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Molecular and Cellular Biology Volume 18, 1998 - Issue 12
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Cell Growth and Development

Requirement of PKR Dimerization Mediated by Specific Hydrophobic Residues for Its Activation by Double-Stranded RNA and Its Antigrowth Effects in Yeast

Rekha C. PatelDepartment of Molecular Biology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio44195
&
Ganes C. SenDepartment of Molecular Biology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio44195Correspondence[email protected]
Pages 7009-7019 | Received 08 May 1998, Accepted 02 Sep 1998, Published online: 28 Mar 2023

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Yongzhan Nie, Li Ding, Peter N. Kao, Robert Braun & Jing-Hua Yang. (2005) ADAR1 Interacts with NF90 through Double-Stranded RNA and Regulates NF90-Mediated Gene Expression Independently of RNA Editing. Molecular and Cellular Biology 25:16, pages 6956-6963.
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Gregory A. Peters, Rune Hartmann, Jun Qin & Ganes C. Sen. (2001) Modular Structure of PACT: Distinct Domains for Binding and Activating PKR. Molecular and Cellular Biology 21:6, pages 1908-1920.
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Bruno Lamontagne, Annie Tremblay & Sherif Abou Elela. (2000) The N-Terminal Domain That Distinguishes Yeast from Bacterial RNase III Contains a Dimerization Signal Required for Efficient Double-Stranded RNA Cleavage. Molecular and Cellular Biology 20:4, pages 1104-1115.
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Articles from other publishers (39)

Evelyn Chukwurah, Victoria Willingham, Madhurima Singh, David Castillo‐Azofeifa & Rekha C. Patel. (2018) Contribution of the two dsRBM motifs to the double‐stranded RNA binding and protein interactions of PACT. Journal of Cellular Biochemistry 119:4, pages 3598-3607.
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Evelyn Chukwurah & Rekha C. Patel. (2018) Stress-induced TRBP phosphorylation enhances its interaction with PKR to regulate cellular survival. Scientific Reports 8:1.
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Stephanie Dabo, Patrick Maillard, Milagros Collados Rodriguez, Marianne Doré Hansen, Sabrina Mazouz, Donna-Joe Bigot, Marion Tible, Geneviève Janvier, Olivier Helynck, Patricia Cassonnet, Yves Jacob, Jacques Bellalou, Anne Gatignol, Rekha C. Patel, Jacques Hugon, Hélène Munier-Lehmann & Eliane F. Meurs. (2017) Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT. Scientific Reports 7:1.
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Tobias Schmidt, Paul Knick, Hauke Lilie, Susann Friedrich, Ralph Peter Golbik & Sven-Erik Behrens. (2016) Coordinated Action of Two Double-Stranded RNA Binding Motifs and an RGG Motif Enables Nuclear Factor 90 To Flexibly Target Different RNA Substrates. Biochemistry 55:6, pages 948-959.
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Peifen Zhang, Yuye Li, Jun Xia, Junfang He, Jieying Pu, Jiong Xie, Siyu Wu, Lianqiang Feng, Xi Huang & Ping Zhang. (2014) IPS-1 plays an essential role in stress granule formation induced by dsRNA through interacting with PKR and mediating its activation. Journal of Cell Science.
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Mimi A. Trinh & Eric Klann. (2013) Translational control by eIF2α kinases in long-lasting synaptic plasticity and long-term memory. Neurobiology of Learning and Memory 105, pages 93-99.
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Tomohiro Yamauchi, Naoto Nakamura, Masashi Hiramoto, Masatoshi Yuri, Hiroyuki Yokota, Masanori Naitou, Masahiro Takeuchi, Kentaro Yamanaka, Aya Kita, Takahito Nakahara, Isao Kinoyama, Akira Matsuhisa, Naoki Kaneko, Hiroshi Koutoku, Masao Sasamata, Masato Kobori, Masao Katou, Shuichi Tawara, Shigeki Kawabata & Kiyoshi Furuichi. (2012) Sepantronium Bromide (YM155) induces disruption of the ILF3/p54nrb complex, which is required for survivin expression. Biochemical and Biophysical Research Communications 425:4, pages 711-716.
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Madhurima Singh & Rekha C. Patel. (2012) Increased interaction between PACT molecules in response to stress signals is required for PKR activation. Journal of Cellular Biochemistry 113:8, pages 2754-2764.
