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Adrianne Wong, Silvia Bogni, Pille Kotka, Esther de Graaff, Vivette D'Agati, Frank Costantini & Vassilis Pachnis. (2005) Phosphotyrosine 1062 Is Critical for the In Vivo Activity of the Ret9 Receptor Tyrosine Kinase Isoform. Molecular and Cellular Biology 25:21, pages 9661-9673.
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R. M. Melillo, M. Santoro, S.-H. Ong, M. Billaud, A. Fusco, Y. R. Hadari, J. Schlessinger & I. Lax. (2001) Docking Protein FRS2 Links the Protein Tyrosine Kinase RET and Its Oncogenic Forms with the Mitogen-Activated Protein Kinase Signaling Cascade. Molecular and Cellular Biology 21:13, pages 4177-4187.
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Articles from other publishers (55)
Lucas A. B. Fisher & Frieder Schöck. (2022) The unexpected versatility of ALP/Enigma family proteins. Frontiers in Cell and Developmental Biology 10.
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Adam Packard, William H. Klein & Frank Costantini. (2021) Ret signaling in ureteric bud epithelial cells controls cell movements, cell clustering and bud formation. Development 148:9.
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Anthony A. Firek, Mia C. Perez, Amber Gonda, Li Lei, Iqbal Munir, Alfred A. Simental, Frances E. Carr, Benjamin J. Becerra, Marino De Leon & Salma Khan. (2017) Pathologic significance of a novel oncoprotein in thyroid cancer progression. Head & Neck 39:12, pages 2459-2469.
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Stephen C. Kales, Marion M. Nau, Anand S. Merchant & Stanley Lipkowitz. (2014) Enigma Prevents Cbl-c-Mediated Ubiquitination and Degradation of RETMEN2A. PLoS ONE 9:1, pages e87116.
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Mahaut de Vareilles, Luis E. C. Conceição, Pedro Gómez-Requeni, Katerina Kousoulaki, Nadège Richard, Pedro M. Rodrigues, Kari E. Fladmark & Ivar Rønnestad. (2012) Dietary Lysine Imbalance Affects Muscle Proteome in Zebrafish (Danio rerio): A Comparative 2D-DIGE Study. Marine Biotechnology 14:5, pages 643-654.
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Cho-Rok Jung, Jung Hwa Lim, Yoonjung Choi, Dae-Ghon Kim, Koo Jeong Kang, Seung-Moo Noh & Dong-Soo Im. (2010) Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice. Journal of Clinical Investigation 120:12, pages 4493-4506.
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Zhao Lin, Valeria Pontelli Navarro, Kathryn M. Kempeinen, Lea M. Franco, Qiming Jin, James V. Sugai & William V. Giannobile. (2010) LMP1 regulates periodontal ligament progenitor cell proliferation and differentiation. Bone 47:1, pages 55-64.
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M. Zheng, H. Cheng, I. Banerjee & J. Chen. (2009) ALP/Enigma PDZ-LIM Domain Proteins in the Heart. Journal of Molecular Cell Biology 2:2, pages 96-102.
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Jennifer Krcmery, Troy Camarata, Andre Kulisz & Hans-Georg Simon. (2010) Nucleocytoplasmic functions of the PDZ-LIM protein family: new insights into organ development. BioEssays 32:2, pages 100-108.
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Michelle Croyle, Nagako Akeno, Jeffrey A. Knauf, Doriano Fabbro, Xu Chen, Jacqueline E. Baumgartner, Heidi A. Lane & James A. Fagin. (2008) RET/PTC-Induced Cell Growth Is Mediated in Part by Epidermal Growth Factor Receptor (EGFR) Activation: Evidence for Molecular and Functional Interactions between RET and EGFR. Cancer Research 68:11, pages 4183-4191.
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Doyeob Kim & Gregory R. Dressler. (2007) PTEN modulates GDNF/RET mediated chemotaxis and branching morphogenesis in the developing kidney. Developmental Biology 307:2, pages 290-299.
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Jan Willem B. de GrootThera P. LinksJohn T. M. PlukkerCornelis J. M. Lips & Robert M. W. Hofstra. (2006) RET as a Diagnostic and Therapeutic Target in Sporadic and Hereditary Endocrine Tumors. Endocrine Reviews 27:5, pages 535-560.
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Angela Iervolino, Rodolfo Iuliano, Francesco Trapasso, Giuseppe Viglietto, Rosa Marina Melillo, Francesca Carlomagno, Massimo Santoro & Alfredo Fusco. (2006) The Receptor-Type Protein Tyrosine Phosphatase J Antagonizes the Biochemical and Biological Effects of RET-Derived Oncoproteins. Cancer Research 66:12, pages 6280-6287.
