19
Views
74
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Alkylpurine–DNA–N-Glycosylase Knockout Mice Show Increased Susceptibility to Induction of Mutations by Methyl Methanesulfonate

, , , , , , , , , , , , & show all
Pages 5828-5837 | Received 31 Mar 1998, Accepted 20 Jul 1998, Published online: 28 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Guido Frosina. (2004) CommentaryDNA Base Excision Repair Defects in Human Pathologies. Free Radical Research 38:10, pages 1037-1054.
Read now
Maria T. A. Ocampo, Wenren Chaung, Dina R. Marenstein, Michael K. Chan, Alvin Altamirano, Ashis K. Basu, Robert J. Boorstein, Richard P. Cunningham & George W. Teebor. (2002) Targeted Deletion of mNth1 Reveals a Novel DNA Repair Enzyme Activity. Molecular and Cellular Biology 22:17, pages 6111-6121.
Read now
John W. Cardinal, Geoffrey P. Margison, Kurt J. Mynett, Allen P. Yates, Donald P. Cameron & Rhoderick H. Elder. (2001) Increased Susceptibility to Streptozotocin-Induced β-Cell Apoptosis and Delayed Autoimmune Diabetes in Alkylpurine- DNA-N-Glycosylase-Deficient Mice. Molecular and Cellular Biology 21:16, pages 5605-5613.
Read now

Articles from other publishers (71)

Jörg Fahrer & Markus Christmann. (2023) DNA Alkylation Damage by Nitrosamines and Relevant DNA Repair Pathways. International Journal of Molecular Sciences 24:5, pages 4684.
Crossref
Yong Li, Peng Mao, Evelina Y. Basenko, Zachary Lewis, Michael J. Smerdon & Wioletta Czaja. (2021) Versatile cell-based assay for measuring DNA alkylation damage and its repair. Scientific Reports 11:1.
Crossref
B. Altakroni, C. Nevin, M. Carroll, C. Murgatroyd, G. Horne, D. R. Brison & A. C. Povey. (2021) The marker of alkyl DNA base damage, N7-methylguanine, is associated with semen quality in men. Scientific Reports 11:1.
Crossref
Nina Seiwert, Daniel Heylmann, Solveig Hasselwander & Jörg Fahrer. (2020) Mechanism of colorectal carcinogenesis triggered by heme iron from red meat. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1873:1, pages 188334.
Crossref
Paul J Caffrey & Sarah Delaney. (2019) Chromatin and other obstacles to base excision repair: potential roles in carcinogenesis. Mutagenesis.
Crossref
Charley C. Gruber & Graham C. Walker. (2018) Incomplete base excision repair contributes to cell death from antibiotics and other stresses. DNA Repair 71, pages 108-117.
Crossref
Jörg Fahrer, Janina Frisch, Georg Nagel, Alexander Kraus, Bastian Dörsam, Adam D. Thomas, Sonja Reißig, Ari Waisman & Bernd Kaina. (2015) DNA repair by MGMT, but not AAG, causes a threshold in alkylation-induced colorectal carcinogenesis. Carcinogenesis 36:10, pages 1235-1244.
Crossref
Wen-Cheng Chou, Ling-Yueh Hu, Chia-Ni Hsiung & Chen-Yang Shen. (2015) Initiation of the ATM-Chk2 DNA damage response through the base excision repair pathway. Carcinogenesis 36:8, pages 832-840.
Crossref
Sameer Agnihotri, Kelly Burrell, Pawel Buczkowicz, Marc Remke, Brian Golbourn, Yevgen Chornenkyy, Aaron Gajadhar, Nestor A. Fernandez, Ian D. Clarke, Mark S. Barszczyk, Sanja Pajovic, Christian Ternamian, Renee Head, Nesrin Sabha, Robert W. Sobol, Michael D. Taylor, James T. Rutka, Chris Jones, Peter B. Dirks, Gelareh Zadeh & Cynthia Hawkins. (2014) ATM Regulates 3-Methylpurine-DNA Glycosylase and Promotes Therapeutic Resistance to Alkylating Agents. Cancer Discovery 4:10, pages 1198-1213.
Crossref
Michael Ensminger, Lucie Iloff, Christian Ebel, Teodora Nikolova, Bernd Kaina & Markus Lӧbrich. (2014) DNA breaks and chromosomal aberrations arise when replication meets base excision repair. Journal of Cell Biology 206:1, pages 29-43.
