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DNA Dynamics and Chromosome Structure

Frequent Loss of the Active Site during Variant Surface Glycoprotein Expression Site Switching In Vitro in Trypanosoma brucei

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Pages 198-205 | Received 10 Sep 1997, Accepted 15 Oct 1997, Published online: 28 Mar 2023

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Fred van Leeuwen, Rudo Kieft, Mike Cross & Piet Borst. (1998) Biosynthesis and Function of the Modified DNA Base β-d-Glucosyl-Hydroxymethyluracil in Trypanosoma brucei. Molecular and Cellular Biology 18:10, pages 5643-5651.
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Emilia Jane McLaughlin, Karinna Rubio-Pena, Annick Dujeancourt-Henry & Lucy Glover. (2022) Transcription Dependent Loss of an Ectopically Expressed Variant Surface Glycoprotein during Antigenic Variation in Trypanosoma brucei. mBio 13:2.
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Bibo Li & Yanxiang Zhao. (2021) Regulation of Antigenic Variation by Trypanosoma brucei Telomere Proteins Depends on Their Unique DNA Binding Activities. Pathogens 10:8, pages 967.
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Bibo Li. (2021) Keeping Balance Between Genetic Stability and Plasticity at the Telomere and Subtelomere of Trypanosoma brucei. Frontiers in Cell and Developmental Biology 9.
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Jennifer Ann Black, Kathryn Crouch, Leandro Lemgruber, Craig Lapsley, Nicholas Dickens, Luiz R.O. Tosi, Jeremy C. Mottram & Richard McCulloch. (2020) Trypanosoma brucei ATR Links DNA Damage Signaling during Antigenic Variation with Regulation of RNA Polymerase I-Transcribed Surface Antigens. Cell Reports 30:3, pages 836-851.e5.
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Núria Sima, Emilia Jane McLaughlin, Sebastian Hutchinson & Lucy Glover. (2019) Escaping the immune system by DNA repair and recombination in African trypanosomes. Open Biology 9:11, pages 190182.
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Rebecca Devlin, Catarina A Marques, Daniel Paape, Marko Prorocic, Andrea C Zurita-Leal, Samantha J Campbell, Craig Lapsley, Nicholas Dickens & Richard McCulloch. (2016) Mapping replication dynamics in Trypanosoma brucei reveals a link with telomere transcription and antigenic variation. eLife 5.
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Bibo Li. (2015) DNA Double-Strand Breaks and Telomeres Play Important Roles in Trypanosoma brucei Antigenic Variation. Eukaryotic Cell 14:3, pages 196-205.
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Lucy Glover, Sam Alsford & David Horn. (2013) DNA Break Site at Fragile Subtelomeres Determines Probability and Mechanism of Antigenic Variation in African Trypanosomes. PLoS Pathogens 9:3, pages e1003260.
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Megan L. Povelones, Eva Gluenz, Marcin Dembek, Keith Gull & Gloria Rudenko. (2012) Histone H1 Plays a Role in Heterochromatin Formation and VSG Expression Site Silencing in Trypanosoma brucei. PLoS Pathogens 8:11, pages e1003010.
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Hee-Sook Kim & George A. M. Cross. (2010) TOPO3α Influences Antigenic Variation by Monitoring Expression-Site-Associated VSG Switching in Trypanosoma brucei. PLoS Pathogens 6:7, pages e1000992.
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Kevin J. VerstrepenGerald R. Fink. (2009) Genetic and Epigenetic Mechanisms Underlying Cell-Surface Variability in Protozoa and Fungi. Annual Review of Genetics 43:1, pages 1-24.
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Christiane Hertz-Fowler, Luisa M. Figueiredo, Michael A. Quail, Marion Becker, Andrew Jackson, Nathalie Bason, Karen Brooks, Carol Churcher, Samah Fahkro, Ian Goodhead, Paul Heath, Magdalena Kartvelishvili, Karen Mungall, David Harris, Heidi Hauser, Mandy Sanders, David Saunders, Kathy Seeger, Sarah Sharp, Jesse E. Taylor, Danielle Walker, Brian White, Rosanna Young, George A. M. Cross, Gloria Rudenko, J. David Barry, Edward J. Louis & Matthew Berriman. (2008) Telomeric Expression Sites Are Highly Conserved in Trypanosoma brucei. PLoS ONE 3:10, pages e3527.