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Yong Zhang, Wei Zhu, Yong-Gang Wang, Xiu-Jie Liu, Li Jiao, Xuan Liu, Zhao-Huan Zhang, Chang-Lin Lu & Cheng He. (2006) Interaction of SH2-Bβ with RET is involved in signaling of GDNF-induced neurite outgrowth. Journal of Cell Science 119:8, pages 1666-1676.
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H. Peterziel & J. Strelau. 2006. Handbook of Neurochemistry and Molecular Neurobiology. Handbook of Neurochemistry and Molecular Neurobiology
69
91
.
Rebecca Hui Kwan Lee, Wai Lap Wong, Chin Ho Chan & Siu Yuen Chan. (2006) Differential effects of glial cell line-derived neurotrophic factor and neurturin in RET/GFRα1-expressing cells. Journal of Neuroscience Research 83:1, pages 80-90.
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Romain Barrès, Teresa Gonzalez, Yannick Le Marchand-Brustel & Jean-François Tanti. (2005) The interaction between the adaptor protein APS and Enigma is involved in actin organisation. Experimental Cell Research 308:2, pages 334-344.
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Gary Loughran, Nollaig C. Healy, Patrick A. Kiely, Merei Huigsloot, Nancy L. Kedersha & Rosemary O'Connor. (2005) Mystique Is a New Insulin-like Growth Factor-I-regulated PDZ-LIM Domain Protein That Promotes Cell Attachment and Migration and Suppresses Anchorage-independent Growth. Molecular Biology of the Cell 16:4, pages 1811-1822.
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Charles A. Bosworth, Chau-Wen Chou, Richard B. Cole & Bernard B. Rees. (2005) Protein expression patterns in zebrafish skeletal muscle: initial characterization and the effects of hypoxic exposure. PROTEOMICS 5:5, pages 1362-1371.
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Crossref
Todd G. Kroll. 2005. Molecular Basis of Thyroid Cancer. Molecular Basis of Thyroid Cancer
85
106
.
Eri Miyagi, Milena Braga-Basaria, Elena Hardy, Vasily Vasko, Kenneth D. Burman, Sissy Jhiang, Motoyasu Saji & Matthew D. Ringel. (2004) Chronic expression of RET/PTC 3 enhances basal and insulin-stimulated PI3 kinase/AKT signaling and increases IRS-2 expression in FRTL-5 thyroid cells. Molecular Carcinogenesis 41:2, pages 98-107.
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Ange Krause, William Zacharias, Troy Camarata, Barbara Linkhart, Evelyn Law, Antje Lischke, Erik Miljan & Hans-Georg Simon. (2004) Tbx5 and Tbx4 transcription factors interact with a new chicken PDZ-LIM protein in limb and heart development. Developmental Biology 273:1, pages 106-120.
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Tokumitsu Watanabe, Masahiro Akishita, Takashi Nakaoka, Hong He, Yukiko Miyahara, Naohide Yamashita, Youichiro Wada, Hiroyuki Aburatani, Masao Yoshizumi, Koichi Kozaki & Yasuyoshi Ouchi. (2004) Caveolin-1, Id3a and two LIM protein genes are upregulated by estrogen in vascular smooth muscle cells. Life Sciences 75:10, pages 1219-1229.
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Efisio Puxeddu, Norisato Mitsutake, Jeffrey A. Knauf, Sonia Moretti, Hei W. Kim, Karen A. Seta, Diane Brockman, Leslie Myatt, David E. Millhorn & James A. Fagin. (2003) Microsomal Prostaglandin E2 Synthase-1 Is Induced by Conditional Expression of RET/PTC in Thyroid PCCL3 Cells through the Activation of the MEK-ERK Pathway. Journal of Biological Chemistry 278:52, pages 52131-52138.
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Jeffrey A Knauf, Hiroaki Kuroda, Saswata Basu & James A Fagin. (2003) RET/PTC-induced dedifferentiation of thyroid cells is mediated through Y1062 signaling through SHC-RAS-MAP kinase. Oncogene 22:28, pages 4406-4412.
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Crossref
Dong Wook Kim, Jung Hwan Hwang, Jae Mi Suh, Ho Kim, Jung Hun Song, Eun Suk Hwang, Il Young Hwang, Ki Cheol Park, Hyo Kyun Chung, Jin Man Kim, Jongsun Park, Brian A. Hemmings & Minho Shong. (2003) RET/PTC (Rearranged in Transformation/Papillary Thyroid Carcinomas) Tyrosine Kinase Phosphorylates and Activates Phosphoinositide-Dependent Kinase 1 (PDK1): An Alternative Phosphatidylinositol 3-Kinase-Independent Pathway to Activate PDK1. Molecular Endocrinology 17:7, pages 1382-1394.