Crossref
Yan Zhu, Dun-Gao Li, Zhao-Gui Sun, Xue-Jin Chen & Man-Xi Jiang. (2012) Differences in chimera formation and germline transmission between E14 and C2J embryonic stem cells in mice. Zygote 22:2, pages 182-186.
Crossref
Wynand P. Roos & Bernd Kaina. (2013) DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosis. Cancer Letters 332:2, pages 237-248.
Crossref
Sameer Agnihotri, Kelly E. Burrell, Amparo Wolf, Sharzhad Jalali, Cynthia Hawkins, James T. Rutka & Gelareh Zadeh. (2012) Glioblastoma, a Brief Review of History, Molecular Genetics, Animal Models and Novel Therapeutic Strategies. Archivum Immunologiae et Therapiae Experimentalis 61:1, pages 25-41.
Crossref
David Svilar, Madhu Dyavaiah, Ashley R. Brown, Jiang-bo Tang, Jianfeng Li, Peter R. McDonald, Tong Ying Shun, Andrea Braganza, Xiao-hong Wang, Salony Maniar, Claudette M. St Croix, John S. Lazo, Ian F. Pollack, Thomas J. Begley & Robert W. Sobol. (2012) Alkylation Sensitivity Screens Reveal a Conserved Cross-species Functionome. Molecular Cancer Research 10:12, pages 1580-1596.
Crossref
Susan S. Wallace, Drew L. Murphy & Joann B. Sweasy. (2012) Base excision repair and cancer. Cancer Letters 327:1-2, pages 73-89.
Crossref
Jun Nakamura, Husamettin Gul, Xu Tian, Scott J. Bultman & James A. Swenberg. (2012) Detection of PIGO-Deficient Cells Using Proaerolysin: A Valuable Tool to Investigate Mechanisms of Mutagenesis in the DT40 Cell System. PLoS ONE 7:3, pages e33563.
Crossref
Dragony Fu, Jennifer A. Calvo & Leona D. Samson. (2012) Balancing repair and tolerance of DNA damage caused by alkylating agents. Nature Reviews Cancer 12:2, pages 104-120.
Crossref
Mark L. Gonzalgo & Alan Keith Meeker. 2012. Campbell-Walsh Urology. Campbell-Walsh Urology 530 567.e16 .
Zoulikha M. Zaïr, Gareth J. Jenkins, Shareen H. Doak, Raj Singh, Karen Brown & George E. Johnson. (2011) N-Methylpurine DNA Glycosylase Plays a Pivotal Role in the Threshold Response of Ethyl Methanesulfonate–Induced Chromosome Damage. Toxicological Sciences 119:2, pages 346-358.
Crossref
Bo Hang. (2010) Formation and Repair of Tobacco Carcinogen-Derived Bulky DNA Adducts. Journal of Nucleic Acids 2010, pages 1-29.
Crossref
N. Cooley, R.H. Elder & A.C. Povey. (2010) The effect of Msh2 knockdown on methylating agent induced toxicity in DNA glycosylase deficient cells. Toxicology 268:1-2, pages 111-117.
Crossref
Abigail E. Wolfe & Patrick J. O’Brien. (2009) Kinetic Mechanism for the Flipping and Excision of 1, N 6 -Ethenoadenine by Human Alkyladenine DNA Glycosylase . Biochemistry 48:48, pages 11357-11369.
Crossref
Brian F. Pachkowski, Keizo Tano, Valeriy Afonin, Rhoderick H. Elder, Shunichi Takeda, Masami Watanabe, James A. Swenberg & Jun Nakamura. (2009) Cells deficient in PARP-1 show an accelerated accumulation of DNA single strand breaks, but not AP sites, over the PARP-1-proficient cells exposed to MMS. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 671:1-2, pages 93-99.
Crossref
M Behmanesh, K Sakumi, N Abolhassani, S Toyokuni, S Oka, Y N Ohnishi, D Tsuchimoto & Y Nakabeppu. (2009) ITPase-deficient mice show growth retardation and die before weaning. Cell Death & Differentiation 16:10, pages 1315-1322.
Crossref
Jahye Kim, Naoya Matsunaga, Satoru Koyanagi & Shigehiro Ohdo. (2009) Clock gene mutation modulates the cellular sensitivity to genotoxic stress through altering the expression of N-methylpurine DNA glycosylase gene. Biochemical Pharmacology 78:8, pages 1075-1082.
