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Molecular and Cellular Biology Volume 18, 1998 - Issue 12
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Gene Expression

The Evolutionarily Conserved Eukaryotic Arginine Attenuator Peptide Regulates the Movement of Ribosomes That Have Translated It

Zhong Wanga Department of Biochemistry and Molecular Biology, Oregon Graduate Institute of Science & Technology, Portland, Oregon97291-1000
,
Peng Fanga Department of Biochemistry and Molecular Biology, Oregon Graduate Institute of Science & Technology, Portland, Oregon97291-1000
&
Matthew S. Sachsa Department of Biochemistry and Molecular Biology, Oregon Graduate Institute of Science & Technology, Portland, Oregon97291-1000;b Department of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland, Oregon97201-3098Correspondence[email protected]
Pages 7528-7536 | Received 17 Jul 1998, Accepted 28 Aug 1998, Published online: 28 Mar 2023

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Jiajie Wei, Cheng Wu & Matthew S. Sachs. (2012) The Arginine Attenuator Peptide Interferes with the Ribosome Peptidyl Transferase Center. Molecular and Cellular Biology 32:13, pages 2396-2406.
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David R. Morris & Adam P. Geballe. (2000) Upstream Open Reading Frames as Regulators of mRNA Translation. Molecular and Cellular Biology 20:23, pages 8635-8642.
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Maja Hemmings-Mieszczak, Thomas Hohn & Thomas Preiss. (2000) Termination and Peptide Release at the Upstream Open Reading Frame Are Required for Downstream Translation on Synthetic Shunt-Competent mRNA Leaders. Molecular and Cellular Biology 20:17, pages 6212-6223.
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Articles from other publishers (45)

Thi Tuong Vi Dang, Jessie Colin & Guilhem Janbon. (2022) Alternative Transcription Start Site Usage and Functional Implications in Pathogenic Fungi. Journal of Fungi 8:10, pages 1044.
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Yury Zgadzay, Olga Kolosova, Artem Stetsenko, Cheng Wu, David Bruchlen, Konstantin Usachev, Shamil Validov, Lasse Jenner, Andrey Rogachev, Gulnara YusupovaMatthew S. Sachs, Albert Guskov & Marat Yusupov. (2022) E-site drug specificity of the human pathogen Candida albicans ribosome . Science Advances 8:21.
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Xifeng Li, Zhe Wang, Yunting Fu, Xi Cheng, Yan Zhang, Baofang Fan, Cheng Zhu & Zhixiang Chen. (2021) Two ubiquitin-associated ER proteins interact with COPT copper transporters and modulate their accumulation. Plant Physiology 187:4, pages 2469-2484.
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Anthony Gaba, Hongyun Wang, Trinisia Fortune & Xiaohui Qu. (2021) Smart-ORF: a single-molecule method for accessing ribosome dynamics in both upstream and main open reading frames. Nucleic Acids Research 49:5, pages e26-e26.
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Thomas E. DeverIvaylo P. IvanovMatthew S. Sachs. (2020) Conserved Upstream Open Reading Frame Nascent Peptides That Control Translation. Annual Review of Genetics 54:1, pages 237-264.
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Martine A Collart & Benjamin Weiss. (2020) Ribosome pausing, a dangerous necessity for co-translational events. Nucleic Acids Research 48:3, pages 1043-1055.
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Ivaylo P. Ivanov, Byung-Sik Shin, Gary Loughran, Ioanna Tzani, Sara K. Young-Baird, Chune Cao, John F. Atkins & Thomas E. Dever. (2018) Polyamine Control of Translation Elongation Regulates Start Site Selection on Antizyme Inhibitor mRNA via Ribosome Queuing. Molecular Cell 70:2, pages 254-264.e6.
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Cheng Wu, Ananya Dasgupta, Lunda Shen, Deborah Bell-Pedersen & Matthew S. Sachs. (2018) The cell free protein synthesis system from the model filamentous fungus Neurospora crassa. Methods 137, pages 11-19.
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Yui Yamashita, Seidai Takamatsu, Michael Glasbrenner, Thomas Becker, Satoshi Naito & Roland Beckmann. (2017) Sucrose sensing through nascent peptide-meditated ribosome stalling at the stop codon of Arabidopsis bZIP11 uORF2 . FEBS Letters 591:9, pages 1266-1277.
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Jan A. L. Van Kan, Joost H. M. Stassen, Andreas Mosbach, Theo A. J. Van Der Lee, Luigi Faino, Andrew D. Farmer, Dimitrios G. Papasotiriou, Shiguo Zhou, Michael F. Seidl, Eleanor Cottam, Dominique Edel, Matthias Hahn, David C. Schwartz, Robert A. Dietrich, Stephanie Widdison & Gabriel Scalliet. (2017) A gapless genome sequence of the fungus Botrytis cinerea . Molecular Plant Pathology 18:1, pages 75-89.