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Piet Borst. 2007. Mobile DNA II. Mobile DNA II 953 971 .
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Etienne Pays, Luc Vanhamme & David Pérez-Morga. (2004) Antigenic variation in Trypanosoma brucei: facts, challenges and mysteries. Current Opinion in Microbiology 7:4, pages 369-374.
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F. Claes, D. Verloo, D.T. De Waal, P.A.O. Majiwa, T. Baltz, B.M. Goddeeris & P. Büscher. (2003) The expression of RoTat 1.2 variable surface glycoprotein (VSG) in Trypanosoma evansi and T. equiperdum. Veterinary Parasitology 116:3, pages 209-216.
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FILIP CLAES, D. VERLOO, D. T. WAAL, T. URAKAWA, P. MAJIWA, B. M. GODDEERIS & P. BÜSCHER. (2002) Expression of RoTat 1.2 Cross-reactive Variable Antigen Type in Trypanosoma evansi and T. equiperdum . Annals of the New York Academy of Sciences 969:1, pages 174-179.
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Matthew Berriman, Neil Hall, Karen Sheader, Frédéric Bringaud, Bela Tiwari, Tomoko Isobe, Sharen Bowman, Craig Corton, Louise Clark, George A.M Cross, Maarten Hoek, Tyiesha Zanders, Magali Berberof, Piet Borst & Gloria Rudenko. (2002) The architecture of variant surface glycoprotein gene expression sites in Trypanosoma brucei. Molecular and Biochemical Parasitology 122:2, pages 131-140.
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Sebastian Ulbert, Inês Chaves & Piet Borst. (2002) Expression site activation in Trypanosoma brucei with three marked variant surface glycoprotein gene expression sites. Molecular and Biochemical Parasitology 120:2, pages 225-235.
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Guoliang Fu & Sara E. Melville. (2002) Polymorphism in the subtelomeric regions of chromosomes of Kinetoplastida. Transactions of the Royal Society of Tropical Medicine and Hygiene 96, pages S31-S40.
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Herlinde Gerrits, Rainer Mußmann, Wilbert Bitter, Rudo Kieft & Piet Borst. (2002) The physiological significance of transferrin receptor variations in Trypanosoma brucei. Molecular and Biochemical Parasitology 119:2, pages 237-247.
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Luc Vanhamme, Etienne Pays, Richard McCulloch & J.David Barry. (2001) An update on antigenic variation in African trypanosomes. Trends in Parasitology 17:7, pages 338-343.
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L Vanhamme, L Lecordier & E Pays. (2001) Control and function of the bloodstream variant surface glycoprotein expression sites in Trypanosoma brucei. International Journal for Parasitology 31:5-6, pages 523-531.
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George A.M. Cross. (2001) African trypanosomes in the 21st century: what is their future in science and in health?. International Journal for Parasitology 31:5-6, pages 427-433.
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Piet Borst & Sebastian Ulbert. (2001) Control of VSG gene expression sites. Molecular and Biochemical Parasitology 114:1, pages 17-27.
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Sara E Melville, Vanessa Leech, Miguel Navarro & George A.M Cross. (2000) The molecular karyotype of the megabase chromosomes of Trypanosoma brucei stock 427. Molecular and Biochemical Parasitology 111:2, pages 261-273.
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Patricia A Blundell & Piet Borst. (1998) Analysis of a variant surface glycoprotein gene expression site promoter of Trypanosoma brucei by remodelling the promoter region. Molecular and Biochemical Parasitology 94:1, pages 67-85.
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