Advanced search
Publication Cover
Molecular and Cellular Biology Volume 18, 1998 - Issue 12
Submit an article Journal homepage
18
Views
67
CrossRef citations to date
0
Altmetric
DNA Dynamics and Chromosome Structure

Identification of a Class of Chromatin Boundary Elements

Olivier CuvierDepartments of Biochemistry and Molecular Biology, University of Geneva, CH-1211 Geneva 4, Switzerland
,
Craig M. HartDepartments of Biochemistry and Molecular Biology, University of Geneva, CH-1211 Geneva 4, Switzerland
&
Ulrich K. LaemmliDepartments of Biochemistry and Molecular Biology, University of Geneva, CH-1211 Geneva 4, SwitzerlandCorrespondence[email protected]
Pages 7478-7486 | Received 24 Jun 1998, Accepted 25 Aug 1998, Published online: 28 Mar 2023

Citations (67)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (7)

Nan Jiang, Eldon Emberly, Olivier Cuvier & Craig M. Hart. (2009) Genome-Wide Mapping of Boundary Element-Associated Factor (BEAF) Binding Sites in Drosophila melanogaster Links BEAF to Transcription. Molecular and Cellular Biology 29:13, pages 3556-3568.
Read now
Rashmi U. Pathak, Nandini Rangaraj, Satish Kallappagoudar, Krishnaveni Mishra & Rakesh K. Mishra. (2007) Boundary Element-Associated Factor 32B Connects Chromatin Domains to the Nuclear Matrix. Molecular and Cellular Biology 27:13, pages 4796-4806.
Read now
Hiroyuki Minami, Junko Takahashi, Asami Suto, Yasushi Saitoh & Ken-ichi Tsutsumi. (2006) Binding of AlF-C, an Orc1-Binding Transcriptional Regulator, Enhances Replicator Activity of the Rat Aldolase B Origin. Molecular and Cellular Biology 26:23, pages 8770-8780.
Read now
Timothy J. Parnell, Emily J. Kuhn, Brian L. Gilmore, Cecilia Helou, Marc S. Wold & Pamela K. Geyer. (2006) Identification of Genomic Sites That Bind the Drosophila Suppressor of Hairy-wing Insulator Protein. Molecular and Cellular Biology 26:16, pages 5983-5993.
Read now
Brian T. Sage, John L. Jones, Amy L. Holmes, Michael D. Wu & Amy K. Csink. (2005) Sequence Elements in cis Influence Heterochromatic Silencing in trans. Molecular and Cellular Biology 25:1, pages 377-388.
Read now
Emily J. Kuhn, Craig M. Hart & Pamela K. Geyer. (2004) Studies of the Role of the Drosophila scs and scs′ Insulators in Defining Boundaries of a Chromosome Puff. Molecular and Cellular Biology 24:4, pages 1470-1480.
Read now
Nathalie Aulner, Caroline Monod, Guillaume Mandicourt, Denis Jullien, Olivier Cuvier, Alhousseynou Sall, Sam Janssen, Ulrich K. Laemmli & Emmanuel Käs. (2002) The AT-Hook Protein D1 Is Essential for Drosophila melanogaster Development and Is Implicated in Position-Effect Variegation. Molecular and Cellular Biology 22:4, pages 1218-1232.
Read now

Articles from other publishers (60)

Neta Herman, Sebastian Kadener & Sagiv Shifman. (2022) The chromatin factor ROW cooperates with BEAF ‐32 in regulating long‐range inducible genes . EMBO reports 23:12.
Crossref
J Keller McKowen, Satya V S P Avva, Mukesh Maharjan, Fabiana M Duarte, Jacob M Tome, Julius Judd, Jamie L Wood, Sunday Negedu, Yunkai Dong, John T Lis & Craig M Hart. (2022) The Drosophila BEAF insulator protein interacts with the polybromo subunit of the PBAP chromatin remodeling complex . G3 Genes|Genomes|Genetics 12:11.
Crossref
Shuai Zhang, Ruixue Wang, Cheng Huang, Ludan Zhang & Lin Sun. (2021) Modulation of Global Gene Expression by Aneuploidy and CNV of Dosage Sensitive Regulatory Genes. Genes 12:10, pages 1606.
Crossref
Mukesh Maharjan, J Keller McKowen & Craig M Hart. (2020) Overlapping but Distinct Sequences Play Roles in the Insulator and Promoter Activities of the Drosophila BEAF-Dependent scs’ Insulator . Genetics 215:4, pages 1003-1012.
Crossref
Yuankai Dong, S V Satya Prakash Avva, Mukesh Maharjan, Janice Jacobi & Craig M Hart. (2020) Promoter-Proximal Chromatin Domain Insulator Protein BEAF Mediates Local and Long-Range Communication with a Transcription Factor and Directly Activates a Housekeeping Promoter in Drosophila . Genetics 215:1, pages 89-101.