Crossref
Chun-Yue I. Lee, James C. Delaney, Maria Kartalou, Gondichatnahalli M. Lingaraju, Ayelet Maor-Shoshani, John M. Essigmann & Leona D. Samson. (2009) Recognition and Processing of a New Repertoire of DNA Substrates by Human 3-Methyladenine DNA Glycosylase (AAG). Biochemistry 48:9, pages 1850-1861.
Crossref
Mengmeng Yang, Stuart G. Jarrett, Rolf Craven & David M. Kaetzel. (2009) YNK1, the yeast homolog of human metastasis suppressor NM23, is required for repair of UV radiation- and etoposide-induced DNA damage. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 660:1-2, pages 74-78.
Crossref
Ram N. Trivedi, Xiao-hong Wang, Elena Jelezcova, Eva M. Goellner, Jiang-bo Tang & Robert W. Sobol. (2008) Human Methyl Purine DNA Glycosylase and DNA Polymerase β Expression Collectively Predict Sensitivity to Temozolomide. Molecular Pharmacology 74:2, pages 505-516.
Crossref
Brian S. Plosky, Ekaterina G. Frank, David A. Berry, Graham P. Vennall, John P. McDonald & Roger Woodgate. (2008) Eukaryotic Y-family polymerases bypass a 3-methyl-2′-deoxyadenosine analog in vitro and methyl methanesulfonate-induced DNA damage in vivo. Nucleic Acids Research 36:7, pages 2152-2162.
Crossref
Albert A. van Zeeland, Anton J.L. de Groot, Georges R. Mohn, Harry van Steeg, Conny van Oostrom, Anne-Marie van Duijn-Goedhart, Leon F.H. Mullenders & Jacob G. Jansen. (2008) Reduced methylation-induced mutagenesis in rat splenocytes in vivo by sub-chronic low dose exposure to N-metyl-N-nitrosourea. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 640:1-2, pages 131-138.
Crossref
Bernd Kaina, Markus Christmann, Steffen Naumann & Wynand P. Roos. (2007) MGMT: Key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents. DNA Repair 6:8, pages 1079-1099.
Crossref
Zdenka Matijasevic & Michael R. Volkert. (2007) Base excision repair sensitizes cells to sulfur mustard and chloroethyl ethyl sulfide. DNA Repair 6:6, pages 733-741.
Crossref
Elisabeth Larsen, Trine J. Meza, Liv Kleppa & Arne Klungland. (2007) Organ and cell specificity of base excision repair mutants in mice. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 614:1-2, pages 56-68.
Crossref
Robert Nilsson. (2006) De Minimus Non Curat Lex - Virtual Thresholds for Cancer Initiation by Tobacco Specific Nitrosamines - Prospects for Harm Reduction by Smokeless Tobacco. International Journal of Occupational Medicine and Environmental Health 19:1.
Crossref
Ping Wang, Anton B. Guliaev, Rhoderick H. Elder & Bo Hang. (2006) Alkylpurine-DNA-N-glycosylase excision of 7-(hydroxymethyl)-1,N6-ethenoadenine, a glycidaldehyde-derived DNA adduct. DNA Repair 5:1, pages 23-31.
Crossref
Johanna Paik, Tod Duncan, Tomas Lindahl & Barbara Sedgwick. (2005) Sensitization of Human Carcinoma Cells to Alkylating Agents by Small Interfering RNA Suppression of 3-Alkyladenine-DNA Glycosylase. Cancer Research 65:22, pages 10472-10477.
Crossref
Deborah E. BarnesTomas Lindahl. (2004) Repair and Genetic Consequences of Endogenous DNA Base Damage in Mammalian Cells. Annual Review of Genetics 38:1, pages 445-476.
Crossref
Errol C. Friedberg & Lisiane B. Meira. (2004) Database of mouse strains carrying targeted mutations in genes affecting biological responses to DNA damage (Version 6). DNA Repair 3:12, pages 1617-1638.
Crossref
Finn Drabløs, Emadoldin Feyzi, Per Arne Aas, Cathrine B. Vaagbø, Bodil Kavli, Marit S. Bratlie, Javier Peña-Diaz, Marit Otterlei, Geir Slupphaug & Hans E. Krokan. (2004) Alkylation damage in DNA and RNA—repair mechanisms and medical significance. DNA Repair 3:11, pages 1389-1407.
Crossref
Bo Hang. (2004) Repair of exocyclic DNA adducts: rings of complexity. BioEssays 26:11, pages 1195-1208.