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Stephen Z. CasterKathrina Castillo, Matthew S. Sachs & Deborah Bell-Pedersen. (2016) Circadian clock regulation of mRNA translation through eukaryotic elongation factor eEF-2. Proceedings of the National Academy of Sciences 113:34, pages 9605-9610.
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Thomas E Dever, Terri Goss Kinzy & Graham D Pavitt. (2016) Mechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae . Genetics 203:1, pages 65-107.
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Chien-Hung Yu, Yunkun Dang, Zhipeng Zhou, Cheng Wu, Fangzhou Zhao, Matthew S. Sachs & Yi Liu. (2015) Codon Usage Influences the Local Rate of Translation Elongation to Regulate Co-translational Protein Folding. Molecular Cell 59:5, pages 744-754.
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Koreaki ItoShinobu Chiba. (2013) Arrest Peptides: Cis -Acting Modulators of Translation . Annual Review of Biochemistry 82:1, pages 171-202.
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Jiajie Wei, Ying Zhang, Ivaylo P. Ivanov & Matthew S. Sachs. (2013) The Stringency of Start Codon Selection in the Filamentous Fungus Neurospora crassa. Journal of Biological Chemistry 288:13, pages 9549-9562.
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Cheng Wu, Jiajie Wei, Pen-Jen Lin, Liwei Tu, Carol Deutsch, Arthur E. Johnson & Matthew S. Sachs. (2012) Arginine Changes the Conformation of the Arginine Attenuator Peptide Relative to the Ribosome Tunnel. Journal of Molecular Biology 416:4, pages 518-533.
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Richard W.P. Smith, Ross C. Anderson, Joel W.S. Smith, Matthew Brook, William A. Richardson & Nicola K. Gray. (2011) DAZAP1, an RNA-binding protein required for development and spermatogenesis, can regulate mRNA translation. RNA 17:7, pages 1282-1295.
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Daniel N Wilson & Roland Beckmann. (2011) The ribosomal tunnel as a functional environment for nascent polypeptide folding and translational stalling. Current Opinion in Structural Biology 21:2, pages 274-282.
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A. A. Bogdanov, N. V. Sumbatyan, A. V. Shishkina, V. V. Karpenko & G. A. Korshunova. (2011) Ribosomal tunnel and translation regulation. Biochemistry (Moscow) 75:13, pages 1501-1516.
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Christina C. Spevak, Ivaylo P. Ivanov & Matthew S. Sachs. (2010) Sequence Requirements for Ribosome Stalling by the Arginine Attenuator Peptide. Journal of Biological Chemistry 285:52, pages 40933-40942.
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Shashi Bhushan, Helge Meyer, Agata L. Starosta, Thomas Becker, Thorsten Mielke, Otto Berninghausen, Michael Sattler, Daniel N. Wilson & Roland Beckmann. (2010) Structural Basis for Translational Stalling by Human Cytomegalovirus and Fungal Arginine Attenuator Peptide. Molecular Cell 40:1, pages 138-146.
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Bijoyita Roy, Justin N. Vaughn, Byung-Hoon Kim, Fujun Zhou, Michael A. Gilchrist & Albrecht G. Von Arnim. (2010) The h subunit of eIF3 promotes reinitiation competence during translation of mRNAs harboring upstream open reading frames. RNA 16:4, pages 748-761.
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Rowland H. Davis. 2010. Cellular and Molecular Biology of Filamentous Fungi. Cellular and Molecular Biology of Filamentous Fungi 339 358 .
Helen Saul, Einat Elharrar, Rachel Gaash, Dror Eliaz, Meital Valenci, Tsofit Akua, Meital Avramov, Neta Frankel, Irina Berezin, Dror Gottlieb, Meirav Elazar, Ora David-Assael, Vered Tcherkas, Keren Mizrachi & Orit Shaul. (2009) The upstream open reading frame of the Arabidopsis AtMHX gene has a strong impact on transcript accumulation through the nonsense-mediated mRNA decay pathway. The Plant Journal 60:6, pages 1031-1042.
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Heather M. Hood, Daniel E. Neafsey, James Galagan & Matthew S. Sachs. (2009) Evolutionary Roles of Upstream Open Reading Frames in Mediating Gene Regulation in Fungi. Annual Review of Microbiology 63:1, pages 385-409.
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Haripriya Ramu, Alexander Mankin & Nora Vazquez-Laslop. (2009) Programmed drug-dependent ribosome stalling. Molecular Microbiology 71:4, pages 811-824.
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Elaine M. YoungmanMegan E. McDonaldRachel Green. (2008) Peptide Release on the Ribosome: Mechanism and Implications for Translational Control. Annual Review of Microbiology 62:1, pages 353-373.
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Heather M. Hood, Christina C. Spevak & Matthew S. Sachs. (2007) Evolutionary changes in the fungal carbamoyl-phosphate synthetase small subunit gene and its associated upstream open reading frame. Fungal Genetics and Biology 44:2, pages 93-104.