Crossref
Chih-Yi Gabriela Lin, Ju-Lan Chao, Huai-Kuang Tsai, Douglas Chalker & Meng-Chao Yao. (2019) Setting boundaries for genome-wide heterochromatic DNA deletions through flanking inverted repeats in Tetrahymena thermophila. Nucleic Acids Research 47:10, pages 5181-5192.
Crossref
Mukesh Maharjan, Robert K. Maeda, François Karch & Craig M. Hart. (2018) Using a phiC31 “Disintegrase” to make new attP sites in the Drosophila genome at locations showing chromosomal position effects. PLOS ONE 13:10, pages e0205538.
Crossref
Shraddha Shrestha, Dong-Ha Oh, J. Keller McKowen, Maheshi Dassanayake & Craig M. Hart. (2018) 4C-seq characterization of Drosophila BEAF binding regions provides evidence for highly variable long-distance interactions between active chromatin. PLOS ONE 13:9, pages e0203843.
Crossref
Nadiya Romanova & Thomas Noll. (2018) Engineered and Natural Promoters and Chromatin-Modifying Elements for Recombinant Protein Expression in CHO Cells. Biotechnology Journal 13:3, pages 1700232.
Crossref
Raphaël Mourad & Olivier Cuvier. 2018. Nuclear Architecture and Dynamics. Nuclear Architecture and Dynamics 171 185 .
S. V. Satya Prakash Avva & Craig M. Hart. (2016) Characterization of the Drosophila BEAF-32A and BEAF-32B Insulator Proteins. PLOS ONE 11:9, pages e0162906.
Crossref
Zhongchen Rao, Jun Duan, Qingyou Xia & Qili Feng. (2016) In silico identification of BESS-DC genes and expression analysis in the silkworm, Bombyx mori. Gene 575:2, pages 478-487.
Crossref
Jutta Vogelmann, Antoine Le Gall, Stephanie Dejardin, Frederic Allemand, Adrien Gamot, Gilles Labesse, Olivier Cuvier, Nicolas Nègre, Martin Cohen-Gonsaud, Emmanuel Margeat & Marcelo Nöllmann. (2014) Chromatin Insulator Factors Involved in Long-Range DNA Interactions and Their Role in the Folding of the Drosophila Genome. PLoS Genetics 10:8, pages e1004544.
Crossref
Priscillia Lhoumaud, Magali Hennion, Adrien Gamot, Suresh Cuddapah, Sophie Queille, Jun Liang, Gael Micas, Pauline Morillon, Serge Urbach, Olivier Bouchez, Dany Severac, Eldon Emberly, Keji Zhao & Olivier Cuvier. (2014) Insulators recruit histone methyltransferase d M es4 to regulate chromatin of flanking genes . The EMBO Journal 33:14, pages 1599-1613.
Crossref
Peter Heger & Thomas Wiehe. (2014) New tools in the box: An evolutionary synopsis of chromatin insulators. Trends in Genetics 30:5, pages 161-171.
Crossref
Leah H. Matzat & Elissa P. Lei. (2014) Surviving an identity crisis: A revised view of chromatin insulators in the genomics era. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1839:3, pages 203-214.
Crossref
Olga Kyrchanova, Dmitry Leman, Alexander Parshikov, Anna Fedotova, Vasily Studitsky, Oksana Maksimenko & Pavel Georgiev. (2013) New Properties of Drosophila scs and scs’ Insulators. PLoS ONE 8:4, pages e62690.
Crossref
Eric Merzetti, Joanne M. Hackett & Denise V. Clark. (2013) Transcriptional regulation of the purine de novo synthesis gene Prat in Drosophila melanogaster. Gene 518:2, pages 280-286.
Crossref
Arumugam Srinivasan & Rakesh K. Mishra. (2012) Chromatin domain boundary element search tool for Drosophila. Nucleic Acids Research 40:10, pages 4385-4395.
Crossref
H. Takagi, Y. Inai, S.-i. Watanabe, S. Tatemoto, M. Yajima, K. Akasaka, T. Yamamoto & N. Sakamoto. (2011) Nucleosome exclusion from the interspecies-conserved central AT-rich region of the Ars insulator. Journal of Biochemistry 151:1, pages 75-87.
Crossref
Miao Gan, Selina Moebus, Harald Eggert & Harald Saumweber. (2011) The Chriz–Z4 complex recruits JIL-1 to polytene chromosomes,a requirement for interband-specific phosphorylation of H3S10. Journal of Biosciences 36:3, pages 425-438.