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Franca Esposito, Giuseppa Chirico, Nicola Montesano Gesualdi, Inmaculada Posadas, Rosario Ammendola, Tommaso Russo, Giuseppe Cirino & Filiberto Cimino. (2003) Protein Kinase B Activation by Reactive Oxygen Species Is Independent of Tyrosine Kinase Receptor Phosphorylation and Requires Src Activity. Journal of Biological Chemistry 278:23, pages 20828-20834.
Crossref
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K Kurokawa, K. Kawai, M. Hashimoto, Y. Ito & M. Takahashi. (2003) Cell signalling and gene expression mediated by RET tyrosine kinase. Journal of Internal Medicine 253:6, pages 627-633.
Crossref
Crossref
George B Segel, Timothy J Woodlock, Jia Xu, Liqiong Li, Raymond E Felgar, Daniel H Ryan, Marshall A Lichtman & Nancy Wang. (2003) Early gene activation in chronic leukemic B lymphocytes induced toward a plasma cell phenotype. Blood Cells, Molecules, and Diseases 30:3, pages 277-287.
Crossref
Crossref
Maria Grazia Borrello, Elena Mercalli, Carla Perego, Debora Degl'Innocenti, Simona Ghizzoni, Elena Arighi, Barbara Eroini, Maria Grazia Rizzetti & Marco A Pierotti. (2002) Differential interaction of Enigma protein with the two RET isoforms. Biochemical and Biophysical Research Communications 296:3, pages 515-522.
Crossref
Crossref
Tea Vallenius & Tomi P. Mäkelä. (2002) Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein. Journal of Cell Science 115:10, pages 2067-2073.
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Toshifumi Fukuda, Kazutoshi Kiuchi & Masahide Takahashi. (2002) Novel Mechanism of Regulation of Rac Activity and Lamellipodia Formation by RET Tyrosine Kinase. Journal of Biological Chemistry 277:21, pages 19114-19121.
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Crossref
Yunshan Liu, Gregory A. Hair, Scott D. Boden, Manjula Viggeswarapu & Louisa Titus. (2002) Overexpressed LIM Mineralization Proteins Do Not Require LIM Domains to Induce Bone. Journal of Bone and Mineral Research 17:3, pages 406-414.
Crossref
Crossref
Ming-Jer Tang, Yi Cai, Si-Jie Tsai, Yang-Kao Wang & Gregory R. Dressler. (2002) Ureteric Bud Outgrowth in Response to RET Activation Is Mediated by Phosphatidylinositol 3-Kinase. Developmental Biology 243:1, pages 128-136.
Crossref
Crossref
Patrick D. Brophy, Lance Ostrom, Katherine M. Lang & Gregory R. Dressler. (2001) Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene. Development 128:23, pages 4747-4756.
Crossref
Crossref
Masahide Takahashi. (2001) The GDNF/RET signaling pathway and human diseases. Cytokine & Growth Factor Reviews 12:4, pages 361-373.
Crossref
Crossref
Giovanni Tallini, Sylvia L. Asa & Gregory N. Fuller. (2001) RET Oncogene Activation in Papillary Thyroid Carcinoma. Advances in Anatomic Pathology 8:6, pages 345-354.
Crossref
Crossref
Maria Vittoria Barone, Leandra Sepe, Rosa Marina Melillo, Alba Mineo, Giovanni Santelli, Carmen Monaco, Maria Domenica Castellone, Donatella Tramontano, Alfredo Fusco & Massimo Santoro. (2001) RET/PTC1 oncogene signaling in PC Cl 3 thyroid cells requires the small GTP-binding protein Rho. Oncogene 20:48, pages 6973-6982.
Crossref
Crossref
Elena Mercalli, Simona Ghizzoni, Elena Arighi, Luisella Alberti, Romina Sangregorio, Maria T Radice, Mikhail L Gishizky, Marco A Pierotti & Maria Grazia Borrello. (2001) Key role of Shc signaling in the transforming pathway triggered by Ret/ptc2 oncoprotein. Oncogene 20:27, pages 3475-3485.
Crossref
Crossref
Kei Kurokawa, Toshihide Iwashita, Hideki Murakami, Hironori Hayashi, Kumi Kawai & Masahide Takahashi. (2001) Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction. Oncogene 20:16, pages 1929-1938.
Crossref
Crossref
Carmen Monaco, Roberta Visconti, Maria Vittoria Barone, Giovanna Maria Pierantoni, Maria Terasa Berlingieri, Claudia De Lorenzo, Alba Mineo, Giancarlo Vecchio, Alfredo Fusco & Massimo Santoro. (2001) The RFG oligomerization domain mediates kinase activation and re-localization of the RET/PTC3 oncoprotein to the plasma membrane. Oncogene 20:5, pages 599-608.