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Eric Anderson, Willythssa S. Pierre-Louis, C. Jason Wong, Jeffrey W. Lary & James L. Cole. (2011) Heparin Activates PKR by Inducing Dimerization. Journal of Molecular Biology 413:5, pages 973-984.
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James K. Jancovich & Bertram L. Jacobs. (2011) Innate Immune Evasion Mediated by the Ambystoma tigrinum Virus Eukaryotic Translation Initiation Factor 2α Homologue. Journal of Virology 85:10, pages 5061-5069.
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Madhurima Singh, Vennece Fowlkes, Indhira Handy, Chandrashekhar V. Patel & Rekha C. Patel. (2009) Essential Role of PACT-Mediated PKR Activation in Tunicamycin-Induced Apoptosis. Journal of Molecular Biology 385:2, pages 457-468.
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Yuan-Yuan Chen, Gang Chen, Zhiqin Fan, Jia Luo & Zun-Ji Ke. (2008) GSK3β and endoplasmic reticulum stress mediate rotenone-induced death of SK-N-MC neuroblastoma cells. Biochemical Pharmacology 76:1, pages 128-138.
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Stephen Fasciano, Amanda Kaufman & Rekha C. Patel. (2007) Expression of PACT is regulated by Sp1 transcription factor. Gene 388:1-2, pages 74-82.
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Vladimir Gelev, Huseyin Aktas, Assen Marintchev, Takuhiro Ito, Dominique Frueh, Michael Hemond, David Rovnyak, Mirijam Debus, Sven Hyberts, Anny Usheva, Jose Halperin & Gerhard Wagner. (2006) Mapping of the Auto-inhibitory Interactions of Protein Kinase R by Nuclear Magnetic Resonance. Journal of Molecular Biology 364:3, pages 352-363.
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Urs von Holzen, Dora Bocangel, Abujiang Pataer, Stephan A. Vorburger, Yanna Liu, Xialolin Lu, Kelly K. Hunt & Stephen G. Swisher. (2005) Role for the double-stranded RNA-activated protein kinase PKR in Ad-TNF-α gene therapy in esophageal cancer. Surgery 138:2, pages 261-268.
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Kung-Yao Chang & Andres Ramos. (2005) The double-stranded RNA-binding motif, a versatile macromolecular docking platform. FEBS Journal 272:9, pages 2109-2117.
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Stephen Fasciano, Brian Hutchins, Indhira Handy & Rekha C. Patel. (2005) Identification of the heparin-binding domains of the interferon-induced protein kinase, PKR. FEBS Journal 272:6, pages 1425-1439.
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Rajnish S. Dave & Roger J. Pomerantz. (2003) RNA interference: on the road to an alternate therapeutic strategy!. Reviews in Medical Virology 13:6, pages 373-385.
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Vishal Gupta, Xu Huang & Rekha C Patel. (2003) The carboxy-terminal, M3 motifs of PACT and TRBP have opposite effects on PKR activity. Virology 315:2, pages 283-291.
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Stephan A Vorburger, Abujiang Pataer, Kazumi Yoshida, Glen N Barber, Weiya Xia, Paul Chiao, Lee M Ellis, Mien-Chie Hung, Stephen G Swisher & Kelly K Hunt. (2002) Role for the double-stranded RNA activated protein kinase PKR in E2F-1-induced apoptosis. Oncogene 21:41, pages 6278-6288.
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Vishal Gupta & Rekha C. Patel. (2002) Proapoptotic protein PACT is expressed at high levels in colonic epithelial cells in mice. American Journal of Physiology-Gastrointestinal and Liver Physiology 283:3, pages G801-G808.
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Tiffany R. Meusel, Kelly E. Kehoe & Farhad Imani. (2002) Protein Kinase R Regulates Double-Stranded RNA Induction of TNF-α But Not IL-1β mRNA in Human Epithelial Cells. The Journal of Immunology 168:12, pages 6429-6435.
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C Vincent Herst, Karen De Smet, Simon Roelens, Marc Frémont, Anne D’Haese & Patrick Englebienne. 2002. Chronic Fatigue Syndrome. Chronic Fatigue Syndrome 131 174 .
Randal Kaufman. 2001. dsRNA Genetic Elements. dsRNA Genetic Elements 37 65 .
