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Molecular and Cellular Biology Volume 18, 1998 - Issue 10
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Cell Growth and Development

Dominant-Negative Mutations in the G-Protein-Coupled α-Factor Receptor Map to the Extracellular Ends of the Transmembrane Segments

Mercedes DosilDepartment of Molecular Genetics and Microbiology, State University of New York, Stony Brook, New York11794-5222
,
Loïc GiotDepartment of Molecular Genetics and Microbiology, State University of New York, Stony Brook, New York11794-5222
,
Colleen DavisDepartment of Molecular Genetics and Microbiology, State University of New York, Stony Brook, New York11794-5222
&
James B. KonopkaDepartment of Molecular Genetics and Microbiology, State University of New York, Stony Brook, New York11794-5222Correspondence[email protected]
Pages 5981-5991 | Received 12 May 1998, Accepted 30 Jun 1998, Published online: 28 Mar 2023

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Jennifer C. Lin, Ken Duell & James B. Konopka. (2004) A Microdomain Formed by the Extracellular Ends of the Transmembrane Domains Promotes Activation of the G Protein-Coupled α-Factor Receptor. Molecular and Cellular Biology 24:5, pages 2041-2051.
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Hanna Forsberg & Per O. Ljungdahl. (2001) Genetic and Biochemical Analysis of the Yeast Plasma Membrane Ssy1p-Ptr3p-Ssy5p Sensor of Extracellular Amino Acids. Molecular and Cellular Biology 21:3, pages 814-826.
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Mercedes Dosil, Kimberly A. Schandel, Ekta Gupta, Duane D. Jenness & James B. Konopka. (2000) The C Terminus of the Saccharomyces cerevisiaeα-Factor Receptor Contributes to the Formation of Preactivation Complexes with Its Cognate G Protein. Molecular and Cellular Biology 20:14, pages 5321-5329.
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Mark E. Dumont & James B. Konopka. (2022) Comparison of Experimental Approaches Used to Determine the Structure and Function of the Class D G Protein-Coupled Yeast α-Factor Receptor. Biomolecules 12:6, pages 761.
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Vaithish Velazhahan, Ning Ma, Nagarajan Vaidehi & Christopher G. Tate. (2022) Activation mechanism of the class D fungal GPCR dimer Ste2. Nature 603:7902, pages 743-748.
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Sara M. Connelly, Rajashri Sridharan, Fred Naider & Mark E. Dumont. (2021) Oligomerization of yeast α-factor receptor detected by fluorescent energy transfer between ligands. Biophysical Journal 120:22, pages 5090-5106.
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Laura Marina Robles, César Millán-Pacheco, Nina Pastor & Gabriel Del Río. (2017) STRUCTURE-FUNCTION STUDIES OF THE ALPHA PHEROMONE RECEPTOR FROM YEAST. TIP 20:1, pages 16-26.
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Alan Bush, Gustavo Vasen, Andreas Constantinou, Paula Dunayevich, Inés Lucía Patop, Matías Blaustein & Alejandro Colman‐Lerner. (2016) Yeast GPCR signaling reflects the fraction of occupied receptors, not the number . Molecular Systems Biology 12:12.
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Rajashri Sridharan, Sara M. Connelly, Fred Naider & Mark E. Dumont. (2016) Variable Dependence of Signaling Output on Agonist Occupancy of Ste2p, a G Protein-coupled Receptor in Yeast. Journal of Biological Chemistry 291:46, pages 24261-24279.
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Serena Gastaldi, Michela Zamboni, Giulia Bolasco, Gianfranco Di Segni & Glauco P. Tocchini-Valentini. (2016) Analysis of random PCR-originated mutants of the yeast Ste2 and Ste3 receptors. MicrobiologyOpen 5:4, pages 670-686.
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Leah S. Cohen, Katrina E. Fracchiolla, Jeff Becker & Fred Naider. (2014) Invited review GPCR structural characterization: Using fragments as building blocks to determine a complete structure. Biopolymers 102:3, pages 223-243.