Crossref
Crossref
Rosa Marina Melillo, Francesca Carlomagno, Gabriella De Vita, Pietro Formisano, Giancarlo Vecchio, Alfredo Fusco, Marc Billaud & Massimo Santoro. (2001) The insulin receptor substrate (IRS)-1 recruits phosphatidylinositol 3-kinase to Ret: evidence for a competition between Shc and IRS-1 for the binding to Ret. Oncogene 20:2, pages 209-218.
Crossref
Crossref
Valerie Besset, Rizaldy P. Scott & Carlos F. Ibáñez. (2000) Signaling Complexes and Protein-Protein Interactions Involved in the Activation of the Ras and Phosphatidylinositol 3-Kinase Pathways by the c-Ret Receptor Tyrosine Kinase. Journal of Biological Chemistry 275:50, pages 39159-39166.
Crossref
Crossref
Sissy M Jhiang. (2000) The RET proto-oncogene in human cancers. Oncogene 19:49, pages 5590-5597.
Crossref
Crossref
Hironori Hayashi, Masatoshi Ichihara, Toshihide Iwashita, Hideki Murakami, Yohei Shimono, Kumi Kawai, Kei Kurokawa, Yoshiki Murakumo, Tsuneo Imai, Hiroomi Funahashi, Akimasa Nakao & Masahide Takahashi. (2000) Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor. Oncogene 19:39, pages 4469-4475.
Crossref
Crossref
George J. Siegel & Neelima B. Chauhan. (2000) Neurotrophic factors in Alzheimer’s and Parkinson’s disease brain. Brain Research Reviews 33:2-3, pages 199-227.
Crossref
Crossref
Noritaka Nakagawa, Masahiko Hoshijima, Miho Oyasu, Naoaki Saito, Katsuyuki Tanizawa & Shun'ichi Kuroda. (2000) ENH, Containing PDZ and LIM Domains, Heart/Skeletal Muscle-Specific Protein, Associates with Cytoskeletal Proteins through the PDZ Domain. Biochemical and Biophysical Research Communications 272:2, pages 505-512.
Crossref
Crossref
Tea Vallenius, Keijo Luukko & Tomi P. Mäkelä. (2000) CLP-36 PDZ-LIM Protein Associates with Nonmuscle α-Actinin-1 and α-Actinin-4. Journal of Biological Chemistry 275:15, pages 11100-11105.
Crossref
Crossref
Michael C. Brown & Christopher E. Turner. (2000) Characterization of paxillin LIM domain-associated serine threonine kinases: Activation by angiotensin II in vascular smooth muscle cells. Journal of Cellular Biochemistry 76:1, pages 99-108.
Crossref
Crossref
Yoshihiro Ishiguro, Toshihide Iwashita, Hideki Murakami, Naoya Asai, Ken-ichi Iida, Hidemi Goto, Tetsuo Hayakawa & Masahide Takahashi. (1999) The Role of Amino Acids Surrounding Tyrosine 1062 in Ret in Specific Binding of the Shc Phosphotyrosine-Binding Domain1. Endocrinology 140:9, pages 3992-3998.
Crossref
Crossref
Hideki Murakami, Toshihide Iwashita, Naoya Asai, Yohei Shimono, Yosuke Iwata, Kumi Kawai & Masahide Takahashi. (1999) Enhanced Phosphatidylinositol 3-Kinase Activity and High Phosphorylation State of Its Downstream Signalling Molecules Mediated by Ret with the MEN 2B Mutation. Biochemical and Biophysical Research Communications 262:1, pages 68-75.
Crossref
Crossref
Toshihide Iwashita, Masashi Kato, Hideki Murakami, Naoya Asai, Yoshihiro Ishiguro, Shinji Ito, Yosuke Iwata, Kumi Kawai, Masami Asai, Kei Kurokawa, Hiroshi Kajita & Masahide Takahashi. (1999) Biological and biochemical properties of Ret with kinase domain mutations identified in multiple endocrine neoplasia type 2B and familial medullary thyroid carcinoma. Oncogene 18:26, pages 3919-3922.
Crossref
Crossref
Pamela M. Guy, Daryn A. Kenny & Gordon N. Gill. (1999) The PDZ Domain of the LIM Protein Enigma Binds to β-Tropomyosin. Molecular Biology of the Cell 10:6, pages 1973-1984.
Crossref
Crossref
Matti S. Airaksinen, Alexey Titievsky & Mart Saarma. (1999) GDNF Family Neurotrophic Factor Signaling: Four Masters, One Servant?. Molecular and Cellular Neuroscience 13:5, pages 313-325.
Crossref
Crossref
Paul W Schenk & B.Ewa Snaar-Jagalska. (1999) Signal perception and transduction: the role of protein kinases. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1449:1, pages 1-24.
Crossref
Crossref