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Molecular and Cellular Biology Volume 17, 1997 - Issue 8
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Research Article

A Transcriptional Mediator Protein That Is Required for Activation of Many RNA Polymerase II Promoters and Is Conserved from Yeast to Humans

Young Chu LeeCenter for Basic Research, Samsung Biomedical Research Institute, Seoul135-230, Korea
,
Soyoung MinCenter for Basic Research, Samsung Biomedical Research Institute, Seoul135-230, Korea
,
Byung Soo GimCenter for Basic Research, Samsung Biomedical Research Institute, Seoul135-230, Korea
&
Young-Joon KimCenter for Basic Research, Samsung Biomedical Research Institute, Seoul135-230, KoreaCorrespondence[email protected]
Pages 4622-4632 | Received 20 Mar 1997, Accepted 12 May 1997, Published online: 29 Mar 2023

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Christophe Leroy, Laëtitia Cormier & Laurent Kuras. (2006) Independent Recruitment of Mediator and SAGA by the Activator Met4. Molecular and Cellular Biology 26:8, pages 3149-3163.
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Qian Tan, Meredith H. Prysak & Nancy A. Woychik. (2003) Loss of the Rpb4/Rpb7 Subcomplex in a Mutant Form of the Rpb6 Subunit Shared by RNA Polymerases I, II, and III. Molecular and Cellular Biology 23:9, pages 3329-3338.
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Byung Soo Gim, Jin Mo Park, Jeong Ho Yoon, Changwon Kang & Young-Joon Kim. (2001) Drosophila Med6 Is Required for Elevated Expression of a Large but Distinct Set of Developmentally Regulated Genes. Molecular and Cellular Biology 21:15, pages 5242-5255.
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Young Chul Lee, Jin Mo Park, Soyoung Min, Sang Jun Han & Young-Joon Kim. (1999) An Activator Binding Module of Yeast RNA Polymerase II Holoenzyme. Molecular and Cellular Biology 19:4, pages 2967-2976.
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Sang Jun Han, Young Chul Lee, Byung Soo Gim, Gi-Hyuck Ryu, Soon Jung Park, William S. Lane & Young-Joon Kim. (1999) Activator-Specific Requirement of Yeast Mediator Proteins for RNA Polymerase II Transcriptional Activation. Molecular and Cellular Biology 19:2, pages 979-988.
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Young Chul Lee & Young-Joon Kim. (1998) Requirement for a Functional Interaction between Mediator Components Med6 and Srb4 in RNA Polymerase II Transcription. Molecular and Cellular Biology 18:9, pages 5364-5370.
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Helen Cho, George Orphanides, Xiaoqing Sun, Xiang-Jiao Yang, Vasily Ogryzko, Emma Lees, Yoshihiro Nakatani & Danny Reinberg. (1998) A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure. Molecular and Cellular Biology 18:9, pages 5355-5363.
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Tong Ihn Lee, John J. Wyrick, Sang Seok Koh, Ezra G. Jennings, Ellen L. Gadbois & Richard A. Young. (1998) Interplay of Positive and Negative Regulators in Transcription Initiation by RNA Polymerase II Holoenzyme. Molecular and Cellular Biology 18:8, pages 4455-4462.
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Articles from other publishers (52)

Linda Warfield, Rafal Donczew, Lakshmi Mahendrawada & Steven Hahn. (2022) Yeast Mediator facilitates transcription initiation at most promoters via a Tail-independent mechanism. Molecular Cell 82:21, pages 4033-4048.e7.
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Daniel S Hassell, Marc G Steingesser, Ashley S Denney, Courtney R Johnson & Michael A McMurray. (2021) Chemical rescue of mutant proteins in living Saccharomyces cerevisiae cells by naturally occurring small molecules . G3 Genes|Genomes|Genetics 11:9.
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Z. Zhuang, R. Ding, Y. Qiu, J. Wu, S. Zhou, J. Quan, E. Zheng, Z. Li, Z. Wu & J. Yang. (2021) A large‐scale genome‐wide association analysis reveals QTL and candidate genes for intramuscular fat content in Duroc pigs. Animal Genetics 52:4, pages 518-522.
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Mirna Kheir GoudaMichael Manhart & Gábor Balázsi. (2019) Evolutionary regain of lost gene circuit function. Proceedings of the National Academy of Sciences 116:50, pages 25162-25171.
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Gwang Sik Kim & Young Chul Lee. (2018) Postrecruitment Function of Yeast Med6 Protein during the Transcriptional Activation by Mediator Complex. Biochemistry Research International 2018, pages 1-9.
