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Gene Expression

Autophosphorylation in the Activation Loop Is Required for Full Kinase Activity In Vivo of Human and Yeast Eukaryotic Initiation Factor 2α Kinases PKR and GCN2

Patrick R. Romanoa Laboratory of Eukaryotic Gene Regulation, National Institute of Child Health and Human Development
,
Minerva T. Garcia-Barrioa Laboratory of Eukaryotic Gene Regulation, National Institute of Child Health and Human Development
,
Xiaolong Zhangb Laboratory of Biophysical Chemistry, National Heart, Lung, and Blood Institute, Bethesda, Maryland20892
,
Qizhi Wangc Cold Spring Harbor Laboratory, Cold Spring Harbor, New York11724
,
Deborah R. Taylorc Cold Spring Harbor Laboratory, Cold Spring Harbor, New York11724
,
Fan Zhanga Laboratory of Eukaryotic Gene Regulation, National Institute of Child Health and Human Development
,
Christopher Herringb Laboratory of Biophysical Chemistry, National Heart, Lung, and Blood Institute, Bethesda, Maryland20892
,
Michael B. Mathewsc Cold Spring Harbor Laboratory, Cold Spring Harbor, New York11724
,
Jun Qinb Laboratory of Biophysical Chemistry, National Heart, Lung, and Blood Institute, Bethesda, Maryland20892
&
Alan G. Hinnebuscha Laboratory of Eukaryotic Gene Regulation, National Institute of Child Health and Human DevelopmentCorrespondence[email protected]
 show all
Pages 2282-2297 | Received 24 Oct 1997, Accepted 22 Dec 1997, Published online: 27 Mar 2023

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Jordan C Wengrod & Lawrence B Gardner. (2015) Cellular adaptation to nutrient deprivation: crosstalk between the mTORC1 and eIF2α signaling pathways and implications for autophagy. Cell Cycle 14:16, pages 2571-2577.
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Andrés Gárriz, Hongfang Qiu, Madhusudan Dey, Eun-Joo Seo, Thomas E. Dever & Alan G. Hinnebusch. (2009) A Network of Hydrophobic Residues Impeding Helix αC Rotation Maintains Latency of Kinase Gcn2, Which Phosphorylates the α Subunit of Translation Initiation Factor 2. Molecular and Cellular Biology 29:6, pages 1592-1607.
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Gregory A. Peters, Rune Hartmann, Jun Qin & Ganes C. Sen. (2001) Modular Structure of PACT: Distinct Domains for Binding and Activating PKR. Molecular and Cellular Biology 21:6, pages 1908-1920.
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Zan Xu & Bryan R. G. Williams. (2000) The B56α Regulatory Subunit of Protein Phosphatase 2A Is a Target for Regulation by Double-Stranded RNA-Dependent Protein Kinase PKR. Molecular and Cellular Biology 20:14, pages 5285-5299.
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Yuguang Shi, Krishna M. Vattem, Ruchira Sood, Jie An, Jingdong Liang, Lawrence Stramm & Ronald C. Wek. (1998) Identification and Characterization of Pancreatic Eukaryotic Initiation Factor 2 α-Subunit Kinase, PEK, Involved in Translational Control. Molecular and Cellular Biology 18:12, pages 7499-7509.
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Hongfang Qiu, Minerva T. Garcia-Barrio & Alan G. Hinnebusch. (1998) Dimerization by Translation Initiation Factor 2 Kinase GCN2 Is Mediated by Interactions in the C-Terminal Ribosome-Binding Region and the Protein Kinase Domain. Molecular and Cellular Biology 18:5, pages 2697-2711.
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