Advanced search
Publication Cover
Molecular and Cellular Biology Volume 17, 1997 - Issue 8
Submit an article Journal homepage
2
Views
28
CrossRef citations to date
0
Altmetric
Research Article

Mutations in the Conserved C-Terminal Sequence in Thyroid Hormone Receptor Dissociate Hormone-Dependent Activation from Interference with AP-1 Activity

Fahri SaatciogluDepartment of Pharmacology, Center for Molecular Genetics, School of Medicine, University of California at San Diego, La Jolla, California92093-0636;Biotechnology Centre of Oslo, University of Oslo, 0371Oslo, Norway
,
Gabriela LopezMetabolic Research Unit, University of California at San Francisco, San Francisco, California94143-0540
,
Bruan L. WestMetabolic Research Unit, University of California at San Francisco, San Francisco, California94143-0540
,
Ebrahim ZandiDepartment of Pharmacology, Center for Molecular Genetics, School of Medicine, University of California at San Diego, La Jolla, California92093-0636
,
Weijun FengMetabolic Research Unit, University of California at San Francisco, San Francisco, California94143-0540
,
Haiping LuDepartment of Pharmacology, Center for Molecular Genetics, School of Medicine, University of California at San Diego, La Jolla, California92093-0636
,
Ali EsmailiDepartment of Pharmacology, Center for Molecular Genetics, School of Medicine, University of California at San Diego, La Jolla, California92093-0636
,
James W. AprilettiMetabolic Research Unit, University of California at San Francisco, San Francisco, California94143-0540
,
Peter J. KushnerMetabolic Research Unit, University of California at San Francisco, San Francisco, California94143-0540
,
John D. BaxterMetabolic Research Unit, University of California at San Francisco, San Francisco, California94143-0540
&
Michael KarinDepartment of Pharmacology, Center for Molecular Genetics, School of Medicine, University of California at San Diego, La Jolla, California92093-0636
 show all
Pages 4687-4695 | Received 29 Jul 1996, Accepted 15 May 1997, Published online: 29 Mar 2023

Citations (28)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Ryoko Ishida-Takahashi, Felicia Rosario, Yusong Gong, Keely Kopp, Zlatina Stancheva, Xiaohong Chen, Edward P. Feener & Martin G. Myers$suffix/text()$suffix/text(). (2006) Phosphorylation of Jak2 on Ser523 InhibitsJak2-Dependent Leptin ReceptorSignaling. Molecular and Cellular Biology 26:11, pages 4063-4073.
Read now
Frédéric Sauvé, Linda D. B. McBroom, Josette Gallant, Anna N. Moraitis, Fernand Labrie & Vincent Giguère. (2001) CIA, a Novel Estrogen Receptor Coactivator with a Bifunctional Nuclear Receptor Interacting Determinant. Molecular and Cellular Biology 21:1, pages 343-353.
Read now

Articles from other publishers (26)