Kelly E. Kehoe, Melissa A. Brown & Farhad Imani. (2001) Double-Stranded RNA Regulates IL-4 Expression. The Journal of Immunology 167:5, pages 2496-2501.
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Aı̈cha Daher, Michèle Longuet, Dominique Dorin, Florence Bois, Emmanuel Segeral, Sylvie Bannwarth, Pier-Luigi Battisti, Damian F. Purcell, Richard Benarous, Catherine Vaquero, Eliane F. Meurs & Anne Gatignol. (2001) Two Dimerization Domains in the Trans-activation Response RNA-binding Protein (TRBP) Individually Reverse the Protein Kinase R Inhibition of HIV-1 Long Terminal Repeat Expression. Journal of Biological Chemistry 276:36, pages 33899-33905.
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Theresa M Rowe & Ganes C Sen. (2001) Organizations and promoter analyses of the human and the mouse genes for PACT, the protein-activator of the interferon-induced protein kinase, PKR. Gene 273:2, pages 215-225.
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Krishna M. Vattem, Kirk A. Staschke & Ronald C. Wek. (2001) Mechanism of activation of the double-stranded-RNA-dependent protein kinase, PKR. European Journal of Biochemistry 268:13, pages 3674-3684.
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Bin Tian & Michael B. Mathews. (2001) Functional Characterization of and Cooperation between the Double-stranded RNA-binding Motifs of the Protein Kinase PKR. Journal of Biological Chemistry 276:13, pages 9936-9944.
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Krishna M. Vattem, Kirk A. Staschke, Shuhao Zhu & Ronald C. Wek. (2001) Inhibitory sequences in the N-terminus of the double-stranded-RNA-dependent protein kinase, PKR, are important for regulating phosphorylation of eukaryotic initiation factor 2α (eIF2α). European Journal of Biochemistry 268:4, pages 1143-1153.
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Fan Zhang, Patrick R. Romano, Tokiko Nagamura-Inoue, Bin Tian, Thomas E. Dever, Michael B. Mathews, Keiko Ozato & Alan G. Hinnebusch. (2001) Binding of Double-stranded RNA to Protein Kinase PKR Is Required for Dimerization and Promotes Critical Autophosphorylation Events in the Activation Loop. Journal of Biological Chemistry 276:27, pages 24946-24958.
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Michael J. Clemens. 2001. Signaling Pathways for Translation. Signaling Pathways for Translation 57 89 .
Chandrashekhar V. Patel, Indhira Handy, Tiffany Goldsmith & Rekha C. Patel. (2000) PACT, a Stress-modulated Cellular Activator of Interferon-induced Double-stranded RNA-activated Protein Kinase, PKR. Journal of Biological Chemistry 275:48, pages 37993-37998.
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Sergei Nekhai, Donald P Bottaro, Girma Woldehawariat, Amy Spellerberg & Raymond Petryshyn. (2000) A cell-permeable peptide inhibits activation of PKR and enhances cell proliferation. Peptides 21:10, pages 1449-1456.
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Ivo Fierro-Monti & Michael B. Mathews. (2000) Proteins binding to duplexed RNA: one motif, multiple functions. Trends in Biochemical Sciences 25:5, pages 241-246.
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Ganes C. Sen. (2000) Novel functions of interferon-induced proteins. Seminars in Cancer Biology 10:2, pages 93-101.
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Maryam Rafie-Kolpin, Peter J. Chefalo, Zareena Hussain, Joyce Hahn, Sheri Uma, Robert L. Matts & Jane-Jane Chen. (2000) Two Heme-binding Domains of Heme-regulated Eukaryotic Initiation Factor-2α Kinase. Journal of Biological Chemistry 275:7, pages 5171-5178.
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Thomas E Dever. (1999) Translation initiation: adept at adapting. Trends in Biochemical Sciences 24:10, pages 398-403.
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Rekha C. Patel, Deborah J. Vestal, Zan Xu, Smarajit Bandyopadhyay, Weidong Guo, Scott M. Erme, Bryan R.G. Williams & Ganes C. Sen. (1999) DRBP76, a Double-stranded RNA-binding Nuclear Protein, Is Phosphorylated by the Interferon-induced Protein Kinase, PKR. Journal of Biological Chemistry 274:29, pages 20432-20437.
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