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Chien-I ChangKimberly A. SchandelDuane D. Jenness. (2014) Interaction among Saccharomyces cerevisiae pheromone receptors during endocytosis . Biology Open 3:4, pages 297-306.
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Austin U. Gehret, Sara M. Connelly & Mark E. Dumont. (2012) Functional and Physical Interactions among Saccharomyces cerevisiae α-Factor Receptors. Eukaryotic Cell 11:10, pages 1276-1288.
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Christian Seibel, Doris Tisch, Christian P. Kubicek & Monika Schmoll. (2012) The role of pheromone receptors for communication and mating in Hypocrea jecorina (Trichoderma reesei). Fungal Genetics and Biology 49:10, pages 814-824.
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Kyeong-Man Kim, Yong-Hun Lee, Ayca Akal-Strader, M. Seraj Uddin, Melinda Hauser, Fred Naider & Jeffrey M. Becker. (2012) Multiple regulatory roles of the carboxy terminus of Ste2p a yeast GPCR. Pharmacological Research 65:1, pages 31-40.
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L.S. Cohen, B. Arshava, A. Neumoin, J.M. Becker, P. Güntert, O. Zerbe & F. Naider. (2011) Comparative NMR analysis of an 80-residue G protein-coupled receptor fragment in two membrane mimetic environments. Biochimica et Biophysica Acta (BBA) - Biomembranes 1808:11, pages 2674-2684.
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Elizabeth Mathew, Anshika Bajaj, Sara M. Connelly, Hasmik Sargsyan, Fa-Xiang Ding, Alexander G. Hajduczok, Fred Naider & Mark E. Dumont. (2011) Differential Interactions of Fluorescent Agonists and Antagonists with the Yeast G Protein Coupled Receptor Ste2p. Journal of Molecular Biology 409:4, pages 513-528.
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Mercedes Dosil & James B. Konopka. 2010. Constitutive Activity in Receptors and Other Proteins, Part B. Constitutive Activity in Receptors and Other Proteins, Part B 329 348 .
Hong X. Wang & James B. Konopka. (2009) Identification of Amino Acids at Two Dimer Interface Regions of the α-Factor Receptor (Ste2). Biochemistry 48:30, pages 7132-7139.
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George K. E. Umanah, Cagdas Son, FaXiang Ding, Fred Naider & Jeffrey M. Becker. (2009) Cross-Linking of a DOPA-Containing Peptide Ligand into Its G Protein-Coupled Receptor. Biochemistry 48:9, pages 2033-2044.
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Chunhua Shi, Matthew F. Paige, Jason Maley & Michèle C. Loewen. (2009) In vitro characterization of ligand-induced oligomerization of the S. cerevisiae G-protein coupled receptor, Ste2p. Biochimica et Biophysica Acta (BBA) - General Subjects 1790:1, pages 1-7.
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Chaoyang Xue, Yen-Ping Hsueh & Joseph Heitman. (2008) Magnificent seven: roles of G protein-coupled receptors in extracellular sensing in fungi. FEMS Microbiology Reviews 32:6, pages 1010-1032.
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Jake Stout, Ethan Romero-Severson, Max O Ruegger & Clint Chapple. (2008) Semidominant Mutations in Reduced Epidermal Fluorescence 4 Reduce Phenylpropanoid Content in Arabidopsis . Genetics 178:4, pages 2237-2251.
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Alexander O. Shpakov & Marianna N. Pertseva. 2008. 151 282 .
Anshika Bajaj, Sara M. Connelly, Austin U. Gehret, Fred Naider & Mark E. Dumont. (2007) Role of extracellular charged amino acids in the yeast α-factor receptor. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1773:6, pages 707-717.
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Francisco J. Alvarez & James B. Konopka. (2007) Identification of an N -Acetylglucosamine Transporter That Mediates Hyphal Induction in Candida albicans . Molecular Biology of the Cell 18:3, pages 965-975.
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A. O. Shpakov. (2007) Serpentine type receptors and heterotrimeric G-proteins in yeasts: Structural-functional organization and molecular mechanisms of action. Journal of Evolutionary Biochemistry and Physiology 43:1, pages 1-25.
