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Molecular and Cellular Biology Volume 18, 1998 - Issue 12
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Gene Expression

Inhibition of Double-Stranded RNA-Dependent Protein Kinase PKR by Vaccinia Virus E3: Role of Complex Formation and the E3 N-Terminal Domain

Patrick R. Romanoa Laboratory of Eukaryotic Gene Regulation, National Institute of Child Health and Human Development, Bethesda, Maryland20892
,
Fan Zhanga Laboratory of Eukaryotic Gene Regulation, National Institute of Child Health and Human Development, Bethesda, Maryland20892
,
Seng-Lai Tanb Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington98195
,
Minerva T. Garcia-Barrioa Laboratory of Eukaryotic Gene Regulation, National Institute of Child Health and Human Development, Bethesda, Maryland20892
,
Michael G. Katzeb Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington98195
,
Thomas E. Devera Laboratory of Eukaryotic Gene Regulation, National Institute of Child Health and Human Development, Bethesda, Maryland20892
&
Alan G. Hinnebuscha Laboratory of Eukaryotic Gene Regulation, National Institute of Child Health and Human Development, Bethesda, Maryland20892Correspondence[email protected]
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Pages 7304-7316 | Received 03 Jun 1998, Accepted 18 Aug 1998, Published online: 28 Mar 2023

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Tomohiro Yamauchi, Naoto Nakamura, Masashi Hiramoto, Masatoshi Yuri, Hiroyuki Yokota, Masanori Naitou, Masahiro Takeuchi, Kentaro Yamanaka, Aya Kita, Takahito Nakahara, Isao Kinoyama, Akira Matsuhisa, Naoki Kaneko, Hiroshi Koutoku, Masao Sasamata, Masato Kobori, Masao Katou, Shuichi Tawara, Shigeki Kawabata & Kiyoshi Furuichi. (2012) Sepantronium Bromide (YM155) induces disruption of the ILF3/p54nrb complex, which is required for survivin expression. Biochemical and Biophysical Research Communications 425:4, pages 711-716.
Crossref
Stacy D. White & Bertram L. Jacobs. (2012) The Amino Terminus of the Vaccinia Virus E3 Protein Is Necessary To Inhibit the Interferon Response. Journal of Virology 86:10, pages 5895-5904.
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Stephanie J. Child, Greg Brennan, Jacquelyn E. Braggin & Adam P. Geballe. (2012) Species Specificity of Protein Kinase R Antagonism by Cytomegalovirus TRS1 Genes. Journal of Virology 86:7, pages 3880-3889.
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Daisy W. Leung, Christopher F. Basler & Gaya K. Amarasinghe. (2012) Molecular mechanisms of viral inhibitors of RIG-I-like receptors. Trends in Microbiology 20:3, pages 139-146.
Crossref
Sergei N. Shchelkunov. (2012) Orthopoxvirus Genes That Mediate Disease Virulence and Host Tropism. Advances in Virology 2012, pages 1-17.
Crossref
Andrew J. Mouland & Miroslav P. Milev. 2012. Dyneins. Dyneins 560 583 .
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Jana Liskova, Jarmila Knitlova, Richard Honner & Zora Melkova. (2011) Apoptosis and necrosis in vaccinia virus-infected HeLa G and BSC-40 cells. Virus Research 160:1-2, pages 40-50.
Crossref
Jazmina L. G. Cruz, Isabel Sola, Martina Becares, Berta Alberca, Joan Plana, Luis Enjuanes & Sonia Zuñiga. (2011) Coronavirus Gene 7 Counteracts Host Defenses and Modulates Virus Virulence. PLoS Pathogens 7:6, pages e1002090.
Crossref
James K. Jancovich & Bertram L. Jacobs. (2011) Innate Immune Evasion Mediated by the Ambystoma tigrinum Virus Eukaryotic Translation Initiation Factor 2α Homologue. Journal of Virology 85:10, pages 5061-5069.
Crossref
Elena Domingo-Gil, René Toribio, José Luis Nájera, Mariano Esteban & Iván Ventoso. (2011) Diversity in Viral Anti-PKR Mechanisms: A Remarkable Case of Evolutionary Convergence. PLoS ONE 6:2, pages e16711.