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Sleiman Bassim, Arnaud Tanguy, Bertrand Genard, Dario Moraga & Rejean Tremblay. (2014) Identification of Mytilus edulis genetic regulators during early development. Gene 551:1, pages 65-78.
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Dotan Sela, Juliana J. Conkright, Lu Chen, Joshua Gilmore, Michael P. Washburn, Laurence Florens, Ronald C. Conaway & Joan Weliky Conaway. (2013) Role for Human Mediator Subunit MED25 in Recruitment of Mediator to Promoters by Endoplasmic Reticulum Stress-responsive Transcription Factor ATF6α. Journal of Biological Chemistry 288:36, pages 26179-26187.
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Suraiya A. Ansari & Randall H. Morse. (2013) Mechanisms of Mediator complex action in transcriptional activation. Cellular and Molecular Life Sciences 70:15, pages 2743-2756.
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Hiroyuki Takahashi, Koji Kasahara & Tetsuro Kokubo. (2009) Saccharomyces cerevisiae Med9 comprises two functionally distinct domains that play different roles in transcriptional regulation . Genes to Cells 14:1, pages 53-67.
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Yuichiro Takagi, James Z. Chadick, Joshua A. Davis & Francisco J. Asturias. (2005) Preponderance of Free Mediator in the Yeast Saccharomyces cerevisiae. Journal of Biological Chemistry 280:35, pages 31200-31207.
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LEONARD P. FREEDMAN & ALFRED A. RESZKA. 2005. Vitamin D. Vitamin D 263 277 .
Stefan Björklund & Claes M Gustafsson. 2004. Proteins in Eukaryotic Transcription. Proteins in Eukaryotic Transcription 43 65 .
Dmitry K Pokholok, Nancy M Hannett & Richard A Young. (2002) Exchange of RNA Polymerase II Initiation and Elongation Factors during Gene Expression In Vivo. Molecular Cell 9:4, pages 799-809.
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Jae Young Kwon, Jeongsil Kim-Ha, Byeong Jae Lee & Junho Lee. (2001) The MED-7 transcriptional mediator encoded by let-49 is required for gonad and germ cell development in Caenorhabditis elegans . FEBS Letters 508:3, pages 305-308.
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Jong Seok Kang, Seung Hyun Kim, Moon Sun Hwang, Sang Jun Han, Young Chul Lee & Young-Joon Kim. (2001) The Structural and Functional Organization of the Yeast Mediator Complex. Journal of Biological Chemistry 276:45, pages 42003-42010.
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Henrik SpåhrCamilla O. SamuelsenVera BaraznenokIsabelle ErnestDanny HuylebroeckJacques E. RemacleTore SamuelssonThomas KieselbachSteen HolmbergClaes M. Gustafsson. (2001) Analysis of Schizosaccharomyces pombe Mediator reveals a set of essential subunits conserved between yeast and metazoan cells . Proceedings of the National Academy of Sciences 98:21, pages 11985-11990.
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Sang Jun Han, Jung-Soon Lee, Jong Seok Kang & Young-Joon Kim. (2001) Med9/Cse2 and Gal11 Modules Are Required for Transcriptional Repression of Distinct Group of Genes. Journal of Biological Chemistry 276:40, pages 37020-37026.
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Björn Sandrock & Jean-Marc Egly. (2001) A Yeast Four-hybrid System Identifies Cdk-activating Kinase as a Regulator of the XPD Helicase, a Subunit of Transcription Factor IIH. Journal of Biological Chemistry 276:38, pages 35328-35333.
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Jae Young Kwon & Junho Lee. (2001) Biological significance of a universally conserved transcription mediator in metazoan developmental signaling pathways. Development 128:16, pages 3095-3104.
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Choon-Ju Jeong, Sang-Hwa Yang, Yueqing Xie, Lei Zhang, Stephen Albert Johnston & Thomas Kodadek. (2001) Evidence That Gal11 Protein Is a Target of the Gal4 Activation Domain in the Mediator. Biochemistry 40:31, pages 9421-9427.
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Claes M. Gustafsson & Tore Samuelsson. (2001) Mediator - a universal complex in transcriptional regulation. Molecular Microbiology 41:1, pages 1-8.
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Ágnes Grallert, Erika Zilahi, Miklós Ida, Z. Szilágyi & M. Sipiczki. (2001) Multifunctional cytokinesis genes in schizosaccharomyces pombes. Acta Biologica Hungarica 52:2-3, pages 315-323.
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Anne Gromöller & Norbert Lehming. (2000) Srb7p is essential for the activation of a subset of genes. FEBS Letters 484:1, pages 48-54.