Crossref
Peter N. Cockerill. (2011) Structure and function of active chromatin and DNase I hypersensitive sites. FEBS Journal 278:13, pages 2182-2210.
Crossref
Hina Sultana, Shreekant Verma & Rakesh K. Mishra. (2011) A BEAF dependent chromatin domain boundary separates myoglianin and eyeless genes of Drosophila melanogaster. Nucleic Acids Research 39:9, pages 3543-3557.
Crossref
Swarnava Roy, Nan Jiang & Craig M. Hart. (2010) Lack of the Drosophila BEAF insulator proteins alters regulation of genes in the Antennapedia complex. Molecular Genetics and Genomics 285:2, pages 113-123.
Crossref
Todd A. Schoborg & Mariano Labrador. (2009) The Phylogenetic Distribution of Non-CTCF Insulator Proteins Is Limited to Insects and Reveals that BEAF-32 Is Drosophila Lineage Specific. Journal of Molecular Evolution 70:1, pages 74-84.
Crossref
Maria Berkaeva, Sergei Demakov, Yuri B. Schwartz & Igor Zhimulev. (2009) Functional analysis of Drosophila polytene chromosomes decompacted unit: the interband. Chromosome Research 17:6, pages 745-754.
Crossref
Ashley M. Bushey, Edward Ramos & Victor G. Corces. (2009) Three subclasses of a Drosophila insulator show distinct and cell type-specific genomic distributions . Genes & Development 23:11, pages 1338-1350.
Crossref
Jing Zhou, Bo O. Zhou, Brian A. Lenzmeier & Jin-Qiu Zhou. (2009) Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagation. Nucleic Acids Research 37:11, pages 3699-3713.
Crossref
O. Kyrchanova, D. Chetverina, O. Maksimenko, A. Kullyev & P. Georgiev. (2008) Orientation-dependent interaction between Drosophila insulators is a property of this class of regulatory elements. Nucleic Acids Research 36:22, pages 7019-7028.
Crossref
Zoltan Villanyi, Bernadett Papp, Szilard Szikora, Imre Boros & Janos Szabad. (2008) The DRE motif is a key component in the expression regulation of the importin-β encoding Ketel gene in Drosophila. Mechanisms of Development 125:9-10, pages 822-831.
Crossref
Man Mohan, Marek Bartkuhn, Martin Herold, Angela Philippen, Nina Heinl, Imke Bardenhagen, Joerg Leers, Robert A H White, Renate Renkawitz-Pohl, Harald Saumweber & Rainer Renkawitz. (2007) The Drosophila insulator proteins CTCF and CP190 link enhancer blocking to body patterning. The EMBO Journal 26:19, pages 4203-4214.
Crossref
Robert K Maeda & François Karch. (2007) Making connections: boundaries and insulators in Drosophila. Current Opinion in Genetics & Development 17:5, pages 394-399.
Crossref
Swarnava Roy, Matthew K Gilbert & Craig M Hart. (2007) Characterization of BEAF Mutations Isolated by Homologous Recombination in Drosophila . Genetics 176:2, pages 801-813.
Crossref
Swarnava Roy, Yian Yee Tan & Craig M. Hart. (2006) A genetic screen supports a broad role for the Drosophila insulator proteins BEAF-32A and BEAF-32B in maintaining patterns of gene expression. Molecular Genetics and Genomics 277:3, pages 273-286.
Crossref
Lourdes Valenzuela & Rohinton T. Kamakaka. (2006) Chromatin Insulators. Annual Review of Genetics 40:1, pages 107-138.
Crossref
O. G. Maksimenko, D. A. Chetverina & P. G. Georgiev. (2006) Insulators of higher eukaryotes: Properties, mechanisms of action, and role in transcriptional regulation. Russian Journal of Genetics 42:8, pages 845-857.
Crossref
Matthew K Gilbert, Yian Yee Tan & Craig M Hart. (2006) The Drosophila Boundary Element-Associated Factors BEAF-32A and BEAF-32B Affect Chromatin Structure. Genetics 173:3, pages 1365-1375.
Crossref
Edward Ramos, Dolanchanpa Ghosh, Ellen Baxter & Victor G Corces. (2006) Genomic Organization of gypsy Chromatin Insulators in Drosophila melanogaster . Genetics 172:4, pages 2337-2349.
Crossref
A. A. Gortchakov, H. Eggert, M. Gan, J. Mattow, I. F. Zhimulev & H. Saumweber. (2005) Chriz, a chromodomain protein specific for the interbands of Drosophila melanogaster polytene chromosomes. Chromosoma 114:1, pages 54-66.
Crossref
Jie Wen, Suming Huang, Svetlana D. Pack, Xiaobing Yu, Stephen J. Brandt & Constance Tom Noguchi. (2005) Tal1/SCL Binding to Pericentromeric DNA Represses Transcription. Journal of Biological Chemistry 280:13, pages 12956-12966.