Crossref
S. N. Shchelkunov. (2011) Evasion of mammalian defense systems by orthopoxviruses. Molecular Biology 45:1, pages 24-35.
Crossref
Margarito Rojas, Carlos F. Arias & Susana López. (2010) Protein Kinase R Is Responsible for the Phosphorylation of eIF2α in Rotavirus Infection. Journal of Virology 84:20, pages 10457-10466.
Crossref
Iván Ventoso, Juan J. Berlanga & José M. Almendral. (2010) Translation Control by Protein Kinase R Restricts Minute Virus of Mice Infection: Role in Parvovirus Oncolysis. Journal of Virology 84:10, pages 5043-5051.
Crossref
L. Galluzzi, O. Kepp, E. Morselli, I. Vitale, L. Senovilla, M. Pinti, L. Zitvogel & G. Kroemer. (2010) Viral strategies for the evasion of immunogenic cell death. Journal of Internal Medicine 267:5, pages 526-542.
Crossref
Richard C. Condit & Richard W. Moyer. 2010. Topley & Wilson's Microbiology and Microbial Infections. Topley & Wilson's Microbiology and Microbial Infections.
Nels C. Elde & Harmit S. Malik. (2009) The evolutionary conundrum of pathogen mimicry. Nature Reviews Microbiology 7:11, pages 787-797.
Crossref
Kristen L. Willis, Samir Patel, Yan Xiang & Joanna L. Shisler. (2009) The effect of the vaccinia K1 protein on the PKR-eIF2α pathway in RK13 and HeLa cells. Virology 394:1, pages 73-81.
Crossref
Ying Wang & Charles E. Samuel. (2009) Adenosine Deaminase ADAR1 Increases Gene Expression at the Translational Level by Decreasing Protein Kinase PKR-Dependent eIF-2α Phosphorylation. Journal of Molecular Biology 393:4, pages 777-787.
Crossref
Bianca Dauber & Thorsten Wolff. (2009) Activation of the Antiviral Kinase PKR and Viral Countermeasures. Viruses 1:3, pages 523-544.
Crossref
Beatriz PerdigueroMariano Esteban. (2009) The Interferon System and Vaccinia Virus Evasion Mechanisms. Journal of Interferon & Cytokine Research 29:9, pages 581-598.
Crossref
Cyril X. GeorgeZhiqun LiKristina M. OkonskiAnn M. TothYing WangCharles E. Samuel. (2009) Tipping the Balance: Antagonism of PKR Kinase and ADAR1 Deaminase Functions by Virus Gene Products. Journal of Interferon & Cytokine Research 29:9, pages 477-487.
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Jean-Baptiste Marq, Stéphane Hausmann, Jeremy Luban, Daniel Kolakofsky & Dominique Garcin. (2009) The Double-stranded RNA Binding Domain of the Vaccinia Virus E3L Protein Inhibits Both RNA- and DNA-induced Activation of Interferon β. Journal of Biological Chemistry 284:38, pages 25471-25478.
Crossref
Priya Ranjan, J. Bradford Bowzard, Joy W. Schwerzmann, Victoria Jeisy-Scott, Takashi Fujita & Suryaprakash Sambhara. (2009) Cytoplasmic nucleic acid sensors in antiviral immunity. Trends in Molecular Medicine 15:8, pages 359-368.
Crossref
Chad Myskiw, Janilyn Arsenio, Rebekah van Bruggen, Yvon Deschambault & Jingxin Cao. (2009) Vaccinia Virus E3 Suppresses Expression of Diverse Cytokines through Inhibition of the PKR, NF-κB, and IRF3 Pathways. Journal of Virology 83:13, pages 6757-6768.
Crossref
J. A.L. Short. (2009) Viral evasion of interferon stimulated genes. Bioscience Horizons 2:2, pages 212-224.
Crossref
Stephanie J. Child & Adam P. Geballe. (2009) Binding and Relocalization of Protein Kinase R by Murine Cytomegalovirus. Journal of Virology 83:4, pages 1790-1799.
Crossref
Stefan Rothenburg, Eun Joo Seo, James S Gibbs, Thomas E Dever & Katharina Dittmar. (2008) Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors. Nature Structural & Molecular Biology 16:1, pages 63-70.