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Austin U. Gehret, Anshika Bajaj, Fred Naider & Mark E. Dumont. (2006) Oligomerization of the Yeast α-Factor Receptor. Journal of Biological Chemistry 281:30, pages 20698-20714.
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Yong-Hun Lee, Fred Naider & Jeffrey M. Becker. (2006) Interacting Residues in an Activated State of a G Protein-coupled Receptor. Journal of Biological Chemistry 281:4, pages 2263-2272.
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Minghang Zhang, Mousumi Goswami & Dale Hereld. (2005) Constitutively Active G Protein-coupled Receptor Mutants Block Dictyostelium Development . Molecular Biology of the Cell 16:2, pages 562-572.
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Fred Naider & Jeffrey M. Becker. (2004) The α-factor mating pheromone of Saccharomyces cerevisiae: a model for studying the interaction of peptide hormones and G protein-coupled receptors. Peptides 25:9, pages 1441-1463.
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Marinella Govoni, Remko A. Bakker, Ineke van de Wetering, Martine J. Smit, Wiro M. B. P. Menge, Henk Timmerman, Sigurd Elz, Walter Schunack & Rob Leurs. (2003) Synthesis and Pharmacological Identification of Neutral Histamine H 1 -Receptor Antagonists . Journal of Medicinal Chemistry 46:26, pages 5812-5824.
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Ayça Akal-Strader, Sanjay Khare, Dong Xu, Fred Naider & Jeffrey M. Becker. (2002) Residues in the First Extracellular Loop of a G Protein-coupled Receptor Play a Role in Signal Transduction. Journal of Biological Chemistry 277:34, pages 30581-30590.
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William Parrish, Markus Eilers, Weiwen Ying & James B Konopka. (2002) The Cytoplasmic End of Transmembrane Domain 3 Regulates the Activity of the Saccharomyces cerevisiae G-Protein-Coupled α-Factor Receptor . Genetics 160:2, pages 429-443.
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Wei-Qun Ding, Susan Kuntz, Michael Böhmig, Bertram Wiedenmann & Laurence J. Miller. (2002) Dominant negative action of an abnormal secretin receptor arising from mRNA missplicing in a gastrinoma. Gastroenterology 122:2, pages 500-511.
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Pamela E. Mentesana, Mercedes Dosil & James B. Konopka. 2002. G Protein Pathways, Part B: G Proteins and their Regulators. G Protein Pathways, Part B: G Proteins and their Regulators 92 111 .
Byung-Kwon Lee, Sanjay Khare, Fred Naider & Jeffrey M. Becker. (2001) Identification of Residues of the Saccharomyces cerevisiae G Protein-coupled Receptor Contributing to α-Factor Pheromone Binding. Journal of Biological Chemistry 276:41, pages 37950-37961.
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Donald Kirsch, William Baumbach, Julia Heinrich, Margaret Lai, Mark Pausch, Laura Sarokin, Sanford Silverman & James Walsh. 2001. Handbook of Drug Screening. Handbook of Drug Screening.
Isolde Erlenbach, Evi Kostenis, Clarice Schmidt, Fadi F. Hamdan, Mark H. Pausch & Jürgen Wess. (2001) Functional expression of M1, M3 and M5 muscarinic acetylcholine receptors in yeast. Journal of Neurochemistry 77:5, pages 1327-1337.
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Kouji Hirota, Kayoko Tanaka, Yoshinori Watanabe & Masayuki Yamamoto. (2001) Functional analysis of the C-terminal cytoplasmic region of the M-factor receptor in fission yeast. Genes to Cells 6:3, pages 201-214.
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Peter Dube, Anthony DeCostanzo & James B. Konopka. (2000) Interaction between Transmembrane Domains Five and Six of the α-Factor Receptor. Journal of Biological Chemistry 275:34, pages 26492-26499.
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Amy F. Roth & Nicholas G. Davis. (2000) Ubiquitination of the PEST-like Endocytosis Signal of the Yeast a-Factor Receptor. Journal of Biological Chemistry 275:11, pages 8143-8153.
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