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Research Article

The Insulin-Induced Signalling Pathway Leading to S6 and Initiation Factor 4E Binding Protein 1 Phosphorylation Bifurcates at a Rapamycin-Sensitive Point Immediately Upstream of p70s6k

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Pages 5426-5436 | Received 18 Mar 1997, Accepted 30 May 1997, Published online: 29 Mar 2023

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Katherine D Bortoff, Adam B Keeton, J Lee Franklin & Joseph L Messina. (2010) Anti-inflammatory action of insulin via induction of Gadd45-β transcription by the mTOR signaling pathway. Hepatic Medicine: Evidence and Research 2, pages 79-85.
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Mario Pende, Sung Hee Um, Virginie Mieulet, Melanie Sticker, Valerie L. Goss, Jurgen Mestan, Matthias Mueller, Stefano Fumagalli, Sara C. Kozma & George Thomas. (2004) S6K1−/−/S6K2−/− Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway. Molecular and Cellular Biology 24:8, pages 3112-3124.
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Xuemin Wang, Wei Li, Josep-Lluis Parra, Anne Beugnet & Christopher G. Proud. (2003) The C Terminus of Initiation Factor 4E-Binding Protein 1 Contains Multiple Regulatory Features That Influence Its Function and Phosphorylation. Molecular and Cellular Biology 23:5, pages 1546-1557.
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Lloyd P. McMahon, Kin M. Choi, Tai-An Lin, Robert T. Abraham & John C. Lawrence$suffix/text()$suffix/text(). (2002) The Rapamycin-Binding Domain Governs Substrate Selectivity by the Mammalian Target of Rapamycin. Molecular and Cellular Biology 22:21, pages 7428-7438.
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Barry D Kahan. (2001) Sirolimus: a comprehensive review. Expert Opinion on Pharmacotherapy 2:11, pages 1903-1917.
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Gregory P. Cosentino, Tobias Schmelzle, Ashkan Haghighat, Stephen B. Helliwell, Michael N. Hall & Nahum Sonenberg. (2000) Eap1p, a Novel Eukaryotic Translation Initiation Factor 4E-Associated Protein in Saccharomyces cerevisiae. Molecular and Cellular Biology 20:13, pages 4604-4613.
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Almut Dufner, Mirjana Andjelkovic, Boudewijn M. T. Burgering, Brian A. Hemmings & George Thomas. (1999) Protein Kinase B Localization and Activation Differentially Affect S6 Kinase 1 Activity and Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 Phosphorylation. Molecular and Cellular Biology 19:6, pages 4525-4534.
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Kianoush Khaleghpour, Stéphane Pyronnet, Anne-Claude Gingras & Nahum Sonenberg. (1999) Translational Homeostasis: Eukaryotic Translation Initiation Factor 4E Control of 4E-Binding Protein 1 and p70 S6 Kinase Activities. Molecular and Cellular Biology 19:6, pages 4302-4310.
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Andrew Jan Waskiewicz, Jeffrey C. Johnson, Bennett Penn, Malathy Mahalingam, Scot R. Kimball & Jonathan A. Cooper. (1999) Phosphorylation of the Cap-Binding Protein Eukaryotic Translation Initiation Factor 4E by Protein Kinase Mnk1 In Vivo. Molecular and Cellular Biology 19:3, pages 1871-1880.
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Franziska Turck, Sara C. Kozma, George Thomas & Ferenc Nagy. (1998) A Heat-Sensitive Arabidopsis thalianaKinase Substitutes for Human p70s6k Function In Vivo. Molecular and Cellular Biology 18:4, pages 2038-2044.
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