Elaine M. RichardsM. Belen Rabaglino, Andrew AntolicCharles E. Wood & Maureen Keller-Wood. (2015) Patterns of gene expression in the sheep heart during the perinatal period revealed by transcriptomic modeling. Physiological Genomics 47:9, pages 407-419.
Crossref
Simon C. Biddie, Sam John, Pete J. Sabo, Robert E. Thurman, Thomas A. Johnson, R. Louis Schiltz, Tina B. Miranda, Myong-Hee Sung, Saskia Trump, Stafford L. Lightman, Charles Vinson, John A. Stamatoyannopoulos & Gordon L. Hager. (2011) Transcription Factor AP1 Potentiates Chromatin Accessibility and Glucocorticoid Receptor Binding. Molecular Cell 43:1, pages 145-155.
Crossref
Aurora Sánchez-PachecoOlaia Martínez-IglesiasMarinela Méndez-Pertuz & Ana Aranda. (2009) Residues K128, 132, and 134 in the Thyroid Hormone Receptor-α Are Essential for Receptor Acetylation and Activity. Endocrinology 150:11, pages 5143-5152.
Crossref
Sangho Lee & Martin L Privalsky. (2005) Multiple mutations contribute to repression by the v-Erb A oncoprotein. Oncogene 24:45, pages 6737-6752.
Crossref
Ghislain M. C. Bonamy, Anne Guiochon-Mantel & Lizabeth A. Allison. (2005) Cancer Promoted by the Oncoprotein v-ErbA May Be Due to Subcellular Mislocalization of Nuclear Receptors. Molecular Endocrinology 19:5, pages 1213-1230.
Crossref
Hege Berghagen, Erlend Ragnhildstveit, Kristin Krogsrud, Gunnar Thuestad, James Apriletti & Fahri Saatcioglu. (2002) Corepressor SMRT Functions as a Coactivator for Thyroid Hormone Receptor T3Rα from a Negative Hormone Response Element. Journal of Biological Chemistry 277:51, pages 49517-49522.
Crossref
Anjali Jain, Amanda Lam, Igor Vivanco, Michael F. Carey & Robert E. Reiter. (2002) Identification of an Androgen-Dependent Enhancer within the Prostate Stem Cell Antigen Gene. Molecular Endocrinology 16:10, pages 2323-2337.
Crossref
Bente Børud, Tuyen Hoang, Marit Bakke, Anne L. Jacob, Johan Lund & Gunnar Mellgren. (2002) The Nuclear Receptor Coactivators p300/CBP/Cointegrator-Associated Protein (p/CIP) and Transcription Intermediary Factor 2 (TIF2) Differentially Regulate PKA-Stimulated Transcriptional Activity of Steroidogenic Factor 1. Molecular Endocrinology 16:4, pages 757-773.
Crossref
Jinsong Zhang, Markus Kalkum, Brian T Chait & Robert G Roeder. (2002) The N-CoR-HDAC3 Nuclear Receptor Corepressor Complex Inhibits the JNK Pathway through the Integral Subunit GPS2. Molecular Cell 9:3, pages 611-623.
Crossref
Thierry Van Reeth, Philippe Gabant, Claude Szpirer & Josiane Szpirer. (2002) Stimulation of the α-fetoprotein promoter by unliganded thyroid hormone receptor in association with protein deacetylation. Molecular and Cellular Endocrinology 188:1-2, pages 99-109.
Crossref
Thomas Slagsvold, Irene Kraus, Katrine Frønsdal & Fahri Saatcioglu. (2001) DNA Binding-independent Transcriptional Activation by the Androgen Receptor through Triggering of Coactivators. Journal of Biological Chemistry 276:33, pages 31030-31036.
Crossref
Gabriela N. Lopez, Christoph W. Turck, Fred Schaufele, Michael R. Stallcup & Peter J. Kushner. (2001) Growth Factors Signal to Steroid Receptors through Mitogen-activated Protein Kinase Regulation of p160 Coactivator Activity. Journal of Biological Chemistry 276:25, pages 22177-22182.
Crossref
Paul Webb, Phuong Nguyen, Cathleen Valentine, Ross V. Weatherman, Thomas S. Scanlan & Peter J. Kushner. (2000) An Antiestrogen-responsive Estrogen Receptor-α Mutant (D351Y) Shows Weak AF-2 Activity in the Presence of Tamoxifen. Journal of Biological Chemistry 275:48, pages 37552-37558.
Crossref
