation. Journal of Biological Chemistry 275:45, pages 34998-35005.
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Alexander Gregorieff, Stéphane Pyronnet, Nahum Sonenberg & André Veillette. (2000) Regulation of SOCS-1 Expression by Translational Repression. Journal of Biological Chemistry 275:28, pages 21596-21604.
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Ramesh K. Ganju, Stephanie A. Brubaker, Rebecca D. Chernock, Shalom Avraham & Jerome E. Groopman. (2000) β-Chemokine Receptor CCR5 Signals through SHP1, SHP2, and Syk. Journal of Biological Chemistry 275:23, pages 17263-17268.
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Nelly Noraz, Klaus Schwarz, Marcos Steinberg, Valérie Dardalhon, Cosette Rebouissou, Robert Hipskind, Wilhelm Friedrich, Hans Yssel, Kevin Bacon & Naomi Taylor. (2000) Alternative Antigen Receptor (TCR) Signaling in T Cells Derived from ZAP-70-deficient Patients Expressing High Levels of Syk. Journal of Biological Chemistry 275:21, pages 15832-15838.
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Tadashi Matsuda, Tetsuya Yamamoto, Hiroyuki Kishi, Akihiko Yoshimura & Atsushi Muraguchi. (2000) SOCS-1 can suppress CD3ζ- and Syk-mediated NF-AT activation in a non-lymphoid cell line. FEBS Letters 472:2-3, pages 235-240.
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Blossom Damania, Maryann DeMaria, Jae U. Jung & Ronald C. Desrosiers. (2000) Activation of Lymphocyte Signaling by the R1 Protein of Rhesus Monkey Rhadinovirus. Journal of Virology 74:6, pages 2721-2730.
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David H. Chu, Nicolai S. C. van Oers, Marie Malissen, Jeff Harris, Melissa Elder & Arthur Weiss. (1999) Pre-T Cell Receptor Signals Are Responsible for the Down-Regulation of Syk Protein Tyrosine Kinase Expression. The Journal of Immunology 163:5, pages 2610-2620.
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Carole Gallet, Jean-Philippe Rosa, Aı̈da Habib, Marilyne Lebret, Sylviane Lévy-Tolédano & Jacques Maclouf. (1999) Tyrosine Phosphorylation of Cortactin Associated with Syk Accompanies Thromboxane Analogue-induced Platelet Shape Change. Journal of Biological Chemistry 274:33, pages 23610-23616.
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Robert Weil, Jean-Pierre LevraudMadeleine Duc Dodon, Christine Bessia, Uriel Hazan, Philippe KourilskyAlain Israël. (1999) Altered Expression of Tyrosine Kinases of the Src and Syk Families in Human T-Cell Leukemia Virus Type 1-Infected T-Cell Lines. Journal of Virology 73:5, pages 3709-3717.
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Sharon Hunter, Norihito Sato, Moo-Kyung Kim, Zhen-Yu Huang, David H Chu, Jong-Gu Park & Alan D Schreiber. (1999) Structural requirements of Syk kinase for Fcγ receptor– phagocytosis. Experimental Hematology 27:5, pages 875-884.
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