Crossref
Anton B. Guliaev, B. Singer & Bo Hang. (2004) Chloroethylnitrosourea-derived ethano cytosine and adenine adducts are substrates for Escherichia coli glycosylases excising analogous etheno adducts. DNA Repair 3:10, pages 1311-1321.
Crossref
Laurie A. Davidson, Danh V. Nguyen, Regina M. Hokanson, Evelyn S. Callaway, Robert B. Isett, Nancy D. Turner, Edward R. Dougherty, Naisyin Wang, Joanne R. Lupton, Raymond J. Carroll & Robert S. Chapkin. (2004) Chemopreventive n -3 Polyunsaturated Fatty Acids Reprogram Genetic Signatures during Colon Cancer Initiation and Progression in the Rat . Cancer Research 64:18, pages 6797-6804.
Crossref
Laurent Gros, Andrei V. Maksimenko, Cyril V. Privezentzev, Jacques Laval & Murat K. Saparbaev. (2004) Hijacking of the Human Alkyl-N-purine-DNA Glycosylase by 3,N4-Ethenocytosine, a Lipid Peroxidation-induced DNA Adduct. Journal of Biological Chemistry 279:17, pages 17723-17730.
Crossref
Barbara Sedgwick. (2004) Repairing DNA-methylation damage. Nature Reviews Molecular Cell Biology 5:2, pages 148-157.
Crossref
Sugiko Watanabe, Takaya Ichimura, Naoyuki Fujita, Shu Tsuruzoe, Izuru Ohki, Masahiro Shirakawa, Michio Kawasuji & Mitsuyoshi Nakao. (2003) Methylated DNA-binding domain 1 and methylpurine–DNA glycosylase link transcriptional repression and DNA repair in chromatin. Proceedings of the National Academy of Sciences 100:22, pages 12859-12864.
Crossref
Robert W. Sobol, Maria Kartalou, Karen H. Almeida, Donna F. Joyce, Bevin P. Engelward, Julie K. Horton, Rajendra Prasad, Leona D. Samson & Samuel H. Wilson. (2003) Base Excision Repair Intermediates Induce p53-independent Cytotoxic and Genotoxic Responses. Journal of Biological Chemistry 278:41, pages 39951-39959.
Crossref
Hilde Nilsen, Gordon Stamp, Sonja Andersen, Geza Hrivnak, Hans E Krokan, Tomas Lindahl & Deborah E Barnes. (2003) Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas. Oncogene 22:35, pages 5381-5386.
Crossref
Julie K. Horton, Donna F. Joyce-Gray, Brian F. Pachkowski, James A. Swenberg & Samuel H. Wilson. (2003) Hypersensitivity of DNA polymerase β null mouse fibroblasts reflects accumulation of cytotoxic repair intermediates from site-specific alkyl DNA lesions. DNA Repair 2:1, pages 27-48.
Crossref
Laurent Gros, Murat K Saparbaev & Jacques Laval. (2002) Enzymology of the repair of free radicals-induced DNA damage. Oncogene 21:58, pages 8905-8925.
Crossref
Christopher M Ward, Peter Stern, Mark A Willington & Ann Marie Flenniken. (2002) Efficient Germline Transmission of Mouse Embryonic Stem Cells Grown in Synthetic Serum in the Absence of a Fibroblast Feeder Layer. Laboratory Investigation 82:12, pages 1765-1767.
Crossref
Brian Plosky, Leona Samson, Bevin P Engelward, Barry Gold, Brenda Schlaen, Themistocles Millas, Michael Magnotti, Jonathan Schor & David A Scicchitano. (2002) Base excision repair and nucleotide excision repair contribute to the removal of N-methylpurines from active genes. DNA Repair 1:8, pages 683-696.
Crossref
Murat Saparbaev, Sophie Langouët, Cyril V. Privezentzev, F. Peter Guengerich, Hongliang Cai, Rhoderick H. Elder & Jacques Laval. (2002) 1,N 2-Ethenoguanine, a Mutagenic DNA Adduct, Is a Primary Substrate of Escherichia coliMismatch-specific Uracil-DNA Glycosylase and Human Alkylpurine-DNA-N-Glycosylase. Journal of Biological Chemistry 277:30, pages 26987-26993.
Crossref
Robert W. SobolDavid E. WatsonJun NakamuraF. Michael YakesEsther HouJulie K. HortonJoseph LadapoBennett Van HoutenJames A. SwenbergKenneth R. TindallLeona D. SamsonSamuel H. Wilson. (2002) Mutations associated with base excision repair deficiency and methylation-induced genotoxic stress. Proceedings of the National Academy of Sciences 99:10, pages 6860-6865.