Crossref
Orla Mulhern, Barry Harrington & Andrew G. Bowie. 2009. Pathogen-Derived Immunomodulatory Molecules. Pathogen-Derived Immunomodulatory Molecules 49 63 .
Stefan Rothenburg, Nikolaus Deigendesch, Madhusudan Dey, Thomas E Dever & Loubna Tazi. (2008) Double-stranded RNA-activated protein kinase PKR of fishes and amphibians: Varying the number of double-stranded RNA binding domains and lineage-specific duplications. BMC Biology 6:1.
Crossref
Andrew G. Bowie & Leonie Unterholzner. (2008) Viral evasion and subversion of pattern-recognition receptor signalling. Nature Reviews Immunology 8:12, pages 911-922.
Crossref
Liang Deng, Peihong Dai, Tanvi Parikh, Hua Cao, Vijay Bhoj, Qinmiao Sun, Zhijian Chen, Taha Merghoub, Alan Houghton & Stewart Shuman. (2008) Vaccinia Virus Subverts a Mitochondrial Antiviral Signaling Protein-Dependent Innate Immune Response in Keratinocytes through Its Double-Stranded RNA Binding Protein, E3. Journal of Virology 82:21, pages 10735-10746.
Crossref
Susana Guerra, Ana Cáceres, Klaus-Peter Knobeloch, Ivan Horak & Mariano Esteban. (2008) Vaccinia Virus E3 Protein Prevents the Antiviral Action of ISG15. PLoS Pathogens 4:7, pages e1000096.
Crossref
Tara HurstAndrew G Bowie. (2008) Innate immune signaling pathways: lessons from vaccinia virus. Future Virology 3:2, pages 147-156.
Crossref
Ping Zhang, Bertram L. Jacobs & Charles E. Samuel. (2008) Loss of Protein Kinase PKR Expression in Human HeLa Cells Complements the Vaccinia Virus E3L Deletion Mutant Phenotype by Restoration of Viral Protein Synthesis. Journal of Virology 82:2, pages 840-848.
Crossref
Elena Domingo-Gil, Eva Pérez-Jiménez, Iván Ventoso, José L. Nájera & Mariano Esteban. (2008) Expression of the E3L Gene of Vaccinia Virus in Transgenic Mice Decreases Host Resistance to Vaccinia Virus and Leishmania major Infections . Journal of Virology 82:1, pages 254-267.
Crossref
Susana Guerra, José Luis Nájera, José Manuel González, Luis A. López-Fernández, Nuria Climent, José M. Gatell, Teresa Gallart & Mariano Esteban. (2007) Distinct Gene Expression Profiling after Infection of Immature Human Monocyte-Derived Dendritic Cells by the Attenuated Poxvirus Vectors MVA and NYVAC. Journal of Virology 81:16, pages 8707-8721.
Crossref
Beau J. Fenner, Winnie Goh & Jimmy Kwang. (2007) Dissection of Double-Stranded RNA Binding Protein B2 from Betanodavirus. Journal of Virology 81:11, pages 5449-5459.
Crossref
M.A. García, E.F. Meurs & M. Esteban. (2007) The dsRNA protein kinase PKR: Virus and cell control. Biochimie 89:6-7, pages 799-811.
Crossref
Derek Ostertag, Traci M. Hoblitzell-Ostertag & Jacques Perrault. (2007) Overproduction of Double-Stranded RNA in Vesicular Stomatitis Virus-Infected Cells Activates a Constitutive Cell-Type-Specific Antiviral Response. Journal of Virology 81:2, pages 503-513.
Crossref
M. A. García, J. Gil, I. Ventoso, S. Guerra, E. Domingo, C. Rivas & M. Esteban. (2006) Impact of Protein Kinase PKR in Cell Biology: from Antiviral to Antiproliferative Action. Microbiology and Molecular Biology Reviews 70:4, pages 1032-1060.
Crossref
Morgan Hakki, Emily E. Marshall, Katherine L. De Niro & Adam P. Geballe. (2006) Binding and Nuclear Relocalization of Protein Kinase R by Human Cytomegalovirus TRS1. Journal of Virology 80:23, pages 11817-11826.
Crossref
Stephanie J. Child, Laura K. Hanson, Crystal E. Brown, Deanna M. Janzen & Adam P. Geballe. (2006) Double-Stranded RNA Binding by a Heterodimeric Complex of Murine Cytomegalovirus m142 and m143 Proteins. Journal of Virology 80:20, pages 10173-10180.