Peter J Kushner, David A Agard, Geoffrey L Greene, Thomas S Scanlan, Andrew K Shiau, Rosalie M Uht & Paul Webb. (2000) Estrogen receptor pathways to AP-1. The Journal of Steroid Biochemistry and Molecular Biology 74:5, pages 311-317.
Crossref
Janet E. Valentine, Eric Kalkhoven, Roger White, Sue Hoare & Malcolm G. Parker. (2000) Mutations in the Estrogen Receptor Ligand Binding Domain Discriminate between Hormone-dependent Transactivation and Transrepression. Journal of Biological Chemistry 275:33, pages 25322-25329.
Crossref
Songcang Chen, Junfeng Cui, Karl Nakamura, Ralff C.J. Ribeiro, Brian L. West & David G. Gardner. (2000) Coactivator-Vitamin D Receptor Interactions Mediate Inhibition of the Atrial Natriuretic Peptide Promoter. Journal of Biological Chemistry 275:20, pages 15039-15048.
Crossref
Carolyn M Klinge. (2000) Estrogen receptor interaction with co-activators and co-repressors☆. Steroids 65:5, pages 227-251.
Crossref
Katherine Ferrell, Caroline R.M Wilkinson, Wolfgang Dubiel & Colin Gordon. (2000) Regulatory subunit interactions of the 26S proteasome, a complex problem. Trends in Biochemical Sciences 25:2, pages 83-88.
Crossref
Jinping An, Ralff C. J. Ribeiro, Paul Webb, Jan-Åke Gustafsson, Peter J. Kushner, John D. Baxter & Dale C. Leitman. (1999) Estradiol repression of tumor necrosis factor-α transcription requires estrogen receptor activation function-2 and is enhanced by coactivators. Proceedings of the National Academy of Sciences 96:26, pages 15161-15166.
Crossref
Yuan-Chun Zhou & David J. Waxman. (1999) STAT5b Down-regulates Peroxisome Proliferator-activated Receptor α Transcription by Inhibition of Ligand-independent Activation Function Region-1trans-Activation Domain. Journal of Biological Chemistry 274:42, pages 29874-29882.
Crossref
I. Peters, W. Weidemann, G. Romalo, D. Knorr, H.-U. Schweikert & K.-D. Spindler. (1999) An androgen receptor mutation in the direct vicinity of the proposed C-terminal α-helix of the ligand binding domain containing the AF-2 transcriptional activating function core is associated with complete androgen insensitivity. Molecular and Cellular Endocrinology 148:1-2, pages 47-53.
Crossref
Tetsuya Tagami, Wen-Xia Gu, Patricia T. Peairs, Brian L. West & J. Larry Jameson. (1998) A Novel Natural Mutation in the Thyroid Hormone Receptor Defines a Dual Functional Domain That Exchanges Nuclear Receptor Corepressors and Coactivators. Molecular Endocrinology 12:12, pages 1888-1902.
Crossref
James W. Apriletti, Ralff CJ Ribeiro, Richard L. Wagner, Weijun Feng, Paul Webb, Peter J. Kushner, Brian L. West, Stefan Nilsson, Thomas S. Scanlan, Robert J. Fletterick & John D. Baxter. (1998) MOLECULAR AND STRUCTURAL BIOLOGY OF THYROID HORMONE RECEPTORS. Clinical and Experimental Pharmacology and Physiology 25:S1, pages S2-S11.
Crossref
Beatrice D. Darimont, Richard L. Wagner, James W. Apriletti, Michael R. Stallcup, Peter J. Kushner, John D. Baxter, Robert J. Fletterick & Keith R. Yamamoto. (1998) Structure and specificity of nuclear receptor–coactivator interactions. Genes & Development 12:21, pages 3343-3356.
Crossref
Katrine Frønsdal, Nikolai Engedal, Thomas Slagsvold & Fahri Saatcioglu. (1998) CREB Binding Protein Is a Coactivator for the Androgen Receptor and Mediates Cross-talk with AP-1. Journal of Biological Chemistry 273:48, pages 31853-31859.
Crossref
Weijun FengRalff C. J. RibeiroRichard L. WagnerHoa NguyenJames W. AprilettiRobert J. FletterickJohn D. BaxterPeter J. KushnerBrian L. West. (1998) Hormone-Dependent Coactivator Binding to a Hydrophobic Cleft on Nuclear Receptors. Science 280:5370, pages 1747-1749.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.