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Molecular and Cellular Biology Volume 18, 1998 - Issue 10
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DNA Dynamics and Chromosome Structure

Hypersensitivity of Ku-Deficient Cells toward the DNA Topoisomerase II Inhibitor ICRF-193 Suggests a Novel Role for Ku Antigen during the G2 and M Phases of the Cell Cycle

Purificación Muñoza Institut de Génétique Moléculaire de Montpellier, CNRS, 34293 Montpellier Cedex 5, FranceCorrespondence[email protected]
,
Malgorzata Z. Zdzienickab Leiden University, 2300 RA Leiden, The Netherlands
,
Jean-Marie Blancharda Institut de Génétique Moléculaire de Montpellier, CNRS, 34293 Montpellier Cedex 5, France
&
Jacques Piettea Institut de Génétique Moléculaire de Montpellier, CNRS, 34293 Montpellier Cedex 5, France
Pages 5797-5808 | Received 05 Mar 1998, Accepted 02 Jul 1998, Published online: 28 Mar 2023

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Brian L. Ruis, Kazi R. Fattah & Eric A. Hendrickson. (2008) The Catalytic Subunit of DNA-Dependent Protein Kinase Regulates Proliferation, Telomere Length, and Genomic Stability in Human Somatic Cells . Molecular and Cellular Biology 28:20, pages 6182-6195.
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Renu Tuteja & Narendra Tuteja. (2000) Ku Autoantigen: A Multifunctional DNA-Binding Protein. Critical Reviews in Biochemistry and Molecular Biology 35:1, pages 1-33.
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Ward Giffin, Wenrong Gong, Caroline Schild-Poulter & Robert J. G. Haché. (1999) Ku Antigen-DNA Conformation Determines the Activation of DNA-Dependent Protein Kinase and DNA Sequence-Directed Repression of Mouse Mammary Tumor Virus Transcription. Molecular and Cellular Biology 19:6, pages 4065-4078.
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Articles from other publishers (19)