Crossref
Diane C Cabelof, Julian J Raffoul, Sunitha Yanamadala, Cirlette Ganir, ZhongMao Guo & Ahmad R Heydari. (2002) Attenuation of DNA polymerase β-dependent base excision repair and increased DMS-induced mutagenicity in aged mice. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 500:1-2, pages 135-145.
Crossref
Robert K. Vinson & Barbara F. Hales. (2001) Expression of base excision, mismatch, and recombination repair genes in the organogenesis-stage rat conceptus and effects of exposure to a genotoxic teratogen, 4-hydroperoxycyclophosphamide. Teratology 64:6, pages 283-291.
Crossref
Hilde Nilsen & Hans E. Krokan. (2001) Base excision repair in a network of defence and tolerance. Carcinogenesis 22:7, pages 987-998.
Crossref
Chris J NorburyIan D Hickson. (2001) Cellular Responses to DNA Damage. Annual Review of Pharmacology and Toxicology 41:1, pages 367-401.
Crossref
Hans E Krokan, Marit Otterlei, Hilde Nilsen, Bodil Kavli, Frank Skorpen, Sonja Andersen, Camilla Skjelbred, Mansour Akbari, Per Arne Aas & Geir Slupphaug. 2001. Base Excision Repair. Base Excision Repair 365 386 .
Bernd Kaina, Kirsten Ochs, Sabine Grösch, Gerhard Frizz, Jochen Lips, Maja Tomicic, Torsten Dunkern & Markus Christmann. 2001. Base Excision Repair. Base Excision Repair 41 54 .
Thomas Lindahl. 2001. Base Excision Repair. Base Excision Repair xvii xxx .
Susan W.P. Wijnhoven, Hanneke J.M. Kool, Corrie M.M. van Teijlingen, Albert A. van Zeeland & Harry Vrieling. (2001) Loss of heterozygosity in somatic cells of the mouse. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 473:1, pages 23-36.
Crossref
E. P. Das-Gupta, C. H. Seedhouse & N. H. Russell. (2000) DNA repair mechanisms and acute myeloblastic leukemia. Hematological Oncology 18:3, pages 99-110.
Crossref
Hans E Krokan, Hilde Nilsen, Frank Skorpen, Marit Otterlei & Geir Slupphaug. (2000) Base excision repair of DNA in mammalian cells. FEBS Letters 476:1-2, pages 73-77.
Crossref
Eyleen J. O'Rourke, Catherine Chevalier, Serge Boiteux, Agnès Labigne, Luis Ielpi & J.Pablo Radicella. (2000) A Novel 3-Methyladenine DNA Glycosylase from Helicobacter pylori Defines a New Class within the Endonuclease III Family of Base Excision Repair Glycosylases. Journal of Biological Chemistry 275:26, pages 20077-20083.
Crossref
Errol C. Friedberg & Lisiane B. Meira. (2000) Database of mouse strains carrying targeted mutations in genes affecting cellular responses to DNA damage. Version 4. Mutation Research/DNA Repair 459:4, pages 243-274.
Crossref
Guido Frosina. (2000) Overexpression of enzymes that repair endogenous damage to DNA. European Journal of Biochemistry 267:8, pages 2135-2149.
Crossref
M. Bignami, M. O'Driscoll, G. Aquilina & P. Karran. (2000) Unmasking a killer: DNA O6-methylguanine and the cytotoxicity of methylating agents. Mutation Research/Reviews in Mutation Research 462:2-3, pages 71-82.
Crossref
T. LINDAHL & D.E. BARNES. (2000) Repair of Endogenous DNA Damage. Cold Spring Harbor Symposia on Quantitative Biology 65:0, pages 127-134.
Crossref
Fabienne Calléja, Jacob G Jansen, Harry Vrieling, Françoise Laval & Albert A van Zeeland. (1999) Modulation of the toxic and mutagenic effects induced by methyl methanesulfonate in Chinese hamster ovary cells by overexpression of the rat N-alkylpurine-DNA glycosylase. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 425:2, pages 185-194.
Crossref
Errol C Friedberg & Lisiane B Meira. (1999) Database of mouse strains carrying targeted mutations in genes affecting cellular responses to DNA damage: version 3. Mutation Research/DNA Repair 433:2, pages 69-87.
Crossref
Anthony E. Pegg. 1999. Advances in Nutrition and Cancer 2. Advances in Nutrition and Cancer 2 253 267 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.