Crossref
Jeffrey O. Langland, John C. Kash, Victoria Carter, Matthew J. Thomas, Michael G. Katze & Bertram L. Jacobs. (2006) Suppression of Proinflammatory Signal Transduction and Gene Expression by the DualNucleic Acid Binding Domains of the Vaccinia Virus E3L Proteins. Journal of Virology 80:20, pages 10083-10095.
Crossref
Liang Deng, Peihong Dai, Wanhong Ding, Richard D. Granstein & Stewart Shuman. (2006) Vaccinia Virus Infection Attenuates Innate Immune Responses and Antigen Presentation by Epidermal Dendritic Cells. Journal of Virology 80:20, pages 9977-9987.
Crossref
Matthew Mulvey, Carolina Arias & Ian Mohr. (2006) Resistance of mRNA Translation to Acute Endoplasmic Reticulum Stress-Inducing Agents in Herpes Simplex Virus Type 1-Infected Cells Requires Multiple Virus-Encoded Functions. Journal of Virology 80:15, pages 7354-7363.
Crossref
Susana Guerra, Luis A. López-Fernández, María Angel García, Angel Zaballos & Mariano Esteban. (2006) Human Gene Profiling in Response to the Active Protein Kinase, Interferon-induced Serine/threonine Protein Kinase (PKR), in Infected Cells. Journal of Biological Chemistry 281:27, pages 18734-18745.
Crossref
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Ian Mohr. (2006) Phosphorylation and dephosphorylation events that regulate viral mRNA translation. Virus Research 119:1, pages 89-99.
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Morgan Hakki & Adam P. Geballe. (2005) Double-Stranded RNA Binding by Human Cytomegalovirus pTRS1. Journal of Virology 79:12, pages 7311-7318.
Crossref
Kung-Yao Chang & Andres Ramos. (2005) The double-stranded RNA-binding motif, a versatile macromolecular docking platform. FEBS Journal 272:9, pages 2109-2117.
Crossref
Jinhua XiangChristina Martinez-SmithMichael GaleJr.Jr., Qing ChangDouglas R. LabrecqueWarren N. SchmidtJack T. Stapleton. (2005) GB Virus Type C NS5A Sequence Polymorphisms: Association with Interferon Susceptibility and Inhibition of PKR-Mediated eIF2α Phosphorylation. Journal of Interferon & Cytokine Research 25:5, pages 261-270.
Crossref
Stephen Fasciano, Brian Hutchins, Indhira Handy & Rekha C. Patel. (2005) Identification of the heparin-binding domains of the interferon-induced protein kinase, PKR. FEBS Journal 272:6, pages 1425-1439.
Crossref
Jeffrey O Langland & Bertram L Jacobs. (2004) Inhibition of PKR by vaccinia virus: role of the N- and C-terminal domains of E3L. Virology 324:2, pages 419-429.
Crossref
Sangeetha Vijaysri, Latha Talasela, Andrew A Mercer, Colin J Mcinnes, Bertram L Jacobs & Jeffrey O Langland. (2003) The Orf virus E3L homologue is able to complement deletion of the vaccinia virus E3L gene in vitro but not in vivo. Virology 314:1, pages 305-314.
Crossref
Simone Hornemann, Olof Harlin, Caroline Staib, Sigrid Kisling, Volker Erfle, Bernd Kaspers, Georg Häcker & Gerd Sutter. (2003) Replication of Modified Vaccinia Virus Ankara in Primary Chicken Embryo Fibroblasts Requires Expression of the Interferon Resistance Gene E3L. Journal of Virology 77:15, pages 8394-8407.
Crossref
Yang-Gyun Kim, Maneesha Muralinath, Teresa Brandt, Matthew Pearcy, Kevin Hauns, Ky Lowenhaupt, Bertram L. Jacobs & Alexander Rich. (2003) A role for Z-DNA binding in vaccinia virus pathogenesis. Proceedings of the National Academy of Sciences 100:12, pages 6974-6979.