Crossref
Sergei Demakov, Andrei Gortchakov, Yuri Schwartz, Valery Semeshin, Sonsoles Campuzano, Juan Modolell & Igor Zhimulev. (2004) Molecular and genetic organization of Drosophila melanogasterpolytene chromosomes: evidence for two types of interband regions. Genetica 122:3, pages 311-324.
Crossref
Jason Blanton, Miklos Gaszner & Paul Schedl. (2003) Protein:protein interactions and the pairing of boundary elements in vivo. Genes & Development 17:5, pages 664-675.
Crossref
Vincent T Cunliffe. (2003) Memory by modification: the influence of chromatin structure on gene expression during vertebrate development. Gene 305:2, pages 141-150.
Crossref
Kojiro Ishii & Ulrich K. Laemmli. (2003) Structural and Dynamic Functions Establish Chromatin Domains. Molecular Cell 11:1, pages 237-248.
Crossref
Nora Engel & Marisa S Bartolomei. 2003. 89 127 .
D.N. Arnosti. (2002) Design and function of transcriptional switches in Drosophila. Insect Biochemistry and Molecular Biology 32:10, pages 1257-1273.
Crossref
Grant C. Bullock, Abby R. Thrower & Mark F. Stinski. (2002) Cellular Proteins Bind to Sequence Motifs in the R1 Element between the HCMV Immune Evasion Genes. Experimental and Molecular Pathology 72:3, pages 196-206.
Crossref
David Donze & Rohinton T. Kamakaka. (2002) Braking the silence: How heterochromatic gene repression is stopped in its tracks. BioEssays 24:4, pages 344-349.
Crossref
Ping Jiang, Jihwan Song, Guoqing Gu, Esfir Slonimsky, En Li & Nadia Rosenthal. (2002) Targeted Deletion of the MLC1f/3f Downstream Enhancer Results in Precocious MLC Expression and Mesoderm Ablation. Developmental Biology 243:2, pages 281-293.
Crossref
Pamela Geyer & Emily Kuhn. 2002. Wiley Encyclopedia of Molecular Medicine. Wiley Encyclopedia of Molecular Medicine.
Pamela Geyer & Emily Kuhn. 2002. Wiley Encyclopedia of Molecular Medicine. Wiley Encyclopedia of Molecular Medicine.
John E. SmithIIIIII & Claire Cronmiller. (2001) The Drosophila daughterless gene autoregulates and is controlled by both positive and negative cis regulation . Development 128:23, pages 4705-4714.
Crossref
Tatiana I. Gerasimova & Victor G. Corces. (2001) Chromatin Insulators and Boundaries: Effects on Transcription and Nuclear Organization. Annual Review of Genetics 35:1, pages 193-208.
Crossref
Fabienne Cléard & Pierre Spierer. (2001) Position‐effect variegation in Drosophila : the modifier Su(var)3‐7 is a modular DNA‐binding protein . EMBO reports 2:12, pages 1095-1100.
Crossref
Monique Zahn-Zabal, Michel Kobr, Pierre-Alain Girod, Markus Imhof, Philippe Chatellard, Maria de Jesus, Florian Wurm & Nicolas Mermod. (2001) Development of stable cell lines for production or regulated expression using matrix attachment regions. Journal of Biotechnology 87:1, pages 29-42.
Crossref
Raffaella Melfi, Franco Palla, Paola Di Simone, Claudia Alessandro, Larissa Calı̀, Letizia Anello & Giovanni Spinelli. (2000) Functional Characterization of the Enhancer Blocking Element of the Sea Urchin Early Histone Gene Cluster Reveals Insulator Properties and Three Essential cis-acting Sequences. Journal of Molecular Biology 304:5, pages 753-763.
Crossref
Nathalie Beaujean, Christine Bouniol-Baly, Caroline Monod, Karima Kissa, Denis Jullien, Nathalie Aulner, Claudine Amirand, Pascale Debey & Emmanuel Käs. (2000) Induction of Early Transcription in One-Cell Mouse Embryos by Microinjection of the Nonhistone Chromosomal Protein HMG-I. Developmental Biology 221:2, pages 337-354.
Crossref
D. ZicklerN. Kleckner. (1999) Meiotic Chromosomes: Integrating Structure and Function. Annual Review of Genetics 33:1, pages 603-754.
Crossref
Rakesh K. Mishra & Francois Karch. (1999) Boundaries that demarcate structural and functional domains of chromatin. Journal of Biosciences 24:3, pages 377-399.
Crossref
Adam C Bell & Gary Felsenfeld. (1999) Stopped at the border: boundaries and insulators. Current Opinion in Genetics & Development 9:2, pages 191-198.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.