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Cheng Wu, Nadia Amrani, Allan Jacobson & Matthew S. Sachs. 2007. Translation Initiation: Extract Systems and Molecular Genetics. Translation Initiation: Extract Systems and Molecular Genetics 203 225 .
Christina C. Spevak, Eun-Hee Park, Adam P. Geballe, Jerry Pelletier & Matthew S. Sachs. (2006) her-2 upstream open reading frame effects on the use of downstream initiation codons. Biochemical and Biophysical Research Communications 350:4, pages 834-841.
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Cheryl A. Woolhead, Arthur E. Johnson & Harris D. Bernstein. (2006) Translation Arrest Requires Two-Way Communication between a Nascent Polypeptide and the Ribosome. Molecular Cell 22:5, pages 587-598.
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Anthony Gaba, Allan Jacobson & Matthew S. Sachs. (2005) Ribosome Occupancy of the Yeast CPA1 Upstream Open Reading Frame Termination Codon Modulates Nonsense-Mediated mRNA Decay. Molecular Cell 20:3, pages 449-460.
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Hitoshi Onouchi, Yoko Nagami, Yuhi Haraguchi, Mari Nakamoto, Yoshiko Nishimura, Ryoko Sakurai, Nobuhiro Nagao, Daisuke Kawasaki, Yoshitomo Kadokura & Satoshi Naito. (2005) Nascent peptide-mediated translation elongation arrest coupled with mRNA degradation in the CGS1 gene of Arabidopsis . Genes & Development 19:15, pages 1799-1810.
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Peng Fang, Christina C. Spevak, Cheng Wu & Matthew S. Sachs. (2004) A nascent polypeptide domain that can regulate translation elongation. Proceedings of the National Academy of Sciences 101:12, pages 4059-4064.
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Yukako Chiba, Ryoko Sakurai, Michiko Yoshino, Kimihiro Ominato, Mari Ishikawa, Hitoshi Onouchi & Satoshi Naito. (2003) S-adenosyl- l -methionine is an effector in the posttranscriptional autoregulation of the cystathionine γ-synthase gene in Arabidopsis . Proceedings of the National Academy of Sciences 100:18, pages 10225-10230.
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Xiaoping Jin, Eileen Turcott, Silvia Englehardt, Gregory J. Mize & David R. Morris. (2003) The Two Upstream Open Reading Frames of Oncogene mdm2 Have Different Translational Regulatory Properties. Journal of Biological Chemistry 278:28, pages 25716-25721.
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Peng Fang, Cheng Wu & Matthew S Sachs. (2002) Neurospora crassa supersuppressor mutants are amber codon-specific. Fungal Genetics and Biology 36:3, pages 167-175.
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Kazuhiro Kondo, Kazuya Shimada, Junji Sashihara, Keiko Tanaka-Taya & Koichi Yamanishi. (2002) Identification of Human Herpesvirus 6 Latency-Associated Transcripts. Journal of Virology 76:8, pages 4145-4151.
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G. Lynn Law, Alexa Raney, Carrie Heusner & David R. Morris. (2001) Polyamine Regulation of Ribosome Pausing at the Upstream Open Reading Frame of S-Adenosylmethionine Decarboxylase. Journal of Biological Chemistry 276:41, pages 38036-38043.
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Scott E. Gold, John W. Duick, Regina S. Redman & Rusty J. Rodriguez. 2001. Agriculture and Food Production. Agriculture and Food Production 199 238 .
Clarence Deffaud & Jean-Luc Darlix. (2000) Rous Sarcoma Virus Translation Revisited: Characterization of an Internal Ribosome Entry Segment in the 5′ Leader of the Genomic RNA. Journal of Virology 74:24, pages 11581-11588.
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Peng Fang, Zhong Wang & Matthew S. Sachs. (2000) Evolutionarily Conserved Features of the Arginine Attenuator Peptide Provide the Necessary Requirements for Its Function in Translational Regulation. Journal of Biological Chemistry 275:35, pages 26710-26719.
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Mikhail M. Pooggin, Thomas Hohn & Johannes Fütterer. (2000) Role of a Short Open Reading Frame in Ribosome Shunt on the Cauliflower Mosaic Virus RNA Leader. Journal of Biological Chemistry 275:23, pages 17288-17296.
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Zhong Wang, Anthony Gaba & Matthew S. Sachs. (1999) A Highly Conserved Mechanism of Regulated Ribosome Stalling Mediated by Fungal Arginine Attenuator Peptides That Appears Independent of the Charging Status of Arginyl-tRNAs. Journal of Biological Chemistry 274:53, pages 37565-37574.
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Marilyn Kozak. (1999) Initiation of translation in prokaryotes and eukaryotes. Gene 234:2, pages 187-208.
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