Crossref
Claudia González-López, José Martínez-Costas, Mariano Esteban & Javier Benavente. (2003) Evidence that avian reovirus σA protein is an inhibitor of the double-stranded RNA-dependent protein kinase. Journal of General Virology 84:6, pages 1629-1639.
Crossref
Robert J Schneider & Ian Mohr. (2003) Translation initiation and viral tricks. Trends in Biochemical Sciences 28:3, pages 130-136.
Crossref
Maria Angel García, Susana Guerra, Jesús Gil, Victoria Jimenez & Mariano Esteban. (2002) Anti-apoptotic and oncogenic properties of the dsRNA-binding protein of vaccinia virus, E3L. Oncogene 21:55, pages 8379-8387.
Crossref
David Khoo, Cesar Perez & Ian Mohr. (2002) Characterization of RNA Determinants Recognized by the Arginine- and Proline-Rich Region of Us11, a Herpes Simplex Virus Type 1-Encoded Double-Stranded RNA Binding Protein That Prevents PKR Activation. Journal of Virology 76:23, pages 11971-11981.
Crossref
Jeffrey O. Langland & Bertram L. Jacobs. (2002) The Role of the PKR-Inhibitory Genes, E3L and K3L, in Determining Vaccinia Virus Host Range. Virology 299:1, pages 133-141.
Crossref
Ying Xiang, Richard C. Condit, Sangeetha Vijaysri, Bertram Jacobs, Bryan R. G. Williams & Robert H. Silverman. (2002) Blockade of Interferon Induction and Action by the E3L Double-Stranded RNA Binding Proteins of Vaccinia Virus. Journal of Virology 76:10, pages 5251-5259.
Crossref
Adolfo García-Sastre. (2002) Mechanisms of inhibition of the host interferon α/β-mediated antiviral responses by viruses. Microbes and Infection 4:6, pages 647-655.
Crossref
Yupeng He & Michael G. Katze. (2002) To Interfere and to Anti-interfere: The Interplay Between Hepatitis C Virus and Interferon. Viral Immunology 15:1, pages 95-119.
Crossref
Vincent P. Smith & Antonio Alcami. (2002) Inhibition of Interferons by Ectromelia Virus. Journal of Virology 76:3, pages 1124-1134.
Crossref
Yitzhak Ben-Asouli, Yona Banai, Yehuda Pel-Or, Alexei Shir & Raymond Kaempfer. (2002) Human Interferon-γ mRNA Autoregulates Its Translation through a Pseudoknot that Activates the Interferon-Inducible Protein Kinase PKR. Cell 108:2, pages 221-232.
Crossref
C. Jungwirth. 2002. 295 326 .
Raymond A. Petryshyn, Sergie Nekhai & Evelio D. Perez-Albuerne. 2002. RNA Binding Proteins. RNA Binding Proteins 175 191 .
Jesús Gil, Joaquín Rullas, José Alcamí & Mariano Esteban. (2001) MC159L protein from the poxvirus molluscum contagiosum virus inhibits NF-κB activation and apoptosis induced by PKR. Journal of General Virology 82:12, pages 3027-3034.
Crossref
Yong Liu, Karen C. Wolff, Bertram L. Jacobs & Charles E. Samuel. (2001) Vaccinia Virus E3L Interferon Resistance Protein Inhibits the Interferon-Induced Adenosine Deaminase A-to-I Editing Activity. Virology 289:2, pages 378-387.
Crossref
Randal Kaufman. 2001. dsRNA Genetic Elements. dsRNA Genetic Elements 37 65 .
Lisa M. Parker, Ivo Fierro-Monti & Michael B. Mathews. (2001) Nuclear Factor 90 Is a Substrate and Regulator of the Eukaryotic Initiation Factor 2 Kinase Double-stranded RNA-activated Protein Kinase. Journal of Biological Chemistry 276:35, pages 32522-32530.
Crossref
Fulvio D'AcquistoSankar Ghosh. (2001) PACT and PKR: Turning on NF-κB in the Absence of Virus. Science's STKE 2001:89.
Crossref
Yupeng He, Seng-Lai Tan, Semih U. Tareen, Sangeetha Vijaysri, Jeffrey O. Langland, Bertram L. Jacobs & Michael G. Katze. (2001) Regulation of mRNA Translation and Cellular Signaling by Hepatitis C Virus Nonstructural Protein NS5A. Journal of Virology 75:11, pages 5090-5098.