Tianze Liu, Lizi Jin, Miao Chen, Zongheng Zheng, Wenjing Lu, Wenhua Fan, Liren Li, Fufu Zheng, Qiaohua Zhu, Huijuan Qiu, Jiani Liu, Manyu Chen, Chunfang Tian, Zheng Hu, Changlin Zhang, Meihua Luo, Jian Li, Tiebang Kang, Lukun Yang, Yizhuo Li & Wuguo Deng. (2019) Ku80 promotes melanoma growth and regulates antitumor effect of melatonin by targeting HIF1-α dependent PDK-1 signaling pathway. Redox Biology 25, pages 101197.
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Defeng Qi, Yuan Hu, Jinhui Li, Tao Peng, Jialin Su, Yun He & Weidong Ji. (2015) Hyperthermia Induces Apoptosis of 786-O Cells through Suppressing Ku80 Expression. PLOS ONE 10:4, pages e0122977.
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Iha Park & Hava Karsenty Avraham. (2006) Cell cycle-dependent DNA damage signaling induced by ICRF-193 involves ATM, ATR, CHK2, and BRCA1. Experimental Cell Research 312:11, pages 1996-2008.
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Tsai-Yun Chen, Jiann-Shiuh Chen, Wu-Chou Su, Ming-Shiuan Wu & Chao-Jung Tsao. (2005) Expression of DNA repair gene Ku80 in lymphoid neoplasm. European Journal of Haematology 74:6, pages 481-488.
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Taku Nakagawa, Yoji Hayashita, Ken Maeno, Akira Masuda, Nobuyoshi Sugito, Hirotaka Osada, Kiyoshi Yanagisawa, Hiromichi Ebi, Kaoru Shimokata & Takashi Takahashi. (2004) Identification of Decatenation G2 Checkpoint Impairment Independently of DNA Damage G2 Checkpoint in Human Lung Cancer Cell Lines. Cancer Research 64:14, pages 4826-4832.
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Vibe H. Oestergaard, Birgitta R. Knudsen & Anni H. Andersen. (2004) Dissecting the Cell-killing Mechanism of the Topoisomerase II-targeting Drug ICRF-193. Journal of Biological Chemistry 279:27, pages 28100-28105.
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Noritaka Adachi, Hiromi Suzuki, Susumu Iiizumi & Hideki Koyama. (2003) Hypersensitivity of Nonhomologous DNA End-joining Mutants to VP-16 and ICRF-193. Journal of Biological Chemistry 278:38, pages 35897-35902.
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N. Hajji, N. Pastor, S. Mateos, I. Domı&#x;nguez & F. Cortés. (2003) DNA strand breaks induced by the anti-topoisomerase II bis-dioxopiperazine ICRF-193. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 530:1-2, pages 35-46.
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Annette K Larsen, Alexandre E Escargueil & Andrzej Skladanowski. (2003) Catalytic topoisomerase II inhibitors in cancer therapy. Pharmacology & Therapeutics 99:2, pages 167-181.
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Caroline Schild-PoulterDiamanto Matheos, Olivia Novac, Bo Cui, Ward Giffin, Marcia T. Ruiz, Gerald B. Price, Maria Zannis-Hadjopoulos & Robert J.G. Haché. (2003) Differential DNA Binding of Ku Antigen Determines Its Involvement in DNA Replication. DNA and Cell Biology 22:2, pages 65-78.
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Diamanto Matheos, Olivia Novac, Gerald B. Price & Maria Zannis-Hadjopoulos. (2003) Analysis of the DNA replication competence of the xrs -5 mutant cells defective in Ku86 . Journal of Cell Science 116:1, pages 111-124.
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MANABU KOIKE. (2002) Dimerization, Translocation and Localization of Ku70 and Ku80 Proteins. Journal of Radiation Research 43:3, pages 223-236.
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Kuan-Chun Huang, Hanlin Gao, Edith F. Yamasaki, Dale R. Grabowski, Shujun Liu, Linus L. Shen, Kenneth K. Chan, Ram Ganapathi & Robert M. Snapka. (2001) Topoisomerase II Poisoning by ICRF-193. Journal of Biological Chemistry 276:48, pages 44488-44494.
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Purificación Muñoz, Fabienne Baus & Jacques Piette. (2001) Ku antigen is required to relieve G2 arrest caused by inhibition of DNA topoisomerase II activity by the bisdioxopiperazine ICRF-193. Oncogene 20:16, pages 1990-1999.
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Eileen M. Lynch, Robert B. Moreland, Irene Ginis, Susan P. Perrine & Douglas V. Faller. (2001) Hypoxia-activated ligand HAL-1/13 is lupus autoantigen Ku80 and mediates lymphoid cell adhesion in vitro. American Journal of Physiology-Cell Physiology 280:4, pages C897-C911.
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Eulette D Arrington, M.Craig Caldwell, T.S Kumaravel, Althaf Lohani, Amar Joshi, Michele K Evans, Hua Tang Chen, Andre Nussenzweig, Nikki J Holbrook & Myriam Gorospe. (2000) Enhanced sensitivity and long-term G2 arrest in hydrogen peroxide-treated Ku80-null cells are unrelated to DNA repair defects. Free Radical Biology and Medicine 29:11, pages 1166-1176.
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M. Koike, T. Awaji, M. Kataoka, G. Tsujimoto, T. Kartasova, A. Koike & T. Shiomi. (1999) Differential subcellular localization of DNA-dependent protein kinase components Ku and DNA-PKcs during mitosis. Journal of Cell Science 112:22, pages 4031-4039.
Crossref
V Sert, C Cans, C Tasca, L Bret-Bennis, E Oswald, B Ducommun & J De Rycke. (1999) The bacterial cytolethal distending toxin (CDT) triggers a G2 cell cycle checkpoint in mammalian cells without preliminary induction of DNA strand breaks. Oncogene 18:46, pages 6296-6304.
Crossref
Sanjeev Galande & Terumi Kohwi-Shigematsu. (1999) Poly(ADP-ribose) Polymerase and Ku Autoantigen Form a Complex and Synergistically Bind to Matrix Attachment Sequences. Journal of Biological Chemistry 274:29, pages 20521-20528.
Crossref

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