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Mark Lee, Sukalyan Chatterjee & Kevin Struhl. (2000) Genetic Analysis of the Role of Pol II Holoenzyme Components in Repression by the Cyc8-Tup1 Corepressor in Yeast. Genetics 155:4, pages 1535-1542.
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Lawrence C. Myers & Roger D. Kornberg. (2000) Mediator of Transcriptional Regulation. Annual Review of Biochemistry 69:1, pages 729-749.
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Sohail Malik & Robert G Roeder. (2000) Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cells. Trends in Biochemical Sciences 25:6, pages 277-283.
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Christophe Rachez & Leonard P. Freedman. (2000) Mechanisms of gene regulation by vitamin D3 receptor: a network of coactivator interactions. Gene 246:1-2, pages 9-21.
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Manolis Papamichos-Chronakis, R.Steven Conlan, Niki Gounalaki, Tjana Copf & Dimitris Tzamarias. (2000) Hrs1/Med3 Is a Cyc8-Tup1 Corepressor Target in the RNA Polymerase II Holoenzyme. Journal of Biological Chemistry 275:12, pages 8397-8403.
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Henrik Spåhr, Jenny Bève, Thomas Larsson, Jörgen Bergström, Karl-Anders Karlsson & Claes M. Gustafsson. (2000) Purification and Characterization of RNA Polymerase II Holoenzyme from Schizosaccharomyces pombe. Journal of Biological Chemistry 275:2, pages 1351-1356.
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Michael Hampsey & Danny Reinberg. (1999) RNA polymerase II as a control panel for multiple coactivator complexes. Current Opinion in Genetics & Development 9:2, pages 132-139.
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Hua Xiao, Yong Tao & Robert G. Roeder. (1999) The Human Homologue of Drosophila TRF-proximal Protein Is Associated with an RNA Polymerase II-SRB Complex. Journal of Biological Chemistry 274:7, pages 3937-3940.
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Darius Balciunas, Cecilia Gälman, Hans Ronne & Stefan Björklund. (1999) The Med1 subunit of the yeast mediator complex is involved in both transcriptional activation and repression. Proceedings of the National Academy of Sciences 96:2, pages 376-381.
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Lawrence C. Myers, Claes M. Gustafsson, Kathleen C. Hayashibara, Patrick O. Brown & Roger D. Kornberg. (1999) Mediator protein mutations that selectively abolish activated transcription. Proceedings of the National Academy of Sciences 96:1, pages 67-72.
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Frank C.P Holstege, Ezra G Jennings, John J Wyrick, Tong Ihn Lee, Christoph J Hengartner, Michael R Green, Todd R Golub, Eric S Lander & Richard A Young. (1998) Dissecting the Regulatory Circuitry of a Eukaryotic Genome. Cell 95:5, pages 717-728.
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Xiaoqing Sun, Yi Zhang, Helen Cho, Paula Rickert, Emma Lees, William Lane & Danny Reinberg. (1998) NAT, a Human Complex Containing Srb Polypeptides that Functions as a Negative Regulator of Activated Transcription. Molecular Cell 2:2, pages 213-222.
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Yi Wei Jiang, Philippe Veschambre, Hediye Erdjument-Bromage, Paul Tempst, Joan W. Conaway, Ronald C. Conaway & Roger D. Kornberg. (1998) Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways. Proceedings of the National Academy of Sciences 95:15, pages 8538-8543.
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Michael Hampsey. (1998) Molecular Genetics of the RNA Polymerase II General Transcriptional Machinery. Microbiology and Molecular Biology Reviews 62:2, pages 465-503.
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Juana M. Gancedo. (1998) Yeast Carbon Catabolite Repression. Microbiology and Molecular Biology Reviews 62:2, pages 334-361.
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Sang Seok Koh, Aseem Z Ansari, Mark Ptashne & Richard A Young. (1998) An Activator Target in the RNA Polymerase II Holoenzyme. Molecular Cell 1:6, pages 895-904.
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Hiroshi Sakurai & Toshio Fukasawa. (1998) Functional Correlation among Gal11, Transcription Factor (TF) IIE, and TFIIH in Saccharomyces cerevisiae. Journal of Biological Chemistry 273:16, pages 9534-9538.
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R.D. KORNBERG. (1998) Mechanism and Regulation of Yeast RNA Polymerase II Transcription. Cold Spring Harbor Symposia on Quantitative Biology 63:0, pages 229-232.
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R.G. ROEDER. (1998) Role of General and Gene-specific Cofactors in the Regulation of Eukaryotic Transcription. Cold Spring Harbor Symposia on Quantitative Biology 63:0, pages 201-218.
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