Crossref
Eric J. Smith, Isabelle Marié, Arun Prakash, Adolfo Garcı́a-Sastre & David E. Levy. (2001) IRF3 and IRF7 Phosphorylation in Virus-infected Cells Does Not Require Double-stranded RNA-dependent Protein Kinase R or IκB Kinase but Is Blocked by Vaccinia Virus E3L Protein. Journal of Biological Chemistry 276:12, pages 8951-8957.
Crossref
John W Barrett, Jing-Xin Cao, Sheela Hota-Mitchell & Grant McFadden. (2001) Immunomodulatory proteins of myxoma virus. Seminars in Immunology 13:1, pages 73-84.
Crossref
Teresa A. Brandt & Bertram L. Jacobs. (2001) Both Carboxy- and Amino-Terminal Domains of the Vaccinia Virus Interferon Resistance Gene, E3L, Are Required for Pathogenesis in a Mouse Model. Journal of Virology 75:2, pages 850-856.
Crossref
Fan Zhang, Patrick R. Romano, Tokiko Nagamura-Inoue, Bin Tian, Thomas E. Dever, Michael B. Mathews, Keiko Ozato & Alan G. Hinnebusch. (2001) Binding of Double-stranded RNA to Protein Kinase PKR Is Required for Dimerization and Promotes Critical Autophosphorylation Events in the Activation Loop. Journal of Biological Chemistry 276:27, pages 24946-24958.
Crossref
Jeremy Poppers, Matthew Mulvey, David Khoo & Ian Mohr. (2000) Inhibition of PKR Activation by the Proline-Rich RNA Binding Domain of the Herpes Simplex Virus Type 1 Us11 Protein. Journal of Virology 74:23, pages 11215-11221.
Crossref
Li-Yun Chang, Woo Young Yang & Don Roth. (2000) Functional Complementation by Wheat eIF2α in the Yeast GCN2-Mediated Pathway. Biochemical and Biophysical Research Communications 279:2, pages 468-474.
Crossref
Deborah R Taylor, Stephanie T Shi & Michael M.C Lai. (2000) Hepatitis C virus and interferon resistance. Microbes and Infection 2:14, pages 1743-1756.
Crossref
Christopher F. Basler, Xiuyan Wang, Elke Mühlberger, Victor Volchkov, Jason Paragas, Hans-Dieter Klenk, Adolfo García-Sastre & Peter Palese. (2000) The Ebola virus VP35 protein functions as a type I IFN antagonist. Proceedings of the National Academy of Sciences 97:22, pages 12289-12294.
Crossref
Makiko Kawagishi-Kobayashi, Chune Cao, Jianming Lu, Keiko Ozato & Thomas E. Dever. (2000) Pseudosubstrate Inhibition of Protein Kinase PKR by Swine Pox Virus C8L Gene Product. Virology 276:2, pages 424-434.
Crossref
Ivo Fierro-Monti & Michael B. Mathews. (2000) Proteins binding to duplexed RNA: one motif, multiple functions. Trends in Biochemical Sciences 25:5, pages 241-246.
Crossref
Domenico TortorellaBenjamin E. GewurzMargo H. FurmanDanny J. SchustHidde L. Ploegh. (2000) Viral Subversion of the Immune System. Annual Review of Immunology 18:1, pages 861-926.
Crossref
Suiyang Li, Kazushige Nagai & Antonis E. Koromilas. (2000) A diminished activation capacity of the interferon-inducible protein kinase PKR in human T lymphocytes. European Journal of Biochemistry 267:6, pages 1598-1606.
Crossref
Ruchira Sood, Amy C Porter, DeAnne Olsen, Douglas R Cavener & Ronald C Wek. (2000) A Mammalian Homologue of GCN2 Protein Kinase Important for Translational Control by Phosphorylation of Eukaryotic Initiation Factor-2α. Genetics 154:2, pages 787-801.
Crossref
T.V. Sharp, F. Moonan, A. Romashko, B. Joshi, G.N. Barber & R. Jagus. (1998) The Vaccinia Virus E3L Gene Product Interacts with both the Regulatory and the Substrate Binding Regions of PKR: Implications for PKR Autoregulation. Virology 250:2, pages 302-315